🧵 NEW PAPER in @bloodjournal.bsky.social! Why do IDH1 mutations almost exclusively drive myeloid #leukemia, while IDH2 mutations occur in both myeloid AND lymphoid cancers? 🤔 #AML #Epigenetics Despite sharing the same biochemical mechanism, they are NOT equivalent. Here's what we found 👇

We’ve welcomed participants from 33 countries at the EACR's Cancer Genomics, Multiomics and Computational Biology conference in Essen this week! 🤩 This afternoon's poster session has sparked many interesting conversations between researchers.

What if brain metastatic cells do not act alone, but form #networks to help them grow? In our new #preprint, we show that #brainmetastases form malignant, gap-junction mediated #networks that drive cell cycle progression & neural features through Ca²⁺ signaling. www.biorxiv.org/content/10.6... 🧵👇

🧬 Der desmoplastische klein- und rundzellige Tumor ist selten, aggressiv und schwer zu behandeln. Forschende am NCT Heidelberg und am @dkfz.bsky.social haben 30 Tumoren umfassend analysiert und für fast alle Betroffenen potenzielle personalisierte Therapieoptionen abgeleitet. (1/2)

Dreaming of a career in cancer research? Join the International PhD Program at DKFZ - Germany’s largest biomedical research center. Explore #cancerresearch including #cancerbiology, #bioinformatics, #epidemiology & #medicalphysics. The Summer Selection is open now 👉 apply here: t1p.de/hl56b

Coconuts

Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...

Private request :) Is your current or previous residences California? - Help my daughter's school project: a small sociological research, which involves a brief survey of current protests in California, US. I promise, only 3-5 minutes :) Many thanks to you all !! 🩷 forms.gle/X5biAwaRtXt7...

We mourn the passing of Peer Bork, EMBO Member since 2000: https://www.embl.org/news/embl-announcements/in-remembrance-of-peer-bork/

New year's first office view.

Cornetto v0.2.0 is now released for using programmable selective nanopore sequencing for genome assembly. GitHub: github.com/hasindu2008/... Paper: nature.com/articles/s41... Datasets: hasindu2008.github.io/cornetto/doc... ... and a banner made by Ira Deveson referring to ‘no boring bits’.

Now free to read in Genetics (@genetics-gsa.bsky.social): "Preventing evolutionary rescue in cancer using two-strike therapy" #mathonco study by @srishtipatil.bsky.social, @armaanahmed.bsky.social, Yannick Viossat and me, determining the optimal time to switch treatments. doi.org/10.1093/gene...

Anthony A. Hyman will become EMBL’s next Director General. He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999. www.embl.org/news/people-...

We are looking for a postdoc to join our team! If you're interested in translating a cutting edge genomics technology (www.nature.com/articles/s41...) to real-life applications in hematology, this is for you. We offer a unique working environment ON THE BEACH: recruitment.crg.eu/content/jobs...

🚀 Thinking about your next big career step in science? The Int'l PhD Program at DKFZ could be a perfect fit for you. 🌍 Work in an international environment, with 500+ doctoral researchers 🔬 Do cutting-edge cancer research Curious? Join our online info session on 20 Nov. Register here: t1p.de/ws7q3

With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend. mpl.mpg.de/news/article... @fau.de 📸 Stephan Spangenberg

It has been an honor for me to have worked in this fantastic project with great scientists and brilliant students for the last few years.

📢 Registration now open for HARPOON Conference, Nov 27–28 2025 in Heidelberg! Precision oncology, multi-omics, & translational research. indico.dkfz.de/event/1230/ @nct-heidelberg.bsky.social @dkfz.bsky.social @vhio.bsky.social @ki.se @crukcamcentre.bsky.social @nkinl.bsky.social @gustaveroussy.fr

That's cool!!!

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.

Your Prime Day reminder that half of Amazon warehouse workers struggle with food & housing costs. A third have had to rely on government assistance like SNAP — which is about to get cut. If Bezos can spend $50M on a wedding, Amazon can afford to treat its workers with dignity.

After so many inspiring talks and thought-provoking conversations, it's now time to go home. Many thanks to the organizers of #EACR2025 for this extraordinary event. Hope to meet everyone again next year in Budapest.

If you are at the #EACR2025 today and interested in integrative genomics of rare cancers, feel free to visit me by the poster P-006 in Pavilion 1 during the poster session.

