We continue with the talk from @icrlordlab.bsky.social focusing on the complexity of synthetic lethality in cancer and how we can move forward in exploiting it @eurocancerdepmap.bsky.social

We are back, starting the afternoon session with a joint talk by Debora Sesia/ @ciriellolab.bsky.social and @aurorasavino.bsky.social / @ioriolab.bsky.social showing their work on the functional assessment of Variants of Unknown Significance through cancer dependency map data analysis

Next we have @emanuelvgo.bsky.social , presenting the work on Minimal Libraries and use of AI-Synthetic Augmentation of CRISPR-Cas9 Screens for Drug Target Discovery

@colmr.bsky.social takes the stage to share the work of his group that aims to understand and predict synthetic lethality between paralogs in cancer

And we finish this session with @epetsalaki.bsky.social showing the potential of using CRISPR data to study context specific signalling and drug responses

Last but not least, we are thrilled to have representatives from academia, industry, foundations and publishers to share with us their take during the roundtable discussion on Bridging Sectors for Translational Impact!

We start with Carmen Herranz-Ors from @sangerinstitute.bsky.social giving us an overview of the impressive work done to generate Tumour Organoid Biobank and develop a 3D Dependency Map @eurocancerdepmap.bsky.social

Now @alejandrapcelab.bsky.social is taking us through the multidimensional map of early adaptation to treatment and how targeting cell plasticity can prevent childhood cancer relapse @eurocancerdepmap.bsky.social

The last session starts with Lodewyk Wessels from @nkinl.bsky.social sharing the work on perturbation response models!

@emanuelvgo.bsky.social insisting the metaphors used in @eurocancerdepmap.bsky.social presentations have strong Portuguese representation 😄

The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social

To wrap up the second session, Roland Rad from the Institute of Molecular Oncology and Functional Genomics is sharing their work on mapping genetic interactions in cancer evolution and therapy @eurocancerdepmap.bsky.social

First session of the @eurocancerdepmap.bsky.social symposium and so much fantastic work presented already! #CancerResearch #TranslationalScience #plasticity

pre-writing a devastating obituary for your enemy is god-tier hating of a kind you don’t often see anymore. renaissance haterism. beautiful stuff.

🚨 THIS IS NOT A DRILL 🚨 We’ve just seen this, by creator “Menapian” - a 4,998-piece set of the Great Exhibition (1851) Crystal Palace - complete with a bonus Megalosaurus and Ichthyosaur… beta.ideas.lego.com/product-idea...

CUH Cancer Support Service are teaming up with local organisations to run a #MentalHealthAwarenessWeek Wellbeing Event on the 16 May at the Cambridge Cancer Help Centre, CB22 5JT. 💚 Come along and find out how local services and teams can assist with mental health. @cuh.nhs.uk

@dereklowe.bsky.social puts it perfectly yet again! #facepalm #AI #machinelearning #dontbelievethehype

No one realized it until recently, but a new drug was forming inside some of the patient-controlled-anaesthesia pumps used in hospitals. Beware the Mannich condensation:

Today I lost an NIH grant training clinicians to do research about intimate partner violence with perinatal women. More women are murdered in the perinatal period than die of obstetric complications. I didn't just lose a grant. We lost an entire cohort of people building careers to prevent that.

If this story checks out according to the below, it is insane and shameful. As I asked on the blog the other day: "What are we turning into?"

If teams forming around the 'Rewiring Cancer Cells' or 'TME Dynamics' Grand Challenges would like to include our high-throughput organoid co-culture signalling technologies please get in touch!

Termination notices going out this afternoon to more than 300 employees of the National Cancer Institute. Access likely ends today. Four weeks paid leave and that’s it. Strong power move for Team Cancer.

Fantastic to see fellow @newnhamcollege.bsky.social alumna @carolcooper.bsky.social this evening at Hart’s bookshop - can highly recommend ‘The History of Medicine in Twelve Objects’ #Medicine #MedicalHistory #HartsBookshop

Fascinating paper on how different races/ethnicities respond differently to anticancer therapies - such an important thing to understand for personalised medicine #CancerResearch aacrjournals.org/cancerdiscov...

Not the banner you want seeing over this article from … checks notes … 8 days ago

Post the amazing science things you have done with federal funding.

If you have been affected by the fires in LA, or are concerned about your ability to keep precious Drosophila strains going during the latest funding crisis, we will host your strains as a backup. Please email me. Please amplify. If you are also able to host fly strains, add your name as well.

At #FOG2025 and interested in drug discovery? Shruti Shikhare will be talking about how we are using #KnowledgeGraphs and #MachineLearming to gain insights - 4.35pm at the Data-Driven Drug Discovery Stage

Do you know a UK-based wheelchair user who works in a lab and would be willing to user-test our prototype of what is believed to be the first-ever lab coat adapted for wheelchair users? Please share far & wide! Interest form: forms.office.com/e/66FhcQjqRT More info: www.ucl.ac.uk/ucl-east/new...

Fabulous Post-Doc Fellowship opportunities 😍 Information on how to get in touch below 👇🏽 www.blackincancer.com/opportunities Black in Cancer (not on BSky I think)

I love this.

Are there any science sleuths from Africa here? Do you know any? Trying to diversify my network. Science sleuth = anyone scanning the scientific literature for problems or potential fraud, in images, tables, statistics, etc. Hit me in DM or here. Thank you ❤️

Seeing images and photos without alt text. Come on folks - we can do better than that. It's a minute (if that) of extra time to make your post more accessible.

Excellent opportunity for a dynamic post-doctoral researcher to join PELi_Cam @ University of Cambridge, and lead exciting end-of-life care research Supported by myself, Prof Stephen Barclay and ARC PEoLC colleagues. 80-100% FTE post. Pls share widely! More details: www.jobs.cam.ac.uk/job/49229/

We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics

We also have 2 bioinformatician / computational biologist / computational scientist positions available in the lab (pre and post-doctoral level). Focus on epigenetic, transcriptomic, and ML. #cfDNA #liquidbiopsy One week left to apply! www.cruk.manchester.ac.uk/recruitment/...

Look like some cool opps here 👀- UCL is offering 7 fully funded Research Opportunity scholarships for under-represented Black and Asian minority ethnic groups. The deadline for applications is 10 January 2025: www.ucl.ac.uk/scholarships...

Download our database of 492 (!) funding opportunities for EARLY-CAREER FACULTY AND RESEARCHERS. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download freely here: research.jhu.edu/rdt/funding-...

Here are some free/open-source sites for the preparation of scientific illustrations, including icon libraries: bioicons.com, scidraw.io, bioart.niaid.nih.gov, inkscape.org, biogdp.com, reactome.org/icon-lib