It’s time for another #ProudestOf Wednesday! Today, we’re spotlighting Matteo Quartagno (@matteoq21.bsky.social), Principal Research Fellow, who’s advancing the field with innovative trial designs as part of our #Methodology research. Here’s what Matteo is #ProudestOf from his work at the Unit 👇

Continuing the legacy of #STAMPEDE in advancing #ProstateCancer care, we celebrate #UrologicalCancerAwarenessMonth by spotlighting STAMPEDE2. This new trial explores 2 innovative treatments: 🔹 Targeted radiation 🔹 Nuclear medicine therapy And plans to add some more. 🔗Learn more:

It’s Wednesday, which means it’s time for another #ProudestOf moment from our incredible team at the Unit! This week, we spotlight Asiyya Tahsin, one of our fantastic research administrators and a member of our #PPI group. We asked Asiyya what she’s #ProudestOf in her work at the Unit 👇

To celebrate #UrologicalCancerAwarenessMonth, we look back at the many achievements of #STAMPEDE, the largest ever trial in advanced #ProstateCancer. After 20 years and 12,000 participants, it has tested 10 different treatments and changed the standard-of-care 4 times. Read more:

To celebrate #WorldSepsisDay, we’re proud to share our work on NeoSep1, a groundbreaking #ClinicalTrial comparing multiple antibiotic regimens to treat babies with #sepsis. 🎧 This #TrialTalk episode explores NeoSep1's rationale and impact 👇

Today is #SepsisAwarenessDay, a moment to recognise the urgent need for better treatments of #sepsis. We're proud to lead the SNAP trial in the UK, investigating the best way to treat Staphylococcus aureus bacterial infections, a common cause of #sepsis. 🔗 Read more about SNAP: buff.ly/GEKw7ZM

Last week was #WorldSexualHealthDay, a great time to spotlight our PROUD trial, which showed that daily PrEP can dramatically reduce #HIV infections among men who have sex with men. A game-changer in prevention, with lasting impact. 📽️ Watch the short video: www.youtube.com/watch?v=RXkR...

Do #ProstateCancer patients benefit from hormone therapy (HT) added to radiotherapy (RT) after surgery? To find out, the #DADSPORT collaborative #SystematicReview & #MetaAnalysis collected aggregate data from 5 eligible trials (4411 pts). @euplatinum.bsky.social www.mrcctu.ucl.ac.uk/news/news-st...

Wednesdays are our #ProudestOf days at the Unit! #ClinicalTrials are a true team effort, and each week we spotlight someone whose expertise makes it all possible. This week, meet Angus Jennings, one of our Medical Statisticians. We asked Angus what he’s #ProudestOf in his work at the Unit 👇

Yesterday marked #WorldRadiotherapyAwarenessDay, a moment to celebrate the life-saving impact of radiotherapy in #CancerCare. We're proud to spotlight ARCHERY, a novel study working to improve the radiotherapy planning pathway in low- & middle-income countries. 🔗More about ARCHERY: buff.ly/KWKe0yX

Wednesday’s here, and so is our latest #ProudestOf moment! This week, we’re celebrating Nav Kaur ‪@sikhmum.bsky.social‬, Executive Assistant to Prof Max Parmar.‬‬‬ Nav’s proudest achievement? Organising the first-ever event for Black History Month at the Unit.

September is #GynaecologicalCancerAwarenessMonth. #OvarianCancer is the most devastating gynaecological cancer in the UK. The UKCTOCS trial involved over 200,000 women to explore if screening could save lives, but it wasn’t without challenges. 🎧 Discover the insights in this #TrialTalk episode:

It’s that time of the week again... Wednesday pride incoming! Here’s this week’s #ProudestOf highlight from Aaron Horsey @aarononops.bsky.social‬, one of our enthusiastic Clinical Trial Managers at the Unit 👇

Midweek already? Let’s celebrate another #ProudestOf moment from our brilliant team at the Unit! This week, we’re hearing from Annabelle South (@annabellesouth.bsky.social), Principal Research Fellow: Research Impact & Communication. She reflects on what she’s #ProudestOf in her work at the Unit👇

🚴It’s #CycleToWorkDay! Cycling to work is great for your health, the planet, and your wallet. We’re celebrating the day with Aaron Horsey, a trial manager and #GreenImpact champion, who shares what his rush hour by bike looks like, both in pictures and in his own words. @aarononops.bsky.social

It’s Wednesday already… which means it’s time to share another #ProudestOf moment from our colleagues at the Unit. This week, we hear from Isabella Jacques, one of our Data Managers. Here’s what Isabella is #ProudestOf in her work at the Unit 👇

