📣 Call for a PhD position in Artificial Intelligence for Protein Science Details of the call can be found at the following link: www.uni-bayreuth.de/job-vacancy-... Please feel free to spread the word!

November is here and for our #WeAreMPIBio #WeAreFML portrait series we’re highlighting postdoctoral researcher Hadeer Elhabashy and her team in the Department of Protein Evolution. Find out more about what drives her, her team's research and how they connect as a team: tinyurl.com/3ez3csd6

OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇

End-to-end protein design in the browser through evedesign. Generate and interactively explore designs in 2D/3D and export them as codon-optimized DNA. The underlying open source framework (released soon) is build to easily add new methods, more on that soon. 🌐 evedesign.bio

Turns out there’s more to life than just being happy. What really matters? Having a purpose. If you haven’t already, watch this TED Talk — it might just change how you define a fulfilling life. youtu.be/y9Trdafp83U?...

“Nothing will be accepted as knowledge or understanding until it has been challenged by someone competent to challenge it.” — Prof. Larry McEnerney, former Director of the University of Chicago Writing Program From his famous lecture (youtu.be/vtIzMaLkCaM?...) Definitely worth watching!

“The move from physics has been the intellectual immigration that has mattered most to biology.” — Horace Freeland Judson, The Eighth Day of Creation

🥇 The Protein People strike again! I’m incredibly proud that my fantastic team and I won the first place at the Health Day of the Max Planck Institutes Tübingen! 🎉 We tackled sporty team challenges, had tons of fun, and built even stronger bonds along the way. A big thank you to the organizers 🙌

Very excited about our latest all-atom generative model proteina, check out the project page (research.nvidia.com/labs/genair/...) and stay tuned for the code release soon!

o3, an AI model developed by the creators of ChatGPT, has been ranked the best AI tool for answering science questions in multiple fields go.nature.com/4lzaWlC

📢 Today’s the day! #genomDESymposium 2025 kicks off in Berlin. Proud to co-host with TMF, BfArM and @denbi.bsky.social – bringing together voices from care, research, infrastructure, policy & patient advocacy. #GHGA #GenomicMedicine #DataForHealth #FAIRData

New EU rules adopted today mean better access for qualified researchers to online data gathered by very large online platforms & search engines. This is important for investigations into systemic risks (e.g illegal content or disinformation). See 👉 europa.eu/!XHYdGN

Got a huge list of protein IDs and want a quick look at their structure models—but it's too much work? I wrote a small script that automatically fetches models from the AlphaFold DB and generates PyMOL images and interactive sessions. Just feed it your list and go! 🔗 github.com/ElhabashyLab...

Our structural core gene pipeline Unicode is now published at GBE 📄 doi.org/10.1093/gbe/... Please also check out @dongwookkim.bsky.social’s 🧵 bsky.app/profile/dong...

Planning to apply for #research #funding from the ERC? From the next application rounds, expect changes to the: • proposal structure • evaluation process • extra funding you can request • eligibility for Starting & Consolidator #Grants (from 2027) More 👇 europa.eu/!RPHWvv

Fantastic Proteins, Fantastic Team, Fantastic Diversity Day! 🪄 At this year's diversity day at @mpi-bio-fml.bsky.social , we shared our fascination with proteins with our colleagues.🧪 Huge thanks to my winning team: @hadeerelhabashy.bsky.social , Alex Waldherr, and Claudio Piselli ❤️

We've updated our AFESM website to now include biome filtering, allowing exploration of protein structures adapted to specific environments. 🌐 afesm.foldseek.com Read more about the work in the skeetorial 🦋 bsky.app/profile/mart... or our preprint 📄 www.biorxiv.org/content/10.1...

Excited to share our new preprint on HLp—a bacterial histone from Leptospira perolatii that forms stable tetramers and wraps ~60 bp of DNA: "DNA Wrapping by a Tetrameric Bacterial Histone" www.biorxiv.org/content/10.1... @mpi-bio-fml.bsky.social

Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights: www.nature.com/articles/s41...

