New preclinical work in #ScienceSignaling reveals how #Tcells respond in real time to signaling inputs of varying intensities and could shed further light on how these cells become activated in the context of immunity and inflammation. https://scim.ag/4qN2h1d

#FluorescenceFriday Proud of our the last paper @cellcommlab.bsky.social & 1st one of @jboixcampos.bsky.social We continue to study #CellMigration & how cells decide where to go: ↖️↗️⬇️? (movie of the actin #cytoskeleton) Full www.science.org/doi/10.1126/... @focalplane.bsky.social @science.org 🧪🔬

Blog post: Chance favors the (theoretically) prepared mind Data is big, machines are learning, so what good is theory anyway? Isn't most discovery driven by serendipity anyway, with theory mostly a "post-mortem"? I argue that this view discounts the value of theory. open.substack.com/pub/arjunraj...

Extremely funny to call the pope “holier-than-thou”

Fig. 6: Mathematical model

Network Medicine is entering a new phase: one that demands we rethink how we study, model and ultimately treat complex diseases. www.sciencedirect.com/science/arti... #ComplexSystems #NetworkScience #Medicine #MedSky 🧪🧬🌐 🧵 1/

Halloween is a nice day to share our new site, where you can find more info on what our team does. It can briefly be summarized as Dynamical Systems (in) Biology: sites.google.com/view/dynamic...

How do dynamics of signalling molecules skew cell fate decisions? With this review we try to move our first steps in the signalling dynamics field, together with the expert lead of @samuzambrano.bsky.social! Kudos to Fulvio, Sara and Erika for their excellent work!

Cells respond to stimuli by activating signaling pathways with a surprising variety of dynamics. Why? As we review here, there is growing evidence connecting dynamics with specific cell fate decisions www.frontiersin.org/journals/cel...

New @nejm.org One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing www.nejm.org/doi/full/10.1056/NEJMoa2400521

How dit life originate in our planet? How can we create it in the lab?Our @royalsocietypublishing.org Theme Issue "Origins of Life: the possible and the actual", coedited with @sfiscience.bsky.social C Kempes and Susan Stepney is out! royalsocietypublishing.org/toc/rstb/202... @manlius.bsky.social

How do you prevent cacio e pepe sauce from congealing? A thoroughly researched answer earned its authors a prize!

I wrote a response to Thomas Friedman's "magical thinking" on AI here: aiguide.substack.com/p/magical-th...

David Baltimore passed away this weekend. A pioneer of molecular virology who won the Nobel prize in medicine & physiology for his discovery of viral reverse transcriptase. This essay he wrote in 2018 reflecting of his 60yr career in science is a great read. www.annualreviews.org/content/jour...

Our @ourworldindata.org we visualise weekly updates of wildfire data from the Global Wildfire Information System. Spain was having a pretty low/average year until the past few weeks when it went roaring past previous years. You can track this data here: ourworldindata.org/wildfires

My new @science.org editorial on the role of scientists in defending democracy is out today. As authoritarianism takes hold in the US, we must fight for the democratic principles that enable a free society and scientists have a key role. I hope you'll join us. www.science.org/doi/10.1126/...

🎯

There is something harder than reviewing a manuscript: reviewing a very bad manuscript.

1. Federal funding for research promotes tech, biomedical, and scientific discovery in the US, and provides training for the sci/tech workforce that has brought immeasurable wealth to the US over the past 75 years. Today's executive order includes a provision that will obliterate both functions.

Carrying on with Session 4 on #EMBLSingleMolecule Day 3 🤓💪🏼 ➡️ 'Decoding Gene Regulation at the Single-Molecule Level through Biophysical Modeling of DNA Footprinting Data' 🎙️ Nacho Molina – Institute of Genetics and Molecular and Cellular Biology @molinalab.bsky.social @igbmc.bsky.social @embl.org

I’m really pleased to share that our paper is out in Developmental Cell! NGN3 oscillates in the developing pancreas and controls the timing of cell differentiation via an incoherent feed-forward motif. For more details check out the comments below and DOI: 10.1016/j.devcel.2025.06.004

My chart on the history of three infectious diseases — smallpox, polio, and measles — before and after a vaccine was available.

