Happy Valentine's Weekend to all, very fortunate to my fantastic group & them being eachothers' Valentines :)

So much already this Fall! Fantastic posters by our undergraduates, Celebrating Nora's 1% on her F31, our annual pumpkin picking outing, & invited Book Chapter just accepted this week (will share when out). Happy Fall to All :)

Happy to have another Summer complete for SUPERS'25! They are a phenomenal group that I'm fortunate to interact with for our 10wk program. Special Congratulations to the Winners of the Stephen W. Tuttle Research Award Orly Perez Frid & Kaitlin Chung & hope to have this program another 5+yrs!

More of this please: “As biologists, we know that rigid binary definitions of sex and gender are not supported by scientific observations,” the authors wrote. “As people, we know that insistence on these rigid definitions harms and marginalizes many who do not easily fit within them.”

📌 Pin to your calendars! 🧪 Protein synthesis and translational control🧪 ⏳Don't miss these deadlines Abstracts Jun 1 ✏️ Register On-site Jul 23 Virtual Aug 27 🖱️https://buff.ly/hs1wWTS #ProteinSynthesis ##TranslationalControl #mRNAtranslation

Cool new work explaining the dynamics of mRNA translation with the ribosome to inhibit SG localization- by the Moon Lab #ribosomes #uORF #mRNATranslation #StressResponse genesdev.cshlp.org/content/earl...

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/... Highlight: Translation dysregulation in cancer as a source for targetable antigens www.sciencedirect.com/science/arti...

🚨New paper!🚨 A comprehensive take on the origins and evolution of translation factors & how these essential players evolved across the tree of life. 🌍🧬 Led by Evrim Fer @uwmadisonmdtp.bsky.social grad student! 👏 Free access: www.sciencedirect.com/science/arti... @cp-trendsgenetics.bsky.social

They are cutting cancer research. They are cutting cancer research. They can deny it all they want, but they are cutting cancer research. These are the cuts being made the DoD CDMRP cancer funding mechanism www.fightcancer.org/sites/defaul...

Oooo pretty new MassSpec data coming in (only slightly hung-up on the 1/78 samples that wasn't perfect lol)

Looking forward to sharing our research @rutgersupress.bsky.social tomorrow @12 Nelson D406

Excited to share our review article "Finding functional microproteins", published in @TrendsGenetics. It was fun writing it together with Alex and @FeiyueYang1 in the lab. #microprotein authors.elsevier.com/a/1kNCscQbJB...

Excited to share our @cp-trendsgenetics.bsky.social Spotlight Article highlighting the development of #ribo-seq by @nickingolia.bsky.social and how it has revolutionized the study of #microproteins! www.sciencedirect.com/science/arti...

Time to share our organelle proteome paper out in @cellcellpress.bsky.social: doi.org/nzwz We created a spatial map of human cells using organelle immunoprecipitation at scale. Locate your fav protein among the 7,600 we mapped across 19 subcellular compartments: organelles.sf.czbiohub.org/ 1/3 🧪

If you had any question that microproteins / micropeptides are the next wave in #cancer 🌊 Well this is the paper that you need to read. 🔎 microproteins 🧬 💻 #RNAsky #genomics #bioinformatics www.biorxiv.org/content/10.1...

The first preprint of 2025! Together with Matvei, @halfacrocodile.bsky.social, & our amazing team, we are excited to share PARADE: an AI framework for designing mRNA UTRs with enhanced cell-type specificity & stability. www.biorxiv.org/content/10.1...

Congratulations to @fendtlab.bsky.social amd @ginevradoglioni.bsky.social for this massive work "Aspartate signalling drives lung metastasis via alternative translation" www.nature.com/articles/s41...

Great work from Gloria Brar’s group on the role of paralogous RNA helicases in the heat shock response. Surprising increase in growth at high temperature and impact of a short motif! Also important implications of the role of biomolecular condensation. Awesome www.cell.com/cell-reports...

