Alliance version 8.3.0 is now live at alliancegenome.org. Release notes are here www.alliancegenome.org/release-notes

I am happy to share my @nature.com News & Views summarizing the recent adjustments to the Global Carbon Budget www.nature.com/articles/d41...

It’s good to see papers start to address LLMs as structural plagiarism — provenance, more hidden than the original words or training data. www.nature.com/articles/s42...

🚀 A long-requested feature just landed in #OpenCloning 🔬🧬 You can now manually annotate sequences and create primers right from the editor ✨ Hope it makes your workflow a bit smoother! 📨 If you want to stay updated with upcoming features, subscribe to the mailing list (link in the comments)

First time on Bsky and first big announcement! I am excited to announce that our new study explaining the missing heritability of many phenotypes using WGS data from ~347,000 UK Biobank participants has just been published in @Nature. Our manuscript is here: www.nature.com/articles/s41....

Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on. (Please repost to reach a broad audience.)

Better than making Marmite. 😝

'When Mendel began his investigation, his first inclination was to try breeding mice of different colors. However, before his mice experiment really got going, Mendel was forced to switch the subject of his experiments to peas by a prudish bishop uncomfortable with animals having sex in the abbey.'

My former mentor, colleague, and friend Hamilton Smith passed away this week. He was a giant in science, a Nobel Laureate, but also one of the nicest people you could ever meet. He will be missed by many. www.jcvi.org/media-center...

R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).

13 years ago, the revolutionary genetic tool #CRISPR/Cas9 was published in Science, work that Emmanuelle Charpentier and Jennifer Doudna won a #NobelPrize for in 2020. On #WorldCRISPRDay, read the landmark paper that describes the discovery: https://scim.ag/42JHuSN

🌎👩‍🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵 Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open. doi.org/10.1101/2024...

Wow, more than 2.4M of assembled bacteria in the new release of ABT! We plan to index these using our efficient colored De Bruijn graph index, Fulgor. We recently conducted experiments with nearly 1M genomes…getting there :) www.biorxiv.org/content/10.1...

Related but cool combo of cytogenetics and phenotype. Know when the first QTL was mapped? Sax, K. 1923. The association of size differences with seed coat pattern and pigmentation in Phaseolus vulgaris. Genetics 8:552-560.

A reminder you/your lab can support FlyBase at Cambridge through the following link. Every bit helps. Please share if you yourself can't donate. www.philanthropy.cam.ac.uk/give-to-camb...

Love today’s #xkcd comic on #MassSpec 🤣

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social! www.biorxiv.org/content/10.1... #Chromatin #Asgard #Archaea #cryoEM

🚨 Teaching bioinformatics? Or learning it solo? Check out my free & open Fundamentals of Bioinformatics course materials: lectures, slides, and exercises — no coding background required. 🔬🧬👩‍💻 📚 github.com/lskatz/funda... ⭐️ Star it, share it, and level up! #bioinformatics #opensource #STEMeducation

"As with software, open DNA & strains promotes innovation around the world. I wish to extend Open Yeast & Yeast Protein Expression Toolkits, now in 50 countries, to permit engineering of Yarrowia lipolytica & creating truly open chassis to support boots on the ground innovators."

Here's another #MegabaseSpark submission, from @osn-scott.bsky.social: "The Open Yarrowia Collection" (detail in reply) Like and repost if you like this idea! #SynBio #RootPath

AlphaFold is amazing but gives you static structures 🧊 In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃 Code: github.com/KULL-Centre/... Colab: github.com/matteo-cagia...

chinnadevarapu.bsky.social has updated his tiny, low cost Pocket Spectrometer design that uses an M5StickC microcontroller and AS7341 spectral sensor - simplified hardware connections and software improvements. Nice job! Details at: github.com/scientistnob...

🚀 First Bluesky Post! 🎉 VMD 2.0 Alpha is here! Released today at BPS 2025, this is the biggest update in 30 years—new UI, real-time ray tracing, fast surfaces, UHD & touchscreen support. Monthly updates coming in 2025! Try it now! #VMD #BPS2025 #MolecularVisualization www.ks.uiuc.edu/Research/vmd...

Re DNA sequence DBs: While sequence is shared across #INSDC databases #ENA #Genbank #DDBJ, the presentation and granularity of annotations/metadata can differ notably, with diff. benefits, impacting searches and downstream analyses. All INSDC databases must be maintained - annotations are important

Delighted to share our latest paper describing a method to read the levels of hundreds of metabolites or drugs in parallel using DNA sequencing. This method, which we call ‘smol-seq’ (Small MOLecule sequencing), harnesses the power of DNA sequencing for metabolite detection: rdcu.be/d8xLv (1/6)

What limits rubisco function? Is it the chemical mechanism? Evolution? In this paper, @prywes.bsky.social et. al explore this question by assaying >99% of single amino acid mutants in Form II rubisco (1/7) doi.org/10.1038/s415...

