Seems important, and I really like the concept. if I follow correctly interepitope competition is permissive whereas intra kills low affinity cells.

Excited that IL-3 is playing a role in the type 2 response here! S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis: Immunity www.cell.com/immunity/ful...

Antibodies, Memory B Cells, and Antigen Valency Reshape B Cell Responses to Drifted Influenza Virus Vaccination https://www.biorxiv.org/content/10.1101/2025.11.07.687210v1

T cell fate is dictated by different antigen presenting cells in response to dietary versus gut epithelial self-antigen https://www.biorxiv.org/content/10.1101/2025.11.06.687030v1

Antibody-mediated feedback modulates interclonal competition in the germinal center https://www.biorxiv.org/content/10.1101/2025.11.06.686519v1

Our B cell Keystone is getting closer! Short talk abstracts and scholarship applications are due on November 13 - get to it! www.keystonesymposia.org/conferences/...

Following from Maria Lafaille's discoveries of a couple of days ago, we found that BCL2, BCLXL or BCLW dominates over MCL1 in the survival of IgE PC, which localise atypically for long-lived cells. Full text link below. kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

Online now: Long-lived IgE plasma cells that reside in the spleen contribute to the persistence of the IgE response

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes https://www.biorxiv.org/content/10.1101/2025.10.30.685663v1

Thank you Diana! Credit to @smguillaume.bsky.social for leading this work. Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS share.google/6zXPfzAaAcva...

I know this is late, but one of the most important PC survival advances in recent years. Key conception. Check it out! doi.org/10.1038/s415... www.nature.com/articles/s41...

Just dropped! Complicated impacts of il21 on gc exit to memory. Kudos to @alidvorscek.bsky.social and Jesse Mulder! IL-21 contributes to type 2 memory B cell formation url: academic.oup.com/jimmunol/art...

HIF-1α+ CD4 T cells coordinate a tissue resident immune cell network in the lung https://www.biorxiv.org/content/10.1101/2025.06.13.659476v1

This is a two-part post. I am privileged to do tax-payer funded research into allergy cures and ways to improve vaccines. My goals are to improve people's lives, stability of the food supply and minimise risks of future pandemics. However,

🎓 PhD positions available @MonashUni Join our lab to explore how neurons and immune cells shape gut immunity! 🧬 Single-cell RNAseq 🔬 3D imaging 🧠 Neuro-immune interactions 👥 Great mentoring & collaborations Apply now 👉 tinyurl.com/Seilletlab

Vaccination in left arm, right arm, or both?? @labphan.bsky.social congrats and looking to you for the answer 😄 Macrophages direct location-dependent recall of B cell memory to vaccination: Cell www.cell.com/cell/fulltex...

New Highlight of @cp-immunity.bsky.social paper by Nelson et al. @loyolachicago.bsky.social reporting that lung-resident IgG1+ memory B cells class-switch to IgE to mediate airway hypersensitivity in asthma #immunosky #immunology #asthma

Great to have our paper out in @pnas.org showing that lung B cells in ectopic germinal centers undergo affinity maturation. @smguillaume.bsky.social @wsfoster.bsky.social @sanmarti92.bsky.social @emae-watson.bsky.social Silvia Innocentin, Grant Kennedy & Alice Denton. doi.org/10.1073/pnas...

New preprint alert 🚨 My team and I are pleased to share our most recent story about how bacterial pathogen (Streptococcus pyogenes, Strep A) exposure induces antibody responses against glycan and protein antigens. For paper: SSRN ssrn.com/abstract=519... biorxiv : doi: doi.org/10.1101/2025...

As a first Bluesky post, I’m happy to share our latest publication @emboreports.org: www.embopress.org/doi/full/10.... Led by Craig McKenzie, we used CRISPR-Cas9 gene editing to investigate how Syndecan-1 (CD138) and -4 (SDC4) influence B-cell development and activation. #ImmunoSky #MonashUni

Cool germinal center acrobatics from Juhee Pae et al, check it out! www.nature.com/articles/s41...

KLF2 expression in IgG plasma cells at their induction site regulates the migration program, say Wataru Ise, Takuya Koike, Tomohiro Kurosaki @osaka_univ_e and colleagues: buff.ly/41bbKEF

Team, this piece is great if you're interested in Abs! TLDR: GC-derived ASC maintain a proliferative burst post-differentiation proportional to affinity/help to explain overrepresentation of high affinity in PC despite differentiation from all affinities. #immunosky www.science.org/doi/10.1126/...

Prof Kjesten Wiig has been appointed Director of the Malaghan Institute as Professor Graham Le Gros continues in a leadership capacity as Deputy Chair of the Trust Board and advisor to the new Director @grahamlegros.bsky.social

Time for a reset...let's go! go.bsky.app/8avwjYw

Wonderful to see the #immunology community growing here. The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added go.bsky.app/PY5tCas go.bsky.app/FmERUoD

And make the second one a bit more esoteric to refine the algorithm #Bcell #TFH #epitope #antibody #germinalcenter #plasmacell #idiotype #heteroclitic #anamnestic #Immunoglobulin #recrudescence

Let's keep this first post simple #Immunology