Gabriel Santpere
@santperelab.bsky.social
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📥 62
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Sofia Ognibene presented a poster at the XIII Bioinformatics and Genomics Conference on a pipeline to analyze Epstein–Barr virus genomes in the context of the
#EBVMS
project 🧬🚀 Great work!
4 days ago
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Great days in Bergen for the EBV-MS consortium meeting. Inspiring discussions, outstanding science, and a truly collaborative spirit. Excited to be part of such a stimulating international effort to unravel the role of EBV in MS.
#EBVMS
#MultipleSclerosis
@researchmar.bsky.social
about 1 month ago
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reposted by
Gabriel Santpere
Suel-Kee Kim
4 months ago
Excited to share our recent study on human-specific features of the cerebellum and the unexpected, novel role of zona pellucida protein 2 (ZP2) in synapse development. Grateful to the Sestan lab and all our collaborators for their outstanding contributions.
www.biorxiv.org/content/10.1...
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Human-specific features of the cerebellum and ZP2-regulated synapse development
Understanding the unique features of the human brain compared to non-human primates has long intrigued humankind. The cerebellum refines motor coordination and cognitive functions, contributing to the...
https://www.biorxiv.org/content/10.1101/2025.09.08.674970v1
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reposted by
Gabriel Santpere
Hospital del Mar Research Institute
5 months ago
Researchers from the Hospital del Mar Research Institute and Yale University have demonstrated how the action of certain
#genes
on precursor cells of
#brain
formation can cause alterations linked to cortical malformations but also to the origin of neuropsychiatric diseases
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reposted by
Gabriel Santpere
Hospital del Mar Research Institute
5 months ago
Linking alterations in precursor cells of brain 🧠 formation with the origin of
#neuropsychiatricdiseases
#bioinformàtica
#neuropsiquiatria
#salutmental
#autisme
#Alzheimer
#TalentMAR
@santperelab.bsky.social
@yaleneuro.bsky.social
@hospitaldelmar.bsky.social
www.researchmar.net/news/742/lin...
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Excited to share our latest work, spearheaded by my brilliant student Xoel Mato and co-led by Nicola Micali. After years of sweat, intense weekly meetings, and meticulous discussion of every panel, we learned a lot from each other. Grateful for the journey!
@researchmar.bsky.social
rdcu.be/evCaU
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Early developmental origins of cortical disorders modeled in human neural stem cells
Nature Communications - The implications of early telencephalic development in cortical disorders remain elusive. Here, the authors define risk gene dynamics and perturbation effects in neural stem...
https://rdcu.be/evCaU
6 months ago
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reposted by
Gabriel Santpere
Navjot Kaur
7 months ago
Excited to showcase as a co-first author our latest work "Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons "https://www.biorxiv.org/content/10.1101/2025.05.20.652233v1
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Mice grow bigger brains when given this stretch of human DNA
www.nature.com/articles/d41...
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Mice grow bigger brains when given this stretch of human DNA
Finding adds to the bigger picture of how humans developed such large brains.
https://www.nature.com/articles/d41586-025-01515-z
7 months ago
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Last week we attended the
#ECCN2025
meeting in Alacant. It was an impressive succession of mind-blowing talks—exhilarating and exhausting. You couldn’t let your guard down for a second! Here are Paula Mayo and Josema Ruiz presenting their posters.
@grib-barcelona.bsky.social
7 months ago
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reposted by
Gabriel Santpere
Parc de Recerca Biomèdica de Barcelona
8 months ago
🦠Although infection by the
#EpsteinBarrVirus
is necessary to develop
#MultipleSclerosis
, only 0.3% of those infected develop it. A new European project with the participation of 3 PRBB centres aims to understand why and the underlying mechanism. More 👇
ellipse.prbb.org/ebv-ms-unvei...
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EBV-MS: Unveiling the relationship between Epstein-Barr virus and multiple sclerosis - El·lipse
A 5-year Horizon Europe-funded project aims to uncover the role of the EBV virus in the onset and progression of the Multiple Sclerosis (MS) disease .
https://ellipse.prbb.org/ebv-ms-unveiling-the-relationship-between-epstein-barr-virus-and-multiple-sclerosis/
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www.uib.no/en/ebvms/177...
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Epstein-Barr Virus and Its Role in Multiple Sclerosis: A Growing Area of Research
In recent years, scientific evidence linking the Epstein-Barr virus (EBV) to the development of Multiple Sclerosis (MS) has grown significantly. EBV, a common herpesvirus that infects most people at s...
https://www.uib.no/en/ebvms/177648/epstein-barr-virus-and-its-role-multiple-sclerosis-growing-area-research
8 months ago
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Our piece on the beautiful work by Cui et al. on the impact of human accelerated regions on neurons is out now!
@grib-barcelona.bsky.social
@researchmar.bsky.social
@cp-trendsgenetics.bsky.social
www.sciencedirect.com/science/arti...
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The impact of human accelerated regions on neuronal development
Human accelerated regions (HARs) are the fastest-evolving sequences in the human genome since the divergence from chimpanzees. Some of these regions a…
https://www.sciencedirect.com/science/article/pii/S0168952525000526
9 months ago
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reposted by
Gabriel Santpere
Quim Testar
9 months ago
He rigut.
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reposted by
Gabriel Santpere
Cedric Boeckx
11 months ago
Great study from Nenad Sestan’s lab and collaborators (led by
@babyamygdala.bsky.social
) on the specification of claustro-amygdalar and ‘palaeocortical’ neurons and circuits — with a key role for TFAP2D dosage, now out in
@nature.com
www.nature.com/articles/s41...
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Specification of claustro-amygdalar and palaeocortical neurons and circuits - Nature
A conserved gene regulatory network involving SOX4, SOX11 and TFAP2D shapes the development of excitatory neurons in ventrolateral pallium and their connectivity with the prefrontal cortex.
https://www.nature.com/articles/s41586-024-08361-5
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reposted by
Gabriel Santpere
Emily R. Trunnell, Ph.D.
12 months ago
Read the full paper from Dennis Joshy, Gabriel Santpere, & Soojin V. Yi of
@ucsantabarbara.bsky.social
&
@researchmar.bsky.social
in
@pnas.org
:
www.pnas.org/doi/10.1073/...
4/8
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PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/10.1073/pnas.2411918121
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reposted by
Gabriel Santpere
Prof Sam Illingworth
12 months ago
🧬 Human Brain Evolution New research reveals rapid, cell-type-specific regulatory evolution in human brains compared to primates, highlighting specialised changes in brain cells that shaped human cognition and behaviour. 🔗
www.pnas.org/doi/10.1073/...
#Neuroscience
#Evolution
#SciComm
🧪
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PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/10.1073/pnas.2411918121
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reposted by
Gabriel Santpere
Chris Stringer
about 1 year ago
Accelerated cell-type-specific regulatory evolution of the human brain | PNAS
www.pnas.org/doi/full/10....
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Accelerated cell-type-specific regulatory evolution of the human brain | PNAS
The molecular basis of human brain evolution is a key piece in understanding the evolution of human-specific cognitive and behavioral traits. Compa...
https://www.pnas.org/doi/full/10.1073/pnas.2411918121
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