Fabai Wu
@fabaiwu.bsky.social
📤 120
📥 129
📝 28
Ass Prof of Microbiology at EITech Ningbo. www.microwulab.com
pinned post!
Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”.
www.nature.com/articles/s41...
#microsky
#archaeasky
loading . . .
Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor - Nature Ecology & Evolution
Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.
https://www.nature.com/articles/s41559-025-02882-6
5 months ago
5
65
32
reposted by
Fabai Wu
Brett Baker
16 days ago
Having a hard time keeping up with the fast-moving field of origin of eukaryotes/Asgards archaea? Our new perspective article can help, we review the status of research over the last decade and where it's going. The archaeal roots of eukaryotic life
www.pnas.org/doi/10.1073/...
7
156
79
Asgard archaea: have we found our microbial ancestors?
link.springer.com/article/10.1...
loading . . .
Asgard archaea: have we found our microbial ancestors? - The EMBO Journal
The discovery of Asgard archaea about a decade ago has greatly reshaped our understanding of archaeal evolution and the origin of eukaryotes. Asgards are currently thought to be the closest prokaryoti...
https://link.springer.com/article/10.1038/s44318-026-00719-x
23 days ago
1
5
1
10 years of massive Asgard undertaking, masterly summarized!
add a skeleton here at some point
23 days ago
0
2
1
reposted by
Fabai Wu
Kassiani Panagiotou
24 days ago
Just over ten years after the discovery of the first Asgard archaeal genomes, we revisit the rapid expansion of this remarkable archaeal lineage. From diverse genomes and metabolisms to eukaryotic signature proteins and the first cultured representatives.
www.nature.com/articles/s41...
loading . . .
Diversity, ecology, cell biology and evolution of the Asgard archaea - Nature Reviews Microbiology
The Asgard archaea have become a cornerstone of archaeal research, particularly for studies aiming to unravel the origin and early evolution of eukaryotes. This Review outlines the current state of th...
https://www.nature.com/articles/s41579-026-01288-w
3
49
28
reposted by
Fabai Wu
Thijs J. G. Ettema 🦠🔬🇳🇱🇸🇪🇪🇺
24 days ago
Finally out in
@natmicrobiol.nature.com
: Prediction of eukaryotic cellular complexity in Asgard archaea using structural modelling. Great work by
@stephkoe.bsky.social
@kassipan.bsky.social
@jvhooff.bsky.social
www.nature.com/articles/s41...
1
72
28
Prediction of eukaryotic cellular complexity in Asgard archaea using structural modelling
add a skeleton here at some point
23 days ago
0
0
0
Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor
add a skeleton here at some point
about 1 month ago
0
4
1
reposted by
Fabai Wu
Thijs J. G. Ettema 🦠🔬🇳🇱🇸🇪🇪🇺
about 1 month ago
Our latest preprint: Together with the team of Jan Löwe,
@danieltamarit.bsky.social
and many others we discovered and characterized several Asgard tubulin genes and propose that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis
www.biorxiv.org/content/10.6...
3
135
65
reposted by
Fabai Wu
Cameron Thrash
2 months ago
Our latest. Led by the very talented
@ahoiching.bsky.social
Cell cycle dysregulation of globally important SAR11 bacteria resulting from environmental perturbation
www.nature.com/articles/s41...
#jcampubs
🌊
loading . . .
Cell cycle dysregulation of globally important SAR11 bacteria resulting from environmental perturbation - Nature Microbiology
Without key cell cycle control genes, SAR11 cells experience aneuploidy and growth inhibition when exposed to changes in nutrients, carbon sources or temperature stress, a vulnerability that may repre...
https://www.nature.com/articles/s41564-025-02237-8
3
52
36
reposted by
Fabai Wu
Victor Tobiasson
2 months ago
Dominant contribution of Asgard archaea to eukaryogenesis. tldr; Best guess, ~ 50% of conserved eukaryotic protein families are from from Asgard archaea!
#science
#biology
#evolution
#nature
#bioinformatics
www.nature.com/articles/s41...
loading . . .
Dominant contribution of Asgard archaea to eukaryogenesis - Nature
A survey of the reconstructed gene set of the last eukaryotic common ancestor shows a consistent link between Asgard archaea and the origin of numerous, functionally diverse eukaryotic genes, dem...
https://www.nature.com/articles/s41586-025-09960-6
2
34
17
reposted by
Fabai Wu
mLife Journal
3 months ago
New Issue Alert — mLife Vol. 4, Issue 6 is out! The issue features 10 open-access papers spanning host–pathogen interactions, bacterial cell division, RNA editing, phage therapy, CRISPR optogenetics, and more. Table of contents here 👉
onlinelibrary.wiley.com/doi/10.1002/...
