Lukas Heumos
@lukasheumos.bsky.social
📤 473
📥 196
📝 14
Research software engineer at Lamin Labs | Steering council at scverse | Postdoc at Fabian Theis lab
reposted by
Lukas Heumos
Luca Marconato
24 days ago
My favorite part of last-year
#scverse
conference was to finally meet in-person many developers that I only knew from their GitHub username! Submissions and travel grant applications close in 3 days. Find out more and apply at
scverse.org/conference2025
@scverse.bsky.social
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Lukas Heumos
Anshul Kundaje
about 1 month ago
scVerse conference is at Stanford this year! Encourage folks (especially Bay Area/West coast folks) to sign up and attend. Cool workshops/talks and other events + great community of developers for one of the most widely used open source software for single cell data analysis!
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It is pretty heart warming to see people start their really good pull request with "this is my first open source contribution. I hope that this is good.". Everyone starts somewhere and we're always happy to guide at
@scverse.bsky.social
.
about 2 months ago
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Lukas Heumos
Gregor Sturm
about 2 months ago
Our benchmark + guidelines for atlas-level differential gene expression of single cells is online:
academic.oup.com/bib/article/...
Bottom line: Use pseudobulk + DESeq2 in simple and pseudobulk + DREAM in more complex settings. Collab w/
@leonhafner.bsky.social
@itisalist.bsky.social
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I hate reference limits of journals so much. I'm sitting here trying to find a few more references to remove despite me knowing that I'll either remove context & evidence for scientific conclusions or not mention tools that very much deserve to be mentioned and cited.
about 2 months ago
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Lukas Heumos
Malte Kuehl
2 months ago
Preprint alert 🚨 Do you use chatbots in your work or even build MCP servers and agentic systems yourself? Or would you like to find a way to use biomedical tools using natural language? Then check out
biocontext.ai
, now out on bioRxiv:
www.biorxiv.org/content/10.1...
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reposted by
Lukas Heumos
scverse
4 months ago
We will have our next community meeting on Tuesday, 2025-06-24 at 18:00 CEST! Sneha Mitra (
@snehamitra.bsky.social
) will speak about SCARlink. (Zoom registration link and more information in thread!)
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Lukas Heumos
Pau Badia i Mompel
4 months ago
Happy to have this finally out! Check out the updated vignettes and if something is broken please open a GitHub issue and I'll have a look 😉👇
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Lukas Heumos
6 months ago
Happy to share CellAnnotator, a lightweight Python package to query OpenAI models for initial cell type annotations:
github.com/quadbio/cell...
Inspired by ideas in
www.nature.com/articles/s41...
and
github.com/VPetukhov/GP...
, implemented as an scVerse ecosystem package with docs and tutorials.
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GitHub - quadbio/cell-annotator: Automatically annotate cell types, consistently across samples.
Automatically annotate cell types, consistently across samples. - quadbio/cell-annotator
https://github.com/quadbio/cell-annotator
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reposted by
Lukas Heumos
scverse
6 months ago
Tomorrow at 2025-04-15 18:00 CEST, we’ll have our next community meeting! Anastasia Litinetskaya will present “Multimodal integration and identification of disease-specific changes in single-cell atlases”. Check out the GitHub repo here:
github.com/theislab/mul...
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GitHub - theislab/multimil: Multimodal weakly supervised learning to identify disease-specific changes in single-cell atlases
Multimodal weakly supervised learning to identify disease-specific changes in single-cell atlases - theislab/multimil
https://github.com/theislab/multimil
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Lukas Heumos
Mikaela Koutrouli
6 months ago
We are back 🔥
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Lukas Heumos
Nature Reviews Genetics
8 months ago
Best practices for single-cell analysis across modalities
go.nature.com/4gJkk3c
#ExpertRecommendation
by
@lukasheumos.bsky.social
et al. (from the
@fabiantheis.bsky.social
lab) - now nearing 250k accesses! Free to read here:
rdcu.be/eabUB
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Best practices for single-cell analysis across modalities - Nature Reviews Genetics
Practitioners in the field of single-cell omics are now faced with diverse options for analytical tools to process and integrate data from various molecular modalities. In an Expert Recommendation art...
https://go.nature.com/4gJkk3c
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reposted by
Lukas Heumos
scverse
8 months ago
🎉 Scanpy 1.11.0 is out! 🎉 just after reaching 2000 stars on GitHub! - sc.pp.sample replaces subsample with many new features - Sparse Dask support pca - session-info2 package for more reproducible notebooks See the release notes:
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Release notes
Version 1.11: 1.11.0 2025-02-14: Release candidates: rc2 2025-01-24, rc1 2024-12-20. Features: rc1 sample() supports both upsampling and downsampling of observations and variables. subsample() is n...
https://buff.ly/4gJJSNv
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We have additional available spots. Please consider joining! It will be a blast.
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8 months ago
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I keep being astonished at how terrible
@microsoft.com
Teams works on Firefox and I certainly don't blame Mozilla for it.
9 months ago
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Ahhh finally I can use
@nextflow.io
to run doom!
github.com/nextflow-io/...
