How can we learn tissue mechanics directly from cell patterns and images? In our new preprint, we introduce VertAX, a differentiable vertex-model framework in JAX for simulating epithelia, inferring parameters, and designing target tissue behaviors. shorturl.at/PUzT0 1/5

Octavia E. Butler, 1998:

Nicola Willis. Donald Trump. 🤝 No boats.

What's a reasonable time frame from issuing invoice to payment, for remote workers on contract to overseas companies? I've contracted for many years, and usually the longest is 4 weeks after invoice. However, current employer is stretching the bounds of reasonable.

The peril of laziness lost bcantrill.dtrace.org/2026/04/12/t...

In the same way as LLMs ate nothing but matrives for next word prediction, humans are nothing more than a bag of organic molecules.

During a thunderstorm, moving clouds generate strong electrical potentials (⛈️-). This induces electric fields in the branches & foliage of trees. These fields generate an imperceptible ultraviolet corona. Trees are literally LIGHTING UP around lightning. Let's talk about it. (📷: William Brune)

This year's #kakapo breeding season has been the biggest on record: - 256 eggs (252 in 2019) - 148 fertile eggs (116 in 2019) - 105 eggs hatched (86 in 2019). It'll be 2+ months until we know how many chicks will fledge (73 in 2019). There are currently 95 alive. #conservation #kakapo2026 #birds

Has anyone (particularly in the AI sphere) been forcibly subscribed to "The Information" - I'm on some kind of mailing list and their unsubscribe doesn't work, and they don't respond to support.

For the first time ever Windows 11 gave me a useful notification about WSL and git Except, when I clicked on it to find out more, it then disappeared and did nothing else. Wonderful!

mRNA vaccine could be curing cancer but instead USA is having a century of humiliation

Potentially found a painful caching bug in astral's uv for python packaging. Unfortunately all out of tokens, and it's a Friday so won't confirm until next week.

Yesterday I spent a little moment to focus all my manifestation energy on a blood clot in Trump's brain. I figure if enough people do it we will influence the simulation's chaotic attractors.

I don't remember seeing an image of Earth before that captures the (thin, fragile, tiny layer of) atmosphere so clearly. I mean, look at that.

Me, an atheist: Your holiness I stand ready to join the crusade against these heretics

I've actually noticed that rightwing tech people are incredibly mid in their tech ability. To be good at tech you have to be able to understand things outside of your normal point of view. So it's a good way to filter out slop people.

States don't have rights, only humans have rights. Therefore no state has a right to exist. States exist by common agreement and diplomacy. And when that fails, and a state causes harm from unchecked aggression, we either submit to it or hobble/destroy it.

Massacre upon massacre in Beirut in the last hour. AUBMC announced a “code disaster.” Over 100 airstrikes in 10 minutes across the country. One hit right behind my house. Sirens ambulances & the smell of sulphur. The city is in total chaos the people in complete panic

There it is—Dated Brent (i.e., spot) crude hits $144.46/bbl, a new all-time high.

Iranian musician Ali Ghamsari has staged a sit-in outside the Damavand power plant in protest against US and Israeli threats to target vital infrastructure. Ghamsari said he would remain at the site and play music there in the hope of helping prevent attacks on Iran’s energy facilities.

real cool feel-good story about how 100 bullies miraculously rescued that one bully who got given a blood nose.

The Scalar

After spending a day trying to get 2.5 GBe networking working, I have concluded it is bad. I will try again when Intel/Reaktek can write stable linux drivers (possibly never?)

Sometimes it takes time for the equity markets to fully appreciate the macro implications of an oil shock.

Personally I don't regard pilots of aircraft who drop bombs on civilians as 'heroes'.

Kind of disgusted by all the Americans celebrating the rescue of a single downed pilot, regardless of the slaughter Americans cause and are responsible for. No self awareness as a nation.

The herpes of the internet is back at it: browsergate.eu

Alternate take: both students and adults should normalize 4 day business weeks. 5 days straight for 2 days off is bullshit.

Services removing user/password and goind to only email address (with one time logins) are making people's online access brittle and making the email address the single point of failure. Not great when you here stories of people losing their e.g. google account due to arbitrary corporate decisions.

Having workers who do nothing for some of the day is a good thing and a sign that your hiring and staffing practices are correct: how else would they be able to handle peak periods? If your employees are constantly busy, you are understaffed.

Things that make me dislike a job: - endless meetings - inabilty to commit to work that takes more than 1 week - time sheeting requirements Things that make me like a job: - building cool shit with chill but competent people

This pull request adding the leaked claude code source code to the dummy non-OSS repo is 🔥 github.com/anthropics/c...

Is the world really going to have to suffer WW3 because the USA can’t impeach a president?

This is the way... 🧪🔌💡☀️💨💧🔋 cleantechnica.com/2026/03/26/u...

Dates for when the oil deliveries stop

It would almost be funny if USA/Israel war of aggression caused AI bubble pop. Because the founders/tech oligarchs all went so hard on supporting Trump, and then Trump goes and completely destablizes the macro environment that allows them to raise capital/debt for power hungry data centers.

Spent the morning pressing 4 large bags of "asian pear" to make cider. Currently waiting for 10L of juice to cool down after boiling it, and will probably start the primary fermentation tomorrow.

Pope Leo this week called universal health coverage a "moral imperative." He also said: “Health cannot be a luxury for the few,” it is “an essential condition for social peace.”

Most vision scientists would bet that single-cone receptive fields exist in primate fovea, but it was not proven until now. It took years of sweat and $ to combine #AOSLO and electrophysiology. Congrats to PhD student Keaton Ramsey and his mentor Lawrence Sincich. www.nature.com/articles/s41...

This is kinda bonkers. In addition, 20 amino acids were found on Ryugu, along with uracil and vitamin B3. These have been found in other instances, but since the samples from Ryugu were collected directly from the asteroid and delivered in sealed capsules, contamination on Earth could be ruled out.

Another word for people with zero introspection and lack of remorse/guilt... sociopath Marc is trying to justify his antisocial personality disorder as normal.

WELL NOW, would you look at that? A massive, 4-YEAR-LONG study of NEARLY 30 MILLION people in France found that individuals who received a COVID-19 mRNA vaccine had a 74% LOWER risk of death from severe COVID-19 compared to unvaccinated individuals and ZERO increased risk of all-cause mortality.

@segyges.bsky.social maybe you already know or i missed some joke, but you are labelled and i believe it's your labeller?

Article 5 is about collective defence against an armed attack on a NATO member, not automatic support for whatever a member chooses to do offensively.

I am immortal, except for the possibility I will die one day.

I have been informed this use is "objectively wasteful" by a timeline stalker. Despite me providing no context about how much time it saved me, what model I used, whether the model was powered by renewable energy, etc.

Great thread if you have a interest in some of the Roman history of our calendar