🎉 ARCHERY has completed recruitment for prostate cancer patients! The study assesses AI software for planning #radiotherapy, aiming to improve access in low- and middle-income countries. Recruitment continues for cervix and head & neck patients. 🎧 Learn more about ARCHERY: bit.ly/3HeyRYU

Capacity strengthening is central to our #ClinicalTrials and #Methodology work. We’re committed to supporting trial teams around the world with the skills and tools they need to lead their own sustainable, successful, and impactful clinical trials. 🔍Take a glimpse into what we do:

Another Wednesday, another chance to share what makes us proud! 😊 This week, we’re spotlighting Sophie Merrick drsophiemerrick.bsky.social, one of our Senior Clinical Research Fellows at the Unit. Here’s what Sophie is #ProudestOf from the Unit’s work 👇

Sharing trial results with participants isn’t just ethical, it’s becoming a legal requirement. But it's not straightforward. We joined a webinar discussing best practices and tools, where we heard examples of how it's been done in South Africa, Mongolia & Zimbabwe. 📺 Watch here: buff.ly/flxyhb0

🆕 Publication alert! New insights from a qualitative study exploring men’s perspectives on #ProstateCancer treatment, focusing on how they weigh convenience, treatment methods, and side effects in their decision-making. 📖 Read the full article: bjui-journals.onlinelibrary.wiley.com/doi/10.1111/...

It’s time for another #ProudestOf Wednesday! #ClinicalTrials rely on #TeamScience, and every week we’re spotlighting the people who make them possible. Today, we celebrate Denise Ward, one of our dedicated Clinical Trial Managers. Here’s what she is proudest of her work at the Unit 👇

To mark #WorldHepatitisDay, we're spotlighting our VIETNarms #ClinicalTrial, which showed that new treatments for #HepatitisC are effective and could help expand access to curative care in diverse settings. 📖 Learn more about the VIETNarms trial:

🎉 First wave recruitment of UNITE4TB flagship trial is now complete! The PARADIGM4TB #ClinicalTrial is testing new drug combinations to help make #TB treatment shorter & more effective. A huge thanks to everyone involved 🙌 🔗 Read more: www.mrcctu.ucl.ac.uk/news/news-st...

#ClinicalTrials rely on #TeamScience, bringing together people with different skills & expertise. To celebrate this, we asked our staff what makes them proud personally and as part of our Unit. In the coming weeks, we’ll share their inspiring answers in our #ProudestOf campaign. Here’s the first👇

📈 New publication alert! Using data from #STAMPEDE and linked health system records, researchers assessed the long-term effects of #ProstateCancer treatment. Adding zoledronic acid to #ADT significantly reduced the risk of bone fractures in men with metastatic disease. 🔗 Paper: buff.ly/LHlYket

🎉 Recruitment is complete for the H-PRIME trial! The study compares high vs low doses of hydroxyurea for sickle cell disease in sub-Saharan Africa, without frequent lab tests. It also examines treatments for malaria & bacterial infections, major causes of early death. 🔗 Read more: bit.ly/4m4YcTQ

📈 Results from the BREATHER+ trial confirm that taking HIV medicines every day without breaks remains the best way to keep the virus under control in young people living with #HIV. These findings were presented today at the #IAS2025 @iasociety.bsky.social. 🔗 Read the full story:

🎉Celebrations continue as James Wyncoll receives the IAS/ANRS Lange/van Tongeren Prize for Young Investigators at #IAS2025! This award highlights his impactful work on identifying predictors of treatment failure in children with HIV in the ODYSSEY trial. Congrats, James! @iasociety.bsky.social

Continuing with celebrations this week…🎉 A big shoutout to Peter Godolphin from our meta-analysis team for receiving the 2025 Early Career Award from the Society for Research Synthesis Methodology! A fantastic recognition of his work on treatment effect variation & collaborative meta-analysis.

🏆 Huge congratulations to our collaborator Pauline Amuge! Her outstanding work on the ODYSSEY and CHAPAS-4 trials won the Best Oral Abstract at the 2025 Workshop on Pediatrics & HIV. A well-deserved recognition of her dedication and the incredible efforts of the entire ODYSSEY and CHAPAS-4 teams!

🌱 We are proud to share that our Green Impact team has earned the Gold Green Impact Award for the 2nd year in a row! From energy-saving to plant-based catering & sustainability training, this reflects the amazing work across ICTM. 🔗UCL's Green Impact: buff.ly/aoaPjZj @sustainableucl.bsky.social

A new national research registry is now open for people with Parkinson’s #PD. JPR@Research+Me connects people with Parkinson’s with research studies that match their interests, helping speed up the search for better treatments. 🔗 Read more about it: www.mrcctu.ucl.ac.uk/news/news-st...

