New publication 📣: Are estimands being correctly used? A review of UK research protocols by Timothy P. Clark, Richard H. Wicentowski, Suzie Cro, Matthew R. Sydes & Brennan C. Kahan trialsjournal.biomedcentral.com/articles/10....

And that's a wrap on this year's NIHR undergraduate internships. It's been a pleasure hosting three rising stars, they've each achieved so much in just 8 weeks. We can't wait to see what the future holds for them. Congratulations Alex, Mahima & Joe and good luck with the rest of your studies.

In our latest adverse event webinar Jeffrey Aronson & Igho Onakpoya discuss their review that looked at how data from clinical study reports compare with data in published trial reports. Catch-up on their talk here: www.statsci.co.uk/webinar-series

In the JAKPPPOT 🎰 trial lead by David Gleason, historical placebo data from the APRICOT trial will be used as an external control arm to explore a signal of effect size. The protocol for this mixed-methods feasibility trial is now available #BMJOpen bmjopen.bmj.com/content/15/8...

Are estimands being correctly used? A new review of protocols led by Timothy Clark shows many incorrectly defined estimand attributes. See the top areas for improvement & full results here: trialsjournal.biomedcentral.com/articles/10.... #Trials

One week left to apply for this exciting opportunity to join our growing statistics team @statsci.bsky.social. Closing 28th August 2025.

Delighted to share registration is open for Professor @vcornelius.bsky.social inaugural lecture -Under pressure: smarter trials for better health outcomes- Thursday, 30 October 2025, 17.30-18.30, Imperial College South Kensington/Online. For details & registration: www.imperial.ac.uk/events/19688...

New publication📣: Incorporation of Patient and Public Involvement in Statistical Methodology Research: Summary of Workshop Proceedings - aimed at addressing barriers to meaningful PPI in statistical methodology research. Open access in Statistics in Medicine onlinelibrary.wiley.com/doi/10.1002/...

New paper posted on Arxiv: "When do composite estimands answer non-causal questions?" This can happen more often than you think, and can have a dramatic impact on trial results (e.g. a false-positive rate of almost 90%) arxiv.org/abs/2506.22610 @timpmorris.bsky.social

Looking forward to this in todays Estimands and Missing data session @ #PSI2025 & being the estimands and missing data bridge between James Bells talk on composite estimand strategies with a continuous outcome & @timpmorris.bsky.social talk on how many multiple imputations you need!

🔈Job alert! We are looking for an ambitious senior trial statistician to join an exciting new partnership between Imperial College London & Imperial College Healthcare NHS Trust, the Fleming Initiative, which aims to tackle antimicrobial resistance (AMR). www.imperial.ac.uk/jobs/search-...

Catch up on all the talks from our Adverse Event special series so far: www.statsci.co.uk/webinar-series

Interested in a new way to impute missing data in clinical trials targeting treatment policy estimands? New blog post introducing **Retrieved Dropout Reference-Based Centred Multiple Imputation**

New Publication 🔊: Investigating the trustworthiness of randomized controlled trials in osteopathic research: a systematic review with meta-analysis by @davidhosch.bsky.social et al in @jclinepi.bsky.social www.jclinepi.com/article/S089...

In 2023 Trials invited submissions that related to the collection, analysis & reporting of adverse events in clinical trials. In this editorial @vcornelius.bsky.social & I summarise the submissions & discuss the implications on applied clinical trials & future methodological research rdcu.be/elLFa

A quick round up of #cctmm25 organised by @imperialctu.bsky.social and NIHR RSS! Day 1 had a range of brilliant speakers and overall was a very inspiring day of clinical trials! Can’t wait for the next one

📢 New job alert. We're recruiting a Lecturer in Digital Health & Clinical Trials @ Imperial Clinical Trials Unit. We're seeking an experienced methodologist looking for a new leadership & research role to help us grow our portfolio of digitally enabled trials. shorturl.at/IioXW Closing 5th May

Meaning the outcome may not be measuring what we thought it was measuring. We used "A four-step strategy for handling missing outcome data in randomised trials affected by a pandemic bmcmedresmethodol.biomedcentral.com/articles/10.... to account for this @suziecro.bsky.social 3/n

Exploring the effect of COVID-19 restrictions on the social functioning scale in a clinical trial of antipsychotic reduction: using multiple imputation to target a hypothetical estimand is out in @jclinepi.bsky.social www.sciencedirect.com/science/arti... 1/n

Looking forward to #CCTMM25 this week! an exciting programme is in store bit.ly/CCTMM25

Our expressions of interest form is now open for anyone who wishes to apply to attend the 'Roadmap Workshop: A road trip for PPI with Trials Methodology Research'. Please click the following link to access it: forms.office.com/e/kx5w4MgHad

New publication led by @proflouisemarston.bsky.social using multiple imputation to target a hypothetical estimand in a pandemic restriction-free world for a trial in schizophrenia - demonstrating the potential impact of the pandemic on the trial results

Only 1 week left to book our 2nd Contemporary Clinical Trials Methodology Meeting, 2-3 April, with the exciting agendas and speakers in store below! >2nd April - statistical >3rd April - trial operations, data systems and data management Register here: www.imperial.ac.uk/events/18598...

SAVE THE DATE! The HRB-TMRN, with @mrcnihrtmrp.bsky.social, is delivering a "Roadmap Workshop: A road trip for PPI with Trials Methodology Research" with Derek Stewart & Katherine Cowan. Expressions of Interests will open very soon. Email us at [email protected] for more information.

