New fully funded PhD opportunity to come and work with me at the University of Glasgow exploring the role of data-driven interventions (audit and feedback) to improve environmental sustainability of the NHS. Deadline to apply: 12th Jan 2026. Find out more here: www.gla.ac.uk/colleges/mvl...

Are estimands being correctly used? A new review of protocols led by Timothy Clark shows many incorrectly defined estimand attributes. See the top areas for improvement & full results here: trialsjournal.biomedcentral.com/articles/10.... #Trials

Another great post fr @chrischirp.bsky.social focusing on @nihr.bsky.social HSDR funding to improve patient's and staff's experiences. Very proud to be involved, & to have the opportunity to work w and learn fr fab colleagues including @instagraham.bsky.social @katiejsheehan.bsky.social

The CONSORT 2025 Statement is here. Essential reading for those involved in the reporting & reviewing of randomized trials. We're proud to see so many #UKCTUNetwork units & individual researchers contributing to this crucial update! 🔗 tinyurl.com/yc3cbh33 #CONSORT2025 #ResearchTransparency

So true re innovative designs at #CCR25 … first trial (the TARGET Protein trial) was a multi-period cluster crossover design! For full details see the (just published) manuscript ja.ma/4kuYRxv

Always a good conference to follow for innovative trial designs in the context of critical care 👇🏻 #CCR25

New 3-post for a research/senior research fellow to work on adaptive longitudinal cluster randomised trials in Melbourne. Interesting work with a great research group. careers.pageuppeople.com/513/cw/en/jo...

Missed the 1st PPI for Statistician Community of Practice webinar on the organising teams PPI? including our @suziecro.bsky.social @rachpips.bsky.social & Laura Gray Jonny Broomfield @beatrizgoulao.bsky.social @kararoyle.bsky.social check out the recording: leicesterbrc.nihr.ac.uk/ppismart/ppi...

Really enjoyed reading this commentary by @kevinweinfurt.bsky.social which proposes strategies to enhance understanding of meaningful changes in #clinicaltrials

I’ve long used FiveThirtyEight’s interactive “Hack Your Way To Scientific Glory” to illustrate the idea of p-hacking when I teach statistics. But ABC/Disney killed the site earlier this month :( So I made my own with #rstats and Observable and #QuartoPub ! stats.andrewheiss.com/hack-your-way/

The Leverhulme Research Centre for Forensic Science’s podcase "Inside Forensic Science" has been shortlisted at the True Crime Awards, category "Outstanding Indie Podcast" 🎉 You can find out more here: www.dundee.ac.uk/projects/ins... #DundeeUni #Saidheans

Are you an expert whose contribution to the media has brought about better public understanding? Then enter our best stats commentary category for this year's journalism awards, previous winners include @chrischirp.bsky.social @kityates.bsky.social Deadline midnight tomorrow ⤵️

🧵Delighted to share a new guest post by Dr Anne Toomey on **8 things scientists can do right now to stand up for science in the US** Thread of her *evidence-based* actions follows, whole post here christinapagel.substack.com/p/eight-thin... 1/11

In a world where we often despair with hopelessness, @chrischirp.bsky.social work is essential. Great ideas about making a difference below 👇🏻👏 open.substack.com/pub/christin...

Morning in the Caledonian Sleeper train (from Aberdeen to London). Absolutely stunning ❤️

TODAY AT 3PM GMT (11AM EDT)! #EpiSky #CausalSky #CIIG

Measuring the environmental impact of health interventions in randomised controlled trials – a scoping review - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Researchers at Aberdeen Uni are looking for ppl in rural & island Scotland to help shape research into healthcare provision for specific medical conditions. Check out the link for more info on the project & how to get involved. www.abdn.ac.uk/iahs/academi... #RuralHealth #IslandHealth

New paper exploring measuring #environmental impact of #health interventions - we found diversity in outcomes, measures, & analysis. Limited involvement of interested parties. Absolutely essential to do better and reach consensus on what's important to measure www.jclinepi.com/article/S089...

🔈Announcing a series of webinars showcasing our 2024 Trials Adverse Event Special Series. Over the course of 2025 we have a range of talks lined up covering trial conduct, analysis, reporting, and public involvement. Please register your interest here: forms.microsoft.com/e/qqNgLTP651

I’ve seen a number of trial applications in development over recent weeks with lots of discussion about appropriate sample size calculations. A good time to remind everyone about the perils of the “sample size samba” 1/8 #MethodologyMonday #111

Endpoint assessment via routinely collected data generates estimates comparable to randomized controlled trial data: analysis of a cluster-randomized trial on fall injury prevention - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Currently low response rates from CTU Directors (n=5), Programmers/Data Managers (n=0), & QA Managers (n=3) working in clinical trials. We need to know what these groups think the challenges are for greener trials. forms.office.com/e/fkeLD8HbMA Please complete &RT @ukctunetwork.bsky.social

Ensuring a trial has an independent data monitoring committee (DMC) is crucial to the safety and oversight of clinical trials. But a question this week was whether there is ever a scenario where a DMC might legitimately be deemed not to be essential 1/8 #MethodologyMonday #110

For no particular reason, if any statisticians based in the US might be looking for a job in the UK, we'll be advertising a couple in the near future. (CRCTU, University of Birmingham)

Want to know how to report a cluster-crossover trial … the CONSORT extension reporting guidance is out 😊 www.bmj.com/content/388/...

