Biorthogonal PEGylation of Hierarchical Porous Metal–Organic Frameworks as Robust, Functional Nanocarriers for Hemoglobin-Based Oxygen Delivery http://dx.doi.org/10.1021/jacs.5c10582

Play a little game and choose the right icon for each role in science. Play our CRediT Roles icon game/survey, and help make scientific authorship clearer and more accessible! creditsurvey.sciux.org #OpenScience #ScienceUX

I had a great time attending and presenting my work at #BMES2025 in San Diego. It was such a nice opportunity to talk about my and others' projects on bone tissue engineering. Thank you everyone for the great talks! 🧪👩‍🔬

🍁 Beautiful autumn atmosphere at #DTU this morning #Autumn #Photography #Nature #Morninglight

Excited to be attending #BMES2025! I will be presenting my work on fabricating oxygen releasing scaffolds for bone tissue engineering in Friday's poster session (T37). Interested in targeting hypoxia, hemoglobin-based oxygen carriers, or bone TE? Please come say hi 😀 🧪👩‍🔬

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

What’s your #1 survival tip for scientific conference season? 👀 Mine: update LinkedIn, sponsor others, and do something fun off-site Read more about why these 3 strategies work on the Thriving Ibis blog: www.thrivingibis.com/post/3-must-... #AcademicSky #WomenInSTEM #WomenInTech #WomenInScience

Excited to be a topic editor for: Synthetic Biology in Pharmacology: Engineering Circuits and Cells for Therapeutics We are seeking articles regarding: - Artificial Cells for Drug Delivery - Metabolic Engineering for Drug Production - Synthetic Gene Circuits tinyurl.com/38j4d6u4 🧪👩‍🔬#Chemsky

Thanks nu.nl for featuring our recent research results on GRACE #bioprinting @natureportfolio.nature.com . Check out the "good news" section (a fitting home and anme!) of Nu . nl of today: 🇳🇱 www.nu.nl/goed-nieuws/... @utrechtuniversity.bsky.social #3dprinting

Scientists at the Wyss have created cellular "backpacks," disk-shaped nanoparticles that can stick to immune cells without being engulfed, and release a steady stream of cytokines into their "host" cells to keep them activated.

Some say that #MOF were discovered in 1900s, but this figure from 1760s clearly show a crystal structure of a MOF with inclusion in pores. Look - metal centers, linkers, guest molecules, all in! #MOF #chemsky #BraggYourPattern reporting from Portugal

New research shows that simply changing how a reaction vessel is positioned on a magnetic stirrer can significantly change a reaction's speed and product quality, influencing the reproducibility of results. #ChemSky #ScienceSky #EduSky

Instant assembly of collagen for tissue engineering and bioprinting ->Nature | More info from EcoSearch

Great to work on this review with Miguel Castilho, @ruidomingues.bsky.social and colleagues - we outline methods to design responsive #biomaterials that enable fabrication of more complex multicellular systems: www.cell.com/trends/biote... #TissueEngineering

Not sure where to publish your research? Here are 7 bookmark-worthy tools that help you decide on the right target journal or repository for your research! A thread. 🧵 #ScienceSky #PhDSky #Postdoc

Check out this recent article from @bioe-stanford.bsky.social‬ on donor variability and 3D culture models influence human mesenchymal stem cell differentiation! Read more here: doi.org/10.1089/ten....

Three new cases reported on using artificial oxygen carriers, by Dr Zhen Mei (UCLA, US). HBOC-201 was successfully used on sickle cell disease patients as bridge therapy and/or as substitute for allogeneic blood transfusion. doi.org/10.1097/MJT.... 🧪 #MedSky #HBOCs

Extremely excited to share our latest research in Nature Communications @naturecomms.bsky.social! We show that inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles. Congratulations to all authors!! rdcu.be/d68EH @umbaltimore.bsky.social

Attended an interesting talk by Prof. Derek Amanatullah (Stanford Med), discussing dormant infections in joint replacements. Concl.: MPS-mediated response as biomarker enables better screening and patient prognosis. doi.org/10.1186/s129... #AcademicSky #MedSky 🧪 @stanfordmedicine.bsky.social

