Hermann Schindelin
@en-hxnu-enment.bsky.social
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Structural biologist and biochemist, University of Wuerzburg
@uniwuerzburg.bsky.social
reposted by
Hermann Schindelin
Christoph Spahn
3 days ago
🚨 Job alert! 🚨 We are looking for a PostDoc to study bacterial secretion and subcellular organization of pathogens during host-pathogen interaction! 🦠🔬💊 More information:
www.uni-wuerzburg.de/en/rvz/resea...
Please share!
#microbiology
#pathogens
#super-resolution
#microscopy
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Hermann Schindelin
GDCh Division of Biochemistry
5 days ago
Are you interested in cutting-edge #Biochemistry and #ChemBio? Join us for the GDCh #Biochemistry2026 conference in Würzburg on March 16th to 18th, 2026. Registration is now open and you can submit an abstract until January 10th, 2026:
veranstaltungen.gdch...
#Biochemistry
#ChemBio?
#Biochemistry2026
/2)
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Hermann Schindelin
Nucleic Acids Research
4 days ago
👏 Congratulations to
@helena-stafflinger.bsky.social
Helena Stafflinger,
@en-hxnu-enment.bsky.social
Hermann Schindelin, Jens Wöhnert and their team on this elegant and paradigm-shifting study uncovering unexpected principles of RNA G-quadruplex formation!
@uniinnsbruck.bsky.social
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Hermann Schindelin
Peter Gleick
7 days ago
This. Thank you
@ellecordova.bsky.social
www.youtube.com/shorts/AYm9w...
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For our scientists
YouTube video by Elle Cordova
https://www.youtube.com/shorts/AYm9w6W5B-E
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Hermann Schindelin
Nature Structural & Molecular Biology
20 days ago
ICYMI: New online: UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6
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UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6
Nature Structural & Molecular Biology, Published online: 05 December 2025; doi:10.1038/s41594-025-01717-zRiechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2 ubiquitin-conjugating enzymes, revealing a hierarchy of E2 activity with cognate E1s.
https://go.nature.com/4iLNfGu
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Hermann Schindelin
Christophe Zimmer
about 1 month ago
Recently out: “Uniform dynamics of cohesin-mediated loop extrusion in living human cells”. In this study led by brilliant former PhD student Thomas Sabaté we use live cell microscopy and polymer simulations to characterize how DNA loops and TADs form in human cells by cohesin-driven extrusion. (1/4)
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Emily Atkin
about 2 months ago
A scoop that I’m not happy to report: CBS News has gutted its climate change reporting team, one of the best in the business, and one of the only ones on cable news that consistently called out fossil fuels as the main source of climate pollution.
heated.world/p/cbs-news-k...
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CBS News kills its climate unit
David Ellison, the new pro-Trump chief executive of Paramount Skydance, has dismantled the best climate change reporting team in cable news.
https://heated.world/p/cbs-news-kills-its-climate-unit
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Hermann Schindelin
Pedro Friedmann Angeli
2 months ago
(1) New preprint from our lab! HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis. Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death. 👉
doi.org/10.1101/2025...
#ferroptosis
#heme
#ironmetabolism
#preprint
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HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis
Modulating the intracellular labile iron pool (LIP) has emerged as a promising strategy to induce ferroptosis in cancer cells, offering a way to overcome resistance to apoptosis-based therapies. One o...
https://doi.org/10.1101/2025.10.14.682408
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Hermann Schindelin
Bettina Böttcher
4 months ago
🧪❄️🔬 We were very surprised to find out that the MscS-like channel YnaI does not tilt its paddle helices to open.... almost overlooked the huge pore in our cryo-EM maps Very proud that this is finally out:
rdcu.be/eB3FF
Well done, Vanessa
@uni-wuerzburg.de
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Hermann Schindelin
Ute Hellmich
5 months ago
A one day double whammy for our very own Eric in
#trypanosome
research! 🧪🥳 Backbone assignments of the essential oxidoreductase from T. cruzi (Chagas disease):
tinyurl.com/ywshhxjt
🧲🦟 and his master piece on the role of fluorine in chemically induced dimerization:
www.biorxiv.org/content/10.1...
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Inhibitor fluorination pattern tunes chemically induced protein dimerization
Chemically induced dimerization of proteins is a powerful approach to regulate biomolecular functions through small molecule ligands acting as 'molecular glues'. Here, we demonstrate that simple, thie...
https://www.biorxiv.org/content/10.1101/2025.07.23.666362v1
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Hermann Schindelin
Maric Lab
5 months ago
Excited to share the new Peptide Libraries volume via Springer Nature (Methods in Molecular Biology series):
link.springer.com/book/10.1007...
19 protocols & perspectives from leading labs on
#PeptideLibraries
design, synthesis &
#screening
. Thanks to co-editor Ronald Frank and all contributors!
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Hermann Schindelin
Pedro Friedmann Angeli
6 months ago
Excited to share that I’ve joined Cell Chemical Biology as an Associate Academic Editor! Looking forward to contributing to the publication of impactful work from the vibrant chem bio community
#ChemicalBiology
#SciencePublishing
#CellPress
#ChemBio
www.cell.com/cell-chemica..
.
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https://www.cell.com/cell-chemica..
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Hermann Schindelin
Bettina Böttcher
6 months ago
Our paper on Lymphostatin is now out (
rdcu.be/etk2v
). It shows
#cryoEM
structures of this huge virulence factor revealing amazing domain reorganisations. Very enjoyable collaborating with the Stevens Lab in Edinburgh and the Boersch Lab in Jena to see how it gets into cells.
