New preprint from the lab! We dig into the regulatory roles of TEs in the mouse placenta, with some surprising findings. Led by the awesome @smamante.bsky.social. Particular kudos to him for navigating the many twists and turns of the project.

The speed at which Oxford Nanopore is cancelling support for their devices is just mind boggling 😳 P2 solo will be decommissioned soon!!! This is not sustainable! @nanoporetech.com

Sad to hear that Oxford Nanopore wants to discontinue the P2Solo later this year in favor of the P2i (the very pricey P2Solo that comes with a GPU to do the basecalling in it) It feels like such a big step in the wrong direction. They are a great sequencing company, not a great GPU upseller...

New Year, New Paper!🎊 Pervasive cis-regulatory co-option of a transposable element family reinforces cell identity across the mouse immune system www.biorxiv.org/content/10.6... Centerpiece of Jason Chobirko's PhD, talented PhD student co-mentored by Andrew Grimson & me. Really excited about it!🧵

We are looking for a Postdoc at the Center for Gene Expression in Copenhagen. Deadline for applications is the 11th of January. If you are interested in 3D chromatin, SMC complexes, and super-resolution microscopy, join us. www.nature.com/naturecareer...

Very happy that this part of my postdoc work is now out as a preprint!! Our findings reveal a new mechanism by which retroviral pandemics may have shaped primate brain evolution 🧬🐒🧠 This was a true team effort! w/ @ofeliakarlsson.bsky.social @raquelgarza.bsky.social @jakobssonlab.bsky.social #TEsky

How do pluripotent stem cells resist harmful interferon responses to safeguard development? Through total epigenetic lockdown of ligands, sensors and effectors of IFN-I. In our preprint, James Holt shares his PhD discoveries on the ground state of immune evasion 😊: www.biorxiv.org/cgi/content/...

Very happy to share our protocols paper for CELLO-seq. This will make single cell long read RNA-seq more accessible and provides analysis guidelines. We hope this helps the #transposon #TEsky community and folks working on #singleCell isoform and allelic #gene expression. doi.org/10.1038/s415...

Is the annotation of viruses in the human genome accurate? We think not. Take a look at our new paper and let us know if you agree! www.science.org/doi/10.1126/...

Come to Lund! We are looking for a postdoc to join the team. #transposons #epigenetics

Join our team as a postdoc and explore the exciting world of transposable elements and developmental biology with us! @imbavienna.bsky.social @vbcscitraining.bsky.social

Another successful year with our workshop at #UniStemDay2025. We explained to high school students how we study human brain evolution using human and monkey brain organoids and looking at gene expression 🧠🐒🔬🧬 w/ @vivienhorvath.bsky.social @ofeliakarlsson.bsky.social @lundstem.bsky.social

I am thrilled to share our story online at @cellpress.bsky.social . Big thanks to all authors: Zhiping, Bill, @lubanlab.bsky.social, Keith & bluesky-less! authors.elsevier.com/c/1kjdaL7PXu... How to tame a genome invader? It takes wild koalas 🐨🐨 to learn it. #Retrovirus #koala #piRNA More below 👇

Read this preprint today from @jakobssonlab.bsky.social lab that profiles and CRISPRi perturbs L1 transcription in hiPSCs and cerebral organoids. It is extremely well done. The L1 CRISPRi phenotype in the organoids is subtle and variable but interesting. 1/n www.biorxiv.org/content/10.1... #TEsky

We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these keywords, apply through the link below. Please spread the word.

We profiled the effects of our CRISPRi system targeting young L1 elements in human pluripotency & brain development. These elements deeply impact our transcriptome, but also have very distinct effects on their nearby genome. Check it out!! 🧬👾 #TEsky #CRISPR #L1 #development #epigenetics

Profiling and targeting young L1s is no easy matter 🧐 check out our new preprint to see how we delve into transcriptional and epigenomic profiling of L1s, and investigate their involvement in pluripotency and early brain development 🧠

🚨 New pre-print from Team Jakobsson! LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development. This work was led by @anitaada.bsky.social, @raquelgarza.bsky.social and @jakobssonlab.bsky.social from the Jakobsson Lab. www.biorxiv.org/content/10.1...