Fully agree with this piece 🧪 In the past, I've contacted a Prof that miscited my paper (we did do the research, just in another ref). No response.. I think the reason is the long process of corrections post publ. So, better to ignore. Wrong citations should be treated easier, it will help everyone

Interesting & short article about artificial blood in Aljazeera, focusing on lab-grown blood (the alternative to HBOCs /PFCs). Also summarizes their main disadvantage: "producing lab-grown blood is currently much more expensive than using donated blood". 1/2 🧪 #chemsky

Another TissueTalk is online, this time with with Prof. Warren Grayson (John Hopkins U, US)🧪 www.youtube.com/watch?v=yNuK... Gave a clear introduction to the use of scRNA-seq in deciphering cells’ expressions during bone regeneration. Looking forward to reading the article on this. #biomaterials

New review paper on artificial O2 carriers by Mohanto et al (Shosun U, KR)🧪 -Products: Hb-, PFC-, stem cell-, bubble-based O2 carriers -Targets incl: anemia, tumor hypoxia, hemor. shock, tissue regeneration, organ preservation -Finishes with key considerations for future doi.org/10.1186/s129...

Another way to showcase the group's research👩‍🎨🧪 www.fanyanggroup.com/paintourrese... Visit the site to see all 14 paintings (and maybe more to come!) #AcademicSky

New HBOC paper out by the Komatsu group (Chuo U, JP)🧪 - HSA-coated SFHbNPs (30 nm), to evade RES - NPs shows good functionality, with p50=8 Torr - Full resuscitation in hemorrhagic shock model, with similar results as the shed autologous blood (SAB) control doi.org/10.1021/acsa... #chemsky

[𝐍𝐞𝐰 𝐛𝐥𝐨𝐠] Only ~10% of drugs have been tested for safety in pregnant women, risking unexpected side effects. In collaboration with esqLABs, Bayer & Placenta Lab we developed an #organonchip platform to study if small molecules can cross the blood-placenta-barrier. Read it here: shorturl.at/5gfpY

📣 We are excited to share our new paper introducing a biofabrication strategy that directly generates branched, endothelial cell-lined networks using a diffusion-based, embedded 3D bioprinting approach: iopscience.iop.org/article/10.1... Led by Betty Cai in collaboration w/ Sungchul Shin!

New paper by Alayash’s group (FDA, CBER center, US), on improving blood storage using curcumin-based formulations.🧪 Incl: biopreservation of RBC membrane integrity, redox balance, and increased longevity in circulation. https://doi.org/10.1038/s41598-024-82943-1 oxygen delivery #Biomaterials

OMG it's out! The latest from Gladstone Institute of Cardiovascular Research: Isha Jain's lab, with an outstanding discovery of a small molecule that can mimic hypoxia, to treat neurodegenerative diseases. The amazing Sylar Blume, an RA in Isha's lab, is first author! www.cell.com/cell/fulltex...

Just signed up for this online seminar! The line-up looks amazing, looking forward to all the topics being discussed 👩‍🔬🧪

Watched last week’s TissueTalk with Prof. Irv Weissman (@StanfordMed, US)🧪 Was especially interested to hear the origin of the ‘don’t eat me/eat me’ signaling of CD47, which is something we wanted to explore with our membrane-coated HBOC NPs as well (1/2). Online: www.youtube.com/watch?v=dKnA...

Maybe with all that is going on in the states no one noticed, but in the Netherlands the university of Twente has fired 46 people from the chem department. One of them is Jeroen Cornelissen. A giant in the field #chemsky www.utoday.nl/news/75215/p...

