📢 Call for Papers — CHP Special Issue Cancer evolves. Tumors adapt. Resistance emerges. Therapies fail. 📘 Molecular Understanding & Therapeutic Targeting of Cancer Heterogeneity and Plasticity 💡 OA | No fees 📅 Apr 30, 2026 (priority; open after) 🔗 www.pivotscipub.com/chp #CancerResearch

📘 CHP Archive Spotlight #12 Original Research (2026) | Wu et al. YAP1 depletion in gastric cancer peritoneal metastases (GCPM) induces compensatory TAZ activation, sustaining tumor progression and metastasis. Reveals adaptive oncogenic signaling via the YAP1–TAZ axis www.pivotscipub.com/chp/3/1/0004

📘 CHP Archive Spotlight #11 Review (2026) | Rasouli et al. HPV-driven cancers show viral integration, genomic instability, and immune escape. This review examines how HPV heterogeneity fuels therapy resistance and highlights combination therapies. 🔗 doi.org/10.47248/chp... #HPV

📘 CHP Archive Spotlight #10 Review (2024) | Markl et al. Cancer is not only molecular — it is physical. Tumors reflect: • Stiffness & ECM remodeling • Cell mechanics • Electrical/thermal states • Solid stress Biophysics shapes heterogeneity. 🔗 doi.org/10.47248/chp... #TumorBiophysics #Mechanobiology

📘 CHP Archive Spotlight #09 Review (2024) | Balk & Goodrich From development to cancer progression, phenotypic plasticity shapes cell fate. This review dissects the molecular drivers linking homeostasis to therapy resistance. 🔗 doi.org/10.47248/chp... #PhenotypicPlasticity #Epigenetics

📘 CHP Archive Spotlight #08 Original Research (2024) | Lim et al. TFAP4 directly reactivates TERT in non-HBV HCC — independent of promoter mutation. CTCF → TFAP4 → TERT axis drives telomerase activation, especially in alcohol-related tumors. 🔗 doi.org/10.47248/chp... #HCC #TERT #Telomerase

📘 CHP Archive Spotlight #07 Review (2024) | Her et al. How do noncoding RNAs drive cancer plasticity? miRNAs, lncRNAs, circRNAs & tRNA fragments regulate stemness, EMT, epigenetics & therapy resistance — with emerging roles as biomarkers & targets. 🔗 doi.org/10.47248/chp... #ncRNA #CancerStemCells

📘 CHP Archive Spotlight #06 Perspective (2024) | Kondo Targeting cancer stem cell heterogeneity & plasticity with a miRNA-dependent AAV system designed to eradicate diverse CSC populations while minimizing side effects. 🔗 doi.org/10.47248/chp... #CancerStemCells #Heterogeneity #AAV

📘 CHP Archive Spotlight #05 Perspective (2024) | Jamroze, Liu & Tang AR signaling inhibitors induce lineage plasticity in prostate cancer, promoting stem-like, mesenchymal & neural states driving CRPC & NEPC progression. 🔗 doi.org/10.47248/chp... #LineagePlasticity #CRPC #CancerStemCells

📘 CHP Archive Spotlight #04 Review (2024) | Chen et al. Linking phenotype ↔ genotype at single-cell resolution. Reviews tools for isolating and profiling individual cells — key to understanding plasticity, metastasis & therapy resistance. 🔗 doi.org/10.47248/chp... #SingleCell #CancerHeterogeneity

📘 CHP Archive Spotlight #02 Original Research (2024) | Wong et al. 📢 New mechanistic insight in CRC liver metastasis: Cancer cells upregulate SMLR1 to engage immunosuppressive TAMs, reshaping the liver niche. 🔗 www.pivotscipub.com/chp/1/1/0003... #ColorectalCancer #TumorMicroenvironment

📘 CHP Archive Spotlight #01 Inaugural Editorial (2024) EIC Dean Tang outlines CHP’s mission: dissecting how cancer heterogeneity, plasticity & tumor microenvironment interactions drive therapy resistance, metastasis & recurrence. 📖 CHP 2024;1(1):0001 🔗 doi.org/10.47248/chp... #TumorPlasticity

📢 We review the mechanisms of immune evasion in breast cancer, focusing on how cellular plasticity and the tumor immune microenvironment cooperate to suppress detection. 🧬 @chp-pivot.bsky.social www.pivotscipub.com/chp/3/1/0001... #breastcancer #ImmuneEvasion #TumorMicroenvironment #CellPlasticity

Fresh from the oven!! Our latest review published in @chp-pivot.bsky.social about the origin of PDAC CSCs and their inner and outer determinants by Diego Navarro and myself. A little bit of inflammation, a little bit of CIN, tons of stemness!! Enjoy!! www.pivotscipub.com/chp/2/2/0010

CHP focuses on cancer cell states, lineage plasticity, and tumor microenvironment dynamics. Since 2024, we’ve published research and reviews advancing this area. Explore: www.pivotscipub.com/chp Looking forward to engaging with the cancer plasticity and heterogeneity community here on Bluesky.