Marc Spehr
@marcspehr.bsky.social
📤 164
📥 124
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Marc Spehr
Geraldine Zimmer-Bensch
28 days ago
What if the DNA methylation enzyme DNMT1 isn’t just about DNA? Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking. A paradigm shift in DNMT1 biology!
www.biorxiv.org/content/10.1...
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A cytosolic function of DNMT1 controls neuronal morphogenesis via microtubule regulation
Proteins traditionally confined to a single cellular compartment are increasingly recognized to exert non-canonical functions in alternative domains. The DNA methyltransferase 1 (DNMT1), classically d...
https://www.biorxiv.org/content/10.1101/2025.10.19.683279v1
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Marc Spehr
Ivan Manzini
3 months ago
🚨 We are looking for 2 PhD students! 🧠🐸👃 Join the Manzini Lab
@jlugiessen.bsky.social
to explore the olfactory system in
#aquatic
#vertebrates
. We mainly use
#amphibians
, combining: 🔬 Imaging 👩🔬 Cell biology 🐝 Behavior 👉
bit.ly/neurophd
🌍
bit.ly/manzinilab
Please share!
#PhD
#neuroscience
#job
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Marc Spehr
Geraldine Zimmer-Bensch
3 months ago
🌍 Open Call! RWTH Aachen University invites postdocs from outside the EU to apply for the “Port to Europe” Fellowship (24 months funding, all disciplines). Start your research journey at one of Europe’s top universities! 🚀 Deadline: Oct 5, 2025. 👉https://rwth-aachen.de/go/id/botjje/lidx/1
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Marc Spehr
RWTH Aachen University
4 months ago
Studie von RWTH-Professorin und ihrem Team in der Fachzeitschrift Nature Communications veröffentlicht 📃💡: Die Forschenden untersuchen die Bedeutung des Enzyms DNMT1 für die Entstehung von Schizophrenie, Autismus und Epilepsie. ➡️ Mehr Infos:
www.rwth-aachen.de/go/id/bouvms...
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Studie liefert Hinweise auf Ursachen neuropsychiatrischer Erkrankungen | RWTH Aachen University | DE
Wenn wichtige molekulare Schalter der Genregulation im Gehirn fehlen oder nicht mehr funktionieren, kann das gravierende Folgen für die Entwicklung eines Menschen haben – mit möglichen Folgen wie Schizophrenie, Autismus und Epilepsie. Forschende der RWTH haben nun im Mausmodell untersucht, welche Rolle das Enzym DNMT1 dabei spielt. Die Ergebnisse wurden in der renommierten Fachzeitschrift Nature Communications veröffentlicht.
https://www.rwth-aachen.de/go/id/bouvms#aaaaaaaaabouvrn
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Jason Shepherd
4 months ago
While I’m a big fan of new technologies that help us study human biology…there’s still no replacement for animal research! See my article in Gen News.
www.genengnews.com/topics/trans...
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Why We Still Need Animal Research in a World of AI and Organoids
The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.
https://www.genengnews.com/topics/translational-medicine/why-we-still-need-animal-research-in-a-world-of-ai-and-organoids/
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Marc Spehr
Julius-Maximilians-Universität Würzburg
6 months ago
Wir begrüßen Professorin
@silkesachse.bsky.social
als neue Leiterin des Lehrstuhls für
#Neurobiologie
und
#Genetik
! Sie kommt aus Jena zu uns (
@mpi-ce.bsky.social
) und erforscht den Geruchssinn von
#Insekten
. ➡️
www.uni-wuerzburg.de/aktuelles/ei...
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Marc Spehr
Tobias Ackels
6 months ago
🚨 Preprint alert! 🚨 Can mice estimate the distance to an odour source? New work led by Cristina Marin and colleagues, jointly supervised by
@andreas-t-schaefer.bsky.social
at the
@crick.ac.uk
and myself. Spoiler alert: Yes, they can! Read the paper here:
bit.ly/43A9tF9
Short 🧵 below
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Highly recommended:
youtu.be/8H34jcpEsFs?...
