A new review from the Doudna Lab lab on tissue-targeted in vivo delivery of gene editors: https://www.nature.com/articles/s41587-025-02945-w #CRISPR #delivery

Treatments for autoimmune diseases have big shortcomings, including high cost and supply shortages. A alternative developed this year from the #RavetchLab achieves the same effectiveness at a fraction of the dose. #RockefellerScience #YearInReview 🔗: https://bit.ly/3HFdsbs

Intracellular competition shapes plasmid population dynamics | Science www.science.org/doi/10.1126/...

1/9 Metagenomics lets us read microbiomes in nature without cultivation, but writing (editing) them in their native context is still a major challenge. Meet MetaEdit: a platform for pathway-scale metagenomic editing inside the gut microbiome. science.org/doi/10.1126/...

Very interesting read! #synbio www.tandfonline.com/doi/full/10....

Excited to launch my postdoc at the Cleveland Clinic Lerner Research Institute! 🧪 In Prof. Dwidar’s lab, I’m harnessing bacterial synthetic biology 🦠to pioneer new therapeutics and shape the future of precision medicine. Let’s do this! 🚀#synbio #PostdocJourney #ClevelandClinic

Wow: Plastic → Tylenol? 🧪♻️💊 A biocompatible Lossen rearrangement—a reaction never seen in nature—occurring INSIDE E. coli Bacteria engineered to convert PET plastic → Tylenol in <24h, with 92% yield + low emissions Stunning blend of chemistry and synthetic biology www.nature.com/articles/s41...

When academics say industries were running after them for recruitment, but they chose a path of passion instead!

The 'Oscar' of food prizes goes to a Brazilian who harnessed the power of bacteria Mariangela Hungria found microbes that were good at capturing nitrogen from the air and turning it into fertilizer for crops. www.npr.org/2025/05/14/n...

Excited to share our latest work, published in a peer-reviewed journal. We studied how Gram +/- probiotic bacteria would adapt in mechanical confinements - key part in understanding the fundamentals of Engineered living materials. Read it here: pubs.acs.org/doi/10.1021/...

Finally, access to a pichia pastoris strain. Time to adapt it enough to become a truly open strain, without the $5000 buy in of the current "open" version. Worst case $20/stab and zero MTA. Evolved with love. Big thanks to @koeng101 off Twitter for sourcing! 💚

#harvard #budgetcut

Article (paywalled) about our pre-print discussing Bioengineered journal’s paper mill problem: www.nature.com/articles/d41... arxiv.org/abs/2503.21267 Thanks to @deadneanderthals.bsky.social @mortenoxe.bsky.social @elisabethbik.bsky.social @smutclyde.bsky.social for letting me tag along!

Lol I have A LOT of work to do before I get even remotely close to the level of protein expression a well designed plasmid can generate. This is pCambia2300 expressing the same RFP circuit (albeit in Agrobacterium; left) and my single copy transposon integration in BL21 Ecoli (right).

From the hasty lab: Evolved microbial diversity enables combinatoric biosensing in complex environments doi.org/10.1101/2025...

"In other words, traditional probiotics don’t really work, but you should give these new ones a try and keep an eye out for more evidence-based probiotics in the future!" #synbio #probiotics

Researchers at @mitchemistry.bsky.social have developed a new system for delivering peptide-based drugs, like GLP-1, by “painting” them on antibodies to improve and prolong their therapeutic effects. They report their results today at #ACSSpring2025: buff.ly/f6oHqxb

Happy to share our genetic toolkit designed to make your gene editing (life) easier, faster and very efficient! Also suitable to build saturated chromosomal variant libraries using oligo-recombineering with extra short homology arms! www.biorxiv.org/content/10.1...

When you grow yeast on yeast extract medium

Synthetic Biology runs on plasmids and we've got some for engineering lactobacilli that are in high demand! So, we finally did the sensible thing and deposited them with Addgene to make them easily accessible - www.addgene.org/Shrikrishnan... Thanks @sourikdey.bsky.social & @marcblanch.bsky.social

Online now: Protein-based molecular imprinting: gelatin nanotraps for interleukin-6 sequestration in inflammation cell models

Good branding

It's hard to express how lucky I feel to have a team that self-organizes a vibrant lunch together on a Saturday and are happy to have their boss there 🤓 We even got to celebrate our wonderful women in science on Women's Day! 👩‍🔬 #womensday

Genetically altered 'woolly mice' express several mammoth-like traits, including the animal's iconic coat. The cuteness, meanwhile, is a complete coincidence. That and more of the best in @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪

Exploring the principles behind antibiotics with limited resistance www.nature.com/articles/s41...

The first night ended in a burial ritual on the beach, symbolically burying our presumptions and assumptions that we brought with us from all over the world, to start the first day of work with an open mind.

