🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity! We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have: (1) more corticospinal neurons (CSNs) (2) better hand dexterity (3) more dexterous climbing, which is linked to CSN number🧵

1st paper from Sadler Lab is out!! Highlights: 1) A. muciniphila reverses sickle cell (SCD) pain, 2) fecal transplant from SCD mice induces pain via bilirubin-TRPM2 vagal signaling, 3) BilR+ bacteria less abundant in SCD patient poo, 4) RNAseq on HUMAN nodose ganglia! www.cell.com/cell-host-mi...

Our department at UT Southwestern Medical Center has openings for TT faculty position! Our Neuroscience Research Division has diverse research programs, from genes to neural circuits to human brain imaging. UTSW has a vibrant/growing neuroscience community! www.nature.com/naturecareer...

It was a lot of fun organizing a session (pain and nausea) at the Korean Neuroscience meeting with Hojoon. Thanks to speakers @karalmarshall.bsky.social @chuchuzhang.bsky.social who flew all the way to Korea with us! Great to catch up with old friends and make new ones. And the food was amazing!

It's been 3 years since I started my lab in 2022. What a journey so far! Anxiety and frustration at times, but grateful to be where I am, especially with my fantastic group of trainees. My fourth year officially(?) started with the 3-year renewal approval for animal protocol and biosafety permit!

Our paper showing decreased KCC2 expression in the human spinal cord in people who died with a history of neuropathic pain is now published in PAIN: journals.lww.com/pain/abstrac... Great work from @oliviadavis.bsky.social and the teams of the De Koninck and Hildebrand labs. ❤️ 🇨🇦 collabs!

Do you have any questions about the current understanding and treatment of #migraine? Check out the newest episode of the Pain Beat moderated by @julietmwirigi.bsky.social! bit.ly/3GGjCYu #migraine#podcast #newepisode #PRF

Grateful for the opportunity and excited to try out some ideas! @hypothesisfund.bsky.social

New paper out in @pnas.org Thalamic CGRP neurons form a spinothalamic pain pathway relaying pain signal to the amygdala & insular, but not sensory cortex to encode the affective dimension of pain. Huge congrats to first author Sukjae Kang & coauthors. www.pnas.org/doi/10.1073/...

I’m very excited to share that I will join the University of Utah Department of Neurobiology as an Assistant Professor in Jan 2026!! 🎉🏔️🏜️ My lab will focus on body–brain interactions in learning & memory — how do signals from our internal organs remodel the brain & behavior?

Molecular and functional diversity of the autonomic nervous system www.nature.com/articles/s41...

Grateful for this amazing opportunity and generous support @klingensteinorg.bsky.social !

Meet the 2025 Klingenstein Neuroscience Fellows! Esther A. & Joseph Klingenstein Fund is pleased to welcome 13 highly promising, early career scientists conducting cutting-edge research. Each will receive $450K over 3 years and join us at our scientific conference.

Honored to be an HHMI FHS! Grateful to brilliant colleagues who push me to think deeply, and to my students whose curiosity & energy make the lab a joy. My grad advisor said in genetic screens, you don’t get what you want—you get what you deserve. Hope we are deserving www.hhmi.org/programs/fre...

Thrilled to join the Rita Allen Scholars community (ritaallen.org/stories/2025...) and grateful for the support! Glad to (re)discover many inspirational colleagues as current and former award in pain scholars.

I’m so honored to be selected as both a 2025 McKnight Scholar and 2025 HHMI Freeman Hrabowski Scholar. And I couldn’t be prouder to share these honors with awesome @ucdavis.bsky.social colleagues 💙💛💙💛 health.ucdavis.edu/news/headlin...

Calling all Neuroscience postdocs! 🧠 Share your research through SPiNES (Seminars from Postdocs in Neuroscience: Extramural Series) from the NYUGSoM Department of Neuroscience. Applications close 08/20/25. Apply today! 👉 nyumc.qualtrics.com/jfe/form/SV_... #Neuroscience #Postdoc #ResearchOpportunity

A little science to brighten your day… We define characteristic postural and paw pressure changes after SCI using Blackbox. www.biorxiv.org/content/10.1...

Very striking results from Bruce Bean's lab performing ephys on human DRG neurons with the new pain 'blockbuster' drug recently approved by the FDA. These results show that even the most potent blocking of Nav1.8 may not be sufficient to silence pain neurons. www.pnas.org/doi/abs/10.1...

With all the chaos and destruction of academic research going on in the US right now, it feels a little weird to post this. But.... New preprint from the lab is now live: www.biorxiv.org/content/10.1... 1/n

Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig

🎈Our latest 🪅 We know that in addition to exteroceptive mechanisms, interoceptive chemosensation is also critical for regulating physiology/behavior. We find that an enteric neuron in worms senses ingested salts via a variant ionotropic receptor (IR like the fly IRs) to regulate salt stress. 1/n

Check out our latest @biorxiv-neursci.bsky.social preprint from our PRECISION Human Pain Network project www.biorxiv.org/content/10.1... "Type I interferons enhance human dorsal root ganglion nociceptor excitability and induce TRPV1 sensitization" led by Úrzula Franco-Enzástiga

Cool new study from @vabraira.bsky.social lab on tactile hypersensitivity associated with chronic pain. Glad we could collaborate. One cool thing Abraira lab did was use high-speed videography plus the PAWS pain detection system for uncovering pain behaviors. www.sciencedirect.com/science/arti...

