Can we design mutations that bias proteins towards desired conformational states? Today in @science.org, we introduce Conformational Biasing (CB), a simple and scalable computational method that uses contrastive scoring by inverse folding models to identify conformation-biasing mutations.

It's finally out!... Using single-cell and spatial transcriptome data, and data imputation, we created BARVISTA, a website able to perform almost genome-wide information on gene expression profiles at single-cell resolution in barley spikes! www.nature.com/articles/s41...

🧵 Just out in Cell after more than 10 years in the making! 🎓 www.cell.com/cell/fulltex... Plants and animals evolve radically different body plans. Do they also operate under fundamentally different molecular evolutionary constraints during organ formation? @cellpress.bsky.social

This is why we always have to push back. This is why we don't take breadcrumbs: either we all make it, or no deal. No complacency, only sense of duty and community 🧪

The U.S. NSF has announced changes to its highly regarded system of reviewing the some 50,000 grant proposals received each year. The move has created uncertainty and anxiety across the U.S. scientific community. Here are five things to know about the changes. ⬇️ https://scim.ag/4aCoSZQ

New episode of #No_Time_To_Read_podcast! 🎙️ I had a wonderful discussion with @ajeetchaudhary.bsky.social Ajeet about his recent Molecular Plant paper. His work made it to the cover as well. Podcast: tinyurl.com/3ppeys36 Article: www.cell.com/molecular-pl...

Dr. No: how to tell your PI to chill out cuz you just passed candidacy and you totally got this

Post tenure, my research will be exclusively on zany shit like this ☺️

“In this study, we identified independent loss-of-function mutations in a WUSCHEL-LIKE HOMEOBOX transcription factor, WOX1, as the genetic basis of the prickleless S locus in both blackberry and red raspberry”

(1/3) Any problem we see around us, somewhere some organism is smart enough to solve this problem already Here is a great example from liquid-stabilizing mechanisms of pitcher plants; Science Advances www.science.org/doi/10.1126/...

TMO5 orchestrates organ patterning in plant shoots This Research Highlight showcases work by Abdul Kareem, Carolyn Ohno and Marcus Heisler (@heisler-lab.bsky.social): journals.biologists.com/dev/article/...

Hey all, I reached out to the PO of my NIGMS MIRA to ask if the gov't shut down, and rescheduling of study sections, might allow for some accommodation to the standard rule that PIs cannot resubmit a MIRA while their MIRA (or other RPG) is under review (waiting in scores or summary statements) 🧪

Live thread of the NSF biology virtual office hour: 🧵

Fusion genes as emerging regulators of plant development and adaptation Hamid et al. nph.onlinelibrary.wiley.com/doi/10.1111/...

"cis-regulatory evolution involves turnover of thousands of individual binding site instances while largely preserving transcription factors’ binding preferences." From: academic.oup.com/mbe/advance-...

Bryophyte-friendly tenure-track position in the UBC Botany department! Deadline on the 19th botany.ubc.ca/job-postings...

A very nice and skillful work by Agata Burian and colleagues characterizing the development of vascular strands around the Arabidopsis shoot apex: www.sciencedirect.com/science/arti...

So structural biology is not dead after all 😋 Not a big surprise The title of this article is exactly in line with what I think. Same applies to LLMs for scientific writing.

@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/

ASSISTANT PROFESSOR IN NON-SEED PLANT DIVERSITY (BRYOPHYTES, FERNS, LYCOPHYTES). Vancouver, Canada. #plantscijobs #plantscijob botany.ubc.ca/job-postings...

Have you ever wondered how new DNA methylation patterns are established? Paradigm shift ahead! We discovered a new mode of DNA methylation targeting in plants that relies on transcription factors and sequence motifs rather than chromatin modifications to regulate the methylome. rdcu.be/eQ6L5 1/8

ARF3-mediated auxin signaling is essential for sex determination in cucumber www.science.org/doi/10.1126/...

Very happy to share this study in collaboration with @jaz-humphreys.bsky.social and @frannybarbs.bsky.social , with our little contribution, on the role of Ck on Sugar-mediated gemma formation @biorxiv-plants.bsky.social www.biorxiv.org/content/10.6...

#TansleyInsight: The discovery of #twilight length sensing in plants and its implications for models of plant #photoperiodism Lau et al. 👇 📖 nph.onlinelibrary.wiley.com/doi/10.1111/... #LatestIssue #PlantScience @uhriglab.bsky.social @mehta-lab.com

#Gibberellin-Driven Bud Break via CsHDZ34 Chao Huang, et al. 📖 nph.onlinelibrary.wiley.com/share/7P3U9I... #PlantScience

Out today... From Bowman lab, MpARF2 is the first essential transcription factor to be described for meristem maintenance in Marchantia. Glad to have contributed to another paper with Eduardo. #plantsciences #evodevo www.sciencedirect.com/science/arti...