We're thrilled to announce that our project has been funded by @asapresearch.bsky.social in partnership with the Michael J. Fox Foundation! 🚀 Excited to continue exploring the role of transposable elements in Parkinson’s disease. Learn more here: www.lunduniversity.lu.se/article/52-m...

Fantastic line up of speakers at the 7th Max Planck Freiburg Epigenetics Meeting! Looking forward to hear about all the interesting science done in the epigenetics field!! 🧬🤓 @mpi-ie.bsky.social

Well done paper from Wenfeng An's lab showing Yy1 activates L1 TF monomers but surprisingly not GF monomers. More monomers = stronger Yy1 activation academic.oup.com/nar/advance-...

The HuSH complex silences retrotransposable elements. We identify HuSH2, centered on TASOR2, targeting KRAB-ZNFs and interferon genes, balancing retrotransposon silencing and immune regulation. www.nature.com/articles/s41...

🧬 🧠 Excited to see it printed! We bring key insights on the epigenetic regulation of SVAs, including SVA-XDP: a polymorphic SVA driving a rare neurodegenerative disorder @jakobssonlab.bsky.social @vivienhorvath.bsky.social #TEworldwide #Transposons #XDP #NSMB + the volume has the cutest cover 🦔

If you like #Transposons 👾 check out this feed and tag your posts with #TEsky! Thanks @tobybarilbio.bsky.social 🤗 bsky.app/profile/did:...

Thrilled to announce that the EMBO workshop «Mobile Genome» will be back in Heidelberg, Nov 4-7th 2025 @EMBLEvents @EMBO. Registration open soon but you can already register interest. Organized with fantastic colleagues @juliusbrennecke @GonzalezLab_BCN @JoePetersLab www.embl.org/about/info/c...

Bluesky tip for newbies: Bluesky has no real algorithm. Likes here do nothing but show the poster that you enjoyed their content. That kindness is always going to be appreciated by creators, but if you want to help to boost something here, you have to repost it so others see it. 🙂

🦋 Hi, BlueSky! We’re Lund Stem Cell Center at Lund University, Sweden—a leader in #StemCellResearch. Follow us for discoveries, research opportunities, and inspiring stories—and join a #Science community focused on the future of #RegenerativeMedicine. 🔗 Learn more about us: www.stemcellcenter.lu.se

Scraping who is on the platform working on #TransposableElements or other types of #RepetitiveDNA Have fun! go.bsky.app/7t5GQAP

Always exciting and rewarding to share what we do in the lab with the new generations. Hopefully we even managed to inspire some young brains! So happy to be able to participate in #Unistemday2024 🧠🧬🔬 @lundstem.bsky.social

We had a great time at #UniStemDay2024 explaining to high school students how we study human brain evolution using human and monkey brain organoids and looking at gene expression 🧠🐒🔬🧬 w/ @lcastilla30.bsky.social and Nino Pandiloski @lundstem.bsky.social

An exciting line up for the upcoming “Neuroepigenetics in health and disease” Segerfalk Symposium here in Lund University 🧬🧠 Probably of interest for some of you in #TEworldwide! More info 👉 www.neuroscience.lu.se/events/seger...

First sequencing run on our new P2 Solo! So exciting 🤩🧬 @nanopore.bsky.social @jakobssonlab.bsky.social #TEsky

Great to join this Bluesky community. For anyone interested in Transposable Elements, there is now a curated feed to all things TEsky, called TEworldwide: bsky.app/profile/did:... Include TEsky and/or TEworldwide in your posts to be featured!

We are looking for a postdoctoral data scientist position to join our supportive and fun group :) Join us @QMBCI in vibrant #London to delve into the analysis of repetitive genome in #cancer! We support for visa applications, career and personal development! www.jobs.ac.uk/job/DFN649/p...

Dear TE family, it is time! The early-bird registration ends January 15th already! Abstract for talks ends February 15th! Start procrastinating by doing something useful: register to #icte2024 ! See you soon! #transposon

Had a great time at the #EMBOMobileGenome conference in Heidelberg 🇩🇪 this week! Lots of interesting talks and also a lot of fun! 🧬🤓 (including some great autumn vibes 🍂)

Very happy to see the first part of my postdoc work out. Thanks for everyone involved, it was a great team effort!😊🧠🧬

Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease https://www.biorxiv.org/content/10.1101/2023.10.20.563233v1