A new theoretical analysis directly links Nernst's theorem to the second law of thermodynamics, correcting a longstanding interpretation and clarifying the inaccessibility of absolute zero. doi.org/g9qkq3

"We thank the reviewers for their helpful comments"

A must read!

This looks so cool: intracellular coupling of HES oscillators. Congrats Nancy and all the co-authors!

No doubt, this is one of the most exciting meetings of the year! And we will present our new method, HiddenFoot 😉: www.biorxiv.org/content/10.1...

These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years. It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.

As the parent of a type-I diabetic, I would like to invite the ignorant piece of shit currently directing the FDA to kiss my ass.

Sweet moment in life, our 25th lab anniversary. In a circle, we looked at each other, a group of people with shared values and a soft approach, who want each other to succeed and be happy. (1/2)

Time for a short thread! We developed HiddenFoot, a biophysics-inspired approach to decode single-molecule footprinting data and infer TF, nucleosome, and RNA Pol II binding profiles on individual DNA molecules. One molecule at a time! www.biorxiv.org/content/10.1... 1/6

Here it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social. I'm so excited about this! www.biorxiv.org/content/10.1...

New research by @kasitc.bsky.social @molinalab.bsky.social @arnaudkr.bsky.social reveals limited RNA polymerase II pausing at mouse promoters compared to flies ➡️ www.embopress.org/doi/full/10....

The website by @quoteinvestigator is one of my favorites. I love learning the backstory of quotes. @quoteinvestigator scrupulously tracks down the real sources, and debunks bogus attributions. It's an oasis of truth (and respect for truth).

Very cool! To put this in context, this ability has been argued to be a signature of "the human singularity" 🤨- www.pnas.org/doi/10.1073/...

I signed this pledge to (further) re-brain Europe and boost our science forms.gle/JEcmcGGiGdQF...

In a rare bit of good news for everyone, the number of new podcasts being created is going down. on.ft.com/4ihZp86 Presumably because everyone already has one

Will this go down as the more harmful parameter fit using a simple model in History?

The importance of moving away from bulk! Occupancy of Pol II at promoters is dramatically different between fly and mouse cells! When looking single molecule! Proud of the team! @kasitc.bsky.social @molinalab.bsky.social doi.org/10.1038/s443...

Our latest study is online in The EMBO Journal. We report a new role for IFN-g in suppressing T follicular helper differentiation and B cell responses upon viral infection and immunization. @unisr.bsky.social @embojournal.org #immunology Enjoy the reading! www.embopress.org/doi/full/10....

Hey! Check out our latest publication. A great collaboration with @longchrom.bsky.social and a nice example of how a negative result, the absence of a response to a transcriptional perturbation, can actually reveal an intriguing gene-specific buffering mechanism. www.science.org/doi/10.1126/...

Very nice to hear voices calling for an strengthening of European research in Italy (article by Bob Sitia): www.editorialedomani.it/politica/eur... ...and in Spain (editorial of El Pais) elpais.com/opinion/2025... We need a stronger Europe, and this also means a stronger research!

A propósito: elpais.com/internaciona...

We're hiring! The Development & Stem Cells department at @igbmc.bsky.social, Strasbourg 🇫🇷 is recruiting a group leader working in cell & developmental biology. Our Integrated Structural Biology department also has an open call. More details below! + contact me for informal enquiries #sciencejobs

#StandUpForScience #FortCollins

The pro-EU demonstration 'una piazza per l'Europa', March 15th in Rome, is a great initiative but... www.comune.roma.it/partecipa/pu... Why not reproducing it in ALL Italian cities? Actually... Why not reproducing it in ALL European cities, from Madrid to Tallinn? (We the 🇪🇺 people are ready!)

Getting my poster ready...

It's been a long journey and a fantastic collaboration with Giannicola Genovese and Luigi Perelli (too bad they're not on 🦋), I'm so grateful this piece is finally out! www.nature.com/articles/s41...

Should biology put complexity first? Thought it might be worth sending this round again, as it seems to be resonating with some. This link should give free access until 1 April. authors.elsevier.com/a/1karS8YyDfuZ5m