this is wild - i was aware of Mary-Claire King's absurdly important discoveries on BRCA / inherited breast cancer but I had no idea that her first PhD paper (King & Wilson 1975, Science, not bad lol) is the "99% of protein coding shared btwn chimps and humans" result www.science.org/doi/abs/10.1...

RosettaFold 3 is here! 🧬🚀 AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release! Congratulations @simonmathis.bsky.social and team!!! ❤️ bioRxiv preprint: www.biorxiv.org/content/10.1...

Boltz-1 update Boltz-1x introduces inference-time steering for much higher physical quality, CUDA kernels for faster, more memory-efficient inference and training. www.biorxiv.org/content/10.1...

BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design https://www.biorxiv.org/content/10.1101/2025.04.06.647261v1

...where a powerful toy slingshot can be used to mount the LoRa node in a tree for better line-of-sight communications with other devices. www.instructables.com/Meshtastic-S...

🚀 Thrilled to share our latest work from Zhang Lab, now published in Science (www.science.org/doi/10.1126/...) We introduce TIGR-Tas, a PAM-free, compact, modular RNA-guided DNA-targeting system in prokaryotes & their viruses. More details coming soon 👀 #TIGR #RNA #GeneEditing #CRISPR

Sequencing by Expansion (SBX) -- a novel, high-throughput single-molecule sequencing technology https://www.biorxiv.org/content/10.1101/2025.02.19.639056v1

Wait-a-minute 3 in 1 COVID, Flu A, and B tests are already available from Amazon. Is the RSV one coming? I missed the memo. a.co/d/4s5izkO

This is pretty cool: Scientists have isolated the gene that may be responsible for the reason grapefruit interferes with some meds. It's not the solution, but it's a start. I love grapefruit but it messes with one of my meds, so this makes me happy. www.scientificamerican.com/article/why-...

Arzeda has been awarded DARPA funding to advance AI-driven protein design—even with limited data! We're pushing the boundaries to create next-gen proteins for national security, sustainability, and beyond. #AI #ProteinDesign www.prnewswire.com/news-release...

Speculative writeup and the webinar Feb 20 web.cvent.com/event/e77566...

From the dependably insightful @aukehoekstra.bsky.social .

Our inability to reliably study algorithmic info ecosystems, and why it matters for #scicomm. Pre-publication version of our forthcoming PNAS piece led by Nicky Krause and Isabelle Freiling : osf.io/preprints/so... (a 🧵)

You guys remember TweetDeck? Bluesky has it, and it's free. Check out 🔗 deck.blue by @gildaswise.com for a multi-column interface. 2/10

NEW paper 🚨! We engineered TNT sensors in soil bacteria for long-term detection of explosive in natural soil, enabling geospatial detection of contaminated soil. This work (led by Erin Essington) included new sensors, circuits, modeling, & a 28-day testing workflow. 1/ www.nature.com/articles/s41...

This is a really cool paper. They developed a reasonably robust circuit to generate patterns.

🧬🖥🧪 Here are some healthy reminders on just how much Illumina still dominates the #genomics space... 😐

🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

The infographic & some extra info here if anyone is interested www.compoundchem.com/2014/08/21/c...

Rumors are that they will release model and weights next week.

Arzeda has now produced and sold 10 tons of ProSweet RebM™ stevia, a natural, zero-calorie sweetener, marking a major step forward in sustainable production for the food industry. #biosky www.businesswire.com/news/home/20...

Washington's Dream, plants! youtube.com/shorts/Mz-Er...

Bluesky has grown to 13M users in a year and a half — thank you all for choosing us! We’ve raised a $15M Series A to support our growth and continue to build an open social network that is designed around you, the user.

New preprint by @jgi.doe.gov's Leo Baumgart, Ronan O'Malley and many others Mapping binding sites of 360 TFs across 10 🌿Brassicaceae genomes. 1.1 million TF-target gene assignments in Arabidopsis thaliana alone!

Design of a biomolecular adaptive controller to restore sustained periodic behavior https://www.biorxiv.org/content/10.1101/2024.10.11.617962v1

Part 1 had me in stitches youtu.be/JYqfVE-fykk?... Part 2 great work youtu.be/VJ62EfUKI3w?...

