In partnership with @pioneerlabs.bsky.social, we’re proposing Tesseract: a large-scale, open microbial phenomics dataset to functionally annotate microbial genomes at scale. 🧬🤖 ✅5M diverse genes x 50 host strains × 100 conditions 🔗 Read the proposal:https://zenodo.org/records/17990299

1/5 To ensure the highest impact and participation, we are adjusting the timeline of the Protein Engineering Tournament. The Tournament will now begin on December 1st, 2025.

🧫 Meet the keynote speakers for the 2025 scverse conference! Erika Alden DeBenedictis, Co-founder of The Align Foundation & CEO of Pioneer Labs @erika-alden.bsky.social ‪ @alignbio.bsky.social @pioneerlabs.bsky.social #scverse #scverse2025 #StructuralBiology #Biotech #Stanford

📣 Evolutionary Scale is supporting the 2025 Protein Engineering Tournament! Teams get sponsored ESM inference through @evolutionaryscale.bsky.social's API (Forge), bringing frontier protein AI models into the competition. Level playing field, real experiments, open results. Register now 👇

Thrilled to welcome Amanda Reider Apel to The Align Foundation as Director of Protein Projects! 🚀 A biotech leader who builds high-impact science and thriving teams, she’ll drive protein engineering strategy while fostering a culture of innovation and collaboration.

Why PETase for our tournament? In 2024, the world made about 30 million tonnes of PET plastic, most from fossil fuels. PETase can degrade PET, but isn’t ready for industrial-scale waste. The challenge: design an improved variant that can change that. Register by Oct 17 alignbio.org/protein-engi...

1/4 We just published the 1st-year update on GROQ-seq: an open access, high-throughput experimental platform capable of testing hundreds of thousands of protein variants per run, running @ NIST and the DAMP Lab. Here’s what we built, learned, and what’s next: #GROQseq #syntheticbiology

1/4 🚀 Announcing the 2025 Protein Engineering Tournament. This year’s challenge: design PETase enzymes, which degrade the type of plastic in bottles. Can AI-guided protein design help solve the climate crisis? Let’s find out! ⬇️ #AIforBiology #ClimateTech #ProteinEngineering #OpenScience

🚨 Align × ATCC are partnering to build the world’s largest public microbial phenotyping dataset. ✅ 1K strains ✅ 1K conditions ✅ 1M reproducible experiments ✅ Open access This experimental platform will use high-throughput automation, linked to ATCC’s authenticated genomes.

Align's GROQ-seq platform just turned 1 🎂 it now supports 7 protein function projects across 6 labs worldwide. 300k variants measured per run @ <$0.05 each, and it works. Not theory. Real infrastructure. Open to the world. 🔗 1-year technical report → hubs.la/Q03mSrW_0

Measuring precise enzyme kinetics (like kcat and Km) is key to understanding enzyme function. But these measurements are most often conducted in singleplex in vitro assays - expensive and tough to scale. 1/7 🧵👇

Q1 at Align = ✅ Team doubled ✅ 65k GROQ-seq datapoints ✅ Genotype-by-Phenotype platform ✅ Global conf. circuit ✅ Tournament prep underway Get the full download → hubs.la/Q03hT_V60 #ProteinEngineering #AIxBiology #SynBio #OpenScience

🚀 New proposal from Align! The experimental platform aims to standardize #microbial #phenotyping & support predictive modeling. 🦠 Capturing data across 1k strains & 1k conditions; using BacterAI; generating high-quality datasets for ML @jensen_lab

We are gearing up for our 2025 Protein Engineering Tournament! 🧬 🏆 Have ideas on what the next community benchmarking competition for protein design and engineering should look like? 💡 💪 Join our organizing committee here: https://buff.ly/3ELqfrb

🚀 Collaborative, AI-Ready datasets would revolutionize life sciences and catalyze progress. Government funding plays a critical role in making this a reality. 📖 Read our policy memo here:

🚀 News from Align! Today, we're sharing our proposal for building a predictive model of protein expression. Check it out here! ➡️ https://buff.ly/3OqtPZf ⬅️ 🌍✨#ProteinExpression #Bioengineering #Collaboration #MachineLearning #DataScience #AlignToInnovate

🌟 Congrats to Cradle on their Series B raise! 🌟 www.cradle.bio/blog/series-b