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RFK Jr. & HHS: Last Week Tonight with John Oliver (HBO)
YouTube video by LastWeekTonight
https://youtu.be/8H34jcpEsFs?si=6TpD9zLGT8TB2S45
7 months ago
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P.S.: If you cannot get enough of this, stop by at our poster at AChemS 2025 on Thursday morning.
add a skeleton here at some point
7 months ago
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www.jneurosci.org/content/45/1...
Excited to see this out (now in print). A fantastic collaboration by former student Rudolf Degen and current PhD student Victoria Switacz, who did an amazing job closing the deal on this one. Give it a read if you like, but beware - it's nerdy ephys at its best.
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Ca2+-Activated Ion Channels Exert Opposite Effects in Different Signaling Compartments of Vomeronasal Sensory Neurons
In most mammals, conspecific chemical cues that drive innate social and sexual behavior are detected by the vomeronasal organ (VNO) and processed in the accessory olfactory bulb (AOB). Chemosensory st...
https://www.jneurosci.org/content/45/16/e2134242025/tab-article-info
7 months ago
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Marc Spehr
The Transmitter
7 months ago
Olfactory neuroscientists have known for a while that their stimuli stink. A new analysis illuminates the extent of the problem. By
@callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/olfaction/sm...
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Smell studies often use unnaturally high odor concentrations, analysis reveals
It’s time to fashion olfactory neuroscience stimuli based on odor concentrations in the wild, say study investigators Elizabeth Hong and Matt Wachowiak.
https://www.thetransmitter.org/olfaction/smell-studies-often-use-unnaturally-high-odor-concentrations-analysis-reveals/?utm_source=bluesky&utm_medium=org-social&utm_campaign=20250416-unnatural-high-odor-concentration
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Marc Spehr
SfN Journals
7 months ago
This Week in The Journal
#JNeurosci
| The Neural Underpinnings of Waiting; Behavioral Outcomes from Neurofibromin Deficiency
www.jneurosci.org/content/45/1...
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This Week in The Journal
The Neural Underpinnings of Waiting Qiang Zheng, Yujing Liu, Yue Huang, Jiaming Cao, Xuanning Wang, and Jianing Yu (see article e1820242025) Waiting is important for action control during motor ta...
https://www.jneurosci.org/content/45/16/etwij45162025
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Marc Spehr
Healthcare in Europe (DE)
8 months ago
Vorzeitige #Wehen und #Präeklampsie können bei einer #Schwangerschaft die #Gesundheit von Mutter und Baby gefährden. Forscher um
@marcspehr.bsky.social
von der
@rwth.bsky.social
und
@physiologyiscool.bsky.social
von
@washumedicine.bsky.social
#Wehen
#Präeklampsie
#Schwangerschaft
#Gesundheit
gen einen zentralen Auslöser dieser Komplikationen.
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Neue Ansätze zur Behandlung von Schwangerschaftskomplikationen
Forschende der RWTH Aachen haben gemeinsam mit einem Team aus St. Louis eine Studie veröffentlicht, die neue Wege für die Behandlung von Schwangerschaftskomplikationen eröffnen könnte.
http://dlvr.it/TJsxKY
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A scientific excursion for us, and a fun collaboration with Polina Lishko and her team. In this new study, led on our end by Lina Kenzler and Jerome Schrőer, we address a molecular mechanism that controls uterine contractions in mice and humans. Enjoy the read.
www.science.org/doi/10.1126/...
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Kir7.1 is the physiological target for hormones and steroids that regulate uteroplacental function
Progesterone and progestins activate Kir7.1 to control uterine excitability, offering insights for preterm birth therapy.
https://www.science.org/doi/10.1126/sciadv.adr5086
9 months ago
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Marc Spehr
Federation of European Neuroscience Societies - FENS
9 months ago
📣 Science matters!
#FENS
and its allies unite in solidarity with the U.S. scientific community facing challenges to research, collaboration, and academic freedom. 🔬 🔗 Read the full statement:
loom.ly/cn7vJR4
#sciencematters
#standupforscience
#sciencenotsilence
#scienceforall
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reposted by
Marc Spehr
9 months ago
2024 marked the 10-year anniversary of the FENS-Kavli Network of Excellence. We warmly invite you to explore the 10-Year Report, showcasing its impact on science, mentoring, outreach, advocacy, and personal achievements.
