CSHL Professor David Spector and grad student Disha Aggarwal examined tissue samples from a 59-year-old woman diagnosed with stage 1 triple-negative breast cancer. Their findings could help inform clinical trials of a drug targeting the long non-coding RNA MALAT1. www.cshl.edu/breast-cance...

A new study from the Furukawa lab (@lab-furukawa.bsky.social) identifies the neurological ‘doorstops’ that keep the brain’s NMDA receptors fully or partially open. The findings could have implications for treating neurodegenerative conditions like #Alzheimers disease. www.cshl.edu/a-doorstop-f...

Synesthesia, shipwrecks, and African elephant all await you in the smelliverse! Get a guided tour from CSHL Professor Alexei Koulakov in our Cocktails & Chromosomes video. @alexkoulakov.bsky.social #NeuroSkyence youtu.be/b5i0gUz3O1I?...

Related and more painful

The mystery of medical diagnosis!

Did you know that breasts have branches? Disturbances to this tree of life can have implications for breast cancer risk. Now, three grad students in CSHL's @caoresco.bsky.social lab have developed a computer model for measuring such changes. #BreastCancerAwareness www.cshl.edu/the-magnetic...

I wrote Jane Goodall's obit for Smithsonian & throughout my reporting, I learned more about what an incredible scientific trailblazer she was. She opened doors for generations of women had such a profound impact on so many people across the world. www.smithsonianmag.com/science-natu...

I have eaten Mexican food every day for the past six days and every meal for the last three. It doesn’t feel the least bit strange. It just feels like living right. And no, I am not currently in Mexico

Plant stem cells shape how crops grow—yet their key regulators remain hidden. CSHL researchers have now mapped these rare cells in maize & Arabidopsis, uncovering new genes tied to growth & productivity. This knowledge could help breed more resilient, high-yield crops. www.cshl.edu/youve-never-...

When Bud Crawford did this to Spence the world should’ve taken more notice. Spence one of the best in generations. That’s how good Crawford is. Canelo is outmatched

Two flagship papers from the International Brain Laboratory, now out in ‪@Nature.com‬: 🧠 Brain-wide map of neural activity during complex behaviour: doi.org/10.1038/s41586-025-09235-0 🧠 Brain-wide representations of prior information in mouse decision-making: doi.org/10.1038/s41586-025-09226-1 +

Last month, the Genome Engineering: CRISPR Frontiers meeting at CSHL brought together the field’s top minds to share unpublished breakthroughs & push the frontier forward. www.cshl.edu/videos/enter...

Invasive microscopic foraminifers hitchhiked to the Long Island Sound more than a century ago, new #ScienceAdvances research finds. https://scim.ag/464QkLF

Call it one of the world’s smallest cat videos. To demonstrate an advance that could one day help build a type of quantum computer, researchers have made a cartoon of Schrödinger’s cat using hundreds of individual atoms, rearranged as often as once every 60 milliseconds. https://scim.ag/4mIDfhL

There’s been a Benz parked on on a lawn on the side of Sunrise Highway in Wantagh with a cardboard sign in the rear windshield reading “Defund Family Court.” It’s been there all week, meaning Nassau cops have chosen to let it sit there. I imagine there’s a good story in this for anyone so inclined.

Met Kool Herc today at a screening of a documentary about Antarctica. Clearly I’m exactly where I need to be in time and space.

Earth is so dope

“In bone marrow alone ~500 million cells are born every min” says Bruce Stillman. Each must duplicate 2+ meters of DNA to avoid errors that can cause cancer & autism. See more from Stillman, @crick.ac.uk’s John Diffley & @uuhsresearch.bsky.social's @jiwasa.bsky.social www.cshl.edu/licensed-to-...

#MusicChallenge 15 years of Cut Chemist "Sound of the Police." 1st listen to this international one turntable/loop pedal/mixer mix. Deep dive into original vinyl from around the world, with some hip-hop bits. The loop pedal has a mostly hypnotic effect. Best to start at the beginning!

Our latest work featured in The Scientist! Sneha Khedkar Did a great job in summarizing the work accessibly while retaining some of the fine details. Happy reading! www.the-scientist.com/batman-signa...

Kool Keith didn't care for the Native Tongues era: open.substack.com/pub/unkut/p/...

Researchers at the renowned Cold Spring Harbor Laboratory have documented 35,000 tomato branches over three years.

Consider the example of a chemical spill.

