Fascinating story here! We will need to monitor these mutations as we start to use these new antibiotics, especially in the Asia Pacific region, where ceftriaxone resistance is already nearly 30% and the ParC D86N is a concern. N. gonorrhoeae is such a humbling bug... #Gonorrhea #AMR

The mission of Harvard Chan School’s Center for Communicable Disease Dynamics (@ccdd-hsph.bsky.social) is to understand how infectious diseases emerge and spread, to train the next generation of scientists and public health officials, and to guide policy with rigorous science.

U.S. gonorrhea rates fell in 2022 and 2023 after nearly a decade of increases—new paper by @kroster.bsky.social and @yhgrad.bsky.social maps out possible drivers, current evidence, and the data needed to understand what is causing the decline. Read more at bit.ly/4aWmc9i

And there it is: FDA has approved zoliflodacin for gonorrhea as well. That makes two new antibiotics to treat this STI and it means a fascinating debate now about how to use these drugs in a way that will delay resistance as much as possible… 🧪 #IDsky

🧪 #gonorrhoea #mustread today's news about 2 new drugs to treat #gonorrhoea Thanks @kakape.bsky.social for opportunity to say, "The availability of two new drugs will lead to an important and likely controversial debate about how best to use them" And to @yhgrad.bsky.social @gardp.bsky.social

New #MicroSky study showing extensive transmission of #AMR E coli transmission in East Africa under One Health framework, led by Patrick Musicha www.sanger.ac.uk/news_item/an...

It's never good news with gonorrrhea, is it 💊 🧫

New preprint: with increasing resistance to ceftriaxone, the last recommended antibiotic for gonorrhea, we urgently need new drugs. Two--zoliflodacin & gepotdiacin--are up for approval by the FDA in Dec. Here we show a point mutation can result in cross-resistance. www.biorxiv.org/content/10.1...

Outstanding work by @jameshay.bsky.social and colleagues on the H3N2 K clade, putting it into historical context, and considering scenarios for what's to come.

Really pleased to share the first paper to come out of the lab. We found that hospital patients were frequently colonised with P. aeruginosa and that the same clone was shared between the gut and the lung. The phylogenies indicate that the clones moved from lung->gut www.nature.com/articles/s41...

New study shows that shifts in SARS‑CoV‑2 Ct value distributions can help nowcast epidemic trends, revealing both strong potential and key real‑world limitations for Ct‑based surveillance. From CCDD alumni TY Lim & @jameshay.bsky.social and faculty @yhgrad.bsky.social at bit.ly/4o37EaN

Now out in @natcomms.nature.com Kudos to @tylim.bsky.social and @jameshay.bsky.social for a huge effort and thanks to all the collaborators for their hard work. See the final version here: www.nature.com/articles/s41...

Excited for the 'AI4ID Symposium: Bridging Infection and Artificial Intelligence' on January 28th at the Broad Institute. The symposium will unite infectious disease researchers, clinicians, and AI experts to discuss how AI can help address the most pressing challenges in infectious diseases.

If you're looking for a faculty position at the intersection of ecology and computing (both broadly defined), please apply to this joint search between the CEE Department and the College of Computing at MIT: cee.mit.edu/people/share...

…is totally missing the point of publishing scientific articles. Science is always a work in progress, never a finished story. We share our observations so that others can test & build on them, to advance collective understanding. AI may not be able to comprehend this but journals and reviewers MUST

Apart from the AI junk part… the notion that one should not offer a potential mechanistic explanation for an observation, without first spending years & (unavailable) $$ trying to test possibilities before sharing the observation with others (who may be better equipped to investigate the mechanism)…

We’re thrilled to honor Dr. Jeanne Marrazzo at #RIAA2025! Appointed Director of NIAID in 2023, she’s a true leader in advancing research and health equity. Join us in celebrating her incredible contributions on October 20, 2025! www.treatmentactiongroup.org/support-us/r...

We are so excited to share that Bailey Bowcutt (@baileybowcutt.bsky.social), PhD student in the Grad Lab, moderated the Harvard Chan Studio event, “Dr. Anthony Fauci: Insights from 50 years of public service.” 🎦 Watch the full interview: youtu.be/qHxR75vO83M?...

Present your #AMR work at our dedicated forum for global researchers and practitioners! 🧫 🗓️ 23-25 March 2026 Submit abstract by 1 December 📩 Share #genomics and big data approaches for navigating the growing complexities in the AMR field. 📎bit.ly/3SWzJUm#AMR#genomics#MicroSky #AMR2026

New STI surveillance data from the CDC shows declines in gonorrhea, chlamydia, and primary and secondary syphilis (though tragically congenital syphilis continues to increase). What explains these declines? (1/2)

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols. Thread 1/n

New preprint reporting a large piece of work by Katherine Jia to define estimands and estimators for direct impact of vaccines with arbitrary rollout schedules arxiv.org/abs/2509.05508 with Alyssa Bilinski, @chrisboyer.bsky.social and me

“I think of antibiotics as infrastructure” @yhgrad.bsky.social interviewed for the Harvard Gazette, 'Racing against antibiotic resistance'. Read it here at bit.ly/47PdOqv

IID truly lived up to the name of the nonprofit they volunteered with—Community Servings! QinQin Yu, a postdoc in the Grad lab, organized a department volunteer outing at Community Servings, which provides medically tailored meals to families facing chronic illness and nutrition insecurity.

