Early-stage #LungCancer diagnoses increased nationally and in all states after screening recommendations in 2013, but fewer than 1 in 5 eligible adults are up to date with screening. ja.ma/3PM2d50

A dose-reduced preoperative radiotherapy regimen (36 Gy in 18 fractions) for liposarcoma offered high local control and low rates of major late toxic effects in a phase 2 trial, supporting use in eligible patients. #ESTRO26 ja.ma/4fniZlk

Nearly half of older adults with metastatic #LungCancer did not receive systemic therapy, and treatment rates changed minimally from 2006 to 2021. ja.ma/42nVC3G

Among US cancer survivors, rates of lifestyle advice from health professionals remained stable 2011–2020, but advice was consistently associated with higher engagement in recommended behaviors. ja.ma/4cMrBAy

In advanced nonsquamous #NonSmallCellLungCancer, tiragolumab plus atezolizumab and chemotherapy did not improve progression-free or overall survival compared with pembrolizumab plus chemotherapy, with similar safety profiles. ja.ma/4vZBDFQ

Maintenance rucaparib provided >5-year progression-free survival for 16% of patients with #PancreaticCancer and BRCA/PALB2 variants; resistance mechanisms were detected in half of those with disease progression. ja.ma/4d0xt83

A 60-year-old woman presented with progressive right lower extremity radiculopathy and numbness, a pigmented skin lesion on the right side of the chest, and right ankle jerk reflex. What is your diagnosis? ja.ma/3QLtyob

Adult T-cell leukemia/lymphoma incidence among non-Hispanic Caribbean-born US residents approaches endemic region levels, with early-life human T-cell leukemia virus type 1 infection via maternal transmission identified as an actionable prevention target. ja.ma/42G9Xs7

Local salvage therapies alone for #ProstateCancer recurrence after radiotherapy maintained >75% androgen deprivation therapy–free survival at 2 years with manageable rates of severe adverse events, supporting their use in selected patients. ja.ma/4djZetv

In advanced nonsquamous #NonSmallCellLungCancer, tiragolumab plus atezolizumab and chemotherapy did not improve progression-free or overall survival compared with pembrolizumab plus chemotherapy, with similar safety profiles. ja.ma/4eiSCwz

📄 This JAMA Oncology Patient Page describes different types of common mouth problems during #cancer treatment and how to care for them. ja.ma/48Cu7qB

The AQUILA trial criteria classified more high-risk smoldering multiple myeloma but most had lower progression risk while the 2/20/20 model more accurately identified those likely to benefit from early treatment. ja.ma/4u8CgLB

Open-source #AI models for #LungCancer EGFR mutation prediction showed high accuracy overall but reduced performance in Asian patients and pleural samples, indicating the need for broader validation. ja.ma/4uatWei

Fifteen-year follow-up of the SWOG S0016 trial demonstrates that 42% of patients with advanced-stage #FollicularLymphoma treated with CHOP-based chemoimmunotherapy achieve functional cure. ja.ma/4u652MT

From 2018 to 2023, use of minimally invasive surgery (MIS) for stage I #OvarianCancer increased, but MIS was linked to higher intraoperative capsule rupture rates and lower overall survival when rupture occurred. ja.ma/4cN6FIh

💬Editorial: SONIA demonstrates that reserving #CDK46 inhibitors for progression is generally appropriate for postmenopausal patients with hormone receptor–positive #BreastCancer, supporting individualized sequencing and shared decision-making. ja.ma/4dZWna1

The AQUILA trial criteria classified more high-risk smoldering multiple myeloma but most had lower progression risk while the 2/20/20 model more accurately identified those likely to benefit from early treatment. ja.ma/3OXZbdy

In recurrent or metastatic #NasopharyngealCancer, tislelizumab plus chemotherapy led to longer overall survival and durable progression-free survival compared with placebo plus chemotherapy. ja.ma/3OWRww2

In localized radiorecurrent #ProstateCancer, salvage focal therapy provided similar 10-year survival outcomes as radical prostatectomy but resulted in substantially fewer perioperative complications. AJWLight LondonProstate1 TaimurShah ja.ma/3OSJhkF

Increasing young-onset #ColorectalCancer mortality in the US was concentrated in lower educational groups, highlighting widening disparities by socioeconomic status. ja.ma/4sGvAmM

Early 18F-fluorodeoxyglucose positron emission tomography after 2 weeks of therapy identified patients w/ metastatic #BreastCancer at higher risk for poor outcomes before standard CT, supporting its use to enhance prognostication and management decisions. ja.ma/4sBfx9L

Bireociclib plus fulvestrant improved progression-free survival and objective response in hormone receptor–positive, ERBB2-negative advanced #BreastCancer after endocrine progression. ja.ma/47ByFgd

Patients with #Cancer aged 15 to 39 who received medical assistance in dying experienced escalating symptoms and often received palliative care later in the disease course compared to the general cancer population. ja.ma/4cMhZ8K

Genomic profiling of consecutive meningiomas found associations between copy number alterations, somatic variants, tumor grade, and patient characteristics, offering insights into prognosis and therapeutic vulnerability. ja.ma/4mkDsZH

After discontinuing pembrolizumab among patients with advanced #NonSmallCellLungCancer survival outcomes were high and subsequent immunotherapy use was rare. ja.ma/4dYbj8L