@fens.org
@kavlifoundation.bsky.social
fenskavlinetwork.org/fkne-10-year...
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Marc Spehr
Ben Saunders
9 months ago
With the huge challenges facing scientists, I call on peer reviewers to reflect on their role as gatekeepers to trainee career development and scientific progress. You can maintain high standards for rigor while being kind and not demanding an extra year of studies for every paper revision.
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Marc Spehr
Tobias Ackels
10 months ago
I am deeply grateful for this award, which not only recognizes my work but also reflects the invaluable contributions of my team, mentors, and supporters! It inspires me to continue working with my lab to deepen our understanding of how we perceive and interpret our environment.
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Marc Spehr
Association for Chemoreception Sciences (AChemS)
10 months ago
⏰ Last chance! Today is the final day to submit your
#AChemS2025
abstract! Submit now:
achems.org/2025/abstrac...
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reposted by
Marc Spehr
Björn Brembs
10 months ago
We are hiring! We are looking for two PhD students interested in the regulation of habit formation. Habits are useful to decrease cognitive load, but carry the risk of becoming stereotyped and hard to control - it’s hard to shake a bad habit. The fruit fly Drosophila also forms habits and we […]
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Original post on mastodon.social
https://mastodon.social/@brembs/113787128988417223
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Marc Spehr
iBehave
11 months ago
🎉✨ Happy New Year ! ✨🎉 Wishing you a year filled with inspiration, discovery, & happiness! Here's to making 2025 remarkable together.
#happynewyear
#thanks
#community
@wisocologne.bsky.social
@unibonn.bsky.social
@dzne.science
@mpinb.mpg.de
@fz_juelich
@rwth.bsky.social
@UniklinikBonn @DLR-PT
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Marc Spehr
Dan Goodman
11 months ago
There's a movement in neuroscience suggesting we should be pursuing bigger bets with larger teams. I think there's a case for doing a bit of this, but I think it's a bad idea to prioritise it for two reasons, and a good case for saying we should be moving in the exact opposite direction. 🧠🧪
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Ardem Patapoutian
11 months ago
I joined 75+
@nobelprize.bsky.social
laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏
www.nytimes.com/2024/12/09/h...
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Marc Spehr
Julian Meeks
12 months ago
On Giving Tuesday, please consider making a donation to a nonprofit like AChemS (
@achems.bsky.social
) that supports academic scientific research, which is essential for building new knowledge about how our bodies work!
add a skeleton here at some point
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Marc Spehr
Tobias Ackels
12 months ago
Check out our new review in PLoS Biology on how dynamic odour information can help mammals to navigate through their environment. Led by the fantastic Anantu Sunil & Olivia Pedroncini, this also marks my first last author publication from the University of Bonn!
journals.plos.org/plosbiology/...
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How do mammals convert dynamic odor information into neural maps for landscape navigation?
Odors contain complex spatiotemporal information that guide animal behavior, but how this information is processed is not fully understood. This Essay discusses recent advances in mammalian olfactory ...
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002908
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Marc Spehr
iBehave
about 1 year ago
🔊Major Breakthrough Researchers from @UniklinikBonn
@unibonn.bsky.social
@rwth.bsky.social
reveal how single neurons respond to smells, images & words! This study in
@natureportfolio.bsky.social
bridges the gap between animal & human olfactory research!👃 📖
www.nature.com/articles/s41...
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Single-neuron representations of odours in the human brain - Nature
Human piriform and mediotemporal neurons encode odours, and signal how we perceive, rate and identify scents.
https://www.nature.com/articles/s41586-024-08016-5
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Marc Spehr
The Transmitter
about 1 year ago
Unlike the primary sensory brain areas that process sights and sounds, the one that decodes scents also responds to other stimuli, such as images and words associated with an odor, according to a study published today in Nature. By
@avaskham.bsky.social
www.thetransmitter.org/sensory-syst...
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https://www.thetransmitter.org/sensory-systems/double-duty-neurons-in-primary-olfactory-cortex-pick-up-on-more-than-just-scent/?utm_source=blueksy&utm_medium=org-social&utm_campaign=20241009-double-duty-neurons-olafactory-cortex
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