Paracetamol use during pregnancy does not increase risk of autism Laurie Tomlinson explains best available evidence shows #paracetamol safe to take during pregnancy & urges parents to seek reputable sources of information, & medical advice from GP. www.lshtm.ac.uk/newsevents/n...

The Americas, Western Pacific, and Europe together hosted almost 90% of oncology trials worldwide. USA alone accounted for nearly 1/3rd... www.nature.com/articles/s41...

The C-index Multiverse arxiv.org/abs/2508.14821

CRAN's Task View for Clinical Trial Design, Monitoring, and Analysis has been updated in September 2025! cran.r-project.org/web/views/Cl... @thomasjaki.bsky.social

UK clinical trials are under pressure www.bmj.com/content/390/...

FDA's draft guidance on the assessment of overall survival in oncology trials www.fda.gov/regulatory-i...

I seem to have been discussing pilot and feasibility studies a lot this week. One question often asked is how big should my pilot/feasibility study be? 1/6 #MethodologyMonday #124

Are estimands being correctly used? A new review of protocols led by Timothy Clark shows many incorrectly defined estimand attributes. See the top areas for improvement & full results here: trialsjournal.biomedcentral.com/articles/10.... #Trials

We are excited to launch our new Research Methods Academy: Seminar Series! Hear from leading experts on innovative and best practice methods to strengthen your research proposal. Find out more and register: www.nihr.ac.uk/news/nihr-la...

I think we need more studies like this, investigating OS surrogates in different malignancies: www.sciencedirect.com/science/arti...

Great resource 👇

Prof @vcornelius.bsky.social @imperialctu.bsky.social @statsci.bsky.social inaugural lecture (in-person in Imperial & online)! 30 October 2025 "Under pressure: smarter trials for better health outcomes" www.imperial.ac.uk/events/19688...

"You can't do good research without a good research acronym." — Doug Altman 😂

Word has it, statisticians are still looking for the perfect estimator.. "depletion of the susceptibles" and other HR limitations, a nice illustration: link.springer.com/article/10.1...

ICH E20's draft on Adaptive Trials focuses almost exclusively on confirmatory trials. Early-phase designs make use of lots of adaptive elements, especially dose optimization, we need more than a paragraph.. www.ema.europa.eu/en/ich-e20-a...

Is this the first ever drug approval for pediatrics with diffuse midline glioma? RANO ORR by BICR = 22% (95% CI: 12, 36), includes adults www.fda.gov/drugs/resour...

From @timpmorris.bsky.social et al's KMunicate guidance: "Interestingly, Paul Meier himself is said to have spoken with bemusement about people plotting KM estimates over time and was not convinced he actually liked it..." bmjopen.bmj.com/content/9/9/...

Job available for a statistician to work on a clinical trials methodology project on improving statistical methods for paediatric cancer ttrials. Cancer Research UK Clinical Trials Unit, University of Birmingham Closes 22 September edzz.fa.em3.oraclecloud.com/hcmUI/Candid...

MRC HTMR Guidance pack www.methodologyhubs.mrc.ac.uk/advice/netwo...

FDA Oncology is organizing a virtual event on the future of registries Day 1: Best Practices for Innovation in Drug Development Day 2: Advancing Drug Development in Pediatric DMG/DIPG Register: events.gcc.teams.microsoft.com/event/00d8a6...

Depending which methods guru you ask every analytical task is “essentially” a missing data problem, a causal inference problem, a Bayesian problem, a regression problem or a machine learning problem

A senior machine learning expert at @stanforduniversity.bsky.social once interrupted a lecture of mine saying that #MachineLearning does not need a minimum sample size. I almost didn't know what to say. Almost.