Roses are red This panel's all men I can't believe we're Having this conversation again #AcademicValentines

New paper on Hb-loaded ZIF-8 NPs by Hosta-Rigau’s group (@DTU_HealthTech, DK)👩‍🔬. This is a continuation on previous work on ZIF-8 HBOCs, assessing their stability, catalytic activity and stealth properties. Happy to have contributed to this project! 🧪 https://buff.ly/42Uqb2q

Just watched TissueTalk with Prof. Ellen Roche (MIT)👩‍🔬 She discusses i.a. how they use soft robotics for addressing end-stage heart failure (via a heart sleeve) and respiratory muscle weakness (via diaphragm support).🧪 Online: www.youtube.com/watch?v=3A2B... #TissueEngineering

Just got back from the annual lab retreat with the Fan Yang group @stanfordmedicine.bsky.social. 🧪👩‍🔬 What a great way to get introduced to all the amazing people and their projects this way! And the locations wasn't bad either 😉 ☀️🦌 #academysky #biomaterials

It is International Day of Women and Girls in Science. Gagandeep Kang’s research on enteric infections has contributed to the rotavirus vaccine rollout in #India, protecting millions of children and shaping a healthier future. for all. 🔬 #WomenInScience #WomenInSTEM

Today is International Day of Women & Girls in Science. Marie Curie, the first woman to win a Nobel Prize. Her contributions have left an indelible mark on the world of science & health & continue to inspire generations of scientists & innovators. 🔬 #WomenInScience #WomenInSTEM

From wound healing to a "human-on-a-chip" -- tissue engineering work in the Bhatia, Griffith, Edelman and Langer labs: web.mit.edu/newsoffice/201…

My first week at @stanfordmedicine.bsky.social: - Giving a presentation about HBOCs🧪👩‍🔬, explaining that there is a lack of available donor blood - Receiving the Stanford Report, encouraging people to donate blood The coincidence is amazing. It’s great to see the active approach they are having here!

We're leading the way in artificial blood research! 🩸🔬 Dr. Allan Doctor is helping to pioneer synthetic blood, transforming trauma care & personal medicine. Learn more about the need to recreate this vital substance in the @newyorker.com! 🔗 bit.ly/3WMXH6P #MedEd #MedSky #Science #PublicHealth

Weekendavisen just published an article regarding artificial blood substitutes, with an interview with Prof. Leticia Hosta-Rigau at DTU Health Tech. Very nice to see our research reach the Danish news! www.weekendavisen.dk/2025-04/idee... 🧪👩‍🔬 #HBOCs #AcademicSky

1st Preprint from Pickering lab!😆 #SciArt Intussusceptive angiogenesis-on-a-chip: Evidence for transluminal vascular bridging by endothelial delamination Real-time transluminal #EndothelialCell pillariogenesis #IntussusceptiveAngiogenesis😎 bioRxiv 2024 www.biorxiv.org/content/10.1...

Wakabayashi et al. (Chuo Uni, Japan) uses PROx as alternative to PEG in HBOCs design. * Polymer conjugation does not alter Hb folding * T- and R-state synthesis allows for p50 modulation * PROx-Hbs have lower viscosity than corresponding PEG-Hbs 🧪 #chemsky

New research on HBOCs from the Bäumler group (Charité-Universitätsmedizin, DE) 🧪 doi.org/10.3390/anti... Interesting findings: * CAT-HbMP has increased oxyHb content * CAT-SOD combination best for protective effect * Controlled Vit C conc (Vit C : Hb = 1:25) gives antioxidant protection

Last week’s TissueTalk with Prof. Don Ingber (Harvard): www.youtube.com/watch?v=akfr... Discusses various models, incl: - Alveoli-on-a-chip: Breathing motion suppresses viral inf & inflamm. - Human-body-chip: Quantitively predicts clinical PK data for 2 drugs 🧪 #TissueEngineering #OrganOnChip 1/2

A previously unknown cellular behavior called ‘cell tumbling’ is reported by Yang et al. @Stanford. Characterized by minute-scale whole-cell movements and rapid hydrogel deformation. Elicited by heightened cytoskeletal and nuclear dynamics. doi.org/10.1038/s415... #TissueEngineering 🧪 1/2

Tags so it ends up on some related feeds: 🧪 #AcademicSky #OrganOnChip #TissueEngineering