Out Now! Faecalibacterium prausnitzii enzyme reprograms PD-L1 trafficking and sensitizes colorectal cancer to immunotherapy in mice #MicroSky

10 years after the first FAMSA paper, its successor is now published in Nat Biotech! We believe that FAMSA2 can enable analyses of large protein collections that were previously unattainable. Thank you, Andrzej and Cedric, for great collaboration www.nature.com/articles/s41...

Alex Kramer, Alan Zhang and friends posted our preprint today. In it, we introduce Panmap, a tool for phylogenetic placement, assembly, lineage abundance estimation, and eDNA assignment using phylogenetic pangenomes. www.biorxiv.org/content/10.6...

Myloasm, our long-read metagenome assembler, is now published! w/ @mgmarin.bsky.social and @lh3lh3.bsky.social Very rewarding after > a year of development and countless hours thinking about assembly. Thanks to beta testers, Li lab, and reviewers who gave very helpful feedback. rdcu.be/famFj

The latest issue of Nature features a deep dive into sedimentary ancient DNA, with insights from our Matrix ERC-StG PI, @veraaldeias.bsky.social highlighting some of the big challenges shaping the field right now.

It's a good day when the first item in your feed is your own work :) @rickbitloo.bsky.social was annoyed that scanning reads for all 96 rapid kit barcodes is bottleneck in Barbell, so he made Sassy2: 13x (150bp) to 4.6x (8kbp) faster than v1 by batch-searching patterns, and >100Gbp/s on 16 threads!

Spatial structure: Shaping the ecology and evolution of microbial communities @femsjournals.bsky.social Microbiology Review by @marcelbaecker.bsky.social et al from @bedutilh.bsky.social @bramvandijk.bsky.social academic.oup.com/femsre/advan...

PhD position in Jena! Unique German-French collaboration to work on integrating phage genomic modules into VirJenDB.org - make sense of #phages, #big_data, #front_end, #back_end, #database. Please apply here 👇 jobs.uni-jena.de/jobposting/c...

If you ever need to fuzzy search some DNA, sassy is your tool. Please spread the word; I think many people just outside my own circle could benefit from this :) cc @rickbitloo.bsky.social github.com/RagnarGrootK...

📣Excited to share our (first) VirJenDB publication! 🎁Check it out to see how your #virus database supports #metadata #biocuration and #bioinformatics integration. 🎶Stay tuned for collaboration opportunities in 2026, including a hackathon at #ViBioM2026! 📃 doi.org/10.1093/nar/... 💻 www.virjendb.org

Check out our new ancient DNA article on the deep time evolution of antimicrobial peptides in the oral microbiome! Learn more about actifensins and test out our new software tool, AMPcombi! A big congratulations especially to Anan and Rosa for all their hard work on this! doi.org/10.1021/jacs...

We worked hard in 2025, will be super busy in 2026 and you will hear all about it. For now, we are ready for a break and wish you all the best of holidays! #MatrixERC #ICArEHB #Neanderthal #Paleolithic #HumanEvolution #Prehistory #AncientDNA #Biomolecules #SedimentDNA #Geoarchaeology

Long read Metagenomics, #phage and #prophage in the gut by Ami Bhatt's group. Beautiful data showing changes in phages over two years #phagesky www.nature.com/articles/s41...

🚨vConTACT3 preprint live!🚨(Peer Review soon...!) vConTACT3 delivers a unified, scalable, and transparent framework for genome-based virus taxonomy — helping translate big viral data into systematic classification. 🔗 Read the preprint: doi.org/10.1101/2025... Improvements details below 👇

🚨New preprint out! We present a foundational genomic resource of human gut microbiome viruses. It delivers high-quality, deeply curated data spanning taxonomy, predicted hosts, structures, and functions, providing a reference for gut virome research. (1/8) www.biorxiv.org/content/10.1...

Great to see this finally published! Metalog: curated and harmonised contextual data for global metagenomics samples now out in @narjournal.bsky.social academic.oup.com/nar/advance-...

We selected the laziest mouse at each round to inoculate the next batch of germfree mice: over rounds of selection and passaging, behavior shifted without changes to the mouse genome: rdcu.be/eM3rO 🦠🧫

Very cool phage study from @jeremyjbarr.bsky.social's lab. Isolation, engineering and ecology of temperate phages from the human gut #microbiomesky #phagesky

Phages evolve fast, or do they? In oysters, some stay identical for years. With >1,200 phages & 600 Vibrio genomes, we reveal long-term stability and new mobile elements. Proud of this collaborative work across our teams (Roscoff-UdeM and @epcrocha.bsky.social www.biorxiv.org/cgi/content/...

The ERC Project MATRIX explores one of the big questions in our past: how Neanderthals disappeared as modern humans spread across Europe. Meet the team behind it and learn more about our research on sediments, ancient DNA, proteins, lipids & human evolution 👉 matrix.icarehb.com

You like phages ? In this publication, we use metaHiC and our new version of the MetaTOR pipeline to challenge the traditional view of phages with a narrow host range. @rkoszul.bsky.social @natmicrobiol.nature.com @cnrs.fr @institutpasteur.bsky.social www.nature.com/articles/s41...

💧🌊 What happens when freshwater bacteria meet their salty counterparts? Our new preprint explores the ecological factors driving community coalescence 👉https://www.biorxiv.org/content/10.1101/2025.09.09.675091v1 @bedutilh.bsky.social @microverse.bsky.social

Happy Birthday, Goethe! 🌿 Though he never saw microbes under a microscope, his holistic view of nature still inspires us today. At the #Microverse, we explore how microbial worlds shape life’s balance – just as Goethe imagined nature as one interconnected whole. Illustration: AI-generated

The microbial composition of metagenomes is identified in seconds by profiling against large databases go.nature.com/3BBVqDC rdcu.be/eCbj4

Plus, it's heaps good timing with preprints for our phage annotation tools Phynteny and Phold coming out in the past few weeks! www.biorxiv.org/content/10.1... www.biorxiv.org/content/10.1...

Stoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage genome annotation #phagesky 1/n www.biorxiv.org/content/10.1...

🚨 New preprint 🚨 My phage annotation tool, Phynteny, finally has a preprint and a brand new version powered by a cool AI transformer architecture and protein language models! #phagesky www.biorxiv.org/content/10.1...

Interested in a tool that aligns millions of proteins in minutes with quality similar to or better than the state-of-the-art utilities? Please take a look at our FAMSA2 paper: www.biorxiv.org/content/10.1... and GH repo: github.com/refresh-bio/...

We (with Clement Coclet, not on Bsky) had the chance to work on a broad "state of viromics" review. We tried to use this to give an overview of how the field changed over the last ~ 15 years, and also what we think are some of the major remaining challenges. Full-text access at -> rdcu.be/excHt

New sylph pre-built databases + taxonomy available for: - GTDB-R226 (143k prok. species) - GlobDB-R226 (>300k prok. species, thanks @daanspeth.bsky.social ) - UHGV (Unified Human Gut Virome Catalog, thanks @apcamargo.bsky.social ) Must update sylph-tax; see docs (sylph-docs.github.io/sylph-tax/)

Faster && more accurate virus sequence clustering with Vclust! Thanks to Andrzej, Sebastian, et al. for the great collaboration. The author list also includes @prozwalak.bsky.social from the VEO Group.