This summarises 95% of all epi papers.

I wrote about a rare genetic variant (a CNV) that appears to reduce the risk of schizophrenia diagnosis by ~5x, and why that's not as unambigously amazing as it sounds, but potentially still a pretty big deal.

This is bananas.

Well played.

I got stuck on the first exercise.

How it started How it’s going

Amazing work from my colleague and postdoc Dr. Isabelle Foote on the genetic architecture of frailty. Encourage you to check it out!!!!

Structural variants are significant contributor to autism. But many SVs & TRs are hard to detect with short reads. Long read sequencing with @pacbio.bsky.social and @nanoporetech.com captures and maps out alot of what short reads miss. So what can LR-WGS tell us about autism? 🧵

Pleased to share our latest paper: academic.oup.com/ije/article/...

NEW EDITORIAL 📢 Seena Fazel and Amir Sariaslan respond to a paper looking at the risk of self-harm in people prescribed gabapentinoids (gabapentin and pregabalin) - a class of drugs which are often used to treat epilepsy and pain disorders Read it in the BMJ: www.bmj.com/content/389/...

Vad har vi lärt oss om beteendegenetik och psykiatrisk epidemiologi i april? Jag har sammanfattat ett antal intressanta artiklar. Dela gärna inlägget i era nätverk 🙏🏼 amirsariaslan.substack.com/p/manadens-l...

Vad har vi lärt oss om beteendegenetik och psykiatrisk epidemiologi i mars? Jag har sammanfattat ett antal intressanta artiklar. Dela gärna inlägget i era nätverk 🙏🏼 amirsariaslan.substack.com/p/manadens-l...

Our new study in BJPsych, for anyone with an interest in a) bridging the gap to clinical usefulness for prediction tools, and b) thinking more clearly about assessing/doing helpful things to reduce violence risk in clinical services for psychosis. doi.org/10.1192/bjp.... (open access)

Ett nytt mässlingsutbrott i Texas har lett till att 259 barn insjuknat sedan januari. Av dessa var 99,2 % ovaccinerade, inklusive ett barn som avled utan att ha några underliggande sjukdomar. www.dshs.texas.gov/news-alerts/...

Does nobody have a calculate? Or common sense? Or a olfactory sensor to do a sniff test? A "new study" finds that 2% of US Adults have been injured at a mass shooting. No. "7% reported having been present." 7% of US adults = 18,346,00 people Are you effing kidding me?

I thought this was some stats sorcery behind my comprehension (CUPED? FWL?) but then I looked it up and…it’s literally just about adjustment for pre-treatment variables?! Why do people keep making up terms 😭 Controlled-experiment Using Pre-Experiment Data, seriously???

"Some people say, 'Oh, you're a hero,' " Harrison told NPR in 2015. "But I'm in a safe room, donating blood. They give me a cup of coffee and something to nibble on. And then I just go on my way. … No problem, no hardship." mensch

Vad har vi lärt oss om beteendegenetik och psykiatrisk epidemiologi i februari? Jag har sammanfattat litteraturen: amirsariaslan.substack.com/p/manadens-l... Dela gärna inlägget i era nätverk 🙏🏼

I dagens inlägg förklarar jag bakgrunden till mitt beslut att ta bort betalväggen i mitt nyhetsbrev "Arv, miljö och slump". Du kan läsa inlägget här: amirsariaslan.substack.com/p/so-long-be...

🚨NEW PAPER! Together with Wuno Akingbuwa (@wonuola.bsky.social) we developed a way to estimate non-linear genetic correlations. It didnt sit well with us that known non-linear relations (e.g. BMI and MDD with a famous U shaped ) are poorly captured in statistical genetics. 🧵

1/3 Tutorial on exploring ecological momentary assessment data is online at AMPPS, with: - Accessible ways to visualize data for better understanding - Models to get some first insights - Further reading boxes for more advanced topics - Reproducible pipeline you can run over your own data

I love all my friends saying things like, “I wish I could make a career off being petty and making diss tracks” after the halftime show, and I’m out here like, “Have you considered academia?”

How was your weekend?

The small details that seem to matter in the end.

