David Helekal
@dhelekal.bsky.social
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📥 179
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Trees, Pathogens, Bayes. Current: Postdoc @ Harvard Chan SPH Prev: PhD @ Warwick
reposted by
David Helekal
Yonatan Grad
4 months ago
Now out in NEJM. Kudos to
@dhelekal.bsky.social
and
@tatumdmortimer.bsky.social
:
www.nejm.org/doi/10.1056/...
add a skeleton here at some point
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reposted by
David Helekal
Tatum Mortimer
5 months ago
If you are an early career research attending
@stihiv2025.org
and interested in learning more about data visualization in R,
@odileharrison.bsky.social
, Sim Dabee, and I are organizing a workshop during the conference (11:30am-1:30pm on Wednesday). Register here:
forms.gle/e4UL1NG62PUD...
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ECR Data Visualisation Workshop
Please complete this application to attend the Data Viz workshop. This event will be held at the 2025 STI & HIV World Congress in Montreal, Canada on Wednesday, July 30th from 11:30-13:30. Effective...
https://forms.gle/e4UL1NG62PUD23Ly5
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reposted by
David Helekal
Yonatan Grad
5 months ago
A fun conversation with Carl this afternoon about his excellent book AIR-BORNE--the recording is available at the HSPH youtube site:
www.youtube.com/user/Harvard...
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reposted by
David Helekal
senjutisaha.bsky.social
5 months ago
One ceftriaxone-resistant
#typhoid
case last year set us on a path that is now live on Emerging Infectious Diseases. 47 cases in months, resistance rose from 0 to 5%. We spoke with patients, sequenced samples. 4.3.1.2.B1 lineage+blaCTX-M-15 on pCROB1.
#AMR
#PublicHealth
wwwnc.cdc.gov/eid/article/...
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Outbreak of Ceftriaxone-Resistant <em>Salmonella enterica</em> Serovar Typhi, Bangladesh, 2024
Ceftriaxone-Resistant <em>Salmonella</em> Typhi, Bangladesh
https://wwwnc.cdc.gov/eid/article/31/7/24-1987_article
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reposted by
David Helekal
Volodymyr Minin 🇺🇦🇺🇸
7 months ago
Looking forward to my visit
@ccdd-hsph.bsky.social
!
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(1/10) New preprint: Expansion of tetM-carrying Neisseria gonorrhoeae in the US, 2018-2024; Link:
www.medrxiv.org/content/10.1...
8 months ago
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How do changes in antibiotic use, various pathways to resistance, multiple drug resistance, and more come together to shape the success and failure of bacterial lineages in a real-world epidemic?
#AMR
#microsky
A preprint:
www.biorxiv.org/content/10.1...
(1/15)
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Quantifying the impact of antibiotic use and genetic determinants of resistance on bacterial lineage dynamics
The dynamics of antimicrobial resistance in bacteria are informed by the fitness advantages conferred by genetic determinants of resistance in the presence of antibiotic pressure and the potential fit...
https://www.biorxiv.org/content/10.1101/2025.02.03.636319v2
9 months ago
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reposted by
David Helekal
Boston Bacterial Meeting
9 months ago
SAVE THE DATE ‼️ 📆 📢 BBM 2025 will be held on June 9-10th at the Harvard Science Center feat. the one and only Dr. Petra Levin as keynote! We can't wait to see you there. Registration and scholarship applications open next week.
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reposted by
David Helekal
Chris Mancuso
over 1 year ago
Why don’t people who live together have the same strains of microbes? Tami Lieberman (
@contaminatedsci.bsky.social
) and I put forward one underexplored reason in our new preprint: Intraspecies warfare restricts strain coexistence in human skin microbiomes
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reposted by
David Helekal
Esther Landhuis
over 1 year ago
My latest for JAMA. Dire headline but focuses on solutions - eg PCR test showing if patient responds to "older" antibiotic, modeling study suggesting how to deploy new drugs w/ national surveillance on shoestring budget.
@yhgrad.bsky.social
@jenabbasi.bsky.social
jamanetwork.com/journals/jam...
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“Super Gonorrhea” Has Arrived
This Medical News article discusses approaches to slow the spread of antimicrobial resistance in Neisseria gonorrhoeae.
https://jamanetwork.com/journals/jama/fullarticle/2818437
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reposted by
David Helekal
Eduardo Rocha
almost 2 years ago
Fully automated assessment of correlated evolution on phylogenetic trees: now out in OA:
doi.org/10.1111/2041...
Thanks to all authors (not yet here). This explains the methodological basis of our recent work on epistatic interactions in the evolution of quinolone resistance:
doi.org/10.1093/molb...
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Evo‐Scope: Fully automated assessment of correlated evolution on phylogenetic trees
Correlated evolution describes how multiple biological traits evolve together. Recently developed methods provide increasingly detailed results of correlated evolution, sometimes at elevated compu...
http://doi.org/10.1111/2041-210X.14190
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