Pretreatment MRI findings including extraprostatic extension and seminal vesicle invasion were independently prognostic for recurrence, metastasis, and mortality after radical prostatectomy. #ProstateCancer ja.ma/4c30MGm

The addition of camrelizumab to chemotherapy produced statistically significant and clinically meaningful 5-year OS benefits compared with chemotherapy alone in the first-line treatment of recurrent or metastatic nasopharyngeal carcinoma. ja.ma/4scbAbA

Low-dose aspirin in older adults was not associated with lower #Cancer incidence over 8.6 years, and cancer mortality risk did not persist beyond the exposure period. ja.ma/415gY58

Among patients with immune checkpoint inhibitor–related cutaneous adverse events, dupilumab therapy was associated with lower 5-year mortality compared to no dupilumab or systemic corticosteroids. ja.ma/415XcXa

Bireociclib plus fulvestrant improved progression-free survival and objective response in hormone receptor–positive, ERBB2-negative advanced #BreastCancer after endocrine progression. ja.ma/4dlp2Gg

Incidentally detected spleen length ≥140 mm or volume ≥500 mL was associated with markedly elevated 5-year risk for hematologic cancer, liver cancer, and cirrhosis in adults from Denmark and the UK. ja.ma/4dDEIVc

The 2025 federal #Medicaid restrictions are projected to cause over 1 million missed #CancerScreening exams and over 150 excess #cancer deaths within 2 years, with substantial impact on younger and vulnerable adults. ja.ma/4vde24i

💬 Editorial: Stereotactic radiation offered modest symptom relief & better long-term neurocognitive outcomes than hippocampal-avoidance whole brain radiation, but was associated with higher rates of new brain metastases & salvage whole brain radiotherapy. ja.ma/4lUhf4e

From @jama.com: The Medicare #Oncology Care Model (OCM) was associated with modest reductions in Medicare payments for beneficiaries receiving #chemotherapy for cancer; however, overall program costs exceeded these spending reductions. ja.ma/4lUgVT8

Guideline-adherent lymph node dissection provided a small survival benefit for patients with high-grade or no lepidic pattern #LungAdenocarcinoma, but not for those with lepidic pattern alone. ja.ma/4s3DJl4

📄 This JAMA Oncology Patient Page discusses benefits and risks of local consolidative therapy for metastatic #LungCancer and which patients might be considered for this treatment. ja.ma/4dg5AL6

Ocular toxic effects including keratopathy, blurred vision, cataract progression, and uveitis were common but generally reversible during mirvetuximab soravtansine therapy for FRα-positive gynecologic cancers. ja.ma/4bBFm4p

PRIME is a validated, interpretable #PancreaticCancer risk model using routine clinical data, supporting risk-based case-finding and integration with biomarker testing for early detection. ja.ma/4uZYJfg

A 52-year-old woman had presented with persistent inflammatory edema of the lower limb and a history of squamous cell carcinoma. What is your diagnosis? ja.ma/4sBKXO0

Among men with #ProstateCancer undergoing hormone therapy, #SGLT2 inhibitor use was associated with lower risk of treatment failure and delayed progression compared with nonuse, supporting potential adjunctive benefit. ja.ma/41ApOb2

Sequential radiotherapy and immunotherapy (#iRT) provided longer overall survival than concurrent iRT for newly diagnosed advanced non–small cell lung cancer, with additional benefit from chemotherapy. ja.ma/3PuvMYw

A 52-year-old woman had presented with persistent inflammatory edema of the lower limb and a history of squamous cell carcinoma. What is your diagnosis? ja.ma/47cV7vZ

💬 Editorial: MELATORCH trial supports PD-1 blockade as standard care over chemotherapy for advanced acral melanoma, yet limited long-term benefit signals the need for novel therapeutic strategies. ja.ma/4bQ0jaB

In a phase 3 trial, toripalimab improved progression-free survival over dacarbazine as first-line treatment in advanced melanoma predominantly of acral subtype, with an acceptable safety profile. ja.ma/4sgQ4TL

CHIP was associated with increased heart failure and ischemic cardiovascular disease risk after #cancer therapy in patients with solid tumors, especially among those with higher #chemotherapy exposure. ja.ma/4dvzHOu

Review: Adjuvant #immunotherapy was often cost-effective in #CancerCare, particularly for early-stage/high-risk cases, but findings varied by cancer type, drug price, and country-specific thresholds. ja.ma/4lPn8js

Bireociclib plus fulvestrant improved progression-free survival and objective response in hormone receptor–positive, ERBB2-negative advanced #BreastCancer after endocrine progression. ja.ma/3Pu3yNl

In 2025, JAMA Oncology received 3738 manuscripts from 74 countries, with original scientific content impacting patient care, research, and policy. Read "JAMA Oncology—The Year in Review, 2025" by Editor in Chief Mary L. (Nora) Disis, MD. ja.ma/4uzIZPD

P85-Ab testing outperformed conventional Epstein-Barr virus-based markers for outpatient nasopharyngeal carcinoma (NPC) diagnosis, with highest sensitivity and specificity among asymptomatic and NPC-nonspecific symptom populations. ja.ma/4drJRj9

Among patients with low-risk #EndometrialCancer, presence of isolated tumor cells in regional lymph nodes was linked to lower 4-year survival without adjuvant therapy compared to node-negative cases. ja.ma/4bkA8bN

