NEW PAPER: "Reporting guidelines for studies involving generative artificial intelligence applications: what do I use, and when?" --> www.nature.com/articles/s41... #HealthTech #ClinicalAI #MachineLearning #MedAI #AIinMedicine #TransparentAI #HealthInnovation #GenAI

Periodic reminder....😀 #Transparency is one of the six core principles underpinning the WHO guidance on #ethics and #governance of #ArtificialIntelligence for health --> who.int/publications... Important to adhere to the TRIPOD+AI reporting standards🙏 --> bmj.com/content/385/... #trustworthyAI

NEW paper "Clinical prediction models using machine learning in oncology: challenges and recommendations" --> tinyurl.com/2h2mcy5h #machinelearning #prediction #statssky #MLsky #methodsmatter

Health tests on the high street: Convenient or confusing? Public Webinar 🗓️ Tuesday 14 October THIS EVENING 6-7pm Register here www.eventbrite.com/e/health-tes... This evening, we are presenting the findings of our evaluations of supermarket self tests, summarising our BMJ papers

Giving a talk today which anyone can watch online: 1pm - 2pm "The Importance of Sample Size for the Development and Evaluation of Clinical Prediction Models" - intended for a broad audience (anyone doing or using prediction model research) imperial-ac-uk.zoom.us/webinar/regi...

Peer review of prediction model studies in oncology needs improvement: a systematic review of open peer review reports from BMC journals - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Saddened to hear of the passing of Drummond Rennie, a quite influential figure. retractionwatch.com/2025/09/15/d...

NEW PAPER "The STARD-AI reporting guideline for diagnostic accuracy studies using #artificialintelligence" --> www.nature.com/articles/s41... #machinelearning #MLsky #statssky #digitalhealth #transparency

www.medrxiv.org/content/10.1... INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.

Job available for a statistician to work on a clinical trials methodology project on improving statistical methods for paediatric cancer ttrials. Cancer Research UK Clinical Trials Unit, University of Birmingham Closes 22 September edzz.fa.em3.oraclecloud.com/hcmUI/Candid...

📌 The SPIRIT 2025 statement updates the guidelines for randomized trial protocols to enhance their completeness, transparency, and consistency, benefiting stakeholders involved in clinical research. ja.ma/4fzMVZS

Reporting guideline for chatbot health advice studies: the Chatbot Assessment Reporting Tool (CHART) statement bmjmedicine.bmj.com/content/4/1/... #llms #chatbots #bioinformatics #healthcare

UKRI award rate halves in seven years as grant applications double. www.researchprofessionalnews.com/rr-news-uk-r...

NEW PAPER: the CHART reporting guideline for studies evaluating generative AI models like #ChatGPT & other #LLMs for providing health advice --> bmjmedicine.bmj.com/content/4/1/... The explanation & elaboration paper --> www.bmj.com/content/390/... #genAI #chatbots #healthadvice #reporting

New paper in BMJ (Research Methods & Reporting): “Dealing with continuous variables and modelling non-linear associations in healthcare data: practical guide” led by Pedro Lopez-Ayala & Tobias Zimmermann with & myself www.bmj.com/content/390/...

Many high street health tests are unfit for purpose and need greater regulation, warn researchers in two studies. These studies highlight issues over accuracy and suitability for public use, they say www.bmj.com/content/390/... www.bmj.com/content/390/...

Post just up: Is multiple imputation making up information? tldr: no. Includes a cheeky simulation study to demonstrate the point. open.substack.com/pub/tpmorris...

This article provides an overview of the current state of handling continuous variables in healthcare research. It discusses the potential limitations of assuming a linear relationship between independent and dependent variables www.bmj.com/content/390/...

NEW PAPER in @bmj.com "Dealing with continuous variables and modelling non-linear associations in healthcare data: practical guide" --> www.bmj.com/content/390/... #methodologymatters #StatsSky #EpiSky

**NEW OPEN-ACCESS PAPER** “A decomposition of Fisher’s information to inform sample size for developing or updating fair and precise clinical prediction models for individual risk—part 1: binary outcomes" - published in Diagnostic & Prognostic Research - implemented in pmstabilityss 1/n

NEW PAPER in @jclinepi.bsky.social looking at the content of open peer-review reports of RCTs in the field of oncology www.jclinepi.com/article/S089... Peer review reports [...] were short (median 276 words), superficial, and rarely constructive #metascience #peerreview #RCTs

Very nice summary of the confusing and often ill-posed metrics.

* New preprint led by Joao Matos & @gscollins.bsky.social "Critical Appraisal of Fairness Metrics in Clinical Predictive AI" - Important, rapidly growing area - But confusion exists - 62 fairness metrics identified so far - Better standards & metrics needed for healthcare arxiv.org/abs/2506.17035

NEW PREPRINT "Critical Appraisal of Fairness Metrics in Clinical Predictive AI" -> arxiv.org/abs/2506.17035 We identified 62 fairness metrics (and growing) - unsurprisingly it's all a bit of a mess...with most metrics not fit for purpose #predictiveAI #fairness #machinelearning #StatsSky #MLSky

And the exciting announcement! The 9th WCRI is set to take place in Vancouver, Canada, in 2026! Look forward to seeing you all there!