#IAS2025 is fast approaching, and the pre-conference International Workshop on Pediatrics & #HIV starts tomorrow! If you are attending, check out the details of talks and posters featuring MRC CTU at UCL trials 👇 www.mrcctu.ucl.ac.uk/news/news-st... @iasociety.bsky.social

📈 STAMPEDE update – Metformin results are out @thelancetoncol.bsky.social The trial tested if adding metformin to standard treatment could slow cancer progression & improve survival in metastatic #ProstateCancer. While no clear survival benefit was found, there were encouraging findings. More in🧵

Are you attending #IAS2025? Don't miss the latest findings from our #HIV trials! Check out the list of talks & posters from MRC CTU at UCL researchers and our partners: buff.ly/FQJgQmx @iasociety.bsky.social

🎉 Recruitment for the RID-TB:Treat #ClinicalTrial is now complete! This study investigates shorter, more effective treatments for latent #TB, paired with additional treatment support. A huge thanks to everyone involved! 🙌 🔗 Learn more about RID-TB: Treat:

Excellent update on the new CONSORT/SPIRIT Statement by Brennan Kahan @mrcctu.bsky.social who discusses the important changes in reporting guidelines for clinical trials. #UKCTUNetwork #TrialStatistics #CTUStats2025 #CONSORT2025

Part 2 of GARDP’s clinical trial on effective antibiotic combinations for newborn sepsis is now underway at Tygerberg Hospital, Cape Town! This potentially lifesaving study aims to recruit 3,000 babies across 2 continents by 2028. 🌍 bit.ly/3FWBaiC @pentafoundation.bsky.social @mrcctu.bsky.social

Yesterday was #MNDAwarenessDay and we are celebrating it by spotlighting our work on MND-SMART, an innovative #ClinicalTrial testing multiple treatments to speed up progress for people living with #MND across the UK. 🔗 Learn more about the trial: mnd-smart.org

📄The BREATHER+ protocol paper is now available! This #ClinicalTrial is exploring whether it's safe for people living with #HIV to take their medication 5 days a week with 2 days off on weekends. 🔗 Read the full protocol: www.sciencedirect.com/science/arti...

Curious about clinical trial designs? Join us on 24 June at 16:00 CEST / 14:00 UTC for #SNIPAFRICA ’s very first webinar: "Statistics: Adaptive designs and their use in AMR research", presented by @mrcctu.bsky.social. 👥 Perfect for all research staff levels Learn more and register👉 lnkd.in/dw_6ARwT

Presented at #CCR25: A trial involving children with severe acute malnutrition and gastroenteritis showed no evidence of a difference in mortality at 96 hours between oral and intravenous rehydration strategies. Full GASTROSAM trial results: nej.md/3TjfSP7 @criticalcarereviews.com

📈 Results from the GASTROSAM trial provide evidence that intravenous #IV rehydration is as safe as oral rehydration for children with severe acute malnutrition #SAM. The findings were published in the @nejm.org and presented at #CCR25. Read the full story 👇 buff.ly/MhEESmM

🚨 LIVE NOW: GASTROSAM Trial Results at #CCR25 The results of the GASTROSAM trial are being presented now at the Critical Care Reviews Meeting 2025 in Belfast. 📺 Watch the livestream here: buff.ly/kv6oAtu

THIS IS BIG❗️ The 1st baby has been enrolled in our clinical trial to evaluate effective #antibiotic combinations for newborns with sepsis. Launched at Tygerberg Hospital, Cape Town, it will be expanded in #Africa & #AsiaPacific. 🌍 bit.ly/44cMLDm @pentafoundation.bsky.social @mrcctu.bsky.social

🚨 Exciting news! The 1st baby has been enrolled in Part 2 of the NeoSep1 trial at Tygerberg Hospital, South Africa. NeoSep1 aims to evaluate effective #antibiotic combinations for babies with sepsis to help choose the best treatment for each baby. Congratulations team! 👏 @gardp.bsky.social‬

🆕New CONSORT & SPIRIT 2025 Guidelines Our colleagues helped shape these updates, making #ClinicalTrial reporting more transparent & useful for everyone. Key changes: ✔️More open science ✔️Better reporting of harms & missing data ✔️Greater harmonisation between guidelines More info: buff.ly/HC1rx31

On #WorldEnvironmentDay, we celebrate our efforts in UCL’s #GreenImpact as Gold Award winners. From partnering with Fairtrade suppliers to promoting sustainable travel & energy-saving practices, we’re committed to reducing our environmental footprint. Our journey towards a greener future continues🌍

📢 Don’t miss this upcoming talk in the Global Oncology Lecture Series by Dr Aggarwal: “Global Trials in Radiation Oncology – Myth or Reality? Lessons from the ARCHERY Study" 📆 June 9 | 7 PM BST 🔗 Zoom link: buff.ly/1eshZsL Meeting ID: 858 6202 0422 Password: 803953