New Journal Article: “Trust in #Scientists and Their Role in Society Across 68 Countries” www.infodocket.com/2025/01/20/j... #science #trustinscience

Two new studies provide some insights on red meat intake, with respect to both potential risks and how they can be mitigated. erictopol.substack.com/p/the-update...

This paper has been a long time coming: We looked at the genomes of historical bacterial samples over a century to look for trends of antibiotic resistance genes, finding multiple instances of them in infections before the age of antibiotics, but an increase in both frequency and mobility after

Microscopy Nodes is now up on bioRxiv! 🚀 This is a Blender extension that seamlessly integrates and visualizes 3D microscopy data (TIF & @zarr.dev). High-quality volume rendering for anyone, in both EM and fluorescence, regardless of computational expertise! 🔬 www.biorxiv.org/content/10.1...

For y’all’s consideration: Use this site to find open source alternatives to whatever app you want to ditch. www.opensourcealternative.to?searchTerm=I...

Here it is... it is exclusive, it is arbitrary, and membership will be determined solely by me. You should be upset if you are included, and also upset if you are not included go.bsky.app/JZc9HXe

I'm happy and humbled to take on a new role with @rcsbpdb.bsky.social. I'll be continuing David Goodsell's work on the Molecule of the Month, starting with my first article on Assembly Line Polyketide Synthases! Check it out (animation included!) pdb101.rcsb.org/motm/301

Build instructions for DIYNAFLUOR, a $40 fluorimeter for DNA quantification - uses 3D printed filter cube, LED source, TSL2591 sensor, cheap 10mm square bandpass filters - with full protocols for SYBR Safe dye measurements github.com/traulab/DIYN... and www.biorxiv.org/content/10.1...

Here's an archived free copy of CL Strong's 1960 book with collected Amateur Scientist columns from Scientific American. Inspiration for citizen science. Forward by Vannevar Bush... archive.org/details/Proj...

Meet Agara Bio, an undergraduate-led community lab 🧪 Agara Bio is an open bio-lab run by undergraduate students at @jhu.edu.

After AlphaFold3 was released with a limited license, a global race began to build the first fully open source replica of the biomolecular prediction model that could be available for commercial use. Read more in MIT News: news.mit.edu/2024/researc...

This is our latest preprint about the biogenesis of the translation proteins in a minimal translation system (PURE). www.biorxiv.org/content/10.1...

It costs around $50 million every year to ensure Signal is robust and available all over the world for anyone whenever they need it. And as a nonprofit, that money comes from all of you; the people who believe that we all deserve a place to speak freely. signal.org/donate/

“There is a lot of pressure to publish in mainstream journals even if we must pay for it,” [Ana María Cetto] says. “Ultimately, our resources go to rich countries so our researchers can have prestige in the community.” Nice piece on open access in Latin America. www.science.org/content/arti...

Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science. www.biorxiv.org/content/10.1...

Does someone have a good post scheduler for bluesky? Usually using @fedica.com, but if I post a link to a paper there, it does not generate a preview, whereas if I directly post the same link, it does. E.g. the preview below did not work with fedica. pubs.acs.org/doi/10.1021/...

Nobel Prize Winners Symposium Hear the contributions of 2024 #NobelPrize laureates in Medicine, Physics and Chemistry in 3 presentations by 🟡Lola F Messina (Fac. Biología UCM) 🟡Jorge Bravo (UAM) 🟡Marta Martínez (CNB-CSIC) Register now nanociencia.imdea.org/es/imdea-nan... #IMDEAnanoSeminars

FreeCAD 1.0 is released! blog.freecad.org/2024/11/19/f...

We are so back 😎 🦋 let us know which dino is your fave!

Waiting for E. coli to get the K. phaffii treatment.

I am ***absurdly*** excited to announce the launch of a new funding opportunity through Experiment dot com!!! You have one month to pitch something wonderful in the realm of plant biology/biotech research and education. $10,000 max grant. PLEASE RE-POST + SHARE!!! 1/3 experiment.com/programs/pla...

Bluesky's firehose is a treasure trove of public data for researchers and developers, and it's completely free. Check out our developer docs: docs.bsky.app

Reminder for those of you new to BSky: You can self-verify by setting your profile name to a domain you own. bsky.social/about/blog/4...

An inspirational superstar of the Microbiology world! 🦑🦠💡