These kind of research are one of the reasons why people lose their trust in science! #cancer #ridiculous forbetterscience.com/2025/02/26/t...

A former Stanford employee was convicted of altering data used in a breast cancer study after she was fired, according to the United States Department of Justice. www.kron4.com/news/bay-are...

In the bubbling world of bioreactors, lonely Lactobacilli are searching for a perfect partner. Will it be strong and stable Cyanobacteria or resourceful Microalgae? We're seeking a PhD candidate to turn microbial matchmaking into productive co-cultures! - tinyurl.com/Alacto @leibnizinm.bsky.social

First time I try an edible GMO 🤩! The purple tomato has two genes added from snapdragons (Antirrhinum) that so the resulting fruit has high levels of antioxidants (purple pigments) made in the whole tomato. And they are flavorful and delicious 😋!

Application deadline approaching! 📣 A quick reminder that the deadline to submit your application for the EngBio CDT is fast approaching! Don't miss your chance to be a part of this incredible opportunity ⚛️ Deadline: midday on Tuesday 4th March How to apply: bit.ly/EngBioCDTOx

Molecular mechanisms at the heart of modern Synthetic Biology inspire stunning choreographies at Asilomar—an unforgettable after-dinner social event! 👏

Online now: Navigating B2B and B2C business models in biotechnology

New in Nat Comm PROBIOTIC 🦠 DRUG 💊 DELIVERY 🚚 Type zero secretion system (T0SS) enables E. coli Nissle to package and deliver enzymes into the bloodstream via OMVs Demonstrated in hyperuricemic mice, this approach outperforms direct secretion for uricase therapy www.nature.com/articles/s41...

Fascinating paper about the potential of phage for local drug delivery by Brian Hsu (Va Tech) and colleagues. (also nice acknowledgment for SeqCoast Genomics @seqcoast.bsky.social!) www.nature.com/articles/s41...

Excited to share this @nature.com interview about the current state of synthetic genomics. Our work on the 57-codon E.coli genome shows that while biological complexity continues to surprise us, advanced omics & massively parallel assays now enable genome engineering & design at unprecedented scale

We celebrate International Day of Women and Girls in Science with our EIROforum partners. 🧪 The eight organisations, including EMBL, teamed up to highlight #WomenInScience across different disciplines. For more inspiration by #EMBLWomenInScience: www.embl.org/news/tag/wom... #SciComm

Science knows no gender—only curiosity, talent, and passion! Yet, women in research still face challenges. Today, we honor their achievements and encourage girls to pursue careers in science. 👩‍🔬 Let’s break down barriers and work together for a future where everyone has equal opportunities!

If the article below (from @shrikrishnans.bsky.social lab) interests you, you may want to follow the weekly curated list of Engineered Living Materials (ELMs) research articles here: biomed.news/bims-enlima/... #engineeredlivingmaterials #ELMs

Today, we've assembled experts in automation and data science to learn and discuss how to accelerate research in materials science 🚀- www.leibniz-inm.de/en/events/ac... 🧵

Engineered living materials (ELMs) have shown considerable promise for therapeutic applications. Find more information in V.S. Tadimarri et. al. #INM publication. Early view version is available: doi.org/10.1002/smll...

Congratulations @jabyrnesci.bsky.social on winning the well-deserved David Vaux Research Integrity Fellowship Award. bit.ly/4aVDilW

We're looking for a post-doctoral candidate to engineer fungi for creating sustainable Engineered Living Materials within the EIC LoopOfFun project. So, if you're looking for a place with exciting research and stable funding, apply here - leibniz-inm.softgarden.io/job/53304534...

Playing now: Tariffs, Future of Cancer and Alzheimer's, Global Debt Cycles | Wall Street Week with Matthew Schrag, Charles Piller, and myself. #Alzheimers #ImageForensics www.bloomberg.com/news/videos/...

Who knew stuffing engineered lactobacilli in a gel would make them better at secreting our engineered proteins? A pleasant surprise for us and a great outcome for engineered living materials - doi.org/10.1002/smll... @marcblanch.bsky.social @varunsays.bsky.social @leibnizinm.bsky.social

C. acnes is the most abundant bacterium on human skin. But what if we could make it the smarterst? 🦠✨ In our new @cellpress.bsky.social #CellSystems study, we programmed C. acnes to actively protect the skin for therapeutic applications! 🛡️ authors.elsevier.com/sd/article/S...

Oh this is so cool! Culture glows despite only in LB; no abx. I really think the Himar1 transposase did its thing. Fully homebrewed chromosomal integration vector, made from scratch and fully open source. Gonna add sacB and integrate my whole library lol. *happy bionerd noises*

I am sure it will invite us to contribute an article for a special issue!

REVIEW: Design and regulation of engineered bacteria for environmental release by Chris Voigt & co #microsky www.nature.com/articles/s41...