For the 12th year in a row, @smidtheart.bsky.social has been ranked #1 in California for Cardiology, Heart, and Vascular Surgery by @usnews.com! www.cedars-sinai.org/newsroom/ced...

Pleased to share our paper: #EVs released from #heart #postMI travel to #brain and cause #neuroinflammation, underlying #depression. Work of Ke Liao, PhD ahajournals.org/doi/epub/10.11…

Online now: NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging

Wonderful Research In Progress update by NIH T32 Fellow, Jonah Zarrow, on developing novel #ncRNA drugs for #Duchenne muscular dystrophy. Important work for #DMD! @eduardomarban.bsky.social @smidtheart.bsky.social @mda.org

Oestrogen Receptor Alpha in Myocyte Maintains Muscle Regeneration in Duchenne Muscular Dystrophy onlinelibrary.wiley.com/doi/full/10....

ICYMI - New #Review on #DNARepair In this Review, Raphael Ceccaldi and @cejkalab.bsky.social discuss the mechanisms and regulation of DNA-end resection, which is crucial for the repair of DNA double-strand breaks by most repair pathways. 🔗 go.nature.com/4iSKphQ

Recent paper published in @jclinical-invest.bsky.social from @eduardomarban.bsky.social & Ke Liao finds a #ncRNA that enhances #Treg cells that could potentially repair heart muscle damage after a #HeartAttack & be applied to a variety of inflammatory disorders. www.cedars-sinai.org/newsroom/pre...

New #SkeletalMuscle paper: Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers. #Myoblue tinyurl.com/4brsea2d

Check out the in-press preview of our @jclinicalinvest paper on regulatory #Tcells — we discovered a #ncRNA that can enhance #Treg dynamics fast enough to improve #MI healing in vivo. New hope for refractory inflammatory and immune conditions? 🔗 www.jci.org/articles/vie...

@russellrogers.bsky.social discussed experiments w/Lefer Lab taking advantage of the mechanistic differences between #GLP1RA & #ncRNA #TY1 as therapeutics for #HFpEF. Compelling evidence for synergistic benefits in two rodent models! Potential for less skeletal muscle loss? @smidtheart.bsky.social

Pleased to share out latest work on cell therapy for #Duchenne. We show #deramiocel therapy initiated early protects against disease-related decline in muscle function. @eduardomarban.bsky.social @smidtheart.bsky.social @stemcellreports.bsky.social @mda.org

Great opening lecture by #HFpEF pioneer @dakheartguy.bsky.social on #sarcomere abnormalities— huge differences in #calcium activated force in #myocytes from obese vs morbidly obese patients. Clinical correlation less evident… @smidtheart.bsky.social #CardioSky

Had a great time at the 75th anniversary meeting of the Muscular Dystrophy Association discussing our work on #ncRNA in #Duchenne MD. Honored to be a recognized as a grant recipient of MDA to study cell-free therapies for #DMD. @mda.org @eduardomarban.bsky.social @smidtheart.bsky.social

New Online! Nuclear and genome dynamics underlying DNA double-strand break repair

Genetic tools for investigating the life cycle of extracellular vesicles

Studying metabolism? Pay attention to time of day Nice collaborative review led by Satchin Panda www.nature.com/articles/s42...

New @NatureComms paper: MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers. #Myoblue tinyurl.com/xmdsv5ez

New @ScienceAdvances paper: Inhibiting EZH2 complements steroid effects in Duchenne muscular dystrophy. #DMD #Myoblue tinyurl.com/3jbcw9fp

Lactic acidosis: implications for human exercise performance link.springer.com/article/10.1...

A short story: “A satellite cell-dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity” @faseborg.bsky.social #myoblue

In 2024, Cedars Sinai performed 682 solid organ transplants, including 137 #HeartTransplants. It is the remarkable generosity of organ donors & their families that allowed our transplant teams to give 682 patients the chance to have longer and healthier lives. 🔗 cedars-sinai.org/newsroom/ced...

Inspiring kickoff to @fda.gov Cell Therapy workshop with keynote lecture by Sally Temple— PSC-derived neural cells are coming into their own! FDA CBER has been highly supportive of this transformative field.

