Did you know that all nuclear pore complexes (NPCs) are not the same? @luskinglab.bsky.social propose a new hypothesis for how nuclear mechanics may impact the compositional plasticity of NPCs with implications for tissue-specific diseases caused by NPC dysfunction. www.nature.com/articles/s41...

Excited to share that my paper on Tau–Microtubule interactions is now published in Nature Physics!🎉 Our work shows that tau goes beyond stabilizing microtubules—it also promotes the removal of defects in the microtubule lattice. www.nature.com/articles/s41...

Thanks to the Cornell Chronicle for highlighting our work! news.cornell.edu/stories/2025...

In small enclosed structures (like vesicles), the flickering of individual ion channels can have substantial effects on membrane voltage and internal ion concentrations. Mean-field conductance-based models break down. We studied what happens: www.biorxiv.org/content/10.1...

How often do you buy a book, then the author makes a series of free videos to help you read/understand the book?! Check out @longformmath.bsky.social 's Youtube videos (youtu.be/2QcJB-Yl7h8?...), On a related note, guess how many times the red and black lines cross with each other😉

Gave my departmental ‘tenure talk’ today, and here is the ‘highlight’ 🤗

Huan and I wrote a review on the rheology and interfacial properties of biomolecular condensates: link.springer.com/article/10.1... Hope it will be useful when you navigate through the large amount of relevant literature! Some of our key points are illustrated in the graphs below.

The Biochemistry Dept at the University of Washington has 2 open positions at the Asst/Assoc Prof level! Please apply and come be my colleague in Seattle! Great science, great students, great collaborations, and a lovely city

Now published! pubs.acs.org/doi/10.1021/...

www.nature.com/articles/s41... Glad to contribute to this new study from Ben Schuster's lab! Check out how phosphorylation changes the membrane interaction of SARS-CoV-2 N protein condensates:

Check out this awesome story about the work of an awesome (former) undergrad in our lab @hollycheng.bsky.social who worked closely w @zs-biophys.bsky.social‬ Howard Stone, James Roggeveen & Huan Wang. bioengineering.princeton.edu/news/2025/st...

A mechano-resistance mechanism in skin adapts to terrestrial locomotion: Cell www.cell.com/cell/fulltex...

Reminds me of this recent article www.science.org/content/arti...

Interfacial effects determine nonequilibrium phase behaviors in chemically driven fluids www.pnas.org/doi/10.1073/...

Many thanks to Ishan and Vishva for writing this nice "News and Views" article on our collaboration with Jie Xu's group (@jie-xu.bsky.social )!

Over the past 6 months, I've been truly amazed by the level of service and dedication of NSF employees. Amid an impossible situation like, you know, a wrecking ball to science, another agency evicting you from your headquarters... THANK A PROGRAM OFFICER for their dedicated efforts amid the chaos.

Review: Accept immediately. With revisions, because we need figures!

Submitted a review two weeks late (for good reasons...); told by the system to check out the other reviewer comments; found the other reviewer comments not yet available🙂

Check it out at PNAS today. Thank you Alexandre for the collaboration!! PK Mem probes offer long time-lapse imaging of cell membrane dynamics. Made possible by Jing Ling, Yitong Liu, and all the collaborators! Available @spirochrome.com

Asked ChatGPT to add a face to a cell (microtubule labelled) we imaged:

Paired t-test 😂

Ordered family meal from Panda Express. Now enjoying these wisdom from lucky cookies 😂

Let me blow your mind further by pointing out that water striders can climb a meniscus by cleverly pulling and pushing on the water surface to locally bend it, and we can tell from the shadow (darker or lighter!) which way it is! Check out Supplementary Video 3 in this amazing paper by Hu & Bush!

