Rammap: github.com/jwanglab/ram... Minimap2 v2.31: github.com/lh3/minimap2...

The Drosophila melanogaster Genetic Reference Panel, Version 3 (DGRP3) https://www.biorxiv.org/content/10.64898/2026.05.29.728783v1

David Reich – Why the Bronze Age was an inflection point in human evolution • "Instead of being quiescent, natural selection is everywhere."

This is really big (if it works!)—a big limitation for the use of R in simulation up to this point has been memory bloat. I’ve had to turn off parallel processing/reduce the number of workers many times in my {targets} workflows due to OOM errors. Hopefully this will solve that problem #RStats

Johnson et al. analyse the genomic signatures of fluctuating selection and introduce statistical strategies for distinguishing it from other modes of selection in population genetic studies. 🔗 doi.org/10.1093/gbe/evag082 #genome #evolution

Reposting this old thread on the "Pervasive findings of directional selection" from ancient DNA. While the authors extended their results in various ways, I think many of these points still stand.

The 16th DrosEU Meeting kicks off this Monday, April 13! 🧬 A great scientific program and discussions await: droseusuz.sciencesconf.org #DrosEU2026 @droseu.bsky.social With support from @occitanie.bsky.social, @umontpellier.bsky.social, GIS Fruit, IGH, GenoPolys, and @sfgenetique.bsky.social

🪰 🧬16th #DrosEU2026 Workshop & Satellite #DrosophilaSuzukii Meeting Conference will take place 13–17 April 2026 in #Montpellier, France 🇫🇷. We look forward to connecting with colleagues across Europe to discuss new research in #Drosophila #genomics #evolution & #CitizenScience +info 👉 droseu.net

“Looking is not the same as seeing, after all, and this may be why some of us may stumble upon discoveries in data that others have already analyzed.” #stats #statistics #DataExploration

I think this is our lab's first paper in a proper ecology journal. We are now card carrying ecologists!

📘 Nouveau livre ! Introduction à la statistique bayésienne avec le logiciel R Découvrez pas à pas la statistique bayésienne et sa mise en œuvre dans R : théorème de Bayes, MCMC, priors, régression, GLM/GLMM et comparaison/validation de modèles. Aux éditions Quae 🙏 📷 Crédit photo : Yann Raulet

Médecin de formation, António Lobo Antunes avait vécu de près les horreurs de la guerre coloniale en Angola. Il en tire un livre coup de poing : le cul de judas. Suivront des dizaines d’autres ouvrages décortiquant le Portugal. Il décède à l’âge de 83 ans. www.lusa.pt/article/4669...

Phenotypic and Genomic Evidence of Adaptive Tracking in Thermal Tolerance of Wild Populations of an Invasive Drosophila. https://www.biorxiv.org/content/10.64898/2026.02.26.708249v1

For those interested, a new version (v3.1.0) of poolfstat is now on CRAN, including new functions and updates, new stats (Fh, Fd, FdM) implemented in sliding.windows.fstat; and a revised vignette. [https://cran.r-project.org/web/packages/poolfstat/index.html](cran.r-project.org/web/packages...)

The #fly community aims to achieve a comprehensive genomic study of the Drosophilidae family. @pankajd.bsky.social @bernardkim.bsky.social @petrovadmitri.bsky.social @darrenobbard.bsky.social present a comparative gene annotation for 301 #Drosophilidae species @plosbiology.org 🧪 plos.io/4c3pyrI

Michel Portal est mort. Il avait 90 ans. Avec lui disparaît l’un des musiciens français les plus singuliers de ces cinquante dernières années, un artiste qui n’a jamais accepté de choisir entre Mozart et Charlie Parker. Entretien de 2015 avec ce musicien inclassable https://l.franceculture.fr/uXP

Very nice work led @drghawkes.bsky.social, showing convergence between rare and common genetic associations, using whole-genome sequencing data to evaluate the contribution of rare non-coding variants for commonly studied anthropometric traits 🧪🧬 www.nature.com/articles/s41...

No bull: This Austrian cow has learned to use tools. Learn more: https://scim.ag/3LYTXNd

Ancestral sequence reconstruction using generative models https://www.biorxiv.org/content/10.64898/2026.01.18.700141v1

For #StandingStoneSunday a #Neolithic human-shaped stela with a necklace and a belt, found in La Serre, Aveyron (#France). The lines on the cheeks are interpreted as facial #tattoos or scars. Dating 3000-2500 BC. In the late neolithic period several cultures living....🧵 1/2 🏺 #archaeology 📷 me

Haller, Ralph & Messer present SLiM 5, a major extension of the SLiM simulation framework for simulating multiple chromosomes, enabling a heightened level of realism for full-genome simulations. 🔗 doi.org/10.1093/molbev/msaf313 #evobio #molbio #compbio

New paper out in the Proceedings of the National Academy of Sciences. We identify regulatory variants shaping embryonic heat tolerance in Drosophila, linking lab selection to clinal and seasonal patterns in wild populations. Link: www.pnas.org/doi/10.1073/...

Now published in gigascience: academic.oup.com/gigascience/.... Key messages: SVs are highly enriched in low-complexity/tandem-repeat regions and are harder to call. They behave differently from transposon insertions. Always stratify if you study SVs.

Now published in Algorithms for Molecular Biology: link.springer.com/article/10.1.... Key message: a tiny CNN model with 7k parameters can capture main splice signals across vertebrates+insect and halves the minimap2 & miniprot junction error rate. I always use this new feature now.