For researchers with limited background in statistics, we have written this gentle introduction to simulation studies (with @timpmorris.bsky.social and other people from the STRATOS initiative): bmjopen.bmj.com/content/10/1...

REF 2029: splitting staff from outputs ‘distressing’ in jobs crisis. Decision to hold fast on portability prompts criticism over potential impact on early career researchers. One of our most-read articles this week. www.researchprofessionalnews.com/rr-news-uk-r...

Medical research is special because it's too often led by high-status novices that don't know they are novices. The worst of these are also arrogant and insecure. Literally everyone else involved in the research has to work around these people. Good morning! 😀 (ICYMI)

The CONSORT 2025 Statement is here. Essential reading for those involved in the reporting & reviewing of randomized trials. We're proud to see so many #UKCTUNetwork units & individual researchers contributing to this crucial update! 🔗 tinyurl.com/yc3cbh33 #CONSORT2025 #ResearchTransparency

At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9 #MethodologyMonday #120

Authors, editors, reviewers, and other potential users should use CONSORT 2025 when writing and evaluating manuscripts of randomized trials to ensure that trial reports are clear and transparent. Learn more in this Special Communication. https://ja.ma/3TlnKQe

How long is acceptable for a journal to make a decision on whether to even review your article? We've got an article under submission for 5 weeks now, and still 'With Editor' for deciding whether to send out for review Surely too long (journal even promises 'quick turnaround for initial decision')

Do Large Language Models (Really) Need Statistical Foundations? arxiv.org/abs/2505.19145 #llms #statistics #artificialintelligence

🆕New CONSORT & SPIRIT 2025 Guidelines Our colleagues helped shape these updates, making #ClinicalTrial reporting more transparent & useful for everyone. Key changes: ✔️More open science ✔️Better reporting of harms & missing data ✔️Greater harmonisation between guidelines More info: buff.ly/HC1rx31

Is anyone willing to share their experiences of submitting to the new RSS journal, Data Science & AI? Thanks 🙏 academic.oup.com/rssdat

Item 10 of the TRIPOD+AI asks (www.bmj.com/content/385/...) "Explain how the study size was arrived at, and justify that the study size was sufficient to answer the research question. Include details of any sample size calculation" Here's why it's important 👇

NEW PAPER "Importance of sample size on the quality and utility of AI-based prediction models for healthcare" www.thelancet.com/journals/lan... We discuss seven reasons why inadequate sample size negatively affects model training, evaluation, and performance. #StatsSky #machinelearning #AI

**New Lancet DH paper** "Importance of sample size on the quality & utility of AI-based prediction models for healthcare" - for broad audience - explains why inadequate SS harms #AI model training, evaluation & performance - pushback to claims SS irrelevant to AI research 👇 tinyurl.com/yrje52fn

European Urology is recruiting associate statistical editors! A high impact journal with long track record of innovations in statistical peer review, this a fantastic opportunity for junior statisticians to gain (paid) experience at a top journal. Email me if interested www.europeanurology.com

Maternal early warning scores shown to be methodologically weak and at high risk of bias - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

A guideline to boost transparency in AI-driven medical prediction models! Evolved from TRIPOD, it ensures studies are reproducible, ethical, and clinically meaningful. Crucial for trustworthy #AI in healthcare. Read the paper: bmj.com/content/385/... #HealthTech

A must read

📣 Calling all Biostatisticians! We’re conducting a global survey to understand your experiences with requests for Questionable Research Practices—how often they occur, how they’re managed, and their potential outcomes. 👉 Survey link: qsurvey.qut.edu.au/jfe/form/SV_... 👉 Study protocol: osf.io/hvyra

Looking forward to giving my invited seminar on Wednesday to the Dept of Biostatistics at Vanderbilt University Medical Center (online 1:30-2:30pm CT) Title: 'The importance of sample size for the development and evaluation of clinical prediction models' Includes new & emerging work 😀

A Consensus Statement in Nature Medicine from CONSORT 2025 provides updated guidance to authors, reviewers and editors, when writing and evaluating manuscripts of randomized trials to ensure that trial reports are clear and transparent. go.nature.com/3Si0p1f #medsky 🧪

Anneke Damen talking about the updated PROBAST+AI tool for assessing risk of bias and quality of predictive AI tools #memtab www.bmj.com/content/388/...

great talk by @msafavi.bsky.social on ‘Value of information analysis: towards a value-based approach in biomarker and prediction model research’ #memtab

last talk before lunch - @glenmartin.bsky.social talking about how to handle missing data across model development, validation and implementation #memtab

sample size is a hot topic…Menelaos Pavlov talking about his work on adapting sample size calculations for the development of predictions models to control for model stability #memtab