Jeff Jones, PhD
@jrjones.bsky.social
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Molecular biologist focused on aging
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Jeff Jones, PhD
Asaf Levy
3 months ago
R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).
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Jeff Jones, PhD
Eric Topol
4 months ago
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
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Jeff Jones, PhD
Elinne Becket, PhD
4 months ago
I'm still mad someone decided to call them H2A, H2B, H3, H4.
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Thrilled to share that I’m starting my lab in the Department of Neuroscience at the University of Florida! We’ll study metabolism in brain aging to better understand Alzheimer’s disease. Excited to build, collab, and discover. Go Gators! 🐊
#Neuro
#Aging
#Alzheimers
#UF
ufresearch.bsky.social
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https://ufresearch.bsky.social
6 months ago
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Jeff Jones, PhD
7 months ago
A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
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Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications
Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...
https://www.nature.com/articles/s41467-025-61111-7
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Jeff Jones, PhD
Eric Topol
8 months ago
Front page, NYT today Nothing has been proven to reverse Alzheimer’s disease, including this false claim gift link
www.nytimes.com/2025/05/21/w...
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Jeff Jones, PhD
The Conversation U.S.
8 months ago
The NSF helped fund the tech in your phone, the models that forecast deadly storms and 268 Nobel prize-winners. The Trump Administration has proposed cutting its budget by 55% – and 1400+ grants are already terminated.
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Unprecedented cuts to the National Science Foundation endanger research that improves economic growth, national security and your life
The Trump administration has terminated hundreds of federal grants that support engineering, biology, geology, computer science, STEM education and much more.
https://buff.ly/6wD6wxd
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Great paper out today by my friend and colleague James Tucker! I'm hopeful that some of these scaffolds have therapeutic value.
www.sciencedirect.com/science/arti...
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Scaffold hopping and sidechain modification from a flavone scaffold lead to discovery of potent, selective CK2A2 inhibitors with favorable properties for CNS activity
The human protein kinase CK2 has long been of interest as a target in oncology, but new evidence is emerging of its role in central nervous system (CN…
https://www.sciencedirect.com/science/article/pii/S0968089625001373?dgcid=author
9 months ago
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Jeff Jones, PhD
Eric Topol
9 months ago
Good summary of this important study linking blood pressure control and reduced dementia
www.nature.com/articles/s41...
add a skeleton here at some point
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Jeff Jones, PhD
Astronomy 🔭
9 months ago
Albert Einstein died on this day, April 18, 1955. It is incredible to hear Albert Einstein explain his famous formula, E=mc².
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Jeff Jones, PhD
Oregon 🕎🎲
10 months ago
Biggest commitment to a 3 second joke I've ever seen
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My annual post for today: In the era of rampant misinformation, April Fools just doesn't seem appropriate or funny
10 months ago
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Conda users will get this Solving Environment: \
10 months ago
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Jeff Jones, PhD
Mark Cuban
10 months ago
From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA
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Jeff Jones, PhD
Society for Neuroscience
10 months ago
Success often requires community support. Discuss practical approaches to creating more accessible & inclusive research settings in this webinar w/
@umarchatterjee.bsky.social
, Kimberly Fiock, PhD, Billie Goolsby, BA,
@brittgratreak.bsky.social
, &
@dwwilliamslab.bsky.social
.
#NeuroSky
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reposted by
Jeff Jones, PhD
Eric Topol
11 months ago
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until
@science.org
today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...
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He would see the entire world burn just to be the king of ashes
11 months ago
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Jeff Jones, PhD
Science Magazine
11 months ago
Breaking news: Thousands of researchers and their supporters, including recently fired federal workers, have gathered across the U.S. in response to layoffs and funding cuts ordered by the Trump administration.
scim.ag/41zlPv4
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Thousands gather across U.S. in Stand Up for Science events
Scientists rally across the country in response to layoffs and funding cuts ordered by the Trump administration
https://scim.ag/41zlPv4
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Jeff Jones, PhD
Technology Connections
11 months ago
A really clarifying question that I think should be asked of basically every politician out there is "what do you imagine power to be and why do you want it?"
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Jeff Jones, PhD
Omar Wasow
11 months ago
Between 2010 and 2024, CDC estimates that flu resulted in an estimated 9.3 million to 41 million illnesses, 120,000 to 710,000 hospitalizations and 6,300 to 52,000 deaths annually. That’s *with* widespread use of the flu vaccine.
www.cdc.gov/flu-burden/p...
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reposted by
Jeff Jones, PhD
Tristan Snell
11 months ago
This is Winston Churchill visiting the White House during World War II. Funny how he isn’t wearing a suit either. Almost like he was a wartime leader defending his country from being slaughtered and wiped out by an authoritarian aggressor.