“The distribution of highly deleterious variants across human ancestry groups”. Preprint with Anastasia Stolyarova and @gcbias.bsky.social: www.biorxiv.org/content/10.1...

NEW Crime in Eng/Wales up by 12%, according to ONS Crime Survey data for year ending Sept 2024. Survey is regarded as reliable indicator of crime trends. 12% rise driven by 19% increase in fraud - 3,858,000 incidents. Increases in violence & theft not thought to be 'statistically significant'.

Nytt inlägg: amirsariaslan.substack.com/p/manadens-l...

Thanks to all who assisted. I have put links and brief descriptions on my webpage. Please let me know if I should add/change anything: sites.google.com/view/jonasvl...

Apropå ingenting funderar jag själv på att gå med i Nordiska motståndsrörelsen för att se hur de resonerar. www.tv4.se/artikel/4f72...

For younger scholars in the social sciences interested in policing, incarceration, etc., Russell Sage Foundation has a new set of grants just for you:

Idag delar jag en sammanfattning av vår studie från i höstas, som handlar om våldsutsatthet och dess koppling till senare risker för psykiatriska sjukdomar, suicidala beteenden och förtida död. Vad vet vi egentligen om dessa samband? amirsariaslan.substack.com/p/utsatthet-...

New CoDE Lab preprint. We investigated whether spatial ability consistently predicts STEM success beyond other cognitive skills and what aspects of spatial ability predict success in STEM more accurately. Link: www.biorxiv.org/content/10.1...

I listen to people at conferences ask questions that aren’t really questions.

Cutting it a bit fine, but here’s my review of the year in neuroscience for 2024 The eighth of these, would you believe? We’ve got dark neurons, tiny monkeys, the most complete brain wiring diagram ever constructed, and much more… Published on The Spike Enjoy! medium.com/the-spike/20...

"A committee of scholars in Finland has decided to downgrade 271 journals from Frontiers and MDPI in their quality rating system, in a move that may discourage researchers from submitting manuscripts to the outlets." retractionwatch.com/2024/12/24/f...

Some people think it's possible to get an unbiased estimate of an indirect effect in real world settings with observational data through mediation analysis...and then there's everyone else who grew up and developed enough sense to realize that fairytales aren't real

Merry Christmas! 🎄🎅

Apropos of nothing, childhood cancer mortality has been driven down substantially thanks to cancer research and better cancer therapies.

Stress has been suggested to increase the risk of type 1 diabetes. We assessed the association of loss-of-1st-degree-relative on risk of type 1 diabetes in 3.5 million Swedish children with >86k losses and >18k diabetes events and found no evidence of such impact.

#jobalert #postdoc #scijob Our lab will be hiring a postdoc to specialize in integrating functional genomics data with GWAS! We're especially interested in how environment shapes eQTL relationships, and how that might help uncover the etiology of PTSD and Eating Disorders.

New preprint! Which regions of the human brain are most strongly related to individual differences in general cognitive functioning? And what are the underlying neurobiological properties of those areas? | bioRxiv | doi: 10.1101/2024.12.17.628670 🧠

Lots of new contributions to the list of awesome statistical genetics, tools, contribute yours either through commenting or ideally through GitHub! In the new year I will write a tutorial/test scripts for the tools, I'll do one tutorial for each like.

www.biorxiv.org/content/10.1... Smart study to test whether lower prediction accuracy in non-Europeans is due to between-population differences in population structure, genetic nurture, or assortative mating.

Läser att en advokat som jobbar med RFK velat få poliovaccinet indraget i USA. Jag har skrivit om polio innan - vilken skräck det var & hur nära utrotning av viruset vi kom tack vare vaccin. Men den är inte utrotad, kan spridas igen i ovaccinerade grupper. www.dn.se/varlden/fars...

For anyone working in adolescent mental health: I *really* recommend reading this important paper about the most commonly used questionnaires (inc SDQ) In short: most of them have poor psychometric properties, so do we even know what they are measuring? www.thelancet.com/journals/lan... (cont)

Standing Desk Celebrates 4th Year At Lowest Possible Setting

Sweater comes with a Stata license.

Åh, Mimmi P.