This was one of the most inspiring talks I've ever heard in my life! #eacr2025

Incredible opening keynote by Charlie Swanton - spanning tumour initiation, aging, environmental exposure and much more 👏👏 #EACR2025 @charlesswanton.bsky.social @crick.ac.uk @helloeacr.bsky.social

„Kinder, die lernen, ihre eigenen Gefühle zu verstehen, können auch die Gefühle anderer besser wahrnehmen.“ Lisa Feldman Barrett #blueLZ

1. LLM-generated code tries to run code from online software packages. Which is normal but 2. The packages don’t exist. Which would normally cause an error but 3. Nefarious people have made malware under the package names that LLMs make up most often. So 4. Now the LLM code points to malware.

The German Science and Humanities Council and the German Rectors' Conference criticise attacks on academic freedom and declares its solidarity with US institutions and scientists. An attack on science anywhere is an attack on science everywhere. #AcademicFreedom #HandsOff

Are you interested in groundbreaking research in the field of personalized cancer therapies? If so, please join us at DKFZ for an exciting and inspiring afternoon and hear from key opinion leaders and rising stars about what is on the horizon.

** Meyenburg-Preis an Michel Sadelain ** 🏆Verleihung im Rahmen des Cancer Research Award Symposiums der Meyenburg-Stiftung 📅 2. April 2025 am Deutschen Krebsforschungszentrum in Heidelberg Programm und Anmeldung unter www.nct-heidelberg.de/das-nct/news... @dkfz.bsky.social

We would love feedback on a new NCBI-BLAST service we are launching today: sky-blast.com Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

New release headed by GHGA Member Kübra Narcı! This pipeline is designed to assess and validate the accuracy of variant calling methods in genomic research.

Heidelberg 2025-02-15

#aufstehenfuerdemokratie Um 11:55 Uhr versammelte sich eine große Gruppe von Wissenschaftlern & Unterstützern, um ein Statement für faktenbasierte Entscheidungen und Demokratie abzugeben: Geht wahlen-mit Verstand! Inspirierende Worte von Prof. E. Winkler und Prof. S. Pfister - Danke an Alle!

Our new paper examining how to analyse longread RNA-seq with no reference genome. We compare approaches for assembly and downstream analysis, from transcript accuracy to differential expression. Lead by @alexyfyf.bsky.social. Thnx to all contributors incl. @qgouil.bsky.social for the pea data!

How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3) doi.org/10.1038/s415...

HOW COOL IS THIS?! Scientists have discovered a new way to destroy cancer cells. By stimulating aminocyanine molecules with near-infrared light, cancer cells vibrate in sync, enough to break apart their membranes! These “molecular jackhammers” DESTROYED 99% of cancer cells! 🧪🧵⬇️

Excited to announce two DFG-funded PhD positions to study Lipid Droplet Heterogeneity in cancer as part of FOR5815. Join us @dkfz-heidelberg if you are interested in #cancermetabolism and #lipidbiology jobs.dkfz.de/en/jobs/1673... jobs.dkfz.de/de/jobs/1673...

Exciting times ahead! The first joint clinical trial of the National Center for Tumor Diseases #OneNCT will address the unresolved question of whether treatment based on multi-layered molecular profiling can improve outcomes in patients with advanced #RareCancers. nct.dkfz.de/en/nct/news/...

Direct RNA sequencing @nanoporetech.com was featured as one of the top 10 innovations of 2024 by The Scientist bit.ly/4gvCV2S

Insider tip: Daniel offers here a very promising project in a very nice workplace. 😉

Bluesky is a wonderful place! 😃 @adrianwoolfson.bsky.social

Happy to share our data on the effects of IDH1-mutations on hematopoietic differentiation today at the #ASH24 poster session and now with #HemeSky!

Bluesky for Science Starter packs for genomics, bioinformatics, #Rstats, Nextflow. Moderation lists. Feeds. Let's rebuild the old scitwitter community and keep this place nice blog.stephenturner.us/p/bluesky-fo... 🧬🖥️🧪

We are happy to share the development of Co-transcriptional Structure Tracking by @leoschaerfen.bsky.social, which measures RNA structure formation during its synthesis in vivo. We are excited to discover the activity of helicases on nascent rRNA! www.biorxiv.org/content/10.1...

It makes so much sense 😊

Hello DKFZ people! I hope this list will grow and help all new bluesky members from our institute to find each other here ☺️ go.bsky.app/V64sJYM

Best practices for germline variant and DNA methylation analysis of second- and third-generation sequencing data. #VariantAnalysis #Epigenetics #ShortRead #LongRead #Sequencing #Genomics #Bioinformatics #BestPractices #HumanGenomics 🧬🖥️ humgenomics.biomedcentral.com/articles/10....