"Reality is the new fiction they say / Truth is truer these days, truth is man-made / If you're here cause you want to be entertained." - Sleater-Kinney (2005)

It's weird. A hundred years ago, only rich people owned cars while everyone else owned horses. Now only rich people own horses while everyone else owns cars. How the stables have turned.

Welcome to the bayou #AHA2025

Industry postdoc opening! My sister dept @ @boehringerglobal.bsky.social Germany (Obesity Research area) is seeking a post-PhD candidate with significant technical expertise in brain ephys & imaging. Feel free to DM me with any further questions.

Voice of reason. #3R #Replace www.nature.com/articles/d41...

I don't think that microdosing a GLP-1 will achieve the first endpoint in this ad, nor do I believe any of the other "outcomes" have been validated in in a fully randomized, placebo-controlled study.

On NAD+ supplement: "The science is almost nonexistent." www.nytimes.com/2025/10/23/w...

Just before everything turns brown for 5 months.

Visceral adipose tissue acts as an endocrine organ that is involved in pathophysiological signalling affecting several organ systems, which contributes to the development of #MetabolicSyndrome https://www.nature.c...

Inaugural bluesky post to say the AWS outage has me thinking about @timmaughan.bsky.social and Infinite Detail even more than normal lol. Feel like every other week something happens that gives me a reason to recommend your book dude

calnewport.com/is-sora-the-... If anything, I'm spending more time offline due to the growing mess of AI slop. Not a bug, but a feature?

Pre-Nor'easter fall vibes with Samson #eastcoast #beastcoast

Oh, the “vomiting ferret” model is absolutely a real thing - I’ve encountered it in my own drug discovery career. They’re one of the smallest animals that show this response- weirdly, rodents can’t do it at all.

Living his best life. Amazing.

Why do optical illusions work? The culprit may be a group of neurons in the visual cortex that help us fill in missing information. @markjohnpost.bsky.social for @washingtonpost.com dives into the science and how it could help demystify visual hallucinations: www.washingtonpost.com/science/2025...

60 seconds of therapy

Despite the lack of recent rain, there sure are plenty of amphibians around my property #herpetology #moss

quick while the government is shut down let’s all switch to metric

Kind of weird that bluesky has a specific feed dedicated to #moss (and the outdoors), but I'm here for it. Here are some of the latest from my little 2-acre plot in the woods.

We have developed a new workflow to map in 3D at single-cell resolution whole human organs. Prof. Rong Fan (Yale) mapped out immune cell populations in the vicinity of ovarian precancerous lesions in healthy women and found no enrichment. More here: www.biorxiv.org/content/10.1...

Even though I've spent most of my career focused on obesity, I'll be at @americanheart.bsky.social in NOLA in early November as my research group at @boehringerglobal.bsky.social builds up our cardiorenal focus. See you there!

That title is a mouthful 😆 Congrats to Darleen, @seeleyrj.bsky.social, @henningfenselau.bsky.social and team. www.sciencedirect.com/science/arti...

It's great to see that the piles of money and enormous amounts of electricity and other resources used to train these models has produced such stunning and useful results. And I'm SUPER glad that google now always shows me this garbage.

From the lizard venom and John Eng, in licensing to clinical development and approval April 28 2005. The remarkable story of Amylin Pharma and exenatide www.nature.com/articles/s42...

Remember to sign up for the Gut-Brain Axis @keystonesymposia.bsky.social meeting in March 2026! Upcoming deadlines: Scholarship Deadline: November 18, 2025 Short Talk Abstract Deadline: November 18, 2025 Organizers: Martin G. Myers, Jr., Darleen A. Sandoval and Tune H Pers keysym.us/KSGutBrain26

Chasing outcomes is often a recipe for disappointment. When you focus on the process, you can find success even if the outcome isn't what you expected. Do the small things each day & you'll develop better habits that will help you reach your goal in the long run.

This article is truly impressive, both for the significance of its findings and the enormous amount of work it represents! Briefly, it demonstrates that the gut-brain vagal axis exerts a considerable influence on dopamine-dependent reward-related processes... 1/n www.biorxiv.org/content/10.1...

Identification of a neural basis for energy expenditure in the mouse arcuate hypothalamus: Neuron www.cell.com/neuron/fullt...

By identifying murine Agrp neurons as a target of LacPhe, the authors suggest this exercise-induced metabolite might have therapeutic benefits in various human diseases. www.nature.com/articles/s42...

FYI, neuro friends: To support ongoing research into mGluR1 function, we now offer two highly selective positive allosteric modulators of mGluR1, BI02982816 and its chemically optimized reiteration BI-1752. Access them for free via #opnMe: www.opnme.com/molecules/mg...

New commentary out from @kevinh-phd.bsky.social and @juliabelluz.bsky.social www.nytimes.com/2025/09/10/o...

"It depends" is the answer to nearly any issue or problem. Embracing nuance and being okay muddling through uncertainty is a vital skill to develop. Not having an instant answer isn't a sign of hedging or not knowing. It's a sign of deep thinking and consideration.

#seenonmyrun: Greyhound telephone pole art and the infamous Tonka truck tree.

More impactful Promethion‑powered research from Dr. O MacDougald & colleagues at University of Michigan - FGF21 + sTGFBR2 gene therapy eases lipodystrophic insulin resistance, temperature‑dependently! 🧪 insight.jci.org/articles/vie...

It’s been a journey! I’m thrilled my book with @kevinh-phd.bsky.social is finally coming out this month! @barnesandnoble.com is offering 25% off pre-orders for FOOD INTELLIGENCE. Place your order at BN.com between now and Friday with code PREORDER25 #BNPreorder www.barnesandnoble.com/w/food-intel...

Congratulations to Sait Şeyhanlı @sonjalorenzlab.bsky.social on securing a coveted Boehringer Ingelheim PhD Fellowship 🎉! The Boehringer Ingelheim Fonds supports exceptional young scientists worldwide in their PhD projects in basic biomedical science. ‬‬‬‬

Calling all collaborators! My colleagues in Biberach are interested in further understanding the mechanisms of GPR149 in both psychiatric- and obesity-related behaviors. Check out the funding opportunity here: www.opnme.com/opn2experts/...

Gladiolas in bloom. The plants I seem to neglect the most on my property somehow end up doing the best?

This is an excellent video from @nytimes.com on the enormous health impact NIH budget cuts and delayed funding will have now and decades in the future. Pass it on!

Dog is my co-pilot.

Potential risk of GLP1RA "yo-yo" effect: Will it lead to an enhanced risk of sarcopenic obesity in older adults? We probably need a few more years with the current molecules in patients to know for sure. www.sciencedirect.com/science/arti...

Our in vivo group is looking to hire a talented lab scientist to support the CKD and MASH portfolio. DM me if you have any specific questions! boehringer-ingelheim.talentry.com/share/job/71...

Online now: Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism

We are both ready for some rain and cooler weather.

My department in bucolic Ridgefield, CT has a senior lab head position open, with a focus on the CKD/MASH portfolio and leading junior scientists: boehringer-ingelheim.talentry.com/share/job/71... #MASH #CKD #boehringer