The 9-valent #HPV vaccine was linked to reduced risk of #HPVRelatedCancers in males aged 9 to 26 years, with consistent protection in both the adolescent and young adult groups. ja.ma/41km0ef

Bireociclib plus fulvestrant improved progression-free survival and objective response in hormone receptor–positive, ERBB2-negative advanced #BreastCancer after endocrine progression. ja.ma/4bFvNBu

Clonal hematopoiesis of indeterminate potential (CHIP) was associated with higher risk of trastuzumab-related cardiotoxicity and heart failure in patients with #BreastCancer. ja.ma/4mcHq6r

Pretreatment MRI findings including extraprostatic extension and seminal vesicle invasion were independently prognostic for recurrence, metastasis, and mortality after radical prostatectomy. #ProstateCancer ja.ma/4c30MGm

The addition of camrelizumab to chemotherapy produced statistically significant and clinically meaningful 5-year OS benefits compared with chemotherapy alone in the first-line treatment of recurrent or metastatic nasopharyngeal carcinoma. ja.ma/4scbAbA

Low-dose aspirin in older adults was not associated with lower #Cancer incidence over 8.6 years, and cancer mortality risk did not persist beyond the exposure period. ja.ma/415gY58

Among patients with immune checkpoint inhibitor–related cutaneous adverse events, dupilumab therapy was associated with lower 5-year mortality compared to no dupilumab or systemic corticosteroids. ja.ma/415XcXa

Bireociclib plus fulvestrant improved progression-free survival and objective response in hormone receptor–positive, ERBB2-negative advanced #BreastCancer after endocrine progression. ja.ma/4dlp2Gg

Incidentally detected spleen length ≥140 mm or volume ≥500 mL was associated with markedly elevated 5-year risk for hematologic cancer, liver cancer, and cirrhosis in adults from Denmark and the UK. ja.ma/4dDEIVc

The 2025 federal #Medicaid restrictions are projected to cause over 1 million missed #CancerScreening exams and over 150 excess #cancer deaths within 2 years, with substantial impact on younger and vulnerable adults. ja.ma/4vde24i

💬 Editorial: Stereotactic radiation offered modest symptom relief & better long-term neurocognitive outcomes than hippocampal-avoidance whole brain radiation, but was associated with higher rates of new brain metastases & salvage whole brain radiotherapy. ja.ma/4lUhf4e

From @jama.com: The Medicare #Oncology Care Model (OCM) was associated with modest reductions in Medicare payments for beneficiaries receiving #chemotherapy for cancer; however, overall program costs exceeded these spending reductions. ja.ma/4lUgVT8

Guideline-adherent lymph node dissection provided a small survival benefit for patients with high-grade or no lepidic pattern #LungAdenocarcinoma, but not for those with lepidic pattern alone. ja.ma/4s3DJl4

📄 This JAMA Oncology Patient Page discusses benefits and risks of local consolidative therapy for metastatic #LungCancer and which patients might be considered for this treatment. ja.ma/4dg5AL6

Ocular toxic effects including keratopathy, blurred vision, cataract progression, and uveitis were common but generally reversible during mirvetuximab soravtansine therapy for FRα-positive gynecologic cancers. ja.ma/4bBFm4p

PRIME is a validated, interpretable #PancreaticCancer risk model using routine clinical data, supporting risk-based case-finding and integration with biomarker testing for early detection. ja.ma/4uZYJfg

A 52-year-old woman had presented with persistent inflammatory edema of the lower limb and a history of squamous cell carcinoma. What is your diagnosis? ja.ma/4sBKXO0

Among men with #ProstateCancer undergoing hormone therapy, #SGLT2 inhibitor use was associated with lower risk of treatment failure and delayed progression compared with nonuse, supporting potential adjunctive benefit. ja.ma/41ApOb2

Sequential radiotherapy and immunotherapy (#iRT) provided longer overall survival than concurrent iRT for newly diagnosed advanced non–small cell lung cancer, with additional benefit from chemotherapy. ja.ma/3PuvMYw

A 52-year-old woman had presented with persistent inflammatory edema of the lower limb and a history of squamous cell carcinoma. What is your diagnosis? ja.ma/47cV7vZ

💬 Editorial: MELATORCH trial supports PD-1 blockade as standard care over chemotherapy for advanced acral melanoma, yet limited long-term benefit signals the need for novel therapeutic strategies. ja.ma/4bQ0jaB

In a phase 3 trial, toripalimab improved progression-free survival over dacarbazine as first-line treatment in advanced melanoma predominantly of acral subtype, with an acceptable safety profile. ja.ma/4sgQ4TL

CHIP was associated with increased heart failure and ischemic cardiovascular disease risk after #cancer therapy in patients with solid tumors, especially among those with higher #chemotherapy exposure. ja.ma/4dvzHOu

Review: Adjuvant #immunotherapy was often cost-effective in #CancerCare, particularly for early-stage/high-risk cases, but findings varied by cancer type, drug price, and country-specific thresholds. ja.ma/4lPn8js

Bireociclib plus fulvestrant improved progression-free survival and objective response in hormone receptor–positive, ERBB2-negative advanced #BreastCancer after endocrine progression. ja.ma/3Pu3yNl