🧬 Oncogenic KRAS mutations (pancreatic, colorectal, lung cancers) stabilize these complexes, sustaining growth signalling. Explore RAS at the complex level → new therapeutic insights. #RAS #KRAS #RASopathies #CancerBiology #ComplexPortal

🔬 𝑵𝒆𝒘! 𝐑𝐀𝐒 𝐬𝐢𝐠𝐧𝐚𝐥𝐥𝐢𝐧𝐠 𝐜𝐨𝐦𝐩𝐥𝐞𝐱𝐞𝐬 𝐢𝐧 𝐭𝐡𝐞 𝐂𝐨𝐦𝐩𝐥𝐞𝐱 𝐏𝐨𝐫𝐭𝐚𝐥 RAS proteins function in multi-protein assemblies that drive MAPK & PI3K signalling.

🌍 Rare Disease Day: When Molecular Complexes Break Rare diseases aren’t just “gene disorders” - many disrupt macromolecular complexes, the molecular machines that keep cells running.

🔎 Exploring predicted complexes in the Complex Portal Beyond curated entries, the portal also includes computationally predicted protein complexes. Quick tour: tinyurl.com/2wph5wua Includes: 🧬 hu.MAP 3.0 🎵 MuSIC 🧪 QSProteome

🎉 Update from the Complex Portal! 🧬 The Complex Portal now links to QSProteome, a community-driven resource for predicted protein complex structures.

🎉 Complex Portal release 252 is out! 🎉 5,296 manually curated biological complexes are now live, in sync with UniProt 2026_01 🚀 Highlights by species: 🧬 Homo sapiens – 2,499 🌱 Arabidopsis thaliana – 228 🧫 Saccharomyces cerevisiae – 634 🧬 Schizosaccharomyces pombe – 145

Complex Portal release 252 is out! 5,296 manually curated biological complexes. www.ebi.ac.uk/complexporta... (in sync with UniProt release 2026_01)

Are you working on challenging projects in structural biology? #EMBOMacromolecular will highlight the strategic use of cutting-edge protein structure prediction methods, and recent advances in in situ structural biology. Apply by 18 Feb to join us at EMBL Grenoble! 🧬 s.embl.org/mmo26-01-bl

🧬 New Year, new health goals - let’s get real: exercise fads, diets & oxygen therapies promise “blood cleansing,” but oxygen transport, circulation, cholesterol, and immune defence rely on real macromolecular complexes, not detox trends.

#ComplexPortal #EMBLEBI #PlantScience #Ecology #UKCEH #Ammonia #Transporterproteins

🌿 Why it matters • Excess NH₄⁺ disrupts growth and cellular balance • Species differ in ammonium tolerance, influencing biodiversity • Human-driven nitrogen favours ammonium-tolerant species 💡 Plants aren’t passive nitrogen absorbers-they actively regulate uptake to balance nutrition and stress.

🌱 Balancing Act: Plants & Ammonium Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing. 💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.

🌱 Balancing Act: Plants & Ammonium Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing. 💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.

Registration is free but essential: tinyurl.com/4v3jf4e9 Speakers: Susie H. and Eliot Ragueneau #Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape

Would you like to learn more about molecular interactions and how to explore them across organisms? Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.

From a farm in the north of England to the frontiers of bioinformatics, our Group Leader Sandra Orchard reflects on a career building the data foundations of modern biology: “AI is showing how vital data curation really is.” www.ebi.ac.uk/about/news/p... 🖥️🧬

Upon her retirement from EMBL-EBI, we thank Sandra for her dedication and foundational work on important open data resources including: UniProt Complex Portal @complexportal.bsky.social Gene Ontology @geneontology.bsky.social IntAct @intact-ebi.bsky.social InterPro @interprodb.bsky.social

#ComplexPortal #PDBe #StructuralBiology #Bioinformatics #ProteinComplexes #LifeSciencesData #EMBL

Follow the link to uncover: 🧩 what the complex does in the cell 🔄 pathways it participates in (Reactome) 🧬 and curated disease links (EFO, MONDO, OMIM). PDBe gives the structure — the Complex Portal adds the biology. Together they tell the full story: structure → function → system.

