What are these? You are looking at embryos of a sea squirt. Each of the 'soap bubbles' is a living cell, about a fourtieth of a millimetre in size. The outlines of the cells are visible thanks to fluorescent markers identified by Hitoyoshi Yasuo @hitoyas.bsky.social see doi.org/10.1101/2024... 🧵

When the clock’s feedback loop breaks, chromatin keeps ticking 🕒 Work from @clocklab-igfl.bsky.social reveals how H3.3-linked PBAF/cBAF shifts sustain BMAL1 activity and reshape circadian chromatine, linking epigenetics to metabolic and ageing control. 🔗 nature.com/articles/s41467-025-64045-2

Ever wondered what drives enhancer-promoter specificity? Why would an enhancer activate one gene rather than another neighboring one? Check our latest preprint, led by @mmasoura.bsky.social, to find out! www.biorxiv.org/content/10.1...

📣 SBIS, a new vital fluorescent probe for live imaging of #brownalgae #kelp in 4D. Just published in J. Cell Science by the Charrier team at the @igflyon.bsky.social. Download PDF on our team webpage here ➡️ shorturl.at/H5A9p with first author Marie Zilliox featured here ➡️ shorturl.at/AMMoH

Our new study, just accepted in the Journal of the Endocrine Society 👉 doi.org/10.1210/jend... We found that semaglutide, beyond its metabolic effects, can exacerbate growth stunting in juvenile mice by reducing energy metabolism, a context-dependent effect of GLP-1 signaling.

Here it is! Postdoctoral position to identify the progenitors sensory organs in the regenerating legs of Parhyale apply here: www.averof-lab.org/pages/tracman 1/3

Comme tous les ans, l’IGFL accueillera la fête de la science la semaine prochaine. Le public général est bienvenu le samedi 4 octobre. Nous espérons vous voir nombreux! www.ens-lyon.fr/indexation/a...

Ces travaux impliquent l'Institut de génomique fonctionnelle de Lyon. @igflyon.bsky.social 👏

So happy to have Dafni @drosostalis.bsky.social at @igflyon.bsky.social today, for an exciting fly physiology talk! “Mind the gut”!

Latest paper elifesciences.org/articles/107... closes an important cycle in our efforts to study regeneration: week-long recordings allow us to observe the behaviour of cells during the entire course of regeneration in a crustacean leg – bright objects in movie are fluorescent nuclei of cells. 1/6

Ces travaux impliquent notamment des scientifiques de l' @igflyon.bsky.social 👏 cc @ensdelyon.bsky.social

Now available in its final form @narjournal.bsky.social ! doi.org/10.1093/nar/... Find out how we can reconstruct enhancer activity in vivo in the Drosophila embryo using scRNAseq data and Optimal Transport.

Excited to host Jean Livet (Institut de la Vision) at IGFL Lyon on June 30th! He’ll share how multicolor labeling and large-volume microscopy reveal the topography and topology of central sensory circuits. A must for connectomics fans! 🧠🔬✨

🦋 Butterflies and beyond! Steven Van Belleghem is now at IGFL revealing how genomes evolve into pangenomes, shaping adaptation and gene regulation in butterflies and Daphnia. Don’t miss this dive into the mysteries of evolution! #EvolutionaryGenomics

🧬 From genomes to pangenomes to adaptation! Join us June 2 at 11am in Salle des Thèses (IGFL) for Steven Van Belleghem’s talk on how structural genome variation and regulatory elements drive evolution—featuring butterflies, beetles, and Daphnia. 🦋🪲🦐

Live now at IGFL: Laure Bally-Cuif (Institut Pasteur) is sharing her fascinating work on the heterogeneity of adult neural stem cells. A deep dive into brain plasticity in action! #Neuroscience #IGFL #StemCells @zenlabpasteur.bsky.social

Congrats to Dr. Laurie Nemoz Billet for earning an Accessit 2025 from @sfbd.bsky.social for her thesis on the role of the ECM in motor nerve development and regeneration in zebrafish! A brilliant contribution to the field. Read more: www.pnas.org/doi/10.1073/... 🎉

🧠 Seminar alert! Laure Bally-Cuif (Pasteur Institute) will present: "Individual cell heterogeneities and population dynamics for adult neural stem cell maintenance" She will show how neural stem cell sub-populations sustain neurogenesis in zebrafish. 📅 05/05/25, 11am, Salle Condorcet ENS Lyon

Time to go mad! Thank you @zaycha.bsky.social for inviting @mads100tist.bsky.social for exciting science on somatosensory neuron diversity.

IGFL will be going mad next Monday, when we host @mads100tist.bsky.social, directly from Basel! We are looking forward to hearing an exciting talk!

Today BioSymposium of the 4 research units at @ensdelyon.bsky.social Great mix of PI and Doc/Postdoc presentations and posters with some live musics tonight @igflyon.bsky.social @lbmcinlyon.bsky.social @ciri-lyon.bsky.social and RDP (not yet on Bluesky I think)

Very excited to host the one and only @mads100tist.bsky.social at @igflyon.bsky.social in Lyon on April 7th! Don't hesitate to pass by for his talk if you're in the city, it promises to be a real treat!