In an effort to pretend life is normal and we can just talk science, our #journalclub today featured Liz on the lasting epigenomic traces of #obesity; Diana on ML-directed #protein #evolution; and James critiqued #iPSC #cardiomyocyte sheets. A welcome distraction from the prevailing woes about NIH.

On Feb 25, @fda.gov is proceeding with its scheduled workshop on #celltherapy. The agenda starts with an address by CBER Director Peter Marks, WarpSpeed hero, and is packed thereafter. Tune in for my session at 230PM EST. 🔗 www.fda.gov/news-events/...

@mkittlesonmd.bsky.social @dakheartguy.bsky.social @russellrogers.bsky.social @eduardomarban.bsky.social @janetweimd.bsky.social @jgoldhaber.bsky.social @keyurshahmd.bsky.social

Our labs got our red on! @russellrogers.bsky.social @ahmedgibrahim.bsky.social @eduardomarban.bsky.social #WearRedDay #GoRedForWomen

Stimulating #labmeeting today by #postdoc Salwa Soussi, PhD on #aging and how it is modulated by novel #RNAdrug #TY1. Strong evidence for central role of #cGAS #STING in cardiac #senescence. Animated discussion followed!

Identifying specific functional roles for senescence across cell types www.cell.com/cell/fulltex...

Native DGC structure rationalizes muscular dystrophy-causing mutations www.nature.com/articles/s41...

Proud to have our own @drmarthagulati.bsky.social of @smidtheart.bsky.social speaking at the first-ever White House Conference on Women’s Health Research, hosted by President Biden and the First Lady.👍👏

We’re excited to have @drmarthagulati.bsky.social at the White House today speaking at the Conference on Advancing Women’s Health Research. POTUS and FLOTUS thank you for this amazing opportunity. youtube.com/live/PQBlGNp...

Generation of self-organized neuromusculoskeletal tri-tissue organoids from human pluripotent stem cells www.cell.com/cell-stem-ce...

REVIEW: Decoding aging clocks: New insights from metabolomics www.cell.com/cell-metabol...

A Vaccine Against Fibroblast Activation Protein Improves Murine Cardiac Fibrosis by Preventing the Accumulation of Myofibroblasts www.ahajournals.org/doi/abs/10.1...

A pleasure and always followed by thoughtful discussion! 👏

Macrophages excite muscle spindles with glutamate to bolster locomotion www.nature.com/articles/s41...

Fibroblast diversification is an embryonic process dependent on muscle contraction www.cell.com/cell-reports...

Interested in RNA therapeutics and regenerative medicine? We have an open postdoc fellowship position in my group at Cedars-Sinai. Apply here: careers.cshs.org/job/los-ange... Please share! 🧬 #postdoc #RNAbiology #RegenerativeMedicine

How to write a good scientific review article. #PhD #scisky #medsky Open Access febs.onlinelibrary.wiley.com/doi/10.1111/...

Mitochondrial calcium uptake declines during aging and is directly activated by oleuropein to boost energy metabolism and skeletal muscle performance www.cell.com/cell-metabol...

A panoramic view of cell population dynamics in mammalian aging www.science.org/doi/10.1126/...

Proteolethargy is a pathogenic mechanism in chronic disease

Updated🥂

This study presents replication-aware single-molecule accessibility mapping (RASAM), a method to nondestructively measure replication status and protein-DNA interactions on chromatin genome-wide. #Cell #scisky Open Access www.cell.com/cell/fulltex...

2024 Albert Lasker Basic Medical Research Award winner Zhijian Chen describes his discovery of cyclic guanosine monophosphate–adenosine monophosphate synthase (cGAS), a DNA-sensing enzyme that triggers inflammation. https://ja.ma/4ibukUD

How to write an excellent Review article @natrevbioeng.bsky.social #scisky #Science #REVIEW Open Access www.nature.com/articles/s44...

tRNAs play an important role in regulating mRNA degradation during translation. @science.org #Biology #scisky #News #Science Read more www.science.org/doi/10.1126/...

Stimulating #labmeeting today by postdoc Jonah Zarrow on #tRNA based new drugs. Continuing the promise of the #EV-based CREDO #ncRNA development paradigm. @smidtheart.bsky.social