#stihiv2025 🧪 Historians make clinicians /scientists think very differently about what we mean by #SexualHealth and disease. Anna Hanley U Birmingham UK 19thC laws continued to have a long hold on attitudes and treatment of women with #STIs Paternalism patriarchy misogyny blame

We are on the lookout for postdocs for two different projects at the intersection of ecology, evolution, and the human microbiome. See thread for more information and reach out!

Please to write this @washingtonpost.com Op-Ed with Eric Rubin about the importance of independent medical journals like ours @nejm.org & @jama.com wapo.st/4kUqfV9

This is a great 🧵 and a great team. Always getting ahead of the curve on thinking about #gonorrhoea #AntimicobialResistance and new drugs #zoliflodacin #gepotidacin Looking forward to hearing more in Montreal @stihiv2025.org

Very interesting preprint! Modeling introduction of 2 new drugs for #gonorrhea, the authors found that equal allocation (introducing at the same time) was better than sequential (introducing after resistance to prior agent) for #AMR Counter to what we normally assume in #ABstewardship. #STIsky

Study hints doxyPEP use coincides with rise in tetracycline-resistant gonorrhea in US A genomic analysis finds the percentage of US gonorrhea isolates carrying tetracycline resistance genes rose from 10% in 2020 to more than 30% in 2024. www.cidrap.umn.edu/a...

We're hiring a modelling postdoc at PSI Oxford for two exciting projects: 1) modelling the early immune responses to Nipah vaccination, and 2) joining the PRESTO team working on immunobridging in vaccine evaluation studies. tinyurl.com/5abbxrjh Get in touch for more info! Deadline 4th August.

Now out in NEJM. Kudos to @dhelekal.bsky.social and @tatumdmortimer.bsky.social : www.nejm.org/doi/10.1056/...

Using doxycycline after unprotected sex — doxy PEP — is effective at reducing some sexually transmitted infections in some people. But new research suggests is probably also driving development of resistance to tetracycline antibiotics in some bacteria. www.statnews.com/2025/07/09/d...

Excited to share our paper on viral load dynamics of West Nile virus in mosquitoes! Key findings: 1. Variation in pooled Ct values from mosquito traps reflect underlying biological and epidemiological mechanisms. 2. WNV prevalence estimates are improved by using Cts rather than +ve/-ve pool status.

📣 We’re recruiting 1-2 Group Leaders! NCMBM is looking for early-career researchers ready to establish their independent research groups! 🧬 With an attractive start-up package, help us shape the future of molecular biosciences and medicine in 🇳🇴 and be part of the @nordicembl.bsky.social!

⚠️ New preprint ⚠️: Two new antibiotics are likely coming for gonorrhea 💊. How should we deploy them in the US to minimize drug resistance? @kroster.bsky.social @dhelekal.bsky.social Eva Rumpler @yhgrad.bsky.social [1/10] www.medrxiv.org/content/10.1...

A thread about ongoing erasing and ignoring science... 🧵

If you are an early career research attending @stihiv2025.org and interested in learning more about data visualization in R, @odileharrison.bsky.social , Sim Dabee, and I are organizing a workshop during the conference (11:30am-1:30pm on Wednesday). Register here: forms.gle/e4UL1NG62PUD...

A fun conversation with Carl this afternoon about his excellent book AIR-BORNE--the recording is available at the HSPH youtube site: www.youtube.com/user/Harvard...

Dr. Yonatan Grad @yhgrad.bsky.social, Professor of immunology and infectious diseases comments on the potential impact of recent decisions related to vaccines made by Health and Human Services Secretary (HHS) Robert F. Kennedy Jr. Read it here at bit.ly/3T2KPqX

Sang Woo (Daniel) Park and I are excited to share a new preprint, "Susceptible host dynamics explain pathogen resilience to perturbations" [1/8] www.biorxiv.org/content/10.1...

"The money the government sends to Harvard is not a subsidy to advance the university's mission. It's a payment for the role Harvard plays in advancing the research mission of the U.S." "This is larger than any individual grant. What we are losing is a future." www.nytimes.com/interactive/...

Deeply affecting article by an @hsph.harvard.edu PhD student denied the opportunity to graduate due to blanket exclusion of Sierra Leone citizens by the US Government. A very particular example of pointless cruelty by the US Government. www.theguardian.com/global-devel...

Explore the important role of #genomics and data-driven technologies for accelerating advances in #AMRresearch, at our Antimicrobial Resistance meeting! #AMR2026 Discover the latest developments informing a dynamic global response to controlling this crisis. 🗓️ 23–25 March 2026 📎 bit.ly/3SWzJUm

Application deadline extended to July 4th - don't miss the opportunity, well worth it

🚨BREAKING: 300+ NIH employees call out the harm of censorship & politicized science in scathing email to Bhattacharya, demanding an end to political interference, a lift on funding freezes, & rehiring of fired staff whose work saves lives. This is historic - insiders are blowing the whistle. 🧵(1/5)

Only 2 weeks to apply - Highly recommended high-level, networking-friendly course on antimicrobials and resistance, in the cosy atmosphere of Merieux Fondation premises near the lake in Annecy, France - go for it if you can!

Anyone that has been around a lab knows that the trainees really drive the research, while most professors just sort of guide the ship. Most innovation comes from our trainees. Old professors like me will be able to survive these cuts, but our young scientists and our future will be destroyed.

Our worst fears about Bhattacharya are being confirmed. "A total shit show." "Trying to create an environment where lies can be treated the same as scientific truth." "Over his head." "Sold his soul." Appreciate the courage of the NIH staffers in letting us know what is happening there.

There is an old saying that "when public health works, it's invisible." This has a lot of truth, but I think there is more going on than just a lack of appreciation for what public health does. apnews.com/article/publ...