Hot off the press: bmcmedresmethodol.biomedcentral.com/articles/10.... In this we confirm empirically some theoretical results about using different summary measures in non-inferiority trials with survival outcomes. tldr: RMST beats HR.

We still have few places available for our short course on sample size calculations. If interested, book your spot by the end of this week!

This new paper explores the best way to implement reference-based multiple imputation for longitudinal binary data in #ClinicalTrials where data are missing after participants deviate from their assigned treatment. Read now👇 https://buff.ly/4jJtGOW @matteoq21.bsky.social @suziecro.bsky.social

Hot off the press! 📣📣In this tutorial we illustrate available multiple imputation approaches for handling longitudinal data including when they are clustered within higher level clusters. A reproducible example with R and Stata code provided! #OpenAccess onlinelibrary.wiley.com/doi/10.1002/...

📢New publication: How to implement Reference-based multiple imputation for longitudinal binary data, lead by @suziecro.bsky.social with @matteoq21.bsky.social Ian White & James Carpenter onlinelibrary.wiley.com/doi/10.1002/...

Stata users: if you want to make ‘kmunicate’-style Kaplan–Meier graphs, I’ve just released a Stata package on GitHub. To get it: . net from raw.githubusercontent.com/tpmorris/kmu... User feedback welcome! 1/

Ian White, Professor of Statistical Methods for Medicine at the MRC Clinical Trials Unit at UCL, has been awarded the 2024 Stata Journal Editor's Prize for his outstanding contributions to the journal. Congratulations Ian! 🎉 Read more about the award 👉 https://buff.ly/3BGCUKU

NEW PREPRINT A detailed overview of 32 popular predictive performance metrics for prediction models arxiv.org/abs/2412.10288

Do carrots or mince pies improve reindeer performance? 🦌 & how can #estimands help Santa's delivery improvement research programme? Find out in ✨All I want for Christmas… is a precisely defined research question ✨ trialsjournal.biomedcentral.com/articles/10....

Asked ChatGPT to do 3 questions I prepared for various assessments in M.Sc. courses. His scores: 1) 42% (fail) 2) 45% (fail) 3) 72% (pass) Unsure whether to be happy or worried about it. Now the plan is to praise it for the wrong answers to train it to lead students astray if they use it.

The next delivery of our short course on sample size calculations will be on the 4th March 2025. We start from the basics and expand to more complex designs, eg factorial, cluster-randomised, MAMS. With Babak Oskooei, Ian White and Andrew Copas. Info&Registration here: www.ucl.ac.uk/clinical-tri...

A similar one is leaving emails as unread in the mailbox. I feel dirty if I have just one there sitting unread for over 5 minutes. Meanwhile, my partner right now has 2435 unread emails, the first of which is probably the gmail welcome email.

I am looking for a PhD student in Medical Statistics. This project aims to develop new methods for design of early phase trials starting from monotherapy and progressing into combinations. More details are in the link. Feel free to contact me if any questions. www.findaphd.com/phds/project...

We pioneer new designs to make #ClinicalTrials more efficient & robust. Next up in our ‘25 at 25’ series: the Response Over Continuous Intervention (ROCI) design. Find out how ROCI trials can help researchers avoid choosing arbitrary treatment options 👇 https://buff.ly/3OhgGll

Grant rejections are tough, but can be fun as well: Reviewer 1: You should have focused more on A! Rev. 2: You should have focused less on A! Rev. 3: I don't like A. Why didn't you apply for a project on B? Decision letter: we won't give you feedback, figure out by yourself why we're rejecting.

We are advertising a new PhD project to work alongside Michelle Clements, Ian White and myself on methods for non-inferiority trials with sparse outcome data. Funding through TMRP available for both UK and international students, please get in touch with me for more info. Deadline: Jan 13th.

Kind of a wasted opportunity to have all 9 digits exactly once in the exponent of 2.

My first Bluesky post, and my first blog in ~4 years (!): this is about the unlikely mashup of an Aesop fable and a paper from @timpmorris.bsky.social, @maartenvsmeden.bsky.social and Tra Pham.