Oh Wow! Cell wall patterning regulates plant stem cell dynamics | Science www.science.org/doi/10.1126/...

We just released IRIS (7+yrs project), a tech we believe will transform cell biology by pairing high-resolution cell images with matched #scRNAseq, letting us interpret cellular form by its molecular ground truth. Huge tx to @JohannesBues, @JoernPezoldt, @CamilleLambert et al. shorturl.at/zgY8Z

Congratulations!!!🥳🥳🥳

Our editors write: - Organ patterning: Phyllotaxis by emerging apical vasculature rdcu.be/eR3Hm A highlight of this paper in @cp-devcell.bsky.social : "Self-organization of vascular strands drives their patterning in the Arabidopsis shoot apex" www.sciencedirect.com/science/arti...

📣 I hereby make my Bluesky debut to announce that our work linking DNA binding affinities and kinetics 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 and 𝘪𝘯 𝘷𝘪𝘷𝘰 for the human transcription factor KLF1 just got published in Cell! @cp-cell.bsky.social www.cell.com/cell/fulltex... Key findings in a thread (1/6):

Ethylene modulates cell wall mechanics for root responses to compaction www.nature.com/articles/s41...

🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.

Very happy to share that this paper is now online on @currentbiology.bsky.social !! 🥳🧪 Check out the final published verion here: www.cell.com/current-biol... #mimuluspropaganda

Beautiful work by Julie aka

Beautifully written & reasoned 3 min read. “To my students and to anyone who might listen, I say: Don’t surrender to AI your ability to read, write and think when others once risked their lives and died for the freedom to do so.” Commentary from a cool prof in 🧵 www.huffpost.com/entry/histor...

Elevated CO2 drives epigenetic reprogramming andchromatin dynamics in Arabidopsis thaliana https://www.biorxiv.org/content/10.1101/2025.11.20.689512v1

It’s finally out! 🎉 Work led by former PhD student @wei-xiao-botany.bsky.social , in collaboration with @bayerlab.bsky.social and @bertderybel.bsky.social AINTEGUMENTA phospho-switch regulates bilateral stem cell activity during secondary growth. 🔗 www.pnas.org/doi/10.1073/... #PlantSciences

MicroRNA166-HD-ZIP III module impacts tuber shape, color and productivity in potato https://www.biorxiv.org/content/10.1101/2025.11.20.685984v1

CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis | Science www.science.org/doi/10.1126/... Very nice work from Holger Puchta & colleagues

Are you a postdoc or assistant professor on the job market? Reminder that our department is hiring! We are a scientifically diverse department looking for a colleague that is excited about science, teaching, and potential collaborations! Please apply by 12/5/25!

Good people!💪🏽

Come do a joint postdoc with me and @tinakim-neuro.bsky.social, splitting your time between Princeton and Columbia. Come design new activity-dependent labeling enzymes and transcriptional reporters optimized for application in the peripheral nervous system. hhmi.wd1.myworkdayjobs.com/en-US/Extern...

📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate. apply.interfolio.com/177622 Suggested deadline: 12/15/2025. @columbiasysbio.bsky.social

A really nice highlight of our recent PLOS Biology paper on leaf giant cells with Frances Clark, @gweissbart.bsky.social , Xihang Wang, and @pauformosa.bsky.social from @cornelluniversity.bsky.social news.cornell.edu/stories/2025...

Direct shoot regeneration using Arabidopsis WIND1 (35S:AtWIND1) + pAtESR:IPT. The idea is WIND1 both reprograms and activates ESR promter, and subsequently activates cytokinin synthesis via pESR:IPT for shoot regeneration. #PlantScience From: www.cell.com/molecular-pl...

New OA Article: "Cambium LBDs promote radial growth by regulating PLL-mediated pectin metabolism" rdcu.be/eP4mp LBD TFs in the cambium drive radial plant growth by regulating PECTATE LYASE-LIKE (PLL) enzymes that remodel cell wall pectin, promoting cell expansion.

Are you a postdoc or Asst. Prof on the job market? Check out our listing and consider applying! The search is very broad and it’s in a great department, location, university! Even with the crazy schedule that comes with being a PI- I love my job @ucdavis.bsky.social @ucdavisvetmed.bsky.social!

Antagonism between blue and red light-signalling controls thallus flatness in Marchantia polymorpha https://www.biorxiv.org/content/10.1101/2025.11.10.687525v1

Words from Elizabeth Kolbert, Pulitzer Prize-winning author of The Sixth Extinction on "When Trees Testify": "Beronda L. Montgomery draws on the experience of Black American...growing up in Arkansas, and her expertise as a plant scientist to....A fascinating, informative, and deeply moving book."