Jessica Buchser
@microbial.bsky.social
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▪️PhD student @ PSU ▪️Gene regulation 🧬 ▪️Structural biology
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Jessica Buchser
Everything Hat Ever Sent You Is Off The Record
3 days ago
Don’t let the frogwater that’s boiling us alive let you skip over this: we murdered another country’s citizens in cold blood, and when their leader objected, we called him a drug dealer and cut off aid to his country. That’s freakish.
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Olúfẹ́mi O. Táíwò
6 days ago
Just received from a colleague: looks like Penn is going to join the universities refusing the extortionary Trump "compact". I do not regret to inform you that we are going to win
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Be so for real right now.
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7 days ago
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NPR
7 days ago
Antimicrobial resistance is responsible for some 1.2 million deaths a year a year and contributes to millions more. Data in the new report shows that the problem is growing at an alarming rate.
n.pr/3J0HVBC
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Study: We're losing the war against drug-resistant infections faster than we thought
Antimicrobial resistance is responsible for some 1.2 million deaths a year a year and contributes to millions more. Data in the new report shows that the problem is growing at an alarming rate.
https://n.pr/3J0HVBC
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Prof Anna Watts
13 days ago
Lol the Nobels can't even acknowledge women's contribution to discovery. But sure let's acknowledge The Machines.
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Dr. Jennifer Glass (she/her)
24 days ago
A reminder to please support non-profit publishers. It’s good for science and scientists. It’s a responsible use of taxpayer dollars. It requires resisting peer pressure to submit to Nature journals. Thanks
@bacteriality.bsky.social
for this helpful slide for microbiology journals.
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Jason Williams
26 days ago
Please share with anyone who cares about NSF support for graduate students and take 30 seconds to sign and leave a comment. The deadline for the 2025 Graduate Research Fellowship Program is about one month away and literally no one can apply.
#NSFGRFP
jasonjwilliamsny.github.io/grfp2025/
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An Open Letter to U.S. STEM Leadership on the NSF Graduate Research Fellowship Program
An Open Letter to U.S. STEM Leadership on the NSF Graduate Research Fellowship Program
https://jasonjwilliamsny.github.io/grfp2025/
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Needhi Bhalla 💅🏽
27 days ago
I often emphasize that there are rarely "silver bullets" that magically solve problems but vaccines are one of the closest things we have and it's mind-boggling and enraging to watch this "debate" unfold during my lifetime
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I can’t quite wrap my head around seeing people suggest tetanus is safer than Tdap because “toxins.” According to them, the safe way to avoid “toxins” in vaccines means exposure to a literal neurotoxin instead.
28 days ago
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Brian Wasik
29 days ago
I still can't get over the suggestion for pregnant women to 'tough it out' spoken by the softest man that has ever lived.
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Rick Porter
about 1 month ago
This mf’er is a hugely unpopular lame duck and people and institutions with actual power are out here acting, for eight months straight, like he’s some goddam immortal emperor. Fuck that noise.
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Jessica Buchser
about 2 months ago
We are all super happy and proud to see our work on the function and evolution of the
#cephalic
#furrow
published in
@nature.com
. Let me say a few things about the background and history of this work on the
#Evolution_of_Morphogenesis
(1/12)
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Jeff Lengyel & TEM Team at Thermo Fisher Scientific
3 months ago
See our new article in Structure! Sub-3 Å resolution protein structure determination by single-particle
#cryoEM
at 100 keV. Really exciting results with 100kV Tundra Cryo-TEM.
www.sciencedirect.com/science/arti...
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Sub-3 Å resolution protein structure determination by single-particle cryo-EM at 100 keV
Cryoelectron microscopy (cryo-EM) has transformed structural biology by providing high-resolution insights into biological macromolecules. We report s…
https://www.sciencedirect.com/science/article/pii/S0969212625002552
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Tominaga K. (tomiken)
3 months ago
A family of linear plasmid phages that detect a quorum-sensing autoinducer exists in multiple bacterial species | bioRxiv
https://www.biorxiv.org/content/10.1101/2025.07.30.667625v1?rss=1
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A family of linear plasmid phages that detect a quorum-sensing autoinducer exists in multiple bacterial species
Temperate phages oscillate between lysogeny, a genomic maintenance state within a bacterial host, and lytic replication, in which the host is killed, and newly made phage particles are released. Successful transmission to new hosts requires that temperate phages appropriately time their transitions from lysogeny to lysis. It is well understood that temperate phages trigger lysis upon detection of host cell stress. Understanding of the breadth of cues that induce lysis expanded with the discovery of phages carrying quorum-sensing receptor genes that promote lytic induction exclusively at high host cell density. Bacteria engage in a cell-cell communication process called quorum sensing, which relies on the production, release, accumulation, and group-wide detection of extracellular signal molecules called autoinducers. Bacteria use quorum sensing to monitor changes in population density and synchronize collective behaviors. The temperate phage VP882 (jVP882) encodes VqmAj – a homolog of its host’s quorum-sensing receptor/transcription factor VqmA. VqmAj allows jVP882 to detect the accumulation of the host autoinducer called DPO. Presumably, launching the lytic induction program at high host cell density maximizes jVP882 transmission to new hosts. Here, by mining sequence databases for linear plasmid phages, we identify VP882-like phages in multiple DPO-producing bacterial species isolated at diverse times and geographic locations. We show that the VqmAj homologs can indeed detect DPO and, in response, activate the lytic pathway. Our observation indicates that jVP882 is a member of a large family of globally-dispersed quorum-sensing-responsive temperate phages.
https://www.biorxiv.org/content/10.1101/2025.07.30.667625v1
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Marc Dionne
5 months ago
My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate.
www.philanthropy.cam.ac.uk/give-to-camb...