My paper looking at using causal forests to determine data driven subgroups is now out! Check it out here:) bmcmedresmethodol.biomedcentral.com/articles/10....

🔈Announcing a series of webinars showcasing our 2024 Trials Adverse Event Special Series. Over the course of 2025 we have a range of talks lined up covering trial conduct, analysis, reporting, and public involvement. Please register your interest here: forms.microsoft.com/e/qqNgLTP651

Registration for our next in-person Contemporary Clinical Trials course is OPEN! This is a bespoke programme for lead investigators who are looking to plan and conduct their own trials There are only 10 places, so register early! Details and registration: www.imperial.ac.uk/clinical-tri...

This new paper explores the best way to implement reference-based multiple imputation for longitudinal binary data in #ClinicalTrials where data are missing after participants deviate from their assigned treatment. Read now👇 https://buff.ly/4jJtGOW @matteoq21.bsky.social @suziecro.bsky.social

A reminder that you have until the 14th of February to take advantage of the early bird pricing for the 2nd Contemporary Clinical Trials Methodology Meeting!

Working on a factorial trial? The Explanation and Elaboration paper for the CONSORT and SPIRIT factorial extensions is now out in @bmj.com It includes: -examples of how to report factorial trials -a methodology summary around the design/conduct/analysis of these trials www.bmj.com/content/388/...

📢New publication: How to implement Reference-based multiple imputation for longitudinal binary data, lead by @suziecro.bsky.social with @matteoq21.bsky.social Ian White & James Carpenter onlinelibrary.wiley.com/doi/10.1002/...

Hot off the press! 📣📣In this tutorial we illustrate available multiple imputation approaches for handling longitudinal data including when they are clustered within higher level clusters. A reproducible example with R and Stata code provided! #OpenAccess onlinelibrary.wiley.com/doi/10.1002/...

How can we implement reference-based multiple imputation to handle #MissingData in #ClinicalTrials for longitudinal binary outcomes? We explored 2 different approaches. Find out which performed best here: onlinelibrary.wiley.com/doi/10.1002/...

Feeling the holiday spirit faded this #BlueMonday? Brighten your day and understand the joy of #estimands in a trial led by Santa—because estimands aren’t just for Christmas! trialsjournal.biomedcentral.com/articles/10....

Register here to attend the **2nd Contemporary Clinical Trials Methodology Meeting** -a fantastic line-up of speakers in store across 1 or 2 days, including statistical day 1 covering multi-arm multi-stage trials, platform trials & target trial emulation! www.imperial.ac.uk/events/18598...

New for 2025 - Our Greener Trials Carbon Footprinting Drop-In Clinics!

Our team—Leila, Suzie, Rachel, and Ellie—in collaboration with Xinxu from the OVG and Claire Waddington published a new article, “Past, Present and Future of Phase 3 Vaccine Trial Design: Rethinking Statistics for the 21st Century.” It’s worth a read! academic.oup.com/cei/advance-...

New paper led by Thomas Drury arxiv.org/abs/2412.12380

In case you are into Christmas and estimands, maybe this article is for you? link.springer.com/article/10.1... "In reality, the statistical elf would have found the sample size was too small (nine reindeers) to estimate these estimands reliably using the discussed methods." #RCT #HRQL

Do mince pies or carrots improve reindeer performance?🥕🥧How can #Estimands help to ensure #Trials answers the question of interest -despite reindeer shenanigans 🦌? Estimands explained this #Christmas in trialsjournal.biomedcentral.com/articles/10.... #AcademicSky #StatsSky #EpiSky #MedSky #SciComm

Our 2024 highlights include: launching the PANTHER platform trial, growing ICTU staff to 120+, hosting the NIHR Imperial & Partners Research Support Service, expanding our trial portfolio (ROMEO, WARRIORS, TRANSFORM) running internships & hosting our first clinical trials methodology meeting.

All I want for Christmas is to know whether eating carrots lead to poor reindeer performance... (and time to post-prandial reindeer laziness) 🤶 Commentary by @suziecro.bsky.social & Rachel Phillips trialsjournal.biomedcentral.com/articles/10....

🥕🥧 Carrots or Mince pie: what fuels Santa's reindeer best? Find out & understand the importance of #estimands to clearly specify trial research questions in ✨All I want for Christmas…is a precisely defined research question✨🎅 shorturl.at/qMB6Y #Trials #AcademicSky #StatsSky #EpiSky #MedSky #SciComm

Read the latest #StatsCI blog post on ICTU’s Insights and Inspirations from #ICTMC2024 - covering Decentralised trials, Adaptive designs, New statistical methods, Estimands, PPI + more! 👇

Great thread on estimands. Loved the point "why the funny word?". Our discussions led by @suziecro.bsky.social found patient partners agree with @richardhooper.bsky.social : bit.ly/4gyqhQS

Hi 👋 This is the new BlueSky account for #StatsCI - a team of statisticians @ Imperial Clinical Trials Unit (Imperial College London) who develop, evaluate and apply contemporary statistical methods to optimise the knowledge gained in medical research. Find out more about us here: www.statsci.co.uk

See also: Estimands framework paper discussion of handling ‘intercurrent events’ (read: post randomisation events) by @brennankahan.bsky.social ; @suziecro.bsky.social and @timpmorris.bsky.social : www.bmj.com/content/384/...

Hot off the preprint server: ‘Efficiency of nonparametric superiority tests based on restricted mean survival time versus the log-rank test under proportional hazards’ Short thread 👇 1/ arxiv.org/abs/2412.06442