Highlights below ⬇️
2
5
5
reposted by
Fabai Wu
mLife Journal
3 months ago
Join the IC-DLI x mLife Webinar on Deep Life Studies! 🗓 Dec 30 | 🕐 13:00 UTC | 🧪 3 exciting talks on: • Deep-sea cold seep microbiomes • Novel methanogens beyond Euryarchaeota • Habitable rock–water systems 📍Zoom ID: 853 4219 3531 | PW: 904477
0
2
4
reposted by
Fabai Wu
Miaoxiao Wang (Roy)
3 months ago
Come to follow the official BlueSky of the journal
#mLife
!
add a skeleton here at some point
0
1
2
reposted by
Fabai Wu
mLife Journal
3 months ago
Insightful Review in
#mLife
! Emerging single-cell sequencing and imaging technologies now allow for the profiling of microbial heterogeneity with unprecedented resolution—capturing phenotypic and spatial diversity within microbial communities. 🔗
doi.org/10.1002/mlf2...
1
2
3
reposted by
Fabai Wu
ISEP
4 months ago
Discovery of rare
#protist
reveals previously unknown branch of eukaryotic tree of life
phys.org/news/2025-11...
Rare microbial relict sheds light on an ancient eukaryotic supergroup
www.nature.com/articles/s41...
#Protists
#Microbes
#Evolution
#Eukaryotes
#TreeOfLife
1
20
4
reposted by
Fabai Wu
Cameron Thrash
4 months ago
An archaeal genetic code with all TAG codons as pyrrolysine
www.science.org/doi/abs/10.1...
#jcampubs
loading . . .
An archaeal genetic code with all TAG codons as pyrrolysine
Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...
https://www.science.org/doi/abs/10.1126/science.adu2404?af=R
2
27
17
reposted by
Fabai Wu
Tanmay Bharat
5 months ago
An Asgard archaeon with internal membrane compartments Brilliant study led by
@fmacleod.bsky.social
and Andriko von Kügelgen. Tight collaboration with
@buzzbaum.bsky.social
and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
10
388
191
Asgards everyday! Another boost to the metabolism at the prokaryote-eukaryote interface.
add a skeleton here at some point
5 months ago
0
2
0
reposted by
Fabai Wu
Daan Speth
10 months ago
I'm happy to announce the latest release of the GlobDB, available at
globdb.org
. The GlobDB is a database of "species dereplicated" microbial genomes, and as of release 226 contains twice the number of species-representative genomes (306,260) than the latest GTDB release.
loading . . .
home | GlobDB
https://globdb.org/
3
114
66
reposted by
Fabai Wu
PLOS Biology
5 months ago
Bacteria rely on retrons for
#phage
defense, but most known systems come from clinical or lab strains.
@seth-shipman.bsky.social
&co identify diverse
#retrons
from environmental
#bacteria
, uncovering their defense mechanisms & using them as
#GenomeEditing
tools
@plosbiology.org
🧪
plos.io/4oDqRAF
1
8
2
How are we replicating our
#DNA
? Find origin in the
#Asgard
#Archaea
!
add a skeleton here at some point
5 months ago
0
4
0
reposted by
Fabai Wu
STCmicrobeblog
5 months ago
chromosome replicationists –
#Archaea
branch, Asgard dept. – take note 👇
#ArchaeaSky
thx
@acritschristoph.bsky.social
for boosting this 🙏
add a skeleton here at some point
1
4
1
Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”.
www.nature.com/articles/s41...
#microsky
#archaeasky
loading . . .
Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor - Nature Ecology & Evolution
Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.
https://www.nature.com/articles/s41559-025-02882-6
5 months ago
5
65
32
reposted by
Fabai Wu
Cees Dekker
11 months ago
Latest
#CDlab
paper on
@biorxivpreprint.bsky.social
: Spatial control of karyopherin binding avidity in NPC mimics revealed by designer FG-Nucleoporins
www.biorxiv.org/content/10.1...
With experiments & MD simulations we study de novo designed proteins for selective transport through nuclear pores
1
12
4
reposted by
Fabai Wu
Alex Bisson
12 months ago
It is the year of the (more?) complex prok multicellularity :)
add a skeleton here at some point
1
11
3
reposted by
Fabai Wu
Cees Dekker
12 months ago
Wow, I feel greatly honored by being awarded the 2026 Biochemical Society Award for Significant Breakthrough or Achievement, as was just announced!
www.biochemistry.org/about-us/new...
It is wonderful that the Biochemical Society honors our contributions to single-molecule biophysics in this way!
add a skeleton here at some point
10
58
8
reposted by
Fabai Wu
Nika Pende
12 months ago
Sooo cool! Congrats
@archaeon-alex.bsky.social
and Co.!
add a skeleton here at some point
1
2
1
We are looking for tenure-track and tenured biologists to join our department: School of Life Sciences at EITech Ningbo. It's a new private university, English taught, benefits and selection are both internationally competitive. Please apply & contact me if you have any questions.
shorturl.at/Rjqku
loading . . .
Tenure-Track and Tenured Positions in Life Sciences, Biotechnology, and Biomedical Engineering - Ningbo, Zhejiang (CN) job with Eastern Institute of Technology, Ningbo - Global Engagement Office | 128...
Seeking dynamic and outstanding individuals to join us in the College of Science and College of Engineering to expand our research capabilities.
https://www.nature.com/naturecareers/job/12836885/tenure-track-and-tenured-positions-in-life-sciences-biotechnology-and-biomedical-engineering?LinkSource=SimilarJobPlatform
12 months ago
0
1
0
you reached the end!!
feeds!
log in