In general I think it's hard to combat scientific misinformation when some of the best research is locked behind an academic paywall, while lots of nonsense gets published free for everyone to read in predatory journals.

Do you like theoretical biology, mathematical&conceptual modelling and want to apply yourself to cutting-edge research at all levels of biology, from molecules to ecosystems? Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Long-term clonal analysis using stochastic models reveals heterogeneity and quiescence of hematopoietic stem cells https://www.biorxiv.org/content/10.1101/2025.09.24.677849v1

This is a great point too- my post was inspired by having spent hours completing a data access request (and source an access fee) whilst work out how to comply with restrictions, all necessary to reproduce published analyses. We need standards for sharing that are straightforward and widely adopted

Increasingly convinced we need Creative Commons type licensing to become standard for dataset sharing in science

Apple trained a protein folding model. Noteworthy result: the architecture that is best at predicting the most common static 3d shape of the protein (models that explicilty encode evolution) aren't the best at predicting protein dynamics: the set (distribution) of shapes a protein can shift into.

Come be my colleague! We are hiring a full-time Lecturer in Organic Chemistry. If you are interested in teaching/curricular development & pedagogy this is a great position for you! Review of applications begins 10/6/25 Happy to answer any questions! Full details here: tinyurl.com/vcorganiclec... 🧪

In the 1990s, the UK and Denmark had some of the worst cancer survival rates compared to other similar countries. Today, Denmark has surged ahead, while the UK still lags behind.

'At the Scripps Research Institute, (...) we created the Computational Biology and Bioinformatics (CBB) affinity group, a trainee-led community for the discussion of computational biology/bioinformatics with the goal of facilitating knowledge exchange.'

The Non-Coding Mutational Landscape of Pancreatic Cancer Reveals Recurrent Somatic Mutations in Enhancer Regions aacrjournals.org/cancerrescom...

Not comfortable with how quickly these sorts of cyber attacks, from manufacturing to retail to vital infrastructure, is becoming a new normal for Europe. The JLR alone is having serious economic repercussions for suppliers, if not resolved this could have knock-on effects for days.

The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data! Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models. Start mining data now: dataminer.depmap.sanger.ac.uk

We're currently looking for a Trials Methodologist/Senior Trials Methodologist to join our team. You can find out more about the role and how to apply here: jobs.icr.ac.uk/vacancies/13... #ResearchJobs #TrialsMethodology🧪

It's not too late to join us for the first Cambridge Head and Neck Cancer Symposium next week! Hear from experts on AI, basic science, translational and clinical research. 📅 25 Sept 2025 | 08:30-15:30 📍CRUK Cambridge Institute, CB2 0RE Register: zurl.co/bi2hk

My column in tomorrow's paper:

FT mag piece from me: Spent a long time looking into the Britannia hotel chain, beneficiaries of a vast amount of taxpayer money via the asylum system on.ft.com/47HEE46

A broad take for 2012's £9K fee in was Min. break-even cost of yr's tuition £ 6.5-7K pa. Cost of renewing crumbling estate c £1.5K pa Cost of added student support c £1K. Note that £7K x (1.03)^13 is > £10K. So w basic inflation, JUST tutition now costs > £10K pa. Current TOTAL fee £9.5K. Oops.

TL:DR it’s harder than we thought. But good longread this on.ft.com/48ay8D0

Steve Reed should reverse Angela Rayner's worst decision (FREE TO READ!) takes.jamesomalley.co.uk/p/build-stev...

"People get upset when you come into a restaurant with your family, because your mere presence is a disturbance and they think they're going to have to fumigate the place once you leave."

Academic authors, here's a peek into the black box of journal publishing from an journal editor if you can bear it:

Except: 1. “The long-term trend was a reduction in cancer mortality, with rates in the UK tumbling by about 22 per cent in the past 10 years” Presumably we care more about that than “early” diagnosis? Focusing on early diagnosis can get confused by overdiagnosis. … on.ft.com/4nhJzgz

Nature research paper: Supervised learning in DNA neural networks go.nature.com/4mOb9lH

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

Mindblowing research out of the wonderful @isemevol.bsky.social (where I'm delighed to be based for the next three months). Opening line: "Living organisms are assumed to produce same-species offspring [1,2]. Here, we report a shift from this norm". 1. Darwin (1859) 2. Mayr (1942).

