Si vous avez des adolescentes qui s'intéressent à l'informatique, je signale qu'il reste des places pour les stages #GirlsCanCode en août et septembre. C'est gratuit et vraiment top. Mes aînées les ont fait en 2018 et 2022, là je viens d'inscrire fille n°3 et elle est ravie. girlscancode.fr

Very happy to see this out! authors.elsevier.com/a/1lSNA3SNvc... We built upon DANCE dataset to predict protein motions directly from sequences, without exploiting 3D structures! Code: github.com/PhyloSofS-Te....

Very happy about this collective effort! We provide the community with variant effect predictions for the whole fly proteome. We validated them with annotations, population polymorphism, and CRISPR experiments. Check out your favorite protein with ProteoCast!

A little discussion with @pierrepo.bsky.social about our MDverse project and its future with the @lumen-eu.bsky.social project (in French). "MDverse, un projet pour explorer les données de la dynamique moléculaire" www.inc.cnrs.fr/fr/cnrsinfo/...

I have two open postdoctoral researcher positions in my group. I am looking for applicants with interest and expertise in computational structural biology and research software development. These positions are part of GANANA, a collaborative European/Indian project Check www.uu.nl/en/organisat...

Excited to share our latest preprint evaluating AlphaFold3, Boltz-1, Chai-1 and Protenix for predicting protein-ligand interactions, featuring our newly introduced benchmark dataset 🌹Runs N’ Poses🌹! www.biorxiv.org/content/10.1... 🧵👇 (1/n)

Cryptic pockets are hidden binding sites in proteins that are not visible in their standard ("apo") structure and only stable in the presence of the right ligand. Here, Bemelmans et al. review how scientists use computer algorithms to detect them. www.sciencedirect.com/science/arti... 🧪 #CompChem

The Rosetta Commons Research Experience for Undergraduates (REU) program accepts applications until February 1, 2025. Apply now and participate in research using the Rosetta Commons software. Learn more here: rosettacommons.org/education/reu/ #REU #RosettaCommons #Undergraduateprogram

Curious about alternative splicing? Kick off the year with our latest review in COSB! authors.elsevier.com/sd/article/S...

🧪 Got a curious 7–11 year-old at home? 🔍 Whether they’re wondering how yeast grows or want to craft some red blood cells, the new Crick Kids website has them covered! 🎉 Discover fun science activities, hands-on experiments, and lots of quizzes 🧬👩‍🔬🔬 👉 Check it out here: kids.crick.ac.uk

🚨 I am super happy to announce that our analysis of how the structure of protein-RNA interfaces evolves is now published (early access) at @plos.bsky.social Computational Biology: doi.org/10.1371/jour... 🧬🧶

#ICYMI: In a Science study, researchers present “Evo”—a #MachineLearning model capable of decoding and designing DNA, RNA, and protein sequences, from molecular to genome scale, with unparalleled accuracy. Learn more: scim.ag/41bmK6u

Chai-1, the open source AF3 clone, is now available with an Apache 2 license github.com/chaidiscover...

Here is the graphical summary of our findings that helped us to engineer new variants of the protein AstaP that are 51 amino acid shorter than WT yet soluble, express well and bind and transfer carotenoids

Very happy to introduce VespaG, for ultra-fast and accurate prediction of protein mutational effects. github.com/JSchlensok/V.... Big thanks to all authors for the great work and effort. Exciting collab with Rost lab! www.biorxiv.org/content/10.1...

Making protein movies from (sparse) static snapshots! Try out ou method DANCE: github.com/PhyloSofS-Te.... And our PDB-wide analysis of protein conformational variability: www.biorxiv.org/content/10.1.... Joint work with Valentin Lombard and Sergei Grudinin.

"Cerebra: a computationally efficient framework for accurate protein structure prediction" presents a structure module without invariant point attention, used in almost all protein structure prediction networks so far (with the notable exception of RosettaFold) www.biorxiv.org/content/10.1...

Join the RCSB PDB Team and transform research and education around the world Open positions include Data Science Workflows Architect, Backend Software Engineer, Senior Front-End Web Developer, and more Details at RCSB PDB: www.rcsb.org/pages/jobs

1/n I'm thrilled to share *Deep generative modelling of the human proteome reveals over a hundred novel genes involved in rare genetic disorders* t.co/DoN4DrSFbS from a wonderful collaboration between the Marks Lab and Dias and Frazer group, with @roseorenbuch as lead! 🧵:

New in Science with @jaescudero.bsky.social . A combinatorially complete fitness landscape with >260.000 E.coli genotypes shows unexpected properties. Despite ~500 fitness peaks in this landscape, adaptive evolution can easily navigate to highest fitness peaks www.science.org/doi/10.1126/...

Update on the Chroma vs RfDiffusion analysis. ProteinMPNN just doesn't like Chroma's backbones (poor prediction of proteinMPNN generated sequences by ESMFold). Interestingly, Chroma's own sequence design method (which was trained in the context of partially noise backbones) loves it! (1/3)