Now published @cp-cellreports.bsky.social! Antibody-mediated TGF-β1 activation for the treatment of diseases caused by deleterious T cell activity: www.cell.com/cell-reports... Fantastic collaboration & massive effort from Sophie Lucas Lab @ de Duve Institute. #CryoEM with @savvideslab.bsky.social.

Fantastic work by the group of @matteoall.bsky.social : a SUN5:Nesprin3 complex at the head:tail junction of sperm cells. 🤯 #teamtomo www.biorxiv.org/content/10.1...

This work is the result of a fantastic collaboration [email protected]! @warred.bsky.social, @a-dsantos.bsky.social , @alisterburt.bsky.social , @tom-hale.bsky.social, @mrclmb.bsky.social,

We are excited to announce the first in-cell structure of a LINC complex within a native nuclear envelope at subnanometer resolution!! #In-cell cryo-ET + #atomistic MD simulations! @tomdendooven.bsky.social et al!! www.biorxiv.org/content/10.1...

This structure is absolutely _nuts_. Lipids are captured marching through the tunnel

Delighted to share our reanalysis of cryo-EM data in EMPIAR-10930, now at: journals.plos.org/plosbiology/... ; revealing the ALK-ALKAL2 assembly with 2:1 stoichiometry and resolving the conundrum introduced by the originally reported 2:2 complex. ALK/LTK-cytokine signalling getting clearer!

In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:

The @structurabio.bsky.social team have been preparing *Amazing* workshops and tutorials on all things related to cryo-EM image analysis, demonstrating deep talent in communication in addition to software design. If you're interested in learning about cryo-EM do yourself a favour and have a look!

I sometimes forget how flexible proteins are. It becomes really apparent when you use NMR states for an animation. That poor cofactor is getting pushed around a lot 😅 #sciart #blender3d #biocatalysis

An amazing cryoEM structure of the membrane-assembled lysosomal mTORC complex from the Hurley lab. @jimhurley.bsky.social www.biorxiv.org/content/10.1...

If pombe wants to be taken seriously as an organism it needs to ferment a better beverage