📣Research participants needed!! Do you work in the field of clinical trials? Please take part in our survey to explore what supports trial team behaviour that will make clinical trials greener. See below for details: osf.io/aerm2?view_o... Survey link: forms.office.com/e/fkeLD8HbMA

Interesting historical principles of clinical trial conduct … Rule 5 “the medical statistician has to be competent” … sure hope we’ve got that one sorted!

Are you aware of #MethodologyMonday for wonderful threads on trial methodology?

Thank you Marion. Currently mapping methods to achieve this, watch this space! 🤓 www.abdn.ac.uk/hsru/what-we...

An issue that often comes up is how to set a “non-inferiority margin” in a non-inferiority trial and how to ensure it is appropriate 1/8 #MethodologyMonday #109

Let us start 2025 in a positive mood: here are 10 methods things researchers can worry *less* about in 2025

So chuffed to have been involved with this research. Living with MLTC’s is hard work and should be acknowledged. The lines of work aren’t static, they ebb and flow with the individual depending on their context. People living with MLTC’s aren’t a homogenous mass. 1/

Ah yes the memories. We gave this one a statistical review (with @timpmorris.bsky.social & @sim0ngates.bsky.social) on August 23, the first of several such reviews we did in conjunction with the statistics working group of the @mrcnihrtmrp.bsky.social. zenodo.org/records/3724...

I love this Rachel & @suziecro.bsky.social , Christmassy Estimands, ho ho ho🌲🎅🤓

New post: ‘Many analyses’ Some musings on studies that look at the impact of analysis choices on inference open.substack.com/pub/tpmorris...

The next delivery of our short course on sample size calculations will be on the 4th March 2025. We start from the basics and expand to more complex designs, eg factorial, cluster-randomised, MAMS. With Babak Oskooei, Ian White and Andrew Copas. Info&Registration here: www.ucl.ac.uk/clinical-tri...

Great 1st paper from Frank You's PhD👏 Review headline-Much of the carbon in trials is associated with human behaviour. We found no studies investigating determinants of these behaviours. Soon to launch survey will help us fill this gap to make our trials greener. papers.ssrn.com/sol3/papers....

I'll probably regret this, but here's my two cents on estimands: a thread.

Great thread on estimands. Loved the point "why the funny word?". Our discussions led by @suziecro.bsky.social found patient partners agree with @richardhooper.bsky.social : bit.ly/4gyqhQS

We have seen a number of trials with non-significant findings at #CCRdownunder. There is often debate then about what next? This paper by Pocock & Stone is a useful discussion piece to inform this type of discussion www.nejm.org/doi/full/10....

We are currently discussing the implications of trial post-randomisation exclusions at #CCRdownunder … the following paper by Dean Fergusson et al is a useful primer on when such exclusions might be acceptable and when they might not www.bmj.com/content/325/...

Hot off the preprint server: ‘Efficiency of nonparametric superiority tests based on restricted mean survival time versus the log-rank test under proportional hazards’ Short thread 👇 1/ arxiv.org/abs/2412.06442

📅SAVE THE DATE(s) ***2nd Contemporary Clinical Trials Methodology Meeting*** from ICTU & NIHR RSS Imperial and partners hub, 2nd & 3rd April 2025. More details with booking link coming soon but for now register interest here: bit.ly/3Zg7yUn

Super helpful considerations for #impsci researchers & #clinicaltrials methodologists on effectiveness-implementation hybrid randomised controlled #trials by @marionkcampbell.bsky.social 👇🏻

Challenges in communicating stats & maths remain a barrier to improve society. We need to find creative solutions to bring people along. Lots of great examples in the latest Maths & data sci network event (including @rachpips.bsky.social and mine's! 😇) www.youtube.com/watch?v=ZZdD... #scicomm

Very helpful reference list to tackle "Common statistical myths". Will now be saved in my favourites! 😊 #medstats #stats

Trying to find a list of references for common stats methods questions, eg covariate adjustment. I know one exists but I haven't saved it, and now can't find it! Help @statsepi.bsky.social @timpmorris.bsky.social @maartenvsmeden.bsky.social @jdwilko.bsky.social #medstats

📅SAVE THE DATE(s) & spread the word about the ***2nd Contemporary Clinical Trials Methodology Meeting*** from ICTU & NIHR RSS Imperial and partners hub, 2nd & 3rd April 2025. Register interest here: bit.ly/3Zg7yUn More details with booking link coming soon!