🧪 BREAKING (good news): Senate subcommittee says NO! to Trump's proposed slashes to NASA & NSF funding. Today, the subcommittee said to keep NASA + NSF funding at $33.9 billion, the same as in FY24. See 7:15 below. Full Senate appropriations committee meets tomorrow about it. 🧵 1/3

Super excited to share that our new study is published @natneuro.nature.com today!! Here we show that intersectin and endophilin form condensates between the active zone and the reserve pool and maintain synaptic vesicles near the active zone for rapid replenishment. rdcu.be/evi5y

Thank you to everyone who made this happen🥺🥺🥺

Our recent collaboration with Ben Schuster's lab to characterize "protein surfactants"! www.biorxiv.org/content/10.1...

Just ordered something from Sigma 😲

Awesome paper alert! Learn about spectrum of chromatin condensate morphologies due to elastocapillary effects (no, liquids do not need to be spherical!), from amazing duo @dnamystrom.bsky.social & Hongbo Zhao, w/ important contributions from co-authors Jorine Eeftens, Mikko Haataja, Andrej Kosmrlj.

Had a blast at the Telluride lipids workshop. Here is a picture of me “trying” to impress @leventallab.bsky.social 😂

Check out this nice podcast, highlighting our recent work with Cliff Brangwynne @brangwynnelab.bsky.social and Howard Stone’s groups. Led by the amazing (not yet Dr.) Holly Cheng! podcasts.apple.com/us/podcast/b...

Very glad and honored to contribute to this cool study. Check out the latest story on my favorite protein "NINJ1": www.nature.com/articles/s41...

Happy to share our latest paper published in Science Advances @aaas.org. Congratulations to my incredible students, Sandeep @sandeeprai.bsky.social, Roopali @roopsiek.bsky.social (co-first author), Anusha @anushasarbahi.bsky.social & Ashish @ashishjoshi.bsky.social. www.science.org/doi/10.1126/...

What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. www.nature.com/articles/s41... in @nature.com ‬ with @yaotianzhang.bsky.social Denes Hnisz & team.

We recorded a talk about our recent work on condensates, take a look before it's taken down! youtu.be/SP-FDbmBZV8?...

We are looking for a postdoc to study biomolecular condensates and/or mechanosensitive membrane proteins. Please help spread the news 🙏 sites.rutgers.edu/shi-lab/look...

Very glad to contribute to this cool study of of nucleoli, led by former Princeton undergrad Holly Cheng! P.S., we all looked much younger when we were working on this project (see picture below) 😁

Nucleoli as biomolecular bubble tea! Congrats to former Princeton ugrad Holly Cheng (now GS @MIT) ->Holly's senior thesis work, a close collab w Roggeveen Wang & @zs-biophys.bsky.social‬ &Stone. Come for the cool movies & stay for the viscoelasticity! www.pnas.org/doi/10.1073/pnas.2407423122

I wrote about the government's attacks on Harvard. Hope this reaches a few persuadable minds. prosyn.org/PhWi74r?h=Ky...

Can sensing of membrane receptors be switched on at tunable threshold densities, without active processing? Proud to share this preprint led by the awesome Dr Foley, please check it out!

First Ph.D. student from the lab! Congratulations, Dr. Wang 🎉

An (urgent) academic question: who is your academic parent-in-law? Is that your wife/husband's advisor, or your advisor's wife/husband?

A suite of bridged rhodamine dyes for fluorescence microscopy, named BriDyes, offers excellent brightness, photostability, solubility, cell permeability, and resistance to photoblueing. www.nature.com/articles/s41...

The Romanian president (Nicușor Dan) beat Terence Tao @teorth.bsky.social in the International Mathematical Olympiads of both 1987 and 1988 😲

Now out in JACS. pubs.acs.org/doi/full/10.... Grateful to thoughtful reviewers who found some errors in our model and encouraged us to make a better one! A renaissance in magnetobiology is coming...

this is cool!

OK, at least part of it has to do with babies starting to roll over and craw after about 5 months...

This is so cool! Single channel recording through Ca2+ imaging in membrane tethers: www.biorxiv.org/content/10.1...

Increased burden of rare risk variants across gene expression networks predisposes to sporadic Parkinson’s disease: Cell Reports www.cell.com/cell-reports...

Thanks Yuping for hosting, that was fun!