Turns out, two of pain’s most famous messengers — Substance P and CGRPα — might not be so essential after all. Mice missing both still felt pain just fine, challenging decades of assumptions about how pain signals travel. buff.ly/ypISrtx

An example of what we in the NIH Intramural program can accomplish. Excited to share our latest paper in close collaboration with Nick Ryba's group. We examined how inflammation transforms representation in somatosensory neurons to cause pain. Lots of surprises here: www.nature.com/articles/s41...

Lots of recent papers discuss the nucleus of the solitary tract in interoception. In this review, we take a sensory processing perspective on how interoceptive signals are encoded in the NTS: www.sciencedirect.com/science/arti...

And it’s published! Congratulations to Ashley on her first author paper! I’m excited to share this with everyone here. Female sex hormones exacerbate retinal neurodegeneration | Science Advances www.science.org/doi/10.1126/...

New preprint from us led by @oliviadavis.bsky.social doing some fantastic work labeling synapses in the human dorsal horn. www.biorxiv.org/content/10.1... This work should lay an important foundation for many future studies.

How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study. www.nature.com/articles/s41...

ACNP Travel Award Submissions open on Thursday, March 31, 2025. For more information, visit https://t.co/zSCC9OJZ51 #ACNP2026 #travelawards

UC Irvine is currently hiring for 2 open faculty positions in stem cell biology and regenerative medicine (one Asst/Assoc Prof and one Assoc/Full Prof). Apply at: recruit.ap.uci.edu/JPF09408. Although the final deadline is Jun 30, please apply prior to Fri Mar 28 to be given full consideration.

Includes 8 of my papers, from PhD work up through recent work. I also learned there is a Kevin M Wright that publishes a lot about reptiles.

#Cancer research needs #neuroscience and neuroscientists. Sharing some thoughts on #CancerNeuroscience, together with Frank Winkler. www.nature.com/articles/s41...

Check out my postdoc work at Ariel Levine’s lab, hot and fresh, describing how you build a dorsal horn! www.biorxiv.org/content/10.1...

This has only been possible through NIH funding. Funding biomedical science through the NIH has been one of the greatest accomplishments of the United States of America for America, and for the world. We are ALL better for the work that passionate scientists funded by the NIH have been able to do.

And science continues… check out our new work led by @rbrianroome.bsky.social

This cure for sickle cell anemia was made possible by NIH-funded research to turn the gene for fetal hemoglobin back on. It was done predominantly by NIH researchers, including intramural researchers on the NIH campus. irp.nih.gov/catalyst/33/...

"This is a massive loss for neuroscience,” says Cory Miller. By @avaskham.bsky.social www.thetransmitter.org/funding/u-s-...

Our Center is a great place to work! If you are looking for a lab technician position, please check out our posting!

99% of new medicines developed by the pharmaceutical industry depend on NIH research jamanetwork.com/journals/jam...

📢🧠 #BrainWeekChat Roll Call! Introduce yourself, what you do, and where you're from! All #BrainAwarenessWeek, we'll be hosting discussions for the #Neuroskyence community. Join by replying to our posts. Use #BrainWeekChat to help others find you! @danafoundation.bsky.social

To understand the brain, we must first understand its parts — the cells. 🧠📈 Together with our partners across the country, we're cataloging cell types in the brain with the most detailed map of the motor cortex ever. 🎬 www.youtube.com/watch?v=ylt2... #BrainWeek #BrainAwarenessWeek #studyBRAIN

It is important for people to see this graph/data. #NIH is the irreplaceable leader of USA leadership in biomedical discovery and development of new therapeutics.

The Ultimate Guide to Instant Noodles. You're welcome. www.eater.com/21299228/bes...

Facing an uncertain financial future, many U.S. neuroscience Ph.D. programs are admitting fewer students. The Transmitter spoke with 20 programs about how the recent changes are affecting their admissions processes. By @claudia-lopez.bsky.social @callimcflurry.bsky.social bit.ly/41ptnk1

We must learn to showcase the practical significance of basic research, demonstrating how seemingly arcane investigations yield transformative applications, writes @tonyzador.bsky.social www.thetransmitter.org/outreach/how...

Please look at the 🧵 from @dingliu.bsky.social summarizing our discovery of brain-wide circuits controlling the emergence and satiation of social drive during social isolation vs grouping

Our paper @dulaclab.bsky.social on social homeostasis is online today! We characterized “social rebound” behavior after social isolation in multiple mouse strains and revealed its neural basis. Intriguingly, soft touch plays a key role in satisfying social need! www.nature.com/articles/s41...

Registration started for the Janelia meeting on spinal cord and brainstem circuits for sensorimotor adaptation across species. Spinal cord is more than a hub, it does supercomputing! www.janelia.org/you-janelia/...