A deep redox proteomics study identifies redox-regulated and druggable cysteines in immune proteins www.nature.com/articles/s41...

Interesting, but how does it know which gene is the mutated one when the two alleles are different? Dose this happen for only deleterious mutations, or also happen for beneficial ones

One of the main stories of my postdoc is finally out! It builds on an intuition from my early days in omics data analysis: our signaling pathways are simply too small, underrepresenting cellular complexity after stimulation. Something obvious, yet surprisingly hard to quantify.

Simple but smart idea💡

A very intriguing press release👍

“It’s a major advance, on the scale of an AlphaFold4. The problem, of course, is that we know nothing of the details.” Isomorphic Lab’s proprietary drug-discovery model is a major advance go.nature.com/3Mm2ZnQ

When I first learned about omics at university, I confidently stopped caring about single proteins. Fast-forward 4 years of a system’s biology PhD, I now have the most amazing favorite single protein which I can’t stop thinking about. Here is the story of how that happened 👀

Rewiring of oncogenic signaling in #DrugResistance is a moving target. In our new study, we used biophysical phosphoproteomics to investigate #BRAF mutant cancer, linking phosphorylation changes to protein function and #MolecularMechanisms through #Multi-Omics integration. tinyurl.com/funsignaling

The Escherichia coli PeptideAtlas Build: Characterizing the Observed Escherichia coli Pan-Proteome and Its Post-Translational Modifications pubs.acs.org/doi/10.... --- #proteomics #prot-paper

In a new Science study, researchers introduce DrugCLIP, a contrastive learning framework that virtually screens small molecules and protein pockets, analyzing protein-ligand interactions 10 million times faster than most standard molecular docking approaches. https://scim.ag/45FfSj2

In this month's Editorial, we highlight some of the Nature Methods editorial team members' favorite papers we published in 2025! www.nature.com/articles/s41...

After working on proteomics for eight years, first time to present a poster but at an AI symposium😅 Happy to know, always happy to learn #AI in drug discovery & development

A Very comprehensive study! Some previous studies have used drug-induced changes in target abundance to identify targets; although it’s not always the case.

popEVE is out in Nature Genetics! 🎉 We built a proteome-wide model that combines cross-species and human population variation to rank missense variants by disease severity and help diagnose rare genetic disorders. rdcu.be/eRu7K

Joined a conference talk a week ago in EMBL, which introduced how mammal cells detoxify m6A and how the accumulation influences metabolism. Was wondering how about bacteria. What’s the function of m6A or m6dA in Ecoli. Very in-time preprint 👋

Finally out! 🤩 Check out our HT- PELSA for high throughput screening！

HT-PELSA, a new proteomics tool by EMBL researchers, processes samples 100x faster and works directly with complex crude cell, tissue, and bacterial lysates – developments which could accelerate drug discovery and basic biological research 💊 🔗 www.embl.org/news/science...

NAD+ is a central molecule in bacterial immunity. An excellent and timely review by Hugo Vausset and Aude Bernheim

Cool!

Congrats!

The emerging roles of long non-coding RNAs in the nervous system www.nature.com/articles/s41...

A new paper reports a proximity labeling-based method termed TAPRIP for profiling RNA-protein interactions in living cells, enabling the identification of circular RNA regulators and RNA G-quadruplex-specific binding proteins www.nature.com/articles/s41...

Wow!

‘Solar-powered’ sea slugs have specialized depots in their cells that store photosynthetic equipment looted from algae https://go.nature.com/4l27lMN

A new Review highlights recent advances in understanding compartmentalized GPCR signaling using chemical biology approaches with a focus on tools for real-time monitoring, site-selective tuning of signaling protein networks and mechanistic screening www.nature.com/articles/s41...

Not directly relevant to the paper: pick up your chemistry as it will definitely help you to better understand many cellular biological processes.

Good to know which metrics should be evaluated from a quantitative perspective

Good to learn how metabolites influence the protein complex formation and the multifaceted functions of metabolites in different processes!

New work @harvard by Miguel Gonzalez-Lozano @harperlabhms.bsky.social & @ernstschmid.bsky.social in Johannes Walter lab charts structural interactome of endosomes. #XL-MS #Alphafold Funded by @asapresearch.parkinsonsroadmap.org & NIH. Science continues-despite attacks www.nature.com/articles/s41...

🚨Our new paper is online🚨 We use zero-distance⚡photo-crosslinking⚡to reveal direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes. #DNA #Chromatin #Proteomics www.cell.com/cell/fulltex...

Want to know how the ligands interact with proteins beyond model cell lines, e.g., in tissues or bacteria? Interested in membrane targets? Check out our High-Throughput PELSA method which allows you do all these cool screenings for dozens of ligands within two hours! www.biorxiv.org/content/10.1...

A recent study constructed a protein and RNA distribution atlas from 21 tissues and 8 cell types to study plasma proteome dynamics. The atlas enables enhanced quantification of organ-enriched protein panels during disease. www.cell.com/cell/fulltex... 🧪

Timescales in Cell Biology

So exciting!