R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).

Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation www.science.org/doi/10.1126/...

I'm still mad someone decided to call them H2A, H2B, H3, H4.

Thrilled to share that I’m starting my lab in the Department of Neuroscience at the University of Florida! We’ll study metabolism in brain aging to better understand Alzheimer’s disease. Excited to build, collab, and discover. Go Gators! 🐊 #Neuro #Aging #Alzheimers #UF ufresearch.bsky.social‬

A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114! www.nature.com/articles/s41... www.science.org/doi/10.1126/...

Front page, NYT today Nothing has been proven to reverse Alzheimer’s disease, including this false claim gift link www.nytimes.com/2025/05/21/w...

The NSF helped fund the tech in your phone, the models that forecast deadly storms and 268 Nobel prize-winners. The Trump Administration has proposed cutting its budget by 55% – and 1400+ grants are already terminated.

Great paper out today by my friend and colleague James Tucker! I'm hopeful that some of these scaffolds have therapeutic value. www.sciencedirect.com/science/arti...

Good summary of this important study linking blood pressure control and reduced dementia www.nature.com/articles/s41...

Albert Einstein died on this day, April 18, 1955. It is incredible to hear Albert Einstein explain his famous formula, E=mc².

Biggest commitment to a 3 second joke I've ever seen

My annual post for today: In the era of rampant misinformation, April Fools just doesn't seem appropriate or funny

Conda users will get this Solving Environment: \

From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA

Success often requires community support. Discuss practical approaches to creating more accessible & inclusive research settings in this webinar w/ @umarchatterjee.bsky.social, Kimberly Fiock, PhD, Billie Goolsby, BA, @brittgratreak.bsky.social, & @dwwilliamslab.bsky.social. #NeuroSky

More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention. www.science.org/doi/10.1126/...

He would see the entire world burn just to be the king of ashes

Breaking news: Thousands of researchers and their supporters, including recently fired federal workers, have gathered across the U.S. in response to layoffs and funding cuts ordered by the Trump administration. scim.ag/41zlPv4

A really clarifying question that I think should be asked of basically every politician out there is "what do you imagine power to be and why do you want it?"

Between 2010 and 2024, CDC estimates that flu resulted in an estimated 9.3 million to 41 million illnesses, 120,000 to 710,000 hospitalizations and 6,300 to 52,000 deaths annually. That’s *with* widespread use of the flu vaccine. www.cdc.gov/flu-burden/p...

This is Winston Churchill visiting the White House during World War II. Funny how he isn’t wearing a suit either. Almost like he was a wartime leader defending his country from being slaughtered and wiped out by an authoritarian aggressor.

I commend every parent who is choosing to do the right thing by vaccinating their child as the measles outbreak spreads. There's no shame in changing your mind on a stance you were wrong about. Especially when it concerns protecting children from disease. www.nbcnews.com/health/healt...

Over on LinkedIn, the head of the Executive Secretariat of the NIH -- a central part of NIH leadership 🧪🩺-- resigned with a lettter worth reading www.linkedin.com/posts/nathan...

This is not the increased brain plasticity I had hoped for... edition.cnn.com/2025/02/03/h...

TO-DO lists will grow if left unchecked

Claims made without evidence can be dismissed without justification

There are currently 67,102 studies registered at clinicaltrials.gov that are (well, were, probably, until this week) actively recruiting participants, and 20,690 studies that are active but not recruiting right now. This is SO many people we're talking about.

"Look back over the past, with its changing empires that rose and fell, and you can foresee the future, too." - Marcus Aurelius

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

Lightsheet microscopy is unparalleled in its ability to resolve whole circuits in the mouse brain. Michelle Bedebaugh let me image one of her Rabies MC3R Cre samples with the 15X objective on my smartSPIM and we are very happy with the results. 🧪

Six decades later, Star Trek may still be the only franchise based on the ideas that diversity is strength, justice is the measure of civilization, bounty is to be shared, peace is worth the price, and all these things can be achieved. We need more shows that look ahead and find goodness.

New research shows aging is not a uniform process. Parts of our bodies start aging earlier than others, right down to our organs and cells.

Carl Sagan nailed it back in 1995.

Spending hours with ChatGPT can save you minutes of reading the documentation.

There is a special circle in hell for publishers who do not make the gutter margins big enough

so many programs have autosaving and cloud-saving now like word n stuff but ctrl-s has been ingrained into my very DNA i will be hitting the fuck out of ctrl-s until i die

RFK Jr wants to gut NIH, which is fun because it’s the primary mechanism to fund biomedical research and because it is underfunded *80 percent* or more of researchers applying for the most common type of grant, known as an R01, don’t get funded.

That feeling when you find a typo in a manuscript you've read 10^10 times, but only after hitting submit 🙃