Direct RNA sequencing is featured as one of The Scientist 2024 Top 10 Innovations. Read to find out how the latest direct RNA #nanopore sequencing kit and flow cell has improved accuracy and output, enabling a more complete picture of the landscape of RNA Read: www.the-scientist.com/2024-top-10-...

What is the best distance-adjusting, multi-channel to go from Eppendorf 1.5/2mL tubes to 96-well plate format?

Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...

Applications for our SUPERS 2025 Summer Internship open today! Share with undergraduates you know interested in learning/studying translational medicine from Cancer Bio, Radiobiology & Imaging, to Medical Physics med.upenn.edu/supers/

@themodzlab.bsky.social worlds colliding ;)

Look forward to reading this in full!

SPATIAL PROTEOMICS is the Method of the Year 2024!!! 🤩🤩🤩 www.nature.com/articles/s41...

Excited to reveal specific reactive oxygen species as sentinel molecules that control localized protein degradation at #mitochondria to adjust electron transport chain abundance, with many implications for the role of ROS in development and disease. www.cell.com/molecular-ce...

Looking forward to enjoying the full taste of RNA! www.embl.org/about/info/c...

Are you a scientist working or interested in RNA Translation? Join our starter pack and share ideas, methodologies and tips to advance our knowledge in how life came to be! #RNA #ribosome go.bsky.app/VN78eTo

The conserved landscape of RNA modifications and transcript diversity across mammalian evolution https://www.biorxiv.org/content/10.1101/2024.11.24.624934v1

Awesome new work on tRNAs and staibilty! Check it out: www.science.org/doi/10.1126/...

endorse, and supported by data from Hannah Toutkoushian in her dissertation. glad to see more about eIF2A escholarship.org/uc/item/6pr6...

#DarkGenome #NoncodingGenome fanatics - this one is for you. 👇 🧬 💻 🧪 #genomics #bioinformatics

Fellow #RNA lovers, please repost 🙏: 2 ERC-funded Post-doc positions are available in our lab to investigate #RNA structural ensemble and their dynamics in living cells. Application link: t.co/pYJ3H3j705

If you are interested in #RNA regulation, translational control, cancer progression, and/or therapy resistance... (+cookies&Shenanigans): The Conn Lab is #Hiring for Postdoc and senior research positions @PennMedicine full description: rnasociety.memberclicks.net/postdoc-and-...

Happy to welcome three Summer Undergraduate Scholars to the lab this Summer: Vinny Dong (PURM), Keiko Luke (SUPERS), and Hemanta Adhikari (PURM). Exited to see & share the discoveries they will make on mRNA selection in response to prostate cancer therapy! csconnlab.com/team

Looking forward to seeing Andrew Hsieh tonight and hearing about some of their lab's fantastic research tomorrow. It's been too long :) Come join us in Smilow @12 (lunch included) to learn more about how RNA is awesome!

Happy Spring to all! Quick Conn Lab updates: Ian received the NSF & Ashley will be attending Penn CancerBio for PhD program :) I'm also truly honored to have received the 2024 Michael P. Nusbaum Graduate Student Mentoring Award. Grateful for such spectacular Mentees!

Happy New Year from the Conn Lab! Celebrated with great company and gift exchange/heisting ;) Great year growing the team, collaborations, and moving along lots of new research. Best wishes to all for 2024! #RNAisAwesome #ConnLabShenanigans

Spurred on by ribosome profiling and other cool methods, translation elongation has grown into a whole field with new surprises all the time (and new relevance for vaccine mRNAs!). Here’s our latest on why synonymous codons aren’t all the same. (Thread) www.biorxiv.org/content/10.1...

We are looking for housekeeping genes (meaning ubiquitously expressed across tissues) that only exist in mouse or human (no ortholog). Anybody know some examples?

Embracing Fall together... apple picking, picking, corn maze, bonfires and #connlabshenanigans