Our paper on polymyxin interacting with the E. coli outer membrane is out! Simulations by the very talented @dheerajprakaash.bsky.social www.nature.com/articles/s42... To scale outer membrane protein island simulated at coarse-grained resolution with portions refined at all atom resolution.

I had a great time at the @bsacandjac.bsky.social ARM workshop! I met some wonderful scientists and had great discussions about my work! Also, I walked away with a poster prize!! Thanks for organising @friendlymicrobe.bsky.social @conmeehan.bsky.social

Two fully-funded PhD openings in my research group at the University of York. If you’re excited about viromes, phage biology, Nanopore sequencing, soils and the odd bit of alpine or agricultural field sampling, we’d love to hear from you! 🌱🦠🏔️ tiny.cc/c4pv001 tiny.cc/e4pv001

Presenting a collection of projects spanning my time at the University of Otago and Newcastle University was a squeeze, but I think I managed! @avertproject.bsky.social @bsacandjac.bsky.social

Just arrived at the BSAC Antibiotic Resistance and Mechanisms workshop in Birmingham, looking forward to some great talks and discussions over the next two days! @bsacandjac.bsky.social @neharamchandani.bsky.social @taylorwr.bsky.social

Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells. See the original preprint-thread for a summary of our findings. www.nature.com/articles/s41... #microsky

Why does daptomycin resistance appear so fast in Enterococcus? We finally have a clue. DAP resistance in enterococci pops up quickly. What’s been missing is why resistance-associated membrane changes look the way they do, and why the classic path of mutations is so predictable.

New paper out in AAC looking at the development of hyper-tolerance and cross-tolerance to cell wall-targeting antimicrobials via mutations in the mevalonate and Epa biosynthesis pathways and the LiaFSR cell envelope stress response. Check it out here: doi.org/10.1128/aac....