Gabriel Santpere
@santperelab.bsky.social
📤 39
📥 62
📝 9
We’re excited to share our new preprint on the mechanisms underlying DNA binding by bHLH transcription factors and how they achieve distinct DNA binding specificities. The study has been spearheaded by Xabier de Martín.
@grib-barcelona.bsky.social
Take a look! 👇
www.biorxiv.org/content/10.6...
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https://www.biorxiv.org/content/10.64898/2026.02.10.705010v1
1 day ago
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Sofia Ognibene presented a poster at the XIII Bioinformatics and Genomics Conference on a pipeline to analyze Epstein–Barr virus genomes in the context of the
#EBVMS
project 🧬🚀 Great work!
about 2 months ago
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Great days in Bergen for the EBV-MS consortium meeting. Inspiring discussions, outstanding science, and a truly collaborative spirit. Excited to be part of such a stimulating international effort to unravel the role of EBV in MS.
#EBVMS
#MultipleSclerosis
@researchmar.bsky.social
3 months ago
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reposted by
Gabriel Santpere
Suel-Kee Kim
5 months ago
Excited to share our recent study on human-specific features of the cerebellum and the unexpected, novel role of zona pellucida protein 2 (ZP2) in synapse development. Grateful to the Sestan lab and all our collaborators for their outstanding contributions.
www.biorxiv.org/content/10.1...
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Human-specific features of the cerebellum and ZP2-regulated synapse development
Understanding the unique features of the human brain compared to non-human primates has long intrigued humankind. The cerebellum refines motor coordination and cognitive functions, contributing to the...
https://www.biorxiv.org/content/10.1101/2025.09.08.674970v1
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reposted by
Gabriel Santpere
Hospital del Mar Research Institute
7 months ago
Researchers from the Hospital del Mar Research Institute and Yale University have demonstrated how the action of certain
#genes
on precursor cells of
#brain
formation can cause alterations linked to cortical malformations but also to the origin of neuropsychiatric diseases
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reposted by
Gabriel Santpere
Hospital del Mar Research Institute
7 months ago
Linking alterations in precursor cells of brain 🧠 formation with the origin of
#neuropsychiatricdiseases
#bioinformàtica
#neuropsiquiatria
#salutmental
#autisme
#Alzheimer
#TalentMAR
@santperelab.bsky.social
@yaleneuro.bsky.social
@hospitaldelmar.bsky.social
www.researchmar.net/news/742/lin...
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Excited to share our latest work, spearheaded by my brilliant student Xoel Mato and co-led by Nicola Micali. After years of sweat, intense weekly meetings, and meticulous discussion of every panel, we learned a lot from each other. Grateful for the journey!
@researchmar.bsky.social
rdcu.be/evCaU
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Early developmental origins of cortical disorders modeled in human neural stem cells
Nature Communications - The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem...
https://rdcu.be/evCaU
7 months ago
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reposted by
Gabriel Santpere
Navjot Kaur
9 months ago
Excited to showcase as a co-first author our latest work "Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons "https://www.biorxiv.org/content/10.1101/2025.05.20.652233v1
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Mice grow bigger brains when given this stretch of human DNA
www.nature.com/articles/d41...
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Mice grow bigger brains when given this stretch of human DNA
Finding adds to the bigger picture of how humans developed such large brains.
https://www.nature.com/articles/d41586-025-01515-z
9 months ago
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Last week we attended the
#ECCN2025
meeting in Alacant. It was an impressive succession of mind-blowing talks—exhilarating and exhausting. You couldn’t let your guard down for a second! Here are Paula Mayo and Josema Ruiz presenting their posters.
@grib-barcelona.bsky.social
9 months ago
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reposted by
Gabriel Santpere
Parc de Recerca Biomèdica de Barcelona
10 months ago
🦠Although infection by the
#EpsteinBarrVirus
is necessary to develop
#MultipleSclerosis
, only 0.3% of those infected develop it. A new European project with the participation of 3 PRBB centres aims to understand why and the underlying mechanism. More 👇
ellipse.prbb.org/ebv-ms-unvei...
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EBV-MS: Unveiling the relationship between Epstein-Barr virus and multiple sclerosis - El·lipse
A 5-year Horizon Europe-funded project aims to uncover the role of the EBV virus in the onset and progression of the Multiple Sclerosis (MS) disease .
https://ellipse.prbb.org/ebv-ms-unveiling-the-relationship-between-epstein-barr-virus-and-multiple-sclerosis/
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www.uib.no/en/ebvms/177...
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Epstein-Barr Virus and Its Role in Multiple Sclerosis: A Growing Area of Research
In recent years, scientific evidence linking the Epstein-Barr virus (EBV) to the development of Multiple Sclerosis (MS) has grown significantly. EBV, a common herpesvirus that infects most people at s...
https://www.uib.no/en/ebvms/177648/epstein-barr-virus-and-its-role-multiple-sclerosis-growing-area-research
10 months ago
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Our piece on the beautiful work by Cui et al. on the impact of human accelerated regions on neurons is out now!
@grib-barcelona.bsky.social
@researchmar.bsky.social
@cp-trendsgenetics.bsky.social
www.sciencedirect.com/science/arti...
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The impact of human accelerated regions on neuronal development
Human accelerated regions (HARs) are the fastest-evolving sequences in the human genome since the divergence from chimpanzees. Some of these regions a…
https://www.sciencedirect.com/science/article/pii/S0168952525000526
10 months ago
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reposted by
Gabriel Santpere
Quim Testar
11 months ago
He rigut.
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reposted by
Gabriel Santpere
Cedric Boeckx
about 1 year ago
Great study from Nenad Sestan’s lab and collaborators (led by
@babyamygdala.bsky.social
) on the specification of claustro-amygdalar and ‘palaeocortical’ neurons and circuits — with a key role for TFAP2D dosage, now out in
@nature.com
www.nature.com/articles/s41...
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Specification of claustro-amygdalar and palaeocortical neurons and circuits - Nature
A conserved gene regulatory network involving SOX4, SOX11 and TFAP2D shapes the development of excitatory neurons in ventrolateral pallium and their connectivity with the prefrontal cortex.
https://www.nature.com/articles/s41586-024-08361-5
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reposted by
Gabriel Santpere
Emily R. Trunnell, Ph.D.
about 1 year ago
Read the full paper from Dennis Joshy, Gabriel Santpere, & Soojin V. Yi of
@ucsantabarbara.bsky.social
&
@researchmar.bsky.social
in
@pnas.org
:
www.pnas.org/doi/10.1073/...
4/8
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PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/10.1073/pnas.2411918121
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reposted by
Gabriel Santpere
Prof Sam Illingworth
about 1 year ago
🧬 Human Brain Evolution New research reveals rapid, cell-type-specific regulatory evolution in human brains compared to primates, highlighting specialised changes in brain cells that shaped human cognition and behaviour. 🔗
www.pnas.org/doi/10.1073/...
#Neuroscience
#Evolution
#SciComm
🧪
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PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/10.1073/pnas.2411918121
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reposted by
Gabriel Santpere
Chris Stringer
about 1 year ago
Accelerated cell-type-specific regulatory evolution of the human brain | PNAS
www.pnas.org/doi/full/10....
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Accelerated cell-type-specific regulatory evolution of the human brain | PNAS
The molecular basis of human brain evolution is a key piece in understanding the evolution of human-specific cognitive and behavioral traits. Compa...
https://www.pnas.org/doi/full/10.1073/pnas.2411918121
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