Chris Mancuso
@mancusosci.bsky.social
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Engineering non-model microbes @ Cultivarium | soft spot for microbiomes and DIY tech | he/him
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Chris Mancuso
Benjamin Wolfe
9 days ago
Such a delight to share our work on the evolution of a cheese rind fungus in
@currentbiology.bsky.social
. This is the fantastic PhD work of
@nicolasleonlouw.bsky.social
and resulted from amazing collaborations, a wedding proposal(!), an undergrad course, & more! 🧵
www.cell.com/current-biol...
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Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation
Using a unique longitudinal sampling approach, Louw et al. demonstrate how a cheese-associated Penicillium population has adapted in an artisan cheese production facility in Vermont, USA. Adaptation i...
https://www.cell.com/current-biology/fulltext/S0960-9822%2825%2901119-4
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Felix M Key
10 days ago
Open postdoc position in in my lab in Berlin
@mpiib-berlin.mpg.de
. Join us to push the frontier in ancient microbial genomics. Please apply until Oct 17th. Reach out in case you have any questions.
www.mpiib-berlin.mpg.de/2193291/job_...
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Nature Microbiology
13 days ago
#Newresearch
This Bayesian statistical method uses timeseries microbiome data to infer interaction modules and is tested using a faecal transplant experiment in mice.
#MicroSky
www.nature.com/articles/s41...
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Learning ecosystem-scale dynamics from microbiome data with MDSINE2 - Nature Microbiology
This Bayesian statistical method uses timeseries microbiome data to infer interaction modules and is tested using a faecal transplant experiment in mice.
https://www.nature.com/articles/s41564-025-02112-6?utm_source=bluesky&utm_medium=social&utm_campaign=nmicrobiol
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Chris Mancuso
Tami Lieberman
13 days ago
We are looking for a postdoc to study single-cell transcriptional heterogeneity in the human skin microbiome. We have a new protocol mostly developed, but need someone to see it through. Experience with protocol dev or RNAseq appreciated. Funded by a new grant from MIT-HEALS.
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MIT CEE
3 months ago
A new study by
@mancusosci.bsky.social
and
@contaminatedsci.bsky.social
shows that intraspecies microbial conflict can block new strains from settling in. If we want long-lasting probiotics, we must account for battles within species, not just between them.
www.nature.com/articles/s41...
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Excited to see our work out in Nature Micro today! Big thanks to everyone involved in seeing it over the finish line!
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3 months ago
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Chris Mancuso
Tami Lieberman
4 months ago
Our work on the facial skin microbiome of non-human primates is out in mSystems! We show there is no close relative of Cutibacterium on the faces of gorillas and chimps at the Lincoln Park Zoo, furthering the mysterious origin of the dominant human skin colonizer.
journals.asm.org/doi/10.1128/...
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The microbiome of the human facial skin is unique compared to that of other hominids | mSystems
Understanding how and why human skin bacteria differ from our closest animal relatives provides crucial insights into human evolution and health. While we have known that human facial skin hosts disti...
https://journals.asm.org/doi/10.1128/msystems.00081-25
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Chris Mancuso
PLOS Biology
4 months ago
#Bacteria
use weapons to outcompete rivals, but what happens if they're transferred?
@prokaryota.bsky.social
@jdpal.bsky.social
&co show that HGT of toxin
#plasmids
is rare but recipients can thrive under relaxed nutrient competition, reshaping bacterial warfare
@plosbiology.org
🧪
plos.io/43vC3X7
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Chris Mancuso
Tami Lieberman
5 months ago
Do people in the same household share strains when they have the same species? How many cells transmit when a strain is shared? Can strain composition be dynamic when species composition is stable? We answer these and related questions for the facial skin microbiome in our latest paper. 🧵[1/10]
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Daria Van Tyne
6 months ago
Excited to share our latest, out today in
@naturemicrobiol.bsky.social
Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium
www.nature.com/articles/s41...
@idpittstop.bsky.social
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Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium - Nature Microbiology
Genomic and functional analyses of healthcare-associated vancomycin-resistant Enterococcus faecium reveal that bacteriocin T8 is enriched in emergent lineages and provides a competitive advantage in v...
https://www.nature.com/articles/s41564-025-01958-0
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Chris Mancuso
Dr. David Miller 🏳️🌈
7 months ago
🧪 The NSF director is lying to you. Let’s fact check 7 claims from yesterday’s letter to the community, while pointing out 3 critical omissions. 🧵
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Chris Mancuso
Dr. Kat Napaaqtuk❄️
8 months ago
Edited for brevity: I expect the professional society that I have supported with national & regional membership dues, conference fees for myself and mentees, journal publication fees, & my time as an editor and reviewer, to support widely held values & to advocate on behalf of ALL microbiologists, 🧵
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Chris Mancuso
Dr. Kat Napaaqtuk❄️
8 months ago
My letter to ASM leaders that I sent is too long to be posted here, so I'm going to post highlights in case anyone else needs information for their letter. 🧵
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Michael Baym
10 months ago
The first review article from my lab, helmed by
@celiasouque.bsky.social
, "From Petri Dishes to Patients to Populations: Scales and Evolutionary Mechanisms Driving Antibiotic Resistance" is now online and open access at Annual Reviews Microbiology:
www.annualreviews.org/content/jour...
