Viewpoint: GLP-1 receptor agonists induce weight loss but may lead to pronounced muscle mass reduction, raising concerns for patients with cancer at risk of frailty and decreased physical function. ja.ma/481cpgf

Rare pathogenic variants in 16 #cancer predisposition genes were linked to both single and multiple cancer diagnoses, suggesting multigene panel testing could be beneficial. ja.ma/4nB2CSF

Semaglutide and tirzepatide prescriptions for obesity have increased among patients with preexisting cancer, with notable variation by cancer type and absence of cancer-specific guidelines. ja.ma/4nHMuPp

AI technologies hold potential to enhance acute myeloid leukemia management by improving risk stratification, early detection, and treatment optimization through integration of clinical, morphological, and genetic data. ja.ma/4hPUaOj

Older age in unrelated donors linked to lower survival in allogeneic hematopoietic cell transplant with conventional calcineurin inhibitor-based graft-vs-host disease prophylaxis, but this association is mitigated with posttransplant cyclophosphamide. ja.ma/4oC1Dms

Consistent moderate physical activity—about 17 metabolic equivalent task-hours/week over 3 decades—was associated with optimally reduced risk of digestive system cancers in a large cohort study. ja.ma/436zTOt

While the use of fertility-preserving #HormonalTherapy for early-stage endometrial #cancer has increased, survival outcomes are comparable to #hysterectomy in patients under 40. ja.ma/4oh9TYY

💬 Editorial: Patients with limited nodal disease after neoadjuvant therapy may avoid axillary lymph node dissection by using limited axillary surgery and radiation. ja.ma/3L8lDyz

Using the MARI protocol, response-guided axillary treatment in patients with limited nodal disease after primary systemic treatment showed a low risk of axillary recurrence. ja.ma/4nu0o7C

Consistent moderate physical activity—about 17 metabolic equivalent task-hours/week over 3 decades—was associated with optimally reduced risk of digestive system cancers in a large cohort study. ja.ma/43ESyRp

💬 Editorial: Women with #BreastCancer and overweight or #obesity have worse outcomes, and while interventions like the BWEL trial show promise in managing weight, more research is needed to enhance treatment options. ja.ma/4ohmlYZ

A telephone-based weight loss intervention induced weight loss in patients with #BreastCancer with #overweight and #obesity across demographic and treatment factors. ja.ma/47Lh1Hj

37% of US adults believe alcohol increases cancer risk, while 53% are unsure, according to a 2024 national survey; misbeliefs persist despite rising alcohol-related cancer rates. ja.ma/42UwBOc

Consistent moderate physical activity—about 17 metabolic equivalent task-hours/week over 3 decades—was associated with optimally reduced risk of digestive system cancers in a large cohort study. ja.ma/4odLrIa

Immune checkpoint inhibitors are independently linked to increased risk of Stevens-Johnson syndrome and toxic epidermal necrolysis, with additive effects observed when combined with high-risk drugs. ja.ma/4nAd8tG

Both combined and progestin-only contraceptives are linked to increased breast cancer risk, with greater risk observed for progestin-only, particularly desogestrel-containing products. ja.ma/47lXKLe

🎧 Listen to authors Yiwen Zhang, PhD, and Edward L. Giovannucci, MD, ScD discuss their article "Consistent Adherence to Physical Activity Guidelines and Digestive System Cancer Risk and Mortality," with Vivek Subbiah, MD. ja.ma/4qn3ZHh

💬 Editorial: Consistent long-term physical activity—about 17 metabolic equivalent task-hours/week over 30 years—was linked to optimally reduced risk of digestive system cancers. ja.ma/47K5l7G

Consistent moderate physical activity—about 17 metabolic equivalent task-hours/week over 3 decades—was associated with optimally reduced risk of digestive system cancers in a large cohort study. ja.ma/47mGPYU

Glucagon-like peptide-1 receptor agonists (#GLP1s) are associated with a reduced overall #cancer risk in adults with #obesity, lowering the risk for endometrial, ovarian, and meningioma cancers. ja.ma/47oliz4

Cisplatin treatment decreased kidney function, with lower baseline eGFR patients at higher CKD risk, and a pretreatment eGFR-based model effectively predicted this risk for clinical use. ja.ma/4nknbTa

Public awareness of #HPV, its vaccine, and its #cancer links is low in the US, especially in the Midwest and South, contributing to suboptimal vaccination rates in these regions. ja.ma/478MnaA

Sintilimab plus axitinib shows a promising objective response rate and progression-free survival with a manageable safety profile for patients with advanced fumarate hydratase–deficient renal cell carcinoma. ja.ma/47KhCYP

Viewpoint: Proposed use of credit screening in clinical settings could enable rapid detection of financial risk at cancer diagnosis, with automated analysis guiding early financial counseling and support. ja.ma/42RteaH

Dexrazoxane use in pediatric AML rose from 0.5% to 98.5% between 2010 and 2021, coinciding with a 50% reduction in ICU-level cardiovascular care, supporting rapid adoption of dexrazoxane for cardioprotection with intensive chemotherapy. ja.ma/3JoW2AC