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Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
https://www.philanthropy.cam.ac.uk/give-to-cambridge/physiology-development-and-neuroscience/drosophila-genetic-database
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PLOS Biology
6 months ago
Why do
#StemCells
have lower levels of facultative
#heterochromatin
, defined by H3K27me3, compared to differentiated cells? By artificially lengthening G1 phase,
@4everbiochemist.bsky.social
&co show that G1 length is an essential determinant of H3K27me3 landscape
@plosbiology.org
🧪
plos.io/4lKfztO
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"spooky simchas" daniel s.
7 months ago
in case you're wondering, "what's the harm in claiming an extinct species has been brought back from the dead" when it most certainly has not, our interior secretary is already using it to justify taking animals off the endangered species list
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Ezra Levin ❌👑
7 months ago
Goal achieved: An unusual number of people in an unusual number of places. 1,300 globally. There were probably more than 10,000 speakers alone at rallies today. Baffling to think about this scale!
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Petra Levin
7 months ago
The “who” is impacted by cancellation of NIH “diversity” awards is much broader than “not white.” Eligibility criteria included individuals who are disabled, economically disadvantaged, grew up in rural communities, first generation college students, homeless…
grants.nih.gov/grants/guide...
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Nature Reviews Microbiology
7 months ago
New online! Genetics, ecology and evolution of phage satellites
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Genetics, ecology and evolution of phage satellites
Nature Reviews Microbiology, Published online: 27 March 2025; doi:10.1038/s41579-025-01156-zIn this Review, Penadés et al. explore the genetics, potential origins and life cycle of phage satellites, and they discuss the impact of these elements on the evolution of other mobile genetic elements and their host bacteria.
https://www.nature.com/articles/s41579-025-01156-z?utm_source=bluesky&utm_medium=social&utm_campaign=nrmicro
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American Fietser
7 months ago
Share the media. The news is compromised. We're starting to boil over.
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Alt NIH Bluesky 🧪
8 months ago
Yes. Journalists should note this: Every science or tech student, age 5-35 today, is looking at the destruction of their career prospects due to Trump and Musk. We should be interviewing those students and talking about the impact to their lives.
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Alt NIH Bluesky 🧪
8 months ago
“Our next generation of researchers are now poised on the edge of this cliff, not knowing if there’s going to be a bridge that’s going to get them to the other side, or if this is it” Musk and Trump are blowing up science careers for every STEM student.
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Tom Di Liberto
8 months ago
Please enjoy my last ever post at
Climate.gov/ENSO
Blog. This afternoon I was fired by the Trump Administration 15 days before my 2yr probationary period ended on March 13. I have worked at NOAA since 2010, and I'm so incredibly proud of the work I did. If anyone wants a quote, let me know.
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Bobby Kogan
8 months ago
House Rs just passed the budget resolution, the first step in their process to enact a bill that'd kick millions off Medicaid & cut SNAP down to just $1.60 per person per meal on avg while cutting taxes for the top 0.1% by $278k - all while increasing the debt 🧵on what's to come and WHERE TO FIGHT
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Nature
8 months ago
The Trump administration's efforts to slash research funding have US graduate students, postdocs and other early-career scientists fearing for their careers. Some might leave the country -- or abandon research altogether.
https://go.nature.com/43ao2zq
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Postdocs and PhD students hit hard by Trump’s crackdown on science
As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.
https://go.nature.com/43ao2zq
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Cedric Feschotte
8 months ago
Feels awkward but necessary to celebrate scientific progress in this imperiled time for US biomedical research. Proud of our latest paper out today exploring the role of transposable elements in antiviral resistance to HIV 🦠
genomebiology.biomedcentral.com/articles/10....
🧵1/n
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Transposable elements may enhance antiviral resistance in HIV-1 elite controllers - Genome Biology
Background Less than 0.5% of people living with HIV-1 are elite controllers (ECs)—individuals who maintain undetectable plasma viremia without antiretroviral therapy, despite having replication-compet...
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-025-03484-y
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Vaughn Cooper
8 months ago
🚨PA colleagues: "Senator Fetterman wants to hear from you about how the federal funding freeze is affecting Pennsylvania." "If your project has been impacted, please fill out our constituent impact form:"
forms.office.com/g/mFv2JAPxpC
Get out your Other Support and share that info!