Opportunity for senior lecturer (associate professor) in School of Chemistry at University of Bristol (UK) ref: ACAD108220 | closing: 30-Sep-2025 #UKChemJobs #ChemJobs #chemsky 🧪 www.bristol.ac.uk/jobs/find/de...

I still remember how amazing it felt to see both these curves, in a pandemic sorely lacking good news the mRNA technology worked so, so much better than we had any right to expect.

Still two weeks left to apply to the #postdoc position in my lab via the @dkfz.bsky.social fellowship program. #epigenomics #hematology #leukemia #computationalbiology #precisiononcology

Great news at last! I believe the MMR misinformation is the main reason they felt it "wasn't the time" previously, despite evidence of effect. Our kids are all vaccinated - I believe quite a number of doctors have sought this out privately for their families. www.bbc.co.uk/news/article...

Perceptions have real effects www.kcl.ac.uk/policy-insti...

You know those moments when you’re trying to prompt the LLM to write some prose or code and it sucks, and it’s frustrating and it turns out faster to do it yourself? That’s the signal you’re doing real new intellectual work, not sampling in “already done by someone but you haven’t met them” space.

🚨 We're hiring! PhD position in Evolutionary Systems Biology at Stockholm University & SciLifeLab 🎓 Focus: evolution, development, computational & mathematical modeling, prediction 📍 Stockholm, Sweden 🕒 4 years, fully-funded 🔍 Details: su.varbi.com/en/what:job/... Please share!

Looks like a targeted screening programme to me. Can't find a recommendation from the National Screening Committee either way on this one. Hope it is being looked at because of the risk of harm and waste.

This is how Derwent church was originally left. People swam out to it, which was deemed too dangerous, so it was later dynamited.

Deeply divided Supreme Court lets NIH grant terminations continue arstechnica.com/science/2025...

📢 Authors, stay sharp! Scammers are sending fake acceptance letters & asking for money - Only trust official email domains - Be wary of payment requests - Use official channels to confirm 🚨 Report suspicious stuff ⤵️ www.springernature.com/gp/legal/piracy #AcademicIntegrity #ScamAlert #SpringerNature

Review @natrevcancer.nature.com Ageing, immune fitness and cancer www.nature.com/articles/s41...

Final call: Applications close September 2! KI is recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. All positions: ki.se/en/about-ki/...

Since I’m ranting in public about screening again, here’s some bonus content I’ve been mithering about for a while: We (in healthcare & public health) treat screening like it’s a special niche activity. But the same issues apply in pretty much everything we call ‘secondary prevention’.

fully agree. i wrote this a couple of years ago about this! www.theguardian.com/commentisfre...

TIL the original paper describing CRISPR, by Francisco Mojica, was rejected by 4 journals and took 2 years to be published

Academic gut-health microbiome research has not really led to efficacious treatments for specific ailments that can be demonstrated in rigorous studies. But they *have* convinced the public that gut health is somehow, vaguely at the root of all illness, and food companies have profited off this.

Not sure how many scientists here have tried Claude Code or similar command line coding assistants. I had a complicated family property tax problem that was best solved by a brute force Monte Carlo simulation approach, so I spent a few days coding up and analyzing a model with Claude Code.

Anyway, these coding assistants are probably fine for simple or cosmetic tasks: tweaking how your plotting function looks, making a website, etc. I am not convinced they will be ready for more any time soon. Giving up intellectual agency to a program is fundamentally problematic.

Conscientiousness is strongly associated with personal and professional success, and even life expectancy. Worryingly, levels of conscientiousness are in decline, especially in the under 40s. Valuable new analysis from @jburnmurdoch.ft.com @data.ft.com on.ft.com/4ftchbz

At the same time, we made thousands of synonymous mutations in endogenous yeast genes and measured their growth. We used careful statistics and controls. Only 3%, 204 of 6874, had a fitness effect! This goes against a controversial recent result that most synonymous mutations had fitness effects.

An exciting negative result!

Exciting opportunity for TT-Ass #Professorship in Quantitative Cell Biology @unibe.ch @izb-unibern.bsky.social! Applicants combining experimental and computational approaches/theory are particularly encouraged. Great colleagues, environment, infrastructure. What's not to like? tinyurl.com/42f3p863