@uni-wuerzburg.de
🧪❄️
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Hermann Schindelin
MeidasTouch
9 months ago
You have to see this. PoliticsGirl and her husband teamed up with the brilliant Timothy Snyder (author of On Tyranny) and the legendary John Lithgow to create something truly powerful. It’s important, it’s urgent—and it needs to be shared far and wide.
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20 Lessons on Tyranny: by Timothy Snyder / read by John Lithgow
YouTube video by PoliticsGirl
https://youtu.be/cXR5HLodsT8?si=e8jOuN9Ebuy2vEtk
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Hermann Schindelin
Alex Holehouse
7 months ago
Now published! Big congrats to first author
@gginell.bsky.social
We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...
add a skeleton here at some point
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Hermann Schindelin
Peter Gleick
7 months ago
The GOP: the anti-Robin-Hoods. Stealing from the poor to give to the rich.
add a skeleton here at some point
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Hermann Schindelin
Santosh Panjikar
9 months ago
Peptide Bonds Unveiled: Enhancing Protein Structure Understanding Explore the complete study here:
doi.org/10.1107/S205...
#StructuralBiology
#AlphaFold
#Biochemistry
#MolecularBiology
#LifeSciences
#ComputationalBiology
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Hermann Schindelin
Pedro Friedmann Angeli
9 months ago
Looks like the US visa application platform still calls X 'Twitter'... guess Elon's feelings are visa-bly hurt 🥁
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Hermann Schindelin
Maric Lab
9 months ago
🚀 Excited to share our latest work in
#JACS
on eSylites! —Synthetic, high-affinity
#ChemicalBiology
probes for
#SuperResolution
#Synapse
visualization & precise mapping in neurons and brain slices—without the need for antibodies, tags, or transfection! 📢 Read more:
pubs.acs.org/doi/10.1021/...
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eSylites: Synthetic Probes for Visualization and Topographic Mapping of Single Excitatory Synapses
The spatiotemporal organization of the postsynaptic density (PSD) is a fundamental determinant of synaptic transmission, information processing, and storage in the brain. The major bottleneck that prevents the direct and precise representation of the nanometer-scaled organization of excitatory glutamatergic synapses is the size of antibodies, nanobodies, and the genetically encoded fluorescent tags. Here, we introduce small, high affinity synthetic probes for simplified, high contrast visualization of excitatory synapses without the limitations of larger biomolecules. In vitro binding quantification together with microscopy-based evaluation identified eSylites, a series of fluorescent bivalent peptides comprising a dye, linker, and sequence composition that show remarkable cellular target selectivity. Applied on primary neurons or brain slices at nanomolar concentrations, eSylites specifically report PSD-95, the key orchestrator of glutamate receptor nanodomains juxtaposed to the presynaptic glutamate release sites that mediate fast synaptic transmission. The eSylite design minimizes a spatial dye offset and thereby enables visualization of PSD-95 with improved localization precision and further time-resolved discrimination. In particular, we find that individual dendritic spines can contain separate nanodomains enriched for either PSD-95 or its closest homologues, PSD-93 or SAP102. Collectively, these data establish eSylites as a broadly applicable tool for simplified excitatory synapse visualization, as well as a high-end microscopy compatible probe for resolving the PSD organization with unprecedented resolution.
https://pubs.acs.org/doi/10.1021/jacs.5c00772
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Hermann Schindelin
Prof. Stefan Rahmstorf
9 months ago
To think that Einstein worked on the campus where I now work, and Hannah Arendt lived just around the corner from my house…
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Hermann Schindelin
Alisia Fadini
10 months ago
Structural biology is in an era of dynamics & assemblies but turning raw experimental data into atomic models at scale remains challenging.
@minhuanli.bsky.social
and I present ROCKET🚀: an AlphaFold augmentation that integrates crystallographic and cryoEM/ET data with room for more! 1/14.
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Shao-Liang Zheng
10 months ago
George Sheldrick will be missed🕯️🕯️🕯️#SHELX
#crystallography
#education
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Hermann Schindelin
Prof. Stefan Rahmstorf
10 months ago
🇩🇪 ist die drittgrößte Volkswirtschaft der Welt. Morgen wählen wir - entweder für eine moderne, klimaneutrale Wirtschaft, oder für die Rückkehr zu Technologien des letzten Jahrhunderts. Lasst euch nicht für dumm verkaufen mit Scheinlösungen, die nur das fossile Geschäftsmodell noch etwas verlängern.
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Hermann Schindelin
Titia Sixma
10 months ago
Today Jan Drenth would have been 100 years, but sadly he passed away last week. He was the founding father of structural biology in the Netherlands and his modesty, his gentle humor and his generosity set the spirit for the amazing environment in Groningen where i did my PhD.
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Jan-Martin Wiarda
11 months ago
Funkstörung Die Zukunft der europäischen
#Forschungsförderung
? Gerade jetzt müsste eine Bundesregierung all ihren europapolitischen Einfluss in die Waagschale werfen. Aber die Deutschen sind mit sich beschäftigt.
#HorizonEurope
In
#ZEITWissen3
und im
#WiardaBlog
:
www.jmwiarda.de/2025/01/27/f...
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Hermann Schindelin
Alison Hoens
11 months ago
The price of open access 🧪https://arxiv.org/abs/2407.16551
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Estimating global article processing charges paid to six publishers for open access between 2019 and 2023
This study presents estimates of the global expenditure on article processing charges (APCs) paid to six publishers for open access between 2019 and 2023. APCs are fees charged for publishing in some ...
https://arxiv.org/abs/2407.16551
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