"The era of the business idiot" freakonometrics.hypotheses.org/87139

this is how you science: "What’s True About the Evolution of Men’s Greater Average Height?- Why men are taller than women may have nothing to do with testosterone—or sexual selection." from @dunsworth.bsky.social and @prosocialworld.bsky.social www.prosocial.world/posts/whats-...

A nice opinion paper (doi.org/10.1016/j.pb... ) from @anneroulin.bsky.social that highlights the need for caution when generalizing about the importance of TEs in local plant adaptation. #TEsky #transposon

Now TWO great new papers on why frequencies of disease genes rarely match expectations Here was the first: www.nature.com/articles/s41...

GWAS has been an incredible discovery tool for human genetics: it regularly identifies *causal* links from 1000s of SNPs to any given trait. But mechanistic interpretation is usually difficult. Our latest work on causal models for this is out yesterday: www.nature.com/articles/s41... A short🧵:

RegEvol: detection of directional selection in regulatory sequences through phenotypic predictions and phenotype-to-fitness functions https://www.biorxiv.org/content/10.1101/2025.11.26.690685v1

Excited to share our latest preprint! @mheuertz.bsky.social & I just completed a review covering methods and empirical studies on adaptive introgression in a climate context. We likely missed a few refs & ideas, so your feedback is highly welcome (ideally by email)! Preprint➡️ doi.org/10.32942/X2B...

The domestic cat may be a far more recent arrival to Europe than previously thought, a new Science study. finds. The results offer new insight into one of humanity’s most enigmatic animal companions and identify North Africa as the cradle of the modern housecat. Learn more: https://scim.ag/44kov1S

I taught (and co-taught) a course on human population genetics from 2000-2024. Having retired, I'm now making all the course materials public: github.com/alanrogers/p... #popgen #evbio

We set out to investigate polygenic footprints of altitude adaptation in a moth species, but instead we uncovered a major selective sweep at genes often associated with insecticide resistance @prrnhd.bsky.social @schifanoalexandre.bsky.social @mgda76.bsky.social @cbgpmontpellier.bsky.social

An efficient, accessible solution for #genome annotation in both research and applied settings www.nature.com/articles/s41...

Début 2025, un gigantesque incendie a ravagé plus de la moitié de l’île Amsterdam. De retour sur place plusieurs mois après, des scientifiques tentent d’en estimer les conséquences sur ce havre de biodiversité à la croisée de l’océan Indien et de l’Antarctique.

Thrilled to finally share the magnum opus of my PhD that focuses on the genetic basis of evolutionary change! Specifically, we know we can map the genetic basis of a trait, but can we tell which genes will underlie the trait shift when it evolves? doi.org/10.1101/2025...

SG: The 'forgotten' curve - the problem of p values. The chance that your replicate experiment of an experiment with p=0.05 will be reproducible is only 0.5 - it's a toss up! Science publication is Darwinian: a survival pressure to publish. royalsocietypublishing.org/doi/full/10.... #IRICSydney

Le groupe LVMH de Bernard Arnault va devenir entièrement propriétaire du magazine économique « Challenges » et des revues « Sciences et Avenir » et « La Recherche ». Les salariés craignent de voir leur indépendance s'envoler. Lire l'article ➡️ https://l.reporterre.net/S0B

This is out now: www.sciencedirect.com/science/arti... Association between lactase persistence and height in the past (indicating people with the persistence allele were better nourished by drinking milk than those without it) provides a potential explanation for why it was under strong selection.

We are in Bluesky and we are happy to share our two last consortium publications: the DrosEU expanded DEST dataset and a Continent-wide study of phenotypic differentiation among European #Drosophila melanogaster populations (1/7)

Genetic architectures of #ComplexTraits vary widely. @yuvalsim.bsky.social @jkpritch.bsky.social @gs2747.bsky.social &co show these diffs arise from mutational target size & heritability per site; when controlled for, all tested traits have similar architectures @plosbiology.org 🧪 plos.io/47mZXqT

7 reasons to use Bayesian inference! statmodeling.stat.columbia.edu/2025/10/11/7...

Just published an interactive article about a magical algorithm known as the Burrows-Wheeler Transform, which powers sequence alignment tools like bowtie and bwa: sandbox.bio/concepts/bwt It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.

Molecular evolution of dietary shifts in ladybirds 🐞 expansions of digestive & detoxifying #gene families in the herbivorous ladybirds, & absence of most plant cell wall-degrading enzymes in the ladybirds from the transition to carnivory link.springer.com/article/10.1...

Red devil spiders from the Canary Islands have a genome half the size of mainland counterparts - Pisarenco, @jrozasub.bsky.social et al. show how purifying selection against slightly deleterious DNA and TE insertions is the primary mechanism. 🔗 doi.org/10.1093/molbev/msaf206 #evobio #molbio #TEsky

Does #dengue virus hijack #mosquitoes' brain? Study led by Felix Hol @pasteur.fr discovered that infected mosquitoes take smaller blood meals. As a result, they bite more often, and potentially infect infect more people. (video in French with English subtitles available) youtu.be/2u_qckfAQa4?...

Dogs are humanity's best friend—but how long has it been that way? 🐕 This Science study investigated ancient dog genomes, revealing a complicated genetic legacy that reflects a long, shared history with humans. Learn more on #InternationalDogDay: https://scim.ag/41mQvR6

For those interested: 🚀 BayPass v3.1 released! 🔹 Improved MCMC adaptive phase 🔹 Computation reduced >6X with default (recommended) options, while keeping similar accuracy 🔹 Plus other minor edits 📖 Details in the manual / changelog 🔗 Repo: forge.inrae.fr/mathieu.gaut...

interesting pre-print arxiv.org/abs/2408.07300