🔬 Noticed the new look PDBe? The refreshed Protein Data Bank in Europe now includes direct links to the Complex Portal! Example: PDB 6OOY → TNFA complex (CPX-8826).

🧫 Explore the curated dataset in IntAct ➡️ tinyurl.com/candidalysin 🎨IntAct Cytoscape visualisation: Candida albicans ECE1 peptides (orange) and their human protein targets (blue) #IntActEBI #Interactome #EMBL

Don’t just publish - be found! 🔍 I didn’t realize how vital biocuration was until I became a curator. A well-curated dataset doesn’t just sit in a paper - it lives on in databases and fuels new discoveries.

🧬 On #GlobalPNHAwarenessDay, we spotlight the GPI-GnT complex - a key enzyme disrupted in PNH, a rare and life-threatening blood disorder. 🧩 Its failure (often via PIGA mutations) removes GPI-anchored proteins, leaving blood cells unprotected from complement attack.

See also @wojtekgalej.bsky.social and tinyurl.com/3sfthabb #MinorSpliceosome #RNAsplicing #snRNP #U12Introns

🕸️ Explore the interactome on the IntAct tinyurl.com/35922511. 🆕 New feature: You can now group nodes by orthology 🧩 — stay tuned for more details! #Immunology #Proteomics #MolecularInteractions #HumanImmuneSystem

The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development. New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf 🔬 More info: tinyurl.com/47ed3er6

The minor spliceosome removes rare U12-type introns—found in essential genes for cell division, DNA repair, and development. New entries in the Complex Portal cover its snRNPs (U11, U12, U4atac, U6atac) and active B-act complex (CPX-26509): tinyurl.com/4wxhkymf 🔬 More info: tinyurl.com/47ed3er6

🧠 Today is #WorldAlzheimersDay. 📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression (tinyurl.com/37exu532). #WorldAlzheimersDay #AlzheimersSociety #Complexportal

💜🧠 World Alzheimer’s Day 🧠💜 IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s. 🔗 Network: tinyurl.com/ynjwhy7y Paper: doi.org/10.3390/ijms24032490 #WorldAlzheimersDay #AlzheimersSociety

🧠 Today is #WorldAlzheimersDay. 📚 Visit the Complex Portal and learn more about gamma-secretase complexes, key to precise cleavage of amyloid precursor protein (APP), who's dysfunction is linked to disease progression (tinyurl.com/37exu532). #WorldAlzheimersDay #AlzheimersSociety #Complexportal

💜🧠 World Alzheimer’s Day 🧠💜 IntAct highlights Tau-F 🧵 & amyloid beta 🧩 PPINs from human brain tissue. The Tau-F network shows mutations P301L/S 🧪 disrupting key pathways linked to Alzheimer’s. 🔗 Network: tinyurl.com/ynjwhy7y Paper: doi.org/10.3390/ijms24032490

IntAct release 251 is out! 1,726,205 binary interactions from 23,716 manually curated publications www.ebi.ac.uk/intact/about... (in sync with UniProt release 2025_03)

🧠 Alzheimer’s research meets precision medicine 📊 IMEx data from IntAct & Complex Portal 🧬 How AD mutations disrupt brain protein networks 🔍 Variant pathways, APP, miRNA 🚀 Toward targeted AD therapies 🔗 doi.org/10.1002/pmic... #KalpanaPannerselvam #IntAct #ComplexPortal #AlzheimersSociety

🧬 New in IntAct: Curated dataset from Pichlmair lab reveals VZV–host interactions in SK-N-BE2 cells. NPHP4 identified as a restriction factor; S862N variant alters interactome. 🎉Congrats Virginie Girault et al! 🔍 Explore: www.ebi.ac.uk/intact/searc... #IntAct #HostPathogen #@a_pichlmair