Editorial: Cardiac surveillance recommendations after breast cancer treatment remain limited, with evidence suggesting most survivors benefit from primary care focused on prevention and management of traditional cardiovascular risk factors. ja.ma/3IYz5Ex

A validated risk model accurately predicted 10-year risk of heart failure or cardiomyopathy in women treated for early-stage breast cancer, integrating clinical and treatment variables available at diagnosis. ja.ma/47fS1q9

Atezolizumab plus bevacizumab optimally balances quality of life preservation and survival benefits for patients with unresectable or advanced hepatocellular carcinoma. ja.ma/47xcF6x

Systematic review: Childhood #cancer survivorship research is concentrated in high-income countries, highlighting a need for broader global studies to ensure equitable outcomes for survivors. ja.ma/4okTrat

ICIs can treat advanced cancers in solid organ transplant recipients, especially cSCC, but overall survival is limited, and mTOR inhibitors with steroids may reduce rejection risk. ja.ma/4ok0Aam

RCT: Bacterial decolonization with mupirocin nasal ointment reduced severe oral mucositis and improves quality of life in nasopharyngeal cancer patients undergoing radiotherapy by decreasing Staphylococcus aureus colonization. ja.ma/4hjiA2j

Cribriform morphology predicted 15-year metastasis in #ProstateCancer, with radiotherapy plus neoadjuvant ADT reducing this risk, while cribriform-negative patients did not benefit from early radical treatment for metastasis prevention. ja.ma/479WydF

Ductal carcinoma in situ (DCIS) score profiling after breast-saving surgery enabled selective radiotherapy, allowing half of women with DCIS to safely avoid radiotherapy while maintaining low 5-year in-breast recurrence rates for all risk groups. ja.ma/4hji3gX

Across the JAMA Network, we seek submission of manuscripts describing original research that examines the application of #AI in clinical settings. 🔗 Learn more about submission criteria: ja.ma/48p3TbH

Sarcomas comprise a heterogeneous group of malignant neoplasms that include genomically simple and genomically complex subtypes. This consensus provides guidelines for efficient, rational use of next-generation sequencing in their clinical management. ja.ma/47rtkIx

#AI-detected tumor-infiltrating lymphocytes in pretreatment metastatic melanoma specimens were associated with response to ICI, improved progression-free survival, and improved overall survival. ja.ma/4o9NCMZ

From @jama.com: #Microplastics are increasingly detected in human tissues, with potential links to cognitive, cardiovascular, and inflammatory outcomes. 📌 Learn more: ja.ma/48vRYZK

Absolute neutrophil count–based eligibility criteria in cancer trials disproportionately exclude Black patients with the Duffy null phenotype, suggesting the need for Duffy status–specific thresholds to improve trial equity. ja.ma/48mmCoo

The importance of oral health may extend to cancer prevention. New research finds that bacteria and fungi from the mouth may affect pancreatic #cancer risk. #microbiome

In a case-control study of long-term childhood cancer survivors, heart radiation therapy, high-dose anthracyclines, and platinum agents were linked with increased risk of symptomatic valvular heart disease, especially at higher doses and longer follow-up. ja.ma/3VVEjDQ

Breast cancer risk for pathogenic variant carriers is substantially higher with a first-degree family history, and risk estimates vary by gene, family history, and other factors, guiding personalized screening and prevention decisions. ja.ma/4nIbzKZ

Specific oral bacteria and fungi were risk factors for pancreatic cancer development, suggesting the potential use of oral microbiota as noninvasive biomarkers for identifying high-risk individuals. ja.ma/4n9QpFm

In a pooled analysis of patients from 15 phase 3 trials, the risk of #coloncancer recurrence after surgery and adjuvant chemotherapy fell below 0.5% by six years, supporting this timepoint as a practical definition of cure to guide patient counseling and follow-up. ja.ma/4764Q7y

A phase 2 trial demonstrated an isotoxic improvement in #cancer control with prostate-specific membrane antigen positron emission tomography-guided intensification of salvage RT after radical prostatectomy. ja.ma/48tWkkb

A 400-mg ribociclib starting dose did not match the efficacy of 600 mg in HR+/ERBB2− advanced breast cancer, but had similar progression-free survival and fewer adverse events. ja.ma/48AGALX

Four-year NATALEE trial results show ribociclib plus NSAI maintains invasive disease-free survival benefit over NSAI alone in hormone receptor–positive/ERBB2-negative early breast cancer. ja.ma/4pULwBQ

A 400-mg ribociclib starting dose did not match the efficacy of 600 mg in HR+/ERBB2− advanced breast cancer, but had similar progression-free survival and fewer adverse events. ja.ma/42dA61P

Four-year NATALEE trial results show ribociclib plus NSAI maintains invasive disease-free survival benefit over NSAI alone in hormone receptor–positive/ERBB2-negative early breast cancer. ja.ma/4nexdWS

More young people are now being diagnosed with lung cancer than in the past. This JAMA Oncology Patient Page describes causes, types, and symptoms of lung cancer in people younger than 50 years and how it can be treated. ja.ma/3Ksu86Z

A 400-mg ribociclib starting dose did not match the efficacy of 600 mg in HR+/ERBB2− advanced breast cancer, but had similar progression-free survival and fewer adverse events. ja.ma/4ni9XqV