Awesome gift to the research community: a compendium of transcriptomic data for the exploration of neocortical development—gene-level transcriptomic data from ~200(!!!) studies of neocortical development & in vitro models Thanks @carlocolantuoni.bsky.social & colleagues 🙏 @natneuro.nature.com 🧪🧠

Today in Nature Neuroscience we have published our exploration of neocortical development leveraging 100's of public datasets. You can interrogate the entire compendium of data at nemoanalytics.org/landing/neoc... and read the paper at www.nature.com/articles/s41....

Adaptive evolution of gene regulatory networks in mammalian neocortex 🏺🧪 www.nature.com/articles/s41... This study uncovers critical components and mammalian-specific evolutionary adaptations within a regulatory node essential for neocortical ExN identity and connectivity.

New co-first author paper on how ZBTB18 shapes excitatory neuron diversity in mammals. Led by Nenad Sestan with an amazing team. Thanks to Xabier de Martin for key work on the regulatory network. @researchmar.bsky.social @grib-barcelona.bsky.social @yaleschoolofmed.bsky.social surl.li/rgawzx

Check out this new study, led by Suel-Kee Kim, Adriana Cherskov, and Nenad Sestan, on human-specific cerebellar biology and the unexpected role of ZP2. Glad to have contributed with excellent work from Xoel Mato and Jose Manuel Ruiz. @researchmar.bsky.social www.cell.com/cell/fulltex...

We’re excited to share our new preprint on the mechanisms underlying DNA binding by bHLH transcription factors and how they achieve distinct DNA binding specificities. The study has been spearheaded by Xabier de Martín. @grib-barcelona.bsky.social Take a look! 👇 www.biorxiv.org/content/10.6...

Sofia Ognibene presented a poster at the XIII Bioinformatics and Genomics Conference on a pipeline to analyze Epstein–Barr virus genomes in the context of the #EBVMS project 🧬🚀 Great work!

Great days in Bergen for the EBV-MS consortium meeting. Inspiring discussions, outstanding science, and a truly collaborative spirit. Excited to be part of such a stimulating international effort to unravel the role of EBV in MS. #EBVMS #MultipleSclerosis @researchmar.bsky.social

Excited to share our recent study on human-specific features of the cerebellum and the unexpected, novel role of zona pellucida protein 2 (ZP2) in synapse development. Grateful to the Sestan lab and all our collaborators for their outstanding contributions. www.biorxiv.org/content/10.1...

Researchers from the Hospital del Mar Research Institute and Yale University have demonstrated how the action of certain #genes on precursor cells of #brain formation can cause alterations linked to cortical malformations but also to the origin of neuropsychiatric diseases

Linking alterations in precursor cells of brain 🧠 formation with the origin of #neuropsychiatricdiseases #bioinformàtica #neuropsiquiatria #salutmental #autisme #Alzheimer #TalentMAR @santperelab.bsky.social @yaleneuro.bsky.social @hospitaldelmar.bsky.social www.researchmar.net/news/742/lin...

Excited to share our latest work, spearheaded by my brilliant student Xoel Mato and co-led by Nicola Micali. After years of sweat, intense weekly meetings, and meticulous discussion of every panel, we learned a lot from each other. Grateful for the journey! @researchmar.bsky.social rdcu.be/evCaU

Excited to showcase as a co-first author our latest work "Adaptive Evolution of Gene Regulatory Networks in Mammalian Neocortical Neurons "https://www.biorxiv.org/content/10.1101/2025.05.20.652233v1

Mice grow bigger brains when given this stretch of human DNA www.nature.com/articles/d41...

Last week we attended the #ECCN2025 meeting in Alacant. It was an impressive succession of mind-blowing talks—exhilarating and exhausting. You couldn’t let your guard down for a second! Here are Paula Mayo and Josema Ruiz presenting their posters. @grib-barcelona.bsky.social

🦠Although infection by the #EpsteinBarrVirus is necessary to develop #MultipleSclerosis, only 0.3% of those infected develop it. A new European project with the participation of 3 PRBB centres aims to understand why and the underlying mechanism. More 👇 ellipse.prbb.org/ebv-ms-unvei...

Our piece on the beautiful work by Cui et al. on the impact of human accelerated regions on neurons is out now! @grib-barcelona.bsky.social @researchmar.bsky.social @cp-trendsgenetics.bsky.social www.sciencedirect.com/science/arti...

He rigut.

Great study from Nenad Sestan’s lab and collaborators (led by @babyamygdala.bsky.social) on the specification of claustro-amygdalar and ‘palaeocortical’ neurons and circuits — with a key role for TFAP2D dosage, now out in @nature.com www.nature.com/articles/s41...

Read the full paper from Dennis Joshy, Gabriel Santpere, & Soojin V. Yi of @ucsantabarbara.bsky.social & @researchmar.bsky.social in @pnas.org: www.pnas.org/doi/10.1073/... 4/8

🧬 Human Brain Evolution New research reveals rapid, cell-type-specific regulatory evolution in human brains compared to primates, highlighting specialised changes in brain cells that shaped human cognition and behaviour. 🔗 www.pnas.org/doi/10.1073/... #Neuroscience #Evolution #SciComm 🧪

Accelerated cell-type-specific regulatory evolution of the human brain | PNAS www.pnas.org/doi/full/10....