New blog post, where I highlight a few interesting papers on astrocyte ultrastructure and function, with papers from the labs of Moritz Helmstädter @mhlab.bsky.social, Kristen Harris, Andrea Volterra, Karin Pernet-Gallay, and Hailan Hu: gcamp6f.com/2025/11/14/i...

Enhanced #Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in #LoweSyndrome By Y. Sharma, P. Raghu et al @ncbsbangalore.bsky.social 🗞️ doi.org/10.1038/s443...

Very excited to share that my PhD work is out! Neurons carry ~5,000–10,000 molecules of PI(4,5)P₂ per μm² of membrane. What happens to human brain development when that number changes? I address this using a disease-in-a-dish model of Lowe Syndrome: www.embopress.org/doi/10.1038/...

Do human iPSC derived microglia also possess similar electrophysiological properties? www.cell.com/trends/neuro...

Latest work out today in @currentbiology.bsky.social We find the fly development gene bicoid is much older than previously thought (~20 million yrs older!) 🪰🧬 To pinpoint its origins we tackled the Diptera phylogeny, providing some resolution (many open questions remain). 🔗 tinyurl.com/2vyuevpy

Research Briefing: Promoter editing generates stable setpoints of gene expression www.nature.com/articles/s41... rdcu.be/eK2FW

Beautiful live-cell imaging of lysosome tubulation along microtubules in this work just out from @lysoluis.bsky.social et al: rupress.org/jcb/article/...

Morphological heterogeneity of human astrocytes in cerebral organoids https://www.biorxiv.org/content/10.1101/2025.09.18.675430v1

A phenotypic brain organoid atlas for neurodevelopmental disorders https://www.biorxiv.org/content/10.1101/2025.09.12.675864v1

For some three billion years, unicellular organisms ruled Earth. Then, around one billion years ago, a new chapter of life began go.nature.com/3JyRV4S

1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

Excited that my co-first author manuscript is now published! Special shoutout to Xuelong Mi in Guoqiang Yu's group, who did all of the development of this fantastic tool, which I’ve applied to segment neuromodulatory and astroglial calcium signals. www.cell.com/cell/fulltex...

☕️Ma et al. show that heterogeneous nuclear ribonucleoprotein U promotes the primed state in human #pluripotent stem cells by interacting with #NuclearMatrix protein, Matrin-3, and regulating primed-specific genes. 👉https://rdcu.be/ebq0W bit.ly/4iiVHLV

PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors 🧪🧠 www.nature.com/articles/s41...

I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social www.nature.com/articles/s41...

Voltage-gated ion channel diversity underlies neuronal excitability and nervous system evolution https://www.biorxiv.org/content/10.1101/2025.02.15.638427v1

I am excited to announce the release of our BioRxiv preprint: “Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics”. 1/

New preprint! A really fun project spearheaded by amazing graduate student @christinaramelow.bsky.social and a collaboration with Srikant Rangaraju's group. www.biorxiv.org/content/10.1...

#GliaPapers #GliaSpecialIssue SPECIAL COVER SPECIAL ISSUE: Glial omics: unraveling mechanisms in health and disease onlinelibrary.wiley.com/toc/10981136... Editorial Unboxing “Omics” in Glial Biology to Understand Neurological Disease here - onlinelibrary.wiley.com/doi/10.1002/...

As promised, here is our NEW preprint on CELL CYCLE ASSOCIATED PIP2 NUCLEAR METABOLISM by our SUPER postdoc Toni Gañez, who knows all the secrets of FUCCI reporters 👇 www.biorxiv.org/content/10.1...

One of those classical papers that anyone interested in iPSC-NSC biology should read. Vertebrate Embryonic Cells Will Become Nerve Cells Unless Told Otherwise: Cell www.cell.com/cell/fulltex...

Hi #neuroscience community! This is one of my favorite posts ever. In close collaboration with @liddelowsa.bsky.social and Ye Zhang, we've built a new tool that we are eager to share! www.webseq.net

Our second preprint, which was spearheaded by @thomasdwkim.bsky.social, uses single-cell multiomic analysis to identify gene regulatory networks controlling neurogenesis and cell fate specification in mouse hypothalamus and prethalamus./1 biorxiv.org/cgi/content/...

First 🦋 post! Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental #glial biology to #stem cells and #tumor biology. rdcu.be/d5ADz A 🧵

How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3) doi.org/10.1038/s415...

It’s been an exciting holiday season for the Lancaster Lab, with not 1, not 2, but 3 new preprints to share! Check ‘em out: doi.org/10.1101/2024... doi.org/10.1101/2024... doi.org/10.1101/2024... Happy holidays and best wishes for 2025 from our lab to yours! 🎄🎉

Altered neuronal network activity and connectivity in human Down Syndrome excitatory cortical neurons https://www.biorxiv.org/content/10.1101/2024.12.27.630530v1

Conversion of silent synapses to AMPA receptor-mediated functional synapses in human cortical organoids https://www.biorxiv.org/content/10.1101/2024.12.21.629885v1

Short-range Fgf signalling patterns hindbrain progenitors to induce the neurogenesis-to-oligodendrogenesis switch Read this #OpenAccess Research Article by Tim Yeung and David Wilkinson @crick.ac.uk: https://doi.org/10.1242/dev.204256

Timely and elaborate review that highlights role of little-known phospholipids in glial biology!

Ever wondered, what happens if phospholipid PIP2 levels are disturbed in neurons? Turns out that, PIP2 and Notch are linked! I highlight these findings in my PhD manuscript, finally out on BioRxiv: www.biorxiv.org/content/10.1...

Enhanced Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in Lowe syndrome https://www.biorxiv.org/content/10.1101/2024.11.25.625332v1