Guest lecture today on Drosophila brain metabolism. Exciting results by Prof. Stefanie Schirmeier from TU Dresden.

Seminar alert! 🧠🔬 Prof. Stefanie Schirmeier (TU Dresden) presents "Metabolic flexibility of the Drosophila nervous system" on March 17th, 11 am at Salle Condorcet. Explore glial cells & adaptive metabolism! #Neuroscience #Metabolism

‪ #TalentsCNRS 🥈 | Découvrez le portrait vidéo de François Leulier, médaille d'argent 2024 du @cnrs.fr, chercheur en biologie et directeur de @igflyon.bsky.social @cnrsbiologie.bsky.social @ensdelyon.bsky.social @francoisleulier.bsky.social 🎬👇 www.youtube.com/watch?v=QKOk...

Big news at IGFL! We’re thrilled to have two MSCA postdocs this year! @ludivinebertonnier.bsky.social (Heude lab) dives into sarcomagenesis through neck development. @luciebernard.bsky.social (Leulier lab) uncovers how early-life nutrition shapes immunity. Exciting science ahead!

Yesterday, IGFL hosted its first Equality Breakfast with Lucie Marchal (CNRS DR07). We tackled the myth that “we can’t say anything here!”—sexist jokes aren’t just jokes; they’re part of GBV. A great turnout showed IGFL’s commitment to inclusion. Let’s keep working for equality! #Equality #Inclusion

1/ 🚨 Excited to share our new study, now published in The Journal of Nutrition! We developed a mouse model of juvenile protein-energy malnutrition (PEM) to assess growth recovery after refeeding with optimal or suboptimal diets. 🧵 www.sciencedirect.com/science/arti...

🌱 New findings on kelp zygotes! Bénédicte Charrier’s team shows how alginate forms a corset, shaping early cell fate. 🔬 Read the Scientific Reports paper: www.nature.com/articles/s41... 🖼️ Kelp zygote: alginate corset (green), nucleus (blue), chloroplasts (red). Length: 30 µm.

Thank you @cnrs.bsky.social @cnrsbiologie.bsky.social for this medal which recognizes the excellence of the work of my lab members over the last 10 years at @igflyon.bsky.social @ENSLyon, an amazing place for discovery science in #EvoDevoPhysio

Congratulations @francoisleulier.bsky.social for being awarded the CNRS Silver Medal for your exceptional scientific achievements!

👏 Big congrats to Eglantine Heude et al. for their amazing work in @naturecomms.bsky.social! Tracing the origins of the tetrapod neck, they show how fish muscles were co-opted for land life. Evolutionary innovation at its finest! #EvoDevo www.nature.com/articles/s41...

Happy @igflyon.bsky.social SAB members and Group leaders!!! 2 intense but very productive days.

Congratulations @francoisleulier.bsky.social, recipient of the Jaffé Prize - Fondation de l'Institut de France. This award honors work or experiences aimed at advancing progress and the well-being of humanity.

🚨Preprint alert! tinyurl.com/2zkmynsd Did you ever dream of reconstruction #spatial single-cell #enhancer activity in a multicellular organism using massively parallel enhancer-reporter assays? Then Spatial-scERA is the method for you! #spatialOMICs

Zayna Chaker, team leader at IGFL and 2024 ERC Starting Grant awardee, explains her research for Lyon Mag. www.lyonmag.com/article/1385...

Enjoy the last article published by Samuel Bosch, Bernard Billoud and Bénédicte Charrier. www.mdpi.com/2223-7747/13...

The IGFL is looking for an Engineer in biology. We will be examining your application with great interest. emploi.cnrs.fr/Offres/MOBIN...

IGFL is very happy to officially welcome Zayna Chaker, whose team will be investigating the mechanisms of adult neurogenesis. Bienvenue à Lyon, Zayna! igfl.ens-lyon.fr/equipes/zayn...

Congratulations to Laurie Nemoz-Billet, Sandrine Bretaud, Florence Ruggiero and colleagues for their latest work “Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons”, published in PNAS. www.pnas.org/doi/10.1073/...

Congratulations to Frédéric Marmigère for his latest publication, which involved members of @clocklab-igfl.bsky.social. elifesciences.org/articles/89287

3-year post-doc on control of cell division orientation in brown algae, in Charrier's group @ IGFL, ENS Lyon, France (bsky.app/profile/igfl...) Job description : ->https://rb.gy/dt0aq9

Congratulations to our director @francoisleulier.bsky.social for being awarded the CNRS silver medal! www.cnrs.fr/fr/cnrsinfo/...

Poste d'IE à pourvoir dans l'équipe "Physiologie intégrative des interactions hôte/microbes". Les candidatures sont à déposer exclusivement sur le portail emploi du CNRS.

For early career researchers: interorgancrosstalk2024.febsevents.org Register! Great topic, great people, great location.

Snippets from the IGFL @igflyon.bsky.social outreach event yesterday: The amphioxus (Branchiostoma lanceolatum) is a close cousin of vertebrates. It lives submerged in the sand, capturing food particles through a filtration mechanism. Photo by Vincent Moncorgé, animals from Hector Escriva

Nous recrutons un•e assistant•e de direction. Les candidatures sont à envoyer à [email protected].