Marburg in Rwanda, 20 cases reported taarifa.rw/rwandas-heal...

Here are some useful links to my work. Please bookmark for easy access! 💚 Open Laboratory Notebook: tinyurl.com/ATGCFFE Open Data Repository: tinyurl.com/ATGCSWEET Web Store for Plasmids and Goodies: atinygreencell.com Binomica Labs GitHub: github.com/Binomica-Labs

Bluesky now has over 10 million users, and I was #1,292,419!

Another group has more or less reproduced AF3, but has built in a way to add spatial constraints for PPI prediction. These constraints lead to huge increases in fraction of models that are correct-ish, without changing fraction that is high-accuracy chaiassets.com/chai-1/paper...

🌍 We have just extracted a NEW global network of researchers and a global 100 scientist top ‘influencers’ on Bluesky. @lassehjorthmadsen.bsky.social and I show that scientists are in a series of distinct communities: mikeyoungacademy.dk/communities-... 😀 All 'likes' and reshares appreciated!

Forgot to add that, while Kekulé’s benzene structure has endured, some of his other structural depictions were less successful. For some reason, his “sausage formulae” never caught on…

Computational design of highly active de novo enzymes https://www.biorxiv.org/content/10.1101/2024.08.02.606416v1

Accelerated enzyme engineering by machine-learning guided cell-free expression https://www.biorxiv.org/content/10.1101/2024.07.30.605672v1

Preventing plasmid multimer formation in commonly used synthetic biology plasmids https://www.biorxiv.org/content/10.1101/2024.07.23.604805v1

Happy 4th. Transglutaminase fact: they're used to improve the texture of hot dogs

Hi all - I have a couple of positions open for lab management and research! Please pass this on to creative and enthusiastic folks who might be interested. (And repost if you don't mind.) Ability to learn/adapt more important than specific skills! Thanks so much. arizona.csod.com/ux/ats/caree...

Induction of Meiosis from Human Pluripotent Stem Cells https://www.biorxiv.org/content/10.1101/2024.05.31.596483v1

If you're interesting in the #H5N1 outbreak in cattle in the US, please have a look at our preliminary analyses just posted. Part 1 of 2: virological.org/t/preliminar...

Bagheera helps Molecule of the Month author David Goodsell create his amazing illustrations. Can you guess which molecule Bagheera is in? #NationalPetMonth #PetsofRCSBPDB pdb101.rcsb.org/motm...

Excited for this live public event with the @bigbiology.bsky.social podcast, addressing ecological restoration in Alaskan Lakes! If you know someone in Alaska who might be interested, please share it with them!

MAIA: An open-source, modular, bioreactor for cities https://www.biorxiv.org/content/10.1101/2024.05.03.592196v1

And AFTER ALL THAT.... #BlueSoup isolate has 98.7 ANI with the Pseudomonas carnis genomes from the Marina De León & @phylogenomics.bsky.social paper jgenomics.com/v09p0055.htm 💀 99.2 ANI with P. NBRC 111137; still digging!

No videos here ... yet. So, here is a cute AlphaFold2 model of the mEmerald labelled nanocages that we used to determine that there are ~120 DCX molecules bound per µm growth cone microtubule🧪 doi.org/10.1101/2024...

De novo design of antibody variable heavy chains (VHH's) using RF diffusion www.biorxiv.org/content/10.1...

Nice list of community science projects here. www.seattletimes.com/pacific-nw-m...

Trikafta changed CF from a death sentence to a treatable condition. It overcomes the deficit of a chloride channel caused by a specific inherited mutation in the CFTR gene, discovered in 1989, and only 30 years later this story was possible. How much quicker will this take these days?

@bioandbaseball.bsky.social any chance you could share that www.liebertpub.com/doi/10.1089/... paper PDF?

Next, an editorial from the Seattle Times on restoring salmon streams. "The course is not cheap, but it is clear: The state must fix the culverts, using the best science possible." WA must stay the course on culvert removal to save salmon www.seattletimes.com/opinion/edit...