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Microsoft Forms
https://forms.office.com/g/mFv2JAPxpC
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Vikram Paralkar
8 months ago
The 'Stand Up For Science" rally is happening around the US on March 7th, spearheaded by graduate students! I have encouraged my lab to attend! Find your city's rally on the website below. The Philadelphia rally is at City Hall March 7th, 12pm to 4pm
standupforscience2025.org/philadelphia...
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Philadelphia, PA
Location: Philadelphia City Hall City Hall, Philadelphia, PA, United States Time: 12-4 PM
https://standupforscience2025.org/philadelphia-pa/
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Michael Baym
8 months ago
Legitmately thrilled to share our latest work, in which
@fernpizza.bsky.social
solved an experimental challenge in plasmid biology as old as the field: measuring how plasmids compete and evolve within individual cells!
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USPS is has safely mailed isopods and other invertebrate critters from my doorstop for a few years now. They are amazing.
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8 months ago
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Dr Steven White
8 months ago
Neat 🦟 paper
www.nature.com/articles/s42...
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Prolonged exposure to heat enhances mosquito tolerance to viral infection - Communications Biology
Single versus multi-generational exposure to increased temperature alters mosquito immune response to viral infection, with implications for mosquito-virus interactions under global change.
https://www.nature.com/articles/s42003-025-07617-8
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Colette Delawalla
8 months ago
Get in dorks, we're going protesting! STAND UP FOR SCIENCE WITH US ON MARCH 7TH, 2025 WASHINGTON DC AND EVERY STATE CAPITOL Because science is for everyone! Find us at
www.standupforscience2025.org
#standupforscience2025
#scienceforall
#sciencenotsilence
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boehninglab
8 months ago
In case it is not clear, this notice is illegal. Universities should continue to submit grants with the contractually obligated and negotiated IDC rates.
grants.nih.gov/grants/guide...
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NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
https://grants.nih.gov/grants/guide/notice-files/NOT-OD-25-068.html
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Drosophila melanogaster or beluga whale
#drosophila
#genetics
8 months ago
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This guy heard all the Super Bowl cheering on our street and said I’m done with this walk 🦅 🦅
#goeagles
#catsky
#philly
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8 months ago
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Colette Delawalla
8 months ago
🚨IF YOU WANT TO BE INVOLVED IN PLANNING OF A NATION WIDE STAND UP FOR SCIENCE PROTEST, WAVE (comment, dm, etc.) IN MY DIRECTION! 🚨
#sciencenotsilence
#standupforscience
#scienceforall
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Sri Kosuri
9 months ago
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
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Alex Wild
9 months ago
It’s super surreal as an actual biologist to see the dipshit brigade mandate their fevered hallucinations as reality. It’s an abuse of both human rights and of science.
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Chanda Prescod-Weinstein 🌌
9 months ago
Speak up, even if your voice shakes when you do it
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Gil Wizen
9 months ago
Whip spider (Paraphrynus laevifrons) covered with chloropid fly puparia. The parasitoid fly attacks the eggs carried by the female. When done, the maggots climb on the "childless" mom's back and pupate. She protects them during this period thanks to her motherly instincts.
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Reassuring article for those of us who need it.
statuskuo.substack.com/p/is-somebod...
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Is Somebody Doing Something?!
Yes. Let me break it down for you.
https://statuskuo.substack.com/p/is-somebody-doing-something
9 months ago
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Leah Greenberg ❌👑
9 months ago
Crowd keeps growing outside Treasury as Members who were DENIED entry speak
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Angie Rasmussen
9 months ago
Out today in
@foreignpolicy.com
: I wrote about what will happen if there is an H5N1 pandemic with Robert F Kennedy, Jr. in charge of safeguarding the health of Americans. If H5N1 begins spreading human to human, the deaths will be counted in millions.🧵👇
foreignpolicy.com/2025/01/30/r...
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Make America Highly Pathogenic Again
If RFK Jr. gets to helm HHS, global health is at risk.
https://foreignpolicy.com/2025/01/30/rfk-jr-rfk-confirmation-bird-flu-pandemic-antivax/
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Angie Rasmussen
9 months ago
Wait.
@asm.org
last I checked, you are not a government agency, so why should this Executive Order apply to a non-governmental professional/scientific society? Why are you obeying an unjust order in advance when doing so clearly hurts the interests of microbiologists you claim to represent?
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Sarah McAnulty, Ph.D.
9 months ago
Well the award for most cowardly, boot-lickingest academic society has squarely gone to the American Society of Microbiology, who has taken down features of various non-white scientists. Absolutely pathetic behavior. Those articles are now coming up as “under review”. Truly sickening cowardice here.
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Jennifer Goff, PhD
9 months ago
I want to expand on the extent to which IDEAA materials have been purged: I wrote an article last year for women’s history month on the history of women in antimicrobial development….DELETED.
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Angie Rasmussen
9 months ago
@charlesgaba.com
is a hero and downloaded CDC’s entire website. A small group of us has come together to preserve this critical resource and make it accessible to the scientific community. More to come. These data are public and they are ours. Deletion disobedience is one way to fight back.
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