The OCTAVE framework for simulating trials: onlinelibrary.wiley.com/doi/10.1002/... will be presented @hrb-tmrn.bsky.social via Zoom universityofgalway-ie.zoom.us/webinar/regi... Apr 16, 2026 01:00 PM (London)

Incidentally detected spleen length ≥140 mm or volume ≥500 mL was associated with markedly elevated 5-year risk for hematologic cancer, liver cancer, and cirrhosis in adults from Denmark and the UK. ja.ma/4dDEIVc

Listen to Scott Berry @statberry.bsky.social hosting Stephen Senn @stephensenn.bsky.social. They discuss adaptive trials www.youtube.com/watch?v=Tnb0...

So you carried out a controlled clinical trial? Bravo. Make sure you carry out a controlled analysis. You can bin those within-group standard errors, comparisons back to baselines and dynamite detonator plots for a start. pubmed.ncbi.nlm.nih.gov/2277879/

Webinar: Enhancing Clinical Study Reporting with the Estimand Framework Tuesday 21st April 2026, 14:00 - 15:30 (GMT) psiweb.org/events/event...

Five tenets for advancing evidence-based precision medicine www.nature.com/articles/s41...

Appraising ML prediction models @maartenvsmeden.bsky.social 1) Share model and code 2) Predictors and language 3) Class imbalance & calibration 4) Model validation sample size 5) Is the model clinically useful in practice? www.jclinepi.com/article/S089...

"In oncology, we have witnessed the evolution of early-stage designs from 3 + 3 designs to continual reassessment methods, to bayesian optimal interval designs, and to posterior predictive design. Similarly, late-stage designs have evolved from Simon 2-stage designs, 1/2

Preprint: On the Calibration of Bayesian Success Criteria and Operating Characteristics for Clinical Trials arxiv.org/pdf/2603.20015

Cool little package on CRAN for adding a download data button into html files created from your Rmd. cran.r-project.org/web/packages...

COMMENTARY: What Makes an Estimand Useful? Guidance on the Choice of Intercurrent Event Strategies @brennankahan.bsky.social @suziecro.bsky.social onlinelibrary.wiley.com/doi/full/10....

Preprint: A critical review of clinical prediction models in oncology: is this SEERious research? @gscollins.bsky.social osf.io/preprints/me...

✨ New open-access book✨ I’ve seen how powerful prediction models can be, but also how often they fall short. We wrote a book, covering not just development, but also when models are needed, and how to ensure real-world impact. www.maastrichtuniversitypress.nl/cpm

Shout out to all the peer reviewers out there insisting we add p-values to Table 1 to check for confounding in an RCT. You are so bad at your job, and will never know it. You think you are great. It must be great to be you.

Webinar on INLA for Biostatistics 19 March, 11 am EST (4 pm London) bayesian.org/isba-industr...

Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals www.nature.com/articles/s41...

A biostatistician vacancy at NASA careers.leidos.com/jobs/1745171...

Happy Pi Day & birthday to Einstein! :D Annual reminder that it's really 2π, aka τ, that is more natural to use, but it is too late now.

Patient-Reported Outcomes to Inform Tolerability Characterization in Cancer Trials: A Critical Perspective on Unresolved Methodological Issues journals.sagepub.com/doi/10.1177/...

R in Pharma's rpact workshop recording www.youtube.com/watch?v=B12t...

Just learnt the difference between & and && in R

Important reflections and considerations for oncology trials by the FDA (2026) ascopubs.org/doi/10.1200/...

The Hochberg Procedure for the Comparison of Multiple End Points jamanetwork.com/journals/jam...

BOP2 with both futility and efficacy analyses www.tandfonline.com/doi/full/10....

Leveraging generative AI to transform statistical analysis plan authoring in clinical trials journals.sagepub.com/doi/10.1177/...