Heard this for the first time on WKCR tonight. I really need to get deeper into Material. I can’t be the first to say Trent Rezor bit this, can I? Anyway, RIP Sly Stone youtu.be/V7qkhfNmL5w?...

President & CEO Bruce Stillman reflects on decades of scientific progress & issues a call to action. As public funding declines & immigration policies tighten, the future of innovation is at risk. The U.S. must continue investing in science & the people behind it. www.cshl.edu/presidents-e...

David McCandlish (@davidmccandlish.bsky.social) & Justin Kinney (@jbkinney.bsky.social) developed a new mathematical approach to improve how we model DNA, RNA, & proteins, making it easier to interpret results & apply them in real-world settings. www.cshl.edu/in-natures-m... ‬

From reading The Hallmarks of Cancer in Spain to sharing pancakes with its author at CSHL—Lucía Téllez Pérez’s journey in cancer research came full circle. Read her inspiring story below. #CancerResearch #CSHL #ScienceLife

Joshua-Klitschko was one of the best fight weeks I ever covered and one of the best fights, 8 years ago today. Check out the video on the anniversary of the bout for my memories of this epic event and subscribe to the YouTube channel! www.youtube.com/watch?v=fqS5...

In a new Science study, researchers describe a neural circuit underlying cachexia-related apathy in a mouse model of cancer. Learn more: scim.ag/4iIQFbq #SciencePerspective

“Life exists at the interface of genetically encoded processes and environmentally driven realities. So too should the biomedical enterprise that studies it.”

Pancreatic cancer is projected to become the second-deadliest cancer by 2030, but new research from CSHL may offer a path forward. Professor David Tuveson & Research Investigator Claudia Tonelli have discovered a way to intercept pancreatic cancer before it fully forms.

I will be selling records in the back-right corner of a giant room this Sunday

🫨 www.cshl.edu/quiz/a-perce...

Had a blast working on this feature with @arkarupbanerjee.bsky.social and @benjocowley.bsky.social. Great job @margaretosborne.bsky.social as always!

Introducing @openrxiv.bsky.social, the new governance model that will operate preeminent preprint servers bioRvix and medRxiv. Learn more about the mission of this novel non-profit empowering scientists to share their research.

My esteemed colleague @misterminsoo.bsky.social is too busy getting dragged across X by K-pop enthusiasts to post here so it is incumbent on me to share this sprawling 9K-word interview of the many-ringed and -voiced @doseone.bsky.social. Do enjoy! toneglow.substack.com/p/tone-glow-...

Talk about flower power! Professor Zach Lippman and his team used CRISPR to uncover which fragments of non-coding DNA dictate how and when plants flower. Their work could help plant breeders produce more desirable crops that flower in the right place and right time. www.cshl.edu/crispr-manip...

Wrote some brain stuff

On #InternationalDayofWomenandGirlsinScience, we honor the groundbreaking contributions of women in a field long dominated by men. No Two Plants, written and directed by women, offers a glimpse into the curiosity that fueled Barbara McClintock’s revolutionary discoveries. @penlindsay.bsky.social

Can a 9,000-year-old mystery of evolution point the way to maize’s future? New @naturecomms.bsky.social paper from @joncahn.bsky.social offers leads in both “directions.” Great summary @cshlnews.bsky.social @byjenamiller.bsky.social

New research from CSHL reveals how quickly the brain adapts to sensory changes. A feedback loop in the olfactory system helps animals reframe sounds and smells in new contexts and fine-tune their responses in real-time. 👃👂

“Serling was following a path laid down by writers and artists in a lot of different cultures who had more to lose than their income—including ones who were, at that very moment, being persecuted by dictators.” — I wrote about Rod Serling today. No reason. www.rogerebert.com/features/the...

Reality goes beyond physics: Why physics will never explain everything | George Ellis iai.tv/articles/rea...

After nearly three decades, a Minnesota summer camp for kids with HIV/AIDS is closing and up for sale... because retroviral drugs are so effective that there aren't enough campers. Science works, y'all. www.startribune.com/closure-of-n...

My old iPhone glitched out today At the Lab.

CSHL’s Martienssen lab and colleagues discovered the role of a common RNA modification in epigenetic inheritance, and what it could mean for combating viruses in plants and mammals. www.cshl.edu/big-clues-em...

Cool study led by Mitra Javadzadeh and Marine Schimel on the function of inter-areal communication in the neocortex, using data from my lab and biologically-constrained latent circuit modelling with Guillaume Hennequin and Yasha Ahmadian #neurosky #neuroskyence www.biorxiv.org/content/10.1...