🧠 Ever wonder how your tongue detects umami or sweetness? 🧂 Umami is sensed by a GPCR made of TAS1R1 + TAS1R3; sweet by TAS1R2 + TAS1R3. 🍜 Both trigger gustducin proteins, sending signals to your brain (and beyond). 🔬 Learn more: Complex Portal: tinyurl.com/ymd4ews9 #TasteReceptors #GPCR

Complex Portal release 251 is out! 5,190 manually curated biological complexes. www.ebi.ac.uk/complexporta... (in sync with UniProt release 2025_03)

🐍 From Dark Myths to Eco Allies: Celebrating #WorldSnakeDay Complex Portal holds several curated venom complexes from Crotalus durissus terrificus, a South American rattlesnake known for its pharmacologically active venom proteins. 🔬 Explore these fascinating complexes: (See tinyurl.com/mz5hmzdf)

Intronic repeats play big roles evolution, gene regulation & disease. They're linked to disorders like Haemophilia & cancer. Cells keep them in check through RNAi-driven heterochromatin formation. See the S. pombe CLR4 complex (CPX-9241) & learn about its involvement in transcriptional silencing.

Do you use EMBL-EBI data resources? We would really appreciate your feedback! Our Interim Director Jo McEntyre explains how you can help us demonstrate the value of our data resources: www.ebi.ac.uk/about/news/a... Survey closes on 16 July: www.surveymonkey.com/r/QGFMBH8?ch... Thank you!

Do you want to learn more about macromolecular complexes? Register for our webinar taking place on 𝗝𝘂𝗹𝘆 𝟵𝘁𝗵, 𝟮𝟬𝟮𝟱! 📅  🔍 Discover more about our latest updates including the Complex Navigator & the integration of ML-predicted complexes (huMap3.0 and MuSIC). ➡️ Register now: tinyurl.com/bdy6wttv

What do Nobel laureates, early-career researchers, and pioneering scientists have in common? 🧬 They all attend EMBL Events! Want in? Whether you're into molecules, cells, or data – there's something for you! 🚀 Subscribe now and stay in the loop: 👉 http://eepurl.com/dv95w9

This month features CUL4A (Q13619). Cullin4-RING E3 ubiquitin ligases (CRL4s) regulate processes including facilitating stalled fork stability & genome integrity. Search the CP using GO:0080008 (tinyurl.com/2zhsy43s) & use the Navigator to explore our range of CRL4 complexes! #MolBiol, #ubiquitin

Very excited that our work describing hu.MAP3.0 is published in @molsystbiol.org. Here we use machine learning to integrate >25k mass spectrometry experiments to place ~70% of human proteins into 15k protein complexes. www.embopress.org/doi/full/10....

First off, this was a wonderful collaboration with @gkust.bsky.social, @kourtissavvas.bsky.social, @sdelcilab.bsky.social, and folks at @complexportal.bsky.social specifically Henning Hermjakob and Sandra Orchard. The project was beautifully led by Sam Fischer and Erin Claussen from my lab.

It is Skin Cancer awareness month! Explore manually curated interactomes of proteins associated with familial melanoma in IntAct. Access the network in IntAct (tinyurl.com/26tc7xtm). #IntAct-ebi, #ComplexPortal, #UniProt, #MelanomaAwareness, #HumanDisease, #SunSafety, #SpotSkinCancer,

May is skin cancer awareness month! We're highlighting Telomerase holoenzyme complex (CPX-265) featuring TERT(UniProt:O14746). ComplexPortal: tinyurl.com/mt7u4wbs & visit UniProt for all melanoma-linked proteins tinyurl.com/mryjvyu7 #MelanomaAwareness, #ComplexPortal, #IntAct-EBI, #UniProt

Thrilled to announce that the protein–protein interactions of 396 SLC transporters, characterized by interaction proteomics from the RESOLUTE project, is now integrated into IntAct! Congratulations to #‪Superti-FurgaLab, #FabianFrommelt Explore the interactome at www.ebi.ac.uk/intact/searc...

We're excited to promote our range of Dynactin & Dynein complexes this month! Visit the Complex Portal to explore the respective orthologous and paralogous complexes! (ebi.ac.uk/complexporta...) #Dynactin, #Dynein, #Intracellulartransport