@glenmartin.bsky.social is giving an online seminar: "Missing Data: The Missing Component in Guidance for Developing, Validating and Implementing Prediction Models" 📅 Date: Tuesday 10th March 2026 🕐 Time: 1–2pm GMT 📍 Location: Online 🔗 Register here to receive the Teams link: lnkd.in/ejk7EFzC

new package alert! {tidychain} is a #rstats packaged inspired by the below authors experience in showing how an excel file was changed / manipulated by looking at the underlying xml files to prove fraud in research datacolada.org/109package usrbinr.codeberg.page/tidychain/

How is it that a paper that claims to show how to do target trial emulation does not address confounding by indication and its ramifications for data collection? www.jclinepi.com/article/S089... #EpiSky #StatsSky

The `bmabasket` package used for Bayesian model averaging in basket trials was apparently removed from CRAN on 2025-12-22 cran.r-project.org/web/packages...

Love this preprint arxiv.org/abs/2506.17141

A great opportunity for a PhD studentship in Sequential Multiple Assignment Randomised Trials (SMARTs) at Imperial's CTU with @vcornelius.bsky.social www.findaphd.com/phds/project...

Evidence of Unreliable Data and Poor Data Provenance in Clinical Prediction Model Research and Clinical Practice www.medrxiv.org/content/10.6...

Major Chinese funder to stop paying fees for 30 pricey open-access journals www.science.org/content/arti...

The scary part of this is that we have created a #Statistics educational system that is guaranteed to create a low bar by teaching formulas, recipes, isolated stat tests, no experimental design, no Bayes, no questioning of assumptions, no questioning outcome variables or study designs, ... #StatsSky

gsDesign2 allows for designing trials with non-proportional hazards 🤩 cran.r-project.org/web/packages...

An important topic for real world studies IMO: Einstein Circle Lecture - (The Lack of) Causal Inference in Prediction Models Feb 19, available via Zoom: www.bihealth.org/en/notices/e...

200+ attendees joined us for this seminar with Mats Stensrud today. If you missed it, you can watch the recording here: youtu.be/KL4eFZcw-sg

1/2 Nail in the coffin of dichotomania: @erik-van-zwet.bsky.social 's paper with @stephensenn.bsky.social and myself just published: onlinelibrary.wiley.com/doi/10.1002/... with extended discussion at discourse.datamethods.org/t/dichotomiz... #Statistics #StatsSky #rct #clinicaltrial

Application of External Control Arms in Oncology Drug Development, 7 April Virtual or in-person in Washington friendsofcancerresearch.org/event/applic...

Evaluating Safety Rules in Ongoing Dose-Escalation Trials Using BOIN: A Comparative Analysis of Criteria and Their Impact on Dose-Level Safety Assessments onlinelibrary.wiley.com/doi/10.1002/...

Haven't read the statistics diaries in the post, but I love the idea of it.

I remember this day and my fascination with what physicists do. Exciting stuff!

crmPack v2.1 now supports backfilling simulations www.rconis.com/blog/crmPack...

Investigating estimand considerations in adaptive trials: a systematic review by @statsci.bsky.social link.springer.com/article/10.1...

The Boston Chapter of the ASA is hosting a free 1-hour webinar to discuss the FDA's draft guidance on Bayesian Methods in Clinical Trials, with Yuan Ji sanofi.zoom.us/webinar/regi... 3 March, 5 PM London time

I wish I didn't have a meeting conflict or I would have liked to attend this rare disease workshop. I do hope that study designers will realize that sequential Bayesian two-arm RCTs are better solutions in many cases: hbiostat.org/bayes/design #Statistics #StatsSky #clinicaltrial

Single arm, RCT or something in between – how to enrich clinical trial design and analysis in rare diseases Tomorrow 3 Feb at 4 pm UK time realised-ihi.eu/do-you-want-...

EMA's Concept Paper for the Development of a Reflection Paper on the use of Bayesian methods in clinical development (PDF) www.ema.europa.eu/en/documents...