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GitHub - nextflow-io/doom: A Nextflow pipeline to play Doom
A Nextflow pipeline to play Doom. Contribute to nextflow-io/doom development by creating an account on GitHub.
https://github.com/nextflow-io/doom?tab=readme-ov-file
9 months ago
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I am Stoked about our upcoming
@scverse.bsky.social
and
@owkin.bsky.social
hackathon, focused on spatial omics data analysis. 📅 March 17-19, 2025 📍 Owkin office, Paris Apply now:
docs.google.com/forms/d/e/1F...
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Scverse x Owkin Hackathon in Paris
We're pleased to announce the next Scverse Hackathon will take place in the Owkin offices in Paris from 17/03/2025 9am to 19/03/2025 1:30pm. This hackathon is a joint initiative between the scverse c...
https://docs.google.com/forms/d/e/1FAIpQLSd41Mf1mN6lYrx7X84lx-KGWtQ3USZTTou7pCfy5ZtdnIFo1Q/viewform
9 months ago
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Why is there still no proper "thank you" emoji on
@github.com
? I am grateful for other peoples time and feel like a thumbs up is kind of like a drive by reaction and a heart isn't always perfectly appropriate
9 months ago
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I actually think that it' awesome that even fundamental packages like numpy, pandas, scipy, and others still develop rapidly and aren't afraid of making big API changes but it's quite time consuming to keep up when one maintains many packages. I can't imagine what e.g. the numba devs go through
9 months ago
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I was just looking at our
@scverse.bsky.social
zulip chat statistics and am super happy about our steady and healthy growth. The two bursts are our official launch in May 2022 and the inaugural scverse conference in September of 2024. Please join us!
scverse.zulipchat.com
10 months ago
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reposted by
Lukas Heumos
scverse
10 months ago
Reminder!Today at 18:00 CET will be the last community meeting of the year!
@lukasheumos.bsky.social
will talk about about pertpy, a Python-based modular framework for the analysis of large-scale perturbation single-cell experiments. Zoom link can be found here:
scverse.zulipchat.com#narrow/chann...
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reposted by
Lukas Heumos
scverse
10 months ago
Next Tuesday at 2024-12-10 18:00 CET, we will hold the last community meeting of the year!
@lukasheumos.bsky.social
will talk about pertpy, a Python-based modular framework for the analysis of large-scale perturbation single-cell experiments. The GitHub repo:
github.com/scverse/pertpy
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GitHub - scverse/pertpy: Perturbation Analysis in the scverse ecosystem.
Perturbation Analysis in the scverse ecosystem. Contribute to scverse/pertpy development by creating an account on GitHub.
https://github.com/scverse/pertpy
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reposted by
Lukas Heumos
scverse
10 months ago
Reminder! Today at 18:00 CET will be another community meeting! Malte Lücken will talk about about Open Problems in Single-Cell Analysis. Zoom link can be found here:
loading . . .
If this message does not go away, try reloading the page.
If this message does not go away, try reloading the page.
https://buff.ly/41esnB1
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reposted by
Lukas Heumos
scverse
11 months ago
Next Tuesday at 2024-11-26 18:00 CET will be another community meeting! Malte Lücken will talk about about Open Problems in Single-Cell Analysis, a community-driven state-of-the-art benchmarking platform to facilitate development of single-cell methods.
https://buff.ly/3CAGxSt
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Open Problems in Single-Cell Analysis – Open Problems in Single Cell Analysis
Computational biology is undergoing a revolution. Recent advances in microfluidic technology enable high-throughput and high-dimensional of individual cells at unprecedented scale. But there’s a…
https://openproblems.bio/
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reposted by
Lukas Heumos
scverse
11 months ago
Explore the scverse Starter Pack! Stay informed about the latest scverse events, software updates, and community news. Everything you need to know about foundational tools for single-cell omics analysis in one place.
go.bsky.app/UvFMa8d
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reposted by
Lukas Heumos
Leander
11 months ago
Super excited to share our Human Neural Organoid Atlas, now out in Nature! Led by
@zhisonghe.bsky.social
@josch1.bsky.social
, and myself, this resource was created from 36 scRNA-seq datasets—totalling over 1.7 million cells! 🔬✨
www.nature.com/articles/s41...
Find out how it can serve you ⏬ 🧵1/8
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An integrated transcriptomic cell atlas of human neural organoids - Nature
A human neural organoid cell atlas integrating 36 single-cell transcriptomic datasets shows cell types and states and estimates transcriptomic similarity between primary and organoid counterparts, sho...
https://www.nature.com/articles/s41586-024-08172-8
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reposted by
Lukas Heumos
Fabian Theis
11 months ago
Thanks - really nice w these starter packs, did that. Meanwhile
@scverse.bsky.social
has also created one - really like that.
bsky.app/starter-pack...
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I am stoked to see our EHR framework ehrapy (
github.com/theislab/ehr...
) being the cover of the most recent Nature Medicine issue. We consider ehrapy a MVP for a much grander ecosystem for EHR analysis like we have for single-cell data (@scverse). Read more:
www.nature.com/articles/s41...
11 months ago
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