⏪ G&D RECAP ⏪ 🗓️ October 2025 RESEARCH COMMUNICATION: Structural basis of nucleosome recognition by the conserved Dsup & HMGN nucleosome-binding motif By Alegrio-Louro et al. and Andres Leschziner ➡️ https://genesdev.cshlp.org/content/39/19-20/1155.full #proteininteractions #proteinstructure #cryoEM

It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...

Did I just see a picture of a phage hijacking its host within the host of that host?!?!? Coolest thing ever.

Giles and Burnley: Ten years of the CCP-EM Spring Symposium ##Cryoem##ElectronCryoMicroscopy##CCPEM... ##IUCrhttps://journals.iucr.org/paper?S2059798325010496

Doppio is a great tool (more of a toolbelt actually) to go all the way from micrographs to deposition!! (and the more people using it, the greater it gets)

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

The peer-reviewed version of our article on the flagellum filament assembly is out! A masterpiece from duo extraordinaire Kailin and Rosa, and an incredibly productive collaboration with Marc Erhardt and Morgan Beeby.

The amazing Sofia Lövestam initiated the below project, when she became interested in the vault particles that we sometimes observe in #cryoEM images of brain-derived #amyloid filaments. www.biorxiv.org/content/10.1...

🦠🧠 MemBrain update! 🧠🦠 We’ve updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics. 🔗 Preprint: doi.org/10.1101/2024... 🔗 Code: github.com/CellArchLab/... 🧵(1/6) #TeamTomo

Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social

REGISTRATION OPEN!! - CNIO meeting, Machines acting on DNA and RNA, 2025 May 28-30th in Madrid, organized by @nogaleslab.bsky.social , @rfleiro.bsky.social , and @oscarllorca.bsky.social

🚨We're recruiting! Interested in making science and computing more environmentally friendly? Now's the time! Very excited to build a research group at Cambridge Uni to expand our Green Algorithms work thanks to the support of the Wellcome Trust www.green-algorithms.org/join-us #AcademicSky #SciSky

Here is a starter pack for CryoEM/ET enthousiasts To be completed go.bsky.app/JmQksC