Longwei Bai
@longweibai.bsky.social
📤 60
📥 111
📝 6
PhD student @Leulier's lab @igfl @ENS de Lyon
reposted by
Longwei Bai
Alex Gould Lab
3 months ago
#Drosophila
calling. Delighted to share our new collection of ShineGAL4 drivers for CNS, FB, muscles, enterocytes, oenocytes and MTs made by
@vgirard.bsky.social
,
@sebsorge.bsky.social
and colleagues
@crick.ac.uk
. All at Bloomington
@bdsc.bsky.social
@dev-journal.bsky.social
tinyurl.com/4jpw9jd6
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reposted by
Longwei Bai
François Leulier
4 months ago
Latest from the lab. MS previously preprinted (see below) and finally published in print
@dev-journal.bsky.social
journals.biologists.com/dev/article/...
Review process via
@reviewcommons.org
and
@dev-journal.bsky.social
1/3
add a skeleton here at some point
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reposted by
Longwei Bai
Dafni Hadjieconomou
4 months ago
📣First preprint of the lab📣 Did that really happen?😅 Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes.
www.biorxiv.org/content/10.6...
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Genetic sex of enteric neurons enables ovarian relaxin to gate maternal gut plasticity
Animals must align intestinal plasticity and feeding with reproductive state, yet the checkpoint that gates these adaptations is unknown. Here we show that an ovary-to-enteric-neuron axis gates the on...
https://www.biorxiv.org/content/10.64898/2026.01.09.698651v1
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reposted by
Longwei Bai
Bardin Lab
5 months ago
Happy 2026 everyone- the time has come to apply! Registration for this exciting Dev Bio conference is until the end of January!
add a skeleton here at some point
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reposted by
Longwei Bai
François Leulier
6 months ago
Revised refereed preprint:
www.biorxiv.org/content/10.1...
Revision work lead by
@longweibai.bsky.social
Our work reveals how the
#microbiota
helps buffer
#malnutrition
: L. plantarum sustains intestinal activity of the steroid hormone ecdysone, expanding the midgut and supporting systemic growth.
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reposted by
Longwei Bai
François Leulier
6 months ago
Latest from the lab by
@longweibai.bsky.social
www.biorxiv.org/content/10.1...
1/6
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A nutrient-sensitive enterokine coordinates developmental plasticity through inter-organ signalling
Animal survival in fluctuating environments depend on the ability to modulate their developmental pace in response to nutrient availability, a phenomenon known as developmental plasticity. In Drosophi...
https://www.biorxiv.org/content/10.1101/2025.11.06.687047v1
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reposted by
Longwei Bai
Julien Colombani & Ditte Andersen lab
8 months ago
Excited to share our last paper describing how intestinal stem cell migration promotes gut regeneration!
www.nature.com/articles/s41...
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Pvf1-Pvr-mediated crosstalk between trachea and gut guides intestinal stem cell migration to promote gut regeneration - Nature Communications
Adult stem cells often reside in specialized niches that they exit upon injury. Here they show that in Drosophila, after damage the gut-associated trachea produces the PDGF-VEGF-related ligand Pvf1, which acts as a guidance cue directing ISC migration toward injury sites.
https://www.nature.com/articles/s41467-025-63704-8
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reposted by
Longwei Bai
10 months ago
Very happy and proud to share the latest work from our lab. Neuroendocrine control of intestinal regeneration through the vascular niche.
www.sciencedirect.com/science/arti...
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Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila
Robust and controlled intestinal regeneration involves reciprocal interactions between the intestinal epithelium and its microenvironment. Here, we id…
https://www.sciencedirect.com/science/article/pii/S1534580725004320
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reposted by
Longwei Bai
Bardin Lab
12 months ago
Very happy to share our latest lab publication! The hard work of
@bboumard.bsky.social
, Gwenn Le Meur and collaborators! Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila: Developmental Cell
authors.elsevier.com/a/1lDFi_Yv6z...
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Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila
Boumard et al. demonstrate gap-junction-dependent tissue-scale nucleotide sharing, which impacts cellular sensitivity to perturbation of nucleotide homeostasis and replication stress. Drosophila wing ...
https://www.cell.com/developmental-cell/fulltext/S1534-5807%2825%2900320-X
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Lastest work from Zhai's lab. mTORC1-mediated nutrient sensing orchestrates metabolic processes to maintain physiological homeostasis and influences organismal ageing in Drosophila.
www.biorxiv.org/content/10.1...
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An Adipose mTORC1 Effector Links Nutrient-induced Ribosomal Protein Translation to Lifespan in Drosophila
Mechanistic target of rapamycin complex 1 (mTORC1) senses nutrient availability to orchestrate metabolic processes critical for physiological homeostasis and organismal ageing. While mTORC1 preferenti...
https://www.biorxiv.org/content/10.1101/2025.05.27.656475v1
12 months ago
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reposted by
Longwei Bai
Igor Iatsenko
12 months ago
Happy to share our new preprint! We explored the mechanisms underlying differences between male and female
#Drosophila
in susceptibility to intestinal
#infection
.
#symbiosky
#immunity
#AcademicSky
#insect
#symbiosis
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Sex Differences in Drosophila Intestinal Metabolism Contribute to Sexually Dimorphic Infection Outcome and Alter Gut Pathogen Virulence
Sexual dimorphism in infection outcomes is a pervasive phenomenon, the underlying mechanisms of which remain incompletely understood. Here, utilizing Pseudomonas entomophila intestinal infection in Dr...
https://www.biorxiv.org/cgi/content/short/2025.05.22.655590v1
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reposted by
Longwei Bai
Eric Topol
about 1 year ago
Discovery of a gut hormone that regulates protein intake, sleep, and influences lifespan
www.nature.com/articles/s42...
(open-access)
@natmetabolism.nature.com
www.nature.com/articles/s42...
in mice and flies
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reposted by
Longwei Bai
Igor Iatsenko
about 1 year ago
Happy to share our latest minireview on Drosophila symbionts in infection: when a friend becomes an enemy | Infection and Immunity
journals.asm.org/doi/10.1128/...
#immunity
#infection
#antimicrobialpeptides
#microbiome
#Drosophila
#AcademicSky
#insect
#endosymbiont
#symbiosis
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Drosophila symbionts in infection: when a friend becomes an enemy | Infection and Immunity
Occupying the interface between host and environment, host-associated microbes play essential roles in interactions with pathogens and influence disease progression (1–4). Considering that most entry ...
https://journals.asm.org/doi/10.1128/iai.00511-24
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reposted by
Longwei Bai
Alex Gould Lab
about 1 year ago
Our latest preprint…Adrien Franchet, Yuhong Jin et al
@crick.ac.uk
show that circulating glutamine drives brain sparing during nutrient restriction. Great collab with labs of Yaël Grosjean and Ian Gilmore.
#metabolism
#Drosophila
#neuralstemcells
www.biorxiv.org/content/10.1...
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reposted by
Longwei Bai
François Leulier
about 1 year ago
The lab will be represented at
#Dros25
.
@longweibai.bsky.social
presenting in the Physiology session on Friday at 5pm after I give the intro to his talk in a plenary Thursday morning 😉.
#Drosophila
#microbiome
friends, let’s catch up and go see Longwei ´s talk he has a really cool story to share.
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reposted by
Longwei Bai
Igor Iatsenko
over 1 year ago
And enjoyed it even more when highlighting it in Cell Host Microbe Free access link here:
authors.elsevier.com/a/1kbY9_hwRX...
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https://authors.elsevier.com/a/1kbY9_hwRXVGct
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