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Jeff Jones, PhD
BK. Titanji
11 months ago
I commend every parent who is choosing to do the right thing by vaccinating their child as the measles outbreak spreads. There's no shame in changing your mind on a stance you were wrong about. Especially when it concerns protecting children from disease.
www.nbcnews.com/health/healt...
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As Texas measles outbreak grows, parents are choosing to vaccinate kids
At least 124 people, mostly babies, children and teens, have been infected. Eighteen people have been hospitalized.
https://www.nbcnews.com/health/health-news/texas-measles-outbreak-grows-parents-vaccinate-rcna193637
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Jeff Jones, PhD
Jack Iwashyna
11 months ago
Over on LinkedIn, the head of the Executive Secretariat of the NIH -- a central part of NIH leadership 🧪🩺-- resigned with a lettter worth reading
www.linkedin.com/posts/nathan...
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This is not the increased brain plasticity I had hoped for...
edition.cnn.com/2025/02/03/h...
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Human brain samples contain an entire spoon’s worth of nanoplastics, study says | CNN
Human brains today contain 50% more plastic than in 2016, a new study found. Brain of people diagnosed with dementia had the most.
https://edition.cnn.com/2025/02/03/health/plastics-inside-human-brain-wellness/index.html
12 months ago
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TO-DO lists will grow if left unchecked
12 months ago
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Jeff Jones, PhD
onion person
12 months ago
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Claims made without evidence can be dismissed without justification
12 months ago
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Jeff Jones, PhD
beetle moses
12 months ago
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Jeff Jones, PhD
Dave Levitan
12 months ago
There are currently 67,102 studies registered at
clinicaltrials.gov
that are (well, were, probably, until this week) actively recruiting participants, and 20,690 studies that are active but not recruiting right now. This is SO many people we're talking about.
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"Look back over the past, with its changing empires that rose and fell, and you can foresee the future, too." - Marcus Aurelius
about 1 year ago
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Jeff Jones, PhD
Bluesky
about 1 year ago
Scientists, academics, researchers: We’re excited to share that
@altmetric.com
is now tracking mentions of your research on Bluesky! 🧪
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reposted by
Jeff Jones, PhD
Jose Maldonado, PhD
about 1 year ago
Lightsheet microscopy is unparalleled in its ability to resolve whole circuits in the mouse brain. Michelle Bedebaugh let me image one of her Rabies MC3R Cre samples with the 15X objective on my smartSPIM and we are very happy with the results. 🧪
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Jeff Jones, PhD
Mark Sumner 🇺🇦
about 1 year ago
Six decades later, Star Trek may still be the only franchise based on the ideas that diversity is strength, justice is the measure of civilization, bounty is to be shared, peace is worth the price, and all these things can be achieved. We need more shows that look ahead and find goodness.
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Jeff Jones, PhD
The Washington Post
about 1 year ago
New research shows aging is not a uniform process. Parts of our bodies start aging earlier than others, right down to our organs and cells.
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Inside your body, aging unfolds at remarkably different rates
New research shows aging is not a uniform process. Parts of our bodies start aging earlier than others, right down to our organs and cells.
https://www.washingtonpost.com/wellness/2024/11/25/longevity-organ-aging-disease/?utm_campaign=wp_main&utm_medium=social&utm_source=bluesky
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reposted by
Jeff Jones, PhD
NightDiver13
about 1 year ago
Carl Sagan nailed it back in 1995.
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Jeff Jones, PhD
Roland Weisleder
about 1 year ago
Spending hours with ChatGPT can save you minutes of reading the documentation.
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Jeff Jones, PhD
Tricia Dearborn
about 1 year ago
There is a special circle in hell for publishers who do not make the gutter margins big enough
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Jeff Jones, PhD
Lord Jeffrey of Nottingham #FBPE 🇬🇧 🇪🇺 🇬🇱
about 1 year ago
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Jeff Jones, PhD
(^^♪
about 1 year ago
so many programs have autosaving and cloud-saving now like word n stuff but ctrl-s has been ingrained into my very DNA i will be hitting the fuck out of ctrl-s until i die
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Jeff Jones, PhD
Dave Levitan
about 1 year ago
RFK Jr wants to gut NIH, which is fun because it’s the primary mechanism to fund biomedical research and because it is underfunded *80 percent* or more of researchers applying for the most common type of grant, known as an R01, don’t get funded.
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about 2 years ago
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That feeling when you find a typo in a manuscript you've read 10^10 times, but only after hitting submit 🙃
over 2 years ago
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you reached the end!!
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