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Chris Mancuso
Aude Bernheim
11 months ago
Out in Nature Microbiology, we predicted phage-bacteria interactions in E. coli species using only genomic information. Adsorption, not defense systems, is the main driver at this scale (relevant for a phage therapy context), leading to tailored cocktails!
www.nature.com/articles/s41...
🧵👇
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Prediction of strain level phage–host interactions across the Escherichia genus using only genomic information - Nature Microbiology
Phage–host interactions are computationally predicted using only genomic information, highlighting future research directions and enabling generation of custom phage cocktails.
https://www.nature.com/articles/s41564-024-01832-5
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Chris Mancuso
Marco Galardini
11 months ago
We used in-vitro laboratory evolution to "stress test" the next generation class of antibiotics based on antisense oligos ("asobiotics"). Head over to our new preprint to find out more!
www.biorxiv.org/content/10.1...
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Chris Mancuso
Matthias Nau
11 months ago
Want to make beautiful scientific figures? Easy! The NIH released a library of 2000+ free scientific illustrations called *BioArt*. Check it out!
bioart.niaid.nih.gov
#AcademicSky
#PsychSciSky
🧠🟦 🧪
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Chris Mancuso
Hansi Lo Wang (he/him)
11 months ago
Dear mail-in voters, If your state's return deadline is Election Day (Nov. 5), the U.S. Postal Service recommends that you mail your ballot by Tuesday (Oct. 29). Sincerely, The reporter who wrote this:
www.npr.org/2024/09/20/n...
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Voters are advised to return their ballots early because of mail delay concerns
Election officials are raising concerns about the U.S. Postal Service's ability to handle this fall’s expected influx of election mail. But USPS say it’s ready to deliver the country’s ballots.
https://www.npr.org/2024/09/20/nx-s1-5111883/us-postal-service-absentee-ballot-mail-voter
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Given the recent X-odus, I'll reintroduce my postdoc research: Commensal skin bacteria not only attack pathogens, but also fight among themselves! This intraspecies (& interspecies) warfare not only limits which strains can coexist on each person, it also makes cool-looking petri dishes 😎
11 months ago
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Being a postdoc is strange. One day you're writing a faculty applications highlighting your unique and valuable skillset, the next you're making 2L of 8x concentrated artificial sweat...
about 1 year ago
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Chris Mancuso
Tami Lieberman
about 1 year ago
We are on the look out for postdocs to join the Lieberman Lab at MIT. Areas include: -Connecting bacterial warfare to strain dynamics in vivo -Evolution and transmission of microbes in humans -Revisiting role of microbes in acne vulgaris Take a look at our recent preprints and reach out!
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Tami Lieberman
about 1 year ago
Those of you at SMBE, check out Poster #86 on Tuesday by grad student Evan Qu: "Phylogeny-aware strain profiling limits false positive detections and quantifies divergence time of novel strains"
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Lots of amazing EEB sessions at
#ASMicrobe
, but consider stopping by B312 at 315 to see how ecoevo dynamics and antagonism play out for S epi living on people!
over 1 year ago
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Chris Mancuso
Tami Lieberman
over 1 year ago
Chris Mancuso
@mancusosci.bsky.social
will be sharing our story in bacterial antagonisms on Sunday at 3:15p in the session on Integrating in silico models in host-microbe biology. Check it out for more antagonism goodness !
#ASMicrobe
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Why don’t people who live together have the same strains of microbes? Tami Lieberman (
@contaminatedsci.bsky.social
) and I put forward one underexplored reason in our new preprint: Intraspecies warfare restricts strain coexistence in human skin microbiomes
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over 1 year ago
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It was so great to see the MIT Microbiome Symposium come to life yesterday after months of planning. The rest of the symposium organizing team and I are so grateful to all the speakers, presenters, panelists, judges, support staff, and sponsors for making this event a success!
over 1 year ago
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Chris Mancuso
Jacob Baker
over 1 year ago
Ever wondered about the origin of the bacteria that call our faces home? 🤔 Our new preprint dives into the fascinating dynamics of the human facial skin microbiome (FSM) and explores the natural history of important microbiome species on people at high resolution. 🧫🧵
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Chris Mancuso
Tami Lieberman
over 1 year ago
Pleased that grad student Jacob Baker's tour de force analysis of intraspecies dynamics in the skin microbiome -- including >4,000 isolates of 2 species from 8 families carefully clustered into lineages and analyzed is now up.
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Chris Mancuso
Laura Markey
almost 2 years ago
Excited to announce a new preprint from the Lieberman Lab
@contaminatedsci.bsky.social
. We use a mouse model to ask: can we use commensal skin bacteria as topical probiotics?
www.biorxiv.org/content/10.1...
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Chris Mancuso
Tami Lieberman
about 2 years ago
I'm excited to share our most theoretical work yet, led by 3rd year PhD student Paul Torrillo. We revisit the old observation that dN/dS depends on the distance between compared sequences. We arrive at a radically different conclusion than current prevailing theory.
www.biorxiv.org/content/10.1...
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I gave a short talk to MIT Physics of Living Systems today. Always fun to discuss your work with a new group of folks!
about 2 years ago
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