I haven't seen the official announcement but would prefer to see more grants instead. I know it is not under the control of the ERC but I hope the EU manages instead to double the ERC budget. Take money away from the other research initiatives if needed.

The age-old trade-off: the more AI remembers you, the smarter and more proactive it gets—but it also means handing over more of your privacy to big corps. Helpful or intrusive? One thing is for sure, I’m not ready to jump in just yet. #AI #Privacy #DataControl #AIEthics

Job alert: Join us in Mainz as Max Planck Research Group Leader (W2) in Molecular Design ...and make your own research dreams happen on de novo design, generative models, proteins, materials ... tinyurl.com/r2xjxnuk @mpip-mainz.mpg.de

Complex Portal release 250 is out! 5,049 manually curated biological complexes. www.ebi.ac.uk/complexporta... (in sync with UniProt release 2025_02)

Are you a beginner in systems biology modelling? Apply to "Mathematics of Life" training course to get hands-on training to model and simulate pathway dynamics and listen to lectures from experts in academia and pharmaceutical industry. Deadline 22nd July ebi.ac.uk/training/event…

Crosslinks can sometimes improve AlphaFold3 models. Crosslinking is an experimental method often used as a source of distance restraints in modeling. In AlphaFold3, instead of using restraints, crosslinks can be included as covalent ligands. Thanks to Agnieszka Obarska-Kosinska for the idea.

AlphaFold is running out of data — so drug firms are building their own version Source: Nature search.app/Ytywt Shared via the Google App

Our latest work has been published! Our additional implementation for Boltz-1 largely improves the stereochemical accuracy of predicted ligand molecule without retraining the model. We also developed a notebook on Google Colaboratory, colab.research.google.com/github/cddla... .

The next big advance since the protein prediction revolution? VantAI has just announced Neo-1. It unifies structure prediction with all-atom de novo generation. Neo-1 excels in predicting ternary complex structures. It also integrates with experimental data for rapid iterative optimization.

This is a great editorial by @alfonsovalencia.bsky.social on the importance and fragility of biomedical databases. Even in normal times, it is a struggle to maintain funding for these resources. More than ever we need to think about the sustainability and robustness of this critical infrastructure.

The EMBO Young Investigator Network supports life scientists in Europe and beyond by providing them with opportunities in networking, training and mentoring, as well as support for their lab members. 🧪 The application deadline is 1 April: www.embo.org/funding/fell... #ResearchFunding #LifeSciences

🧪🧬🔬 Postdoc in Computational Structural Biology at the @biozentrum.unibas.ch & @sib.swiss in Basel, Switzerland. www.biozentrum.unibas.ch/open-positio... The position is initially funded for 3 years, possibility to start immediately. #StructurePrediction, #Bioinformatics, #Uniprot3D, #AI

Join the Interdisciplinary Postdoc Fellowship Program at the European Molecular Biology Laboratory (EMBL), one of the best places to do research in modern biology and develop your career. Great opportunities for statisticians, comp. biologists, AI experts, mathem. modelers! www.embl.org/eipod-linc

🚨 We're hiring! 🚨 The Ewald Lab at EMBL-EBI is looking for a postdoctoral researcher in multi-omics, machine learning, and predictive toxicology to analyze a groundbreaking toxicology dataset as part of the OASIS Consortium. More details & application here: lnkd.in/eHD7DMdX

On 7 March ‘Stand Up for Science’ rallies slated to take place in 32 cities around the country. The main event, in Washington DC, is spearheaded by a group of five researchers, most of them graduate students. www.nature.com/articles/d41...

Join us in Heidelberg for the 2nd edition of #EMBOComp3D! 🧬 Explore cutting-edge AI-driven innovations and classical methods in biomolecular research, new sessions on drug design, and make contacts during the job fair. Submit your abstract by 26 Aug 👉 s.embl.org/csb25-01-bl