A 69-year-old male patient presented with worsening new-onset oral ulcerations and pain. He had myelodysplastic syndrome and underwent an allogeneic hematopoietic stem cell transplant 18 months prior. What is your diagnosis? See the answer: ja.ma/4bkxzXg

Solid #OrganTransplant recipients with a history of pretransplant #cancer had higher risks of developing posttransplant cancers of the same type, including breast, lung, kidney, urinary bladder, liver, colorectal, and melanoma. ja.ma/3P55z2p

Solid #OrganTransplant recipients with a history of pretransplant #cancer had higher risks of developing posttransplant cancers of the same type, including breast, lung, kidney, urinary bladder, liver, colorectal, and melanoma. ja.ma/4rxMDH7

Older adults with advanced #cancer mainly prioritized quality of life, but their treatment preferences were not associated with differences in survival, hospitalization, or adverse effects. ja.ma/4bf65m0

📄 This JAMA Oncology Patient Page describes different types of common mouth problems during #cancer treatment and how to care for them. ja.ma/4l3V5w3

Oral upadacitinib achieved rapid resolution and pruritus relief in severe immune checkpoint inhibitor–related #Dermatitis, with no serious treatment-related adverse events. ja.ma/3MVSbwT

Older adults with advanced cancer mainly prioritized quality of life, but their treatment preferences were not associated with differences in survival, hospitalization, or adverse effects. ja.ma/402woqm

In patients with advanced solid tumors, survival improved when genomic therapy matching was based on robust clinical trial evidence; investigational or repurposed biomarker matches did not provide benefit. ja.ma/4rJFbtq

Definitive radiotherapy with or without chemotherapy in anterior nasal cavity cancers achieved high rates of long-term organ preservation & favorable local recurrence rates for patients who declined rhinectomy or had unresectable disease. ja.ma/4bRp7ke

📢 This Special Communication describes obstacles to sharing data and biospecimens and proposes strategies to enhance access and collaboration. ja.ma/4tJmdVk

Adjuvant imatinib was associated with longer recurrence-free and overall survival in high-risk patients with KIT exon 9–mutated gastrointestinal stromal tumors, with similar outcomes for 400 mg/d vs 800 mg/d dosing. ja.ma/3MExci3

Immune checkpoint inhibitor–induced #diabetes occurred in 0.52% of patients across 158 National Cancer Institute trials, with higher incidence for combination immunotherapy and lower rates when combined with #chemotherapy. ja.ma/4qPeORG

💬 Editorial: Most women in the WISDOM trial preferred tailored, risk-based #BreastCancer screening, highlighting its patient acceptability and supporting a shift from age-based protocols. ja.ma/4rD4e1h

Among over 7000 patients with #cancer, higher baseline fatigue before systemic therapy was linked to an increased risk of severe, life-threatening, and fatal adverse events. ja.ma/3ZIIjJE

Fifteen-year follow-up of the SWOG S0016 trial demonstrates that 42% of patients with advanced-stage #FollicularLymphoma treated with CHOP-based chemoimmunotherapy achieve functional cure. ja.ma/4s6Fm1F

Quadrivalent #HPV vaccination was associated with lower rates of high-grade vulvovaginal lesions, especially among women vaccinated at ages 10 to 16, in a large cohort study. ja.ma/3MyKqN1

In recurrent or metastatic #NasopharyngealCancer, tislelizumab plus chemotherapy led to longer overall survival and durable progression-free survival compared with placebo plus chemotherapy. ja.ma/4ays9sv

💬 Viewpoint: Effective stroke care for patients with cancer requires rapid interdisciplinary communication, clear documentation of prognosis and goals of care, and urgent application of acute stroke therapies. ja.ma/4qCkTAA

The MyLungHealth randomized trial found that digital tools improved eligibility assessment and CT ordering for #LungCancer screening, but gains in scan completion were limited. ja.ma/4rShe2y

💬 Viewpoint: Nonfinancial conflicts, including relationships and beliefs, can shape #Oncology research outcomes, highlighting the need for routine disclosure and management to support scientific credibility. ja.ma/4cgkHDR

First-line CDK4/6 inhibitor use did not improve overall survival vs second-line use in advanced hormone receptor–positive, ERBB2-negative #BreastCancer and increased grade ≥3 adverse events. ja.ma/4rZItIE

💬 Editorial: Cancer-related cognitive impairment frequently affects #BreastCancer survivors and may persist for years after treatment, with greater risk among those receiving chemoendocrine therapy. ja.ma/3Ms515S

In this secondary analysis of the RxPONDER trial, chemoendocrine therapy was associated with greater and more persistent self-reported cognitive impairment than endocrine therapy alone in both pre- and postmenopausal women with #BreastCancer. ja.ma/3MyvbUu

This study demonstrates that therapy with Bruton tyrosine kinase inhibitors for B-cell malignant diseases significantly increases the risk of pericardial effusion and several other cardiovascular events compared with alternative regimens. ja.ma/4tOvon4

💬 Editorial: Precision adjuvant therapy for stage III #ColonCancer may be enhanced through molecular profiling for ctDNA status and PIK3CA mutation, informing use of celecoxib or aspirin alongside standard treatment. ja.ma/3MAsX6V