Viewpoint: FDA analysis of primary clinical trial data frequently uncovers risks and flaws not apparent in published studies, highlighting the importance for clinicians to consider these regulatory insights in their treatment decisions. ja.ma/4nxMv8M

Key points from a recent @jamaoncology.com study on whether risk of pancreatic cancer could be linked to poor oral bacteria and fungi.

Many elevated PSA levels normalize within a year, but consistently high values warrant direct diagnostic evaluation without repeated testing. ja.ma/46xmBLD

🔊 Listen to Jiyoung Ahn, PhD, of New York University, discuss with @viveksubbiah.bsky.social, MD, about whether the oral bacterial and fungal microbiome is associated with the development of pancreatic #cancer. Listen now: ja.ma/41Vzuh9

Specific oral bacteria and fungi were risk factors for pancreatic cancer development, suggesting the potential use of oral microbiota as noninvasive biomarkers for identifying high-risk individuals. ja.ma/3K9xbAU

Pembrolizumab combined with platinum-based chemotherapy showed a 39.4% response rate and manageable toxicity as a potential first-line treatment for advanced penile squamous cell carcinoma. ja.ma/486yf2H

Viewpoint: Recognizing the heterogeneity of small cell lung cancer, efforts are underway to apply precision oncology through molecular subtyping and targeted therapies for tailored treatment. ja.ma/46xBWvU

Viewpoint: Prostate cancer screening is shifting toward a more beneficial and less harmful approach by using MRI-targeted strategies, which reduce unnecessary biopsies and overdiagnosis. ja.ma/48f0BYg

Following trastuzumab deruxtecan approval, HER2 IHC 3+ testing across 65,000 solid tumors demonstrates varied prevalence. ja.ma/3JoJOb0

Following trastuzumab deruxtecan approval, HER2 IHC 3+ testing across 65,000 solid tumors demonstrates varied prevalence. ja.ma/3KkXRi7

Viewpoint: Oncology is shifting toward personalized, less aggressive treatments for "good-risk" metastatic prostate cancer and similar tumors, prioritizing efficacy and quality of life over overtreatment. ja.ma/4mYy2mD

Patient-reported outcomes, such as higher health status and lower symptom burden, are independently associated with improved overall survival in cancer patients. ja.ma/3IeBPwZ

Approximately one-third of patients treated on TT 2 protocol and half of those treated on TT 3A protocol were alive at 15 to 20 years post-diagnosis. ja.ma/4mtZmsK

High-dose aumolertinib is associated with long-term survival benefit for patients with untreated EGFR-variant NSCLC and brain metastases. ja.ma/4mQbsvT

Preoperative stereotactic radiation therapy (SRT) for resectable brain metastases was found to be safe and reduced the time to treatment completion compared to postoperative SRT. ja.ma/3HL8A4D

"Caring for fasting oncology patients during Ramadan requires a thoughtful, individualized approach." This Viewpoint discusses how oncology clinicians can provide culturally sensitive care for Muslim cancer patients fasting during Ramadan. ja.ma/4mTQzR5

Combining utidelone and bevacizumab may effectively treat ERBB2-negative metastatic breast cancer with brain metastases. ja.ma/4lzTdd6

📌 Most viewed this week from JAMA Oncology: Glucagon-like peptide-1 receptor agonists (#GLP1s) are associated with a reduced overall #cancer risk in adults with #obesity, lowering the risk for endometrial, ovarian, and meningioma cancers. ja.ma/4m5MHLj#GLP1s

Viewpoint explores the growing complexity of #cancer care and the essential role of #AI-enhanced decision support tools in helping oncologists manage evolving treatment options and maintain high-quality patient care. ja.ma/462onUO

With an estimated 1.8 million deaths annually, primary lung cancer is the leading cause of cancer-related deaths. This Review discusses the controversies and challenges in the treatment of synchronous oligometastatic NSCLC without an AGA. ja.ma/4p7USti

Proton craniospinal irradiation significantly improves survival outcomes compared to involved-field radiotherapy for patients with leptomeningeal metastases from non–small cell lung cancer and breast cancer. ja.ma/46lHf2n

Early variation in circulating tumor DNA (ctDNA) can predict long-term progression-free and overall survival in patients with dMMR/MSI-H metastatic colorectal cancer treated with immune checkpoint inhibitors. ja.ma/3V8W6GW

Induction-concurrent chemotherapy does not significantly improve progression-free survival compared with concurrent-adjuvant chemotherapy in high-risk N2–3 nasopharyngeal carcinoma. ja.ma/3HJjgRd

Cancer rates among people with HIV have declined for certain types, like non-Hodgkin lymphoma and Kaposi sarcoma, due to improved HIV care, though the risk for other cancers remains largely unchanged. ja.ma/45Kve5c

Despite high insurance coverage rates, individuals diagnosed with #cancer in Massachusetts experienced increases in medical debt, with those having bladder and colorectal cancer facing additional increases. ja.ma/4p1IivY

Rare pathogenic variants in 16 #cancer predisposition genes were linked to both single and multiple cancer diagnoses, suggesting multigene panel testing could be beneficial. ja.ma/4oWqYZ9

Viewpoint: Trust in medicine has declined due to the #COVID19 pandemic and abundant online health information, highlighting the need for transparent, patient-focused communication. ja.ma/3UQXtdw

While the use of fertility-preserving #HormonalTherapy for early-stage endometrial #cancer has increased, survival outcomes are comparable to #hysterectomy in patients under 40. ja.ma/4n10vHQ

Editorial: Patients with limited nodal disease after neoadjuvant therapy may avoid axillary lymph node dissection by using limited axillary surgery and radiation. ja.ma/4fVGmAK

Using the MARI protocol, response-guided axillary treatment in patients with limited nodal disease after primary systemic treatment showed a low risk of axillary recurrence. ja.ma/4pbVO02

Initiating fecal immunochemical test screening for colorectal cancer at ages 40 to 49 leads to reductions in #ColorectalCancer mortality and incidence. ja.ma/4lCOU0Q

In childhood cancer survivors, obesity was linked to a higher risk of various subsequent neoplasm types, while increased physical activity was associated with a reduced risk. ja.ma/3JHuDcV

A telephone-based weight loss intervention induced significant weight loss in patients with breast cancer with overweight and obesity across demographic and treatment factors. ja.ma/41mC27L

Most viewed this week from JAMA Oncology: A deep learning #AI model showed improved accuracy over existing biomarkers in predicting immune checkpoint inhibitor treatment response in advanced non-small cell lung #cancer patients. ja.ma/4lFnMy0#AI

Viewpoint: As palliative care clinicians, we urge the adoption of buprenorphine as a first-line opioid for cancer pain due to its effectiveness and safety profile. ja.ma/41im7at

A telephone-based weight loss intervention induced significant weight loss in patients with breast cancer with overweight and obesity across demographic and treatment factors. ja.ma/45RTUZv

Most viewed this week from JAMA Oncology: A deep learning #AI model showed improved accuracy over existing biomarkers in predicting immune checkpoint inhibitor treatment response in advanced non-small cell lung #cancer patients. ja.ma/4lH2Jve#AI

Viewpoint discusses how ovarian cancer screening remains ineffective in reducing mortality, prompting experts to advocate for personalized preventive strategies tailored to individual risk profiles. ja.ma/3UE5dzt

Study demonstrated cisplatin treatment was followed by a predictable decrease in the estimated glomerular filtration rate (eGFR), placing patients with a lower baseline eGFR at the highest risk of CKD. ja.ma/477aAyq

Glucagon-like peptide-1 receptor agonists (#GLP1s) are associated with a reduced overall cancer risk in adults with obesity, lowering the risk for endometrial, ovarian, & meningioma cancers, while potentially increasing the risk for kidney cancer. ja.ma/45NBeu5

A telephone-based weight loss intervention induced significant weight loss in patients with breast cancer with overweight and obesity across demographic and treatment factors. ja.ma/3JrfLPW

Viewpoint: A tailored, tiered approach to cancer center accreditation could increase hospital participation by addressing existing barriers and aligning costs with hospital capabilities. ja.ma/455uSWu

Prophylactic radiation therapy to the contralateral breast in BRCA1/2 mutation carriers with early breast cancer significantly the onset of contralateral breast cancer compared to surveillance alone. ja.ma/4oa2BH6

Most viewed this week from JAMA Oncology: A deep learning #AI model showed improved accuracy over existing biomarkers in predicting immune checkpoint inhibitor treatment response in advanced non-small cell lung #cancer patients. ja.ma/41Azpza#AI

Many childhood cancer survivors with severe sensorineural hearing loss (SNHL) due to treatments like platinum chemotherapy and radiotherapy are now eligible for cochlear implant candidacy evaluations. ja.ma/4o00qFL

Public awareness of #HPV, its vaccine, and its #cancer links is low in the US, especially in the Midwest and South, contributing to suboptimal vaccination rates in these regions. ja.ma/4lslFNZ

Editor's Note from @jama.com: Author Kenneth Kehl, a medical oncologist and services researcher at DCFI, joins JAMA+ AI Editor in Chief Roy Perlis to discuss the MatchMiner #AI tool developed by @danafarber.bsky.social. ja.ma/45B9rN3

From @jama.com: Launch prices for self-administered anticancer drugs under Medicare Part D increased between 2010 and 2025, outpacing inflation despite the Inflation Reduction Act. ja.ma/3JBSWcf

Systematic review: Childhood #cancer survivorship research is concentrated in high-income countries, highlighting a need for broader global studies to ensure equitable outcomes for survivors. ja.ma/4mgpIhR

Most viewed this week from JAMA Oncology: A deep learning #AI model showed improved accuracy over existing biomarkers in predicting immune checkpoint inhibitor treatment response in advanced non